One-pot total synthesis of K1 HGF domain
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S. S. a chain. b chain. Hepatocyte growth factor 90 kD. N. K1. K2. K3. K4. 85 Aa. 3 disulfide bridges. K1 weak MET Tyrosine kinase receptor agonist (Holmes, O. J. Mol. Biol. 2007 , 367 , 395) Part of HGF high affinity binding site. One-pot total synthesis of K1 HGF domain. - PowerPoint PPT Presentation
Transcript of One-pot total synthesis of K1 HGF domain
Diapositive 1
One-pot total synthesis of K1 HGF domain
85 Aa3 disulfide bridgesK1K2K3K4Na chainSS
K1 weak MET Tyrosine kinase receptor agonist (Holmes, O. J. Mol. Biol. 2007, 367, 395)Part of HGF high affinity binding site Hepatocyte growth factor 90 kDb chain
Disulfide bonds
Biologically active MET activation, M
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