For further information about Volcano and its products, please visit www.volcanocorp.com.Volcano, the Volcano logo, iFR, and Verrata are registered trademarks of Volcano Corporation. instant wave-Free Ratio and CORE are trademarks of Volcano Corporation. Consult instructions for use. 601-0500.39/002

Volcano CorporationCorporate Headquarters3721 Valley Centre Drive, Suite 500San Diego, CA 92130 USAPhone: 800-228-4728Fax: 858-720-0325

Volcano Europe BVBA/SPRLEU Authorized RepresentativeExcelsiorlaan 41B-1930 Zaventem BelgiumPhone: +32 2 679 1076 Fax: +32 2 679 1079

Volcano JapanJapan HeadquartersMita NN Bldg. 24F4-1-23, Shiba, Minato-ku, Tokyo108-0014 JapanPhone: +81-3-6414-8700Fax: +81-3-6414-8701

Verrata® Pressure Guide Wire Quickly Disconnect and Reliably Reconnect

WIRESYSTEMMULTI-MODALITY

• Improved* proximal wire design resists kinks and repels moisture

• Clip connector has multiple back-up contact points for a secure signal

Part Number Description10185 Verrata Pressure Guide Wire, 185 cm, Straight

10185J Verrata Pressure Guide Wire, 185 cm, J-Shape

10300 Verrata Pressure Guide Wire, 300 cm, Straight

10300J Verrata Pressure Guide Wire, 300 cm, J-Shape

435-0100.30 iFR® Modality

CORE01 CORE™ Precision Guided Therapy System

COREmb120 CORE™ Mobile Precision Guided Therapy System

ONE Knowthe Road

iFR Scout™ technology reveals the physiologic profile of the entire

vessel, so when you encounter diffuse disease or serial lesions

you can make informed treatment decisions. Make the shift to

functionally guided treatment with iFR Scout.

and strategically map your approach

CORE™ Precision Guidance System Provides CHOICE to Meet your Needs• CORE™ Control Pad – Touch control in the sterile field

• CORE™ Integrated Precision Guidance System

• CORE™ Mobile Precision Guidance System

• FFR and iFR® Modality Compatible

*Compared to PrimeWire Prestige Plus. Data on file.

Physiology is more than a justification tool. Hyperemia-free iFR Scout™ pullback technology makes it easier to assess physiology before, during and after your procedure.

The iFR Scout™ pullback shows that the vessel is physiologically significant, with areas of focal disease (1 and 2) and diffuse disease(3).

Which areas of the vessel are most physiologically significant?

Simplifying Workflow

iFR Scout™ pullback technology reveals the physiologic profile of the entire vessel.

Providing Choice

• Switch between iFR® and FFR using the same wire, on the same system.

• LIVE iFR® values and Pd/Pa measurements provide real-time physiologic feedback.

Building Evidence

• Over 4000 patients have been studied with the iFR® modality.

• The hybrid iFR®/ FFR approach has a 94.0% match to FFR1 and 65.1% of patients may be spared from hyperemic agents.2The most significant gradient is in the mid-vessel

lesion with diffuse proximal disease.

Plan the Treatment Strategy

After placing two DES in the areas of focal disease, iFR Scout pullback demonstrates a functional gain from 0.85 to 0.92.

Confirm the Result

1. Using the iFR cut points of 0.85 and 0.94 matches best with an FFR ischemic cut-point of 0.80 with a specificity of 90.7% and sensitivity of 96.2%.

2. The ADVISE II study illustrated a 5.8%, i.e. (17+23)/690, classification discordance between the iFR Hybrid Approach and FFR. Among 477 lesions that would be assessed without hyperemia by the iFR Hybrid Approach, 40 (17+23) were due to classification discordance.

3. Escaned J. ADVISE II: A Prospective, Registry Evaluation of iFR vs FFR. TCT 2013. Lecture conducted from San Francisco.

Make the Shift fromJustification to Guidance

iFR Scout™ Pullback Technology

iFR ≤ 0.85Treat

iFR ≥ 0.93Do Not Treat

Hybrid iFR/FFRApproach

iFR Between0.86 and 0.92Perform FFR

1.00

0.95

0.90

0.85

0.805 10 15 20 25 30

1.00

0.95

0.90

0.85

0.805 10 15 20 25 30

iFR®

Distal

0.92

iFR®

Distal

0.85

LIVE iFR® ValuesiFR® Pd/PaPaPd

0.840.90

7870

12:43:47 PM

32

3

2

1

1