Olea25® hydroxytyrosol neuroprotect cytoprotect

Olea25® Hydroxytyrosol

Olive Leaf Extract

Neuroprotective Support

Role of Neurodegenerative Prevention

bauerhealthaction.com

The Mediterranean Diet

Health Benefits

Lower mortality rate in countries around the Mediterranean Region.

Major ingredient of the Mediterranean Diet is the Olive and Olive Oil.


Olea25®

Hydroxytyrosol

The Medicinal Value of the Olive Fruit and Leaf (Olea Europaea)

Medicinal and Nutritional Value

Extracts of Olive Leaf have been used for Promoting Health and Preservation for Millennia.

Polyphenol Hydroxytyrosol


https://upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Hydroxytyrosol_structure.png/200px-Hydroxytyrosol_structure.png

Olea25®

Hydroxytyrosol

● Antioxidant

● Anti-inflammatory

● Cardioprotective

● Antitumoral

● Antidiabetic

● Antimicrobial

● Neuroprotective

Health Promoting Properties of

Hydroxytyrosol


Olea25®

Hydroxytyrosol


Bioactive Polyphenol from

Olive Leaf Extract

Polyphenols: Neuroprotective Actions

David Vauzour, “Dietary Polyphenols as Modulators of Brain Functions: Biological

Actions and Molecular Mechanisms Underpinning Their Beneficial Effects,” Oxidative

Medicine and Cellular Longevity, vol. 2012, Article ID 914273, 16 pages, 2012. doi:10.1155

/2012/914273


Modulation of Neuronal Dysfunction by Dietary

Polyphenols

Powerful Antioxidant

Hydroxytyrosol Strongest in vitro

Antioxidant potential

among all the Olive

Polyphenols

Visioli F, Bellomo G, Galli C.. Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys Res Commun (1998)247(1):60–4.10.1006/bbrc.1998.8735

Olea25®

Hydroxytyrosol


OLEA25® Hydroxytyrosol Fights 5 Free Radicals

Description: Olea25 Olive Leaf 25% Hydroxytyrosol Powdertrademark by Certified Nutraceutical, Inc (Certificate of Analysis).


http://www.certifiednutra.com/products_olea25.php

http://www.certifiednutra.com/products_olea25.php

Olea25®

Hydroxytyrosol

Oxidative Stress ⇒ Disease

● Aging● Arteriosclerosis● Cancer● Neurodegenerative

Diseases○ Parkinson’s Disease(PD)○ Alzheimer’s Disease

(AD)

Antioxidant Capacity

15X higher than Green Tea

3X higher than CoQ10.


Olea25® Hydroxytyrosol


Antioxidant

Cancer

Diabetes Mellitus

NeurodegenerativeDisease

CardiovascularDisease


Sources of Polyphenol-Hydroxytyrosol

(3,4-dihydroxyphenylethanol; DOPET)

Exogenous:

Ingestion of Natural Products that contain HT, or it’s precursors.

Endogenous:

Derived from Dopamine Oxidative Metabolism

Olea25®

Hydroxytyrosol


Olea25®

Hydroxytyrosol

● Hydroxytyrosol Promotes the Cells Own Defenses Against Oxidative Stress

● Protects Neurogenesis

● Modulates Mitochondrial Function

Neuroprotective Support


Olea25®

Hydroxytyrosol Imbalance between Reactive Oxygen Species (ROS) Production and Antioxidant Defense System

Neurodegenerative Disease

Causation


Olea25®

Hydroxytyrosol

Alzheimer’s Disease

● Prevents Tau formation● Protects neuronal cells

against toxicity● Prevents Pro-Inflammatory

Cytokines & Immunological Mediators

Reversing Neurodegenerative

Disease


Olea25®

Hydroxytyrosol

● Improved synaptic plasticity

● Down regulates inflammatory activity

● Increases Glutathione “brain antioxidant”

Crosses Blood-Brain Barrier


Olea25®

Hydroxytyrosol

Resistance of Cellular DNA Damage

● Resists Brain Cell Oxidative Stress

● Protects Neuronal Cells

Cytoprotective Effects


Olea25®

Hydroxytyrosol

Attenuates Toxicity

● ROS● Nitric oxide

overproduction● ↓ mitochondrial

membrane potential● ↓ cellular peroxide

formation

Cytoprotective Effects


Olea25®

Hydroxytyrosol ● Mediated by

reduction if oxidative & nitrosative stress

● Reduction in pro-inflammatory interleukin levels

Cytoprotective Mechanisms


Olea25®

Hydroxytyrosol

● Direct Scavenging ROS generated during oxidative stress

● Activates Cellular Signaling Pathways

● Induction of Phase II Detoxifying Enzymes via NrF2 Activation

BiotransformationAntioxidant Properties


Olea25®

Hydroxytyrosol

● Activates NrF2 in tissue beneficial in neurodegenerative disease

● Increases activity of 3 Glutathione related enzymes


Mitochondria Protective

Learn More


http://bauerhealthaction.com/olea25-page/

http://bauerhealthaction.com/olea25-page/

Scientific-based nutraceutical for your clients.

Olive Leaf extract utilizing botanical extraction technology

Olea25™ is manufactured under GMP and ISO Certifications and the quality control system guarantees each item on the certificate of analysis and the traceability from raw material to final extract.


Olea25®

Hydroxytyrosol

Olea25®

Hydroxytyrosol

Applications of Olea25

Hydroxytyrosol

● Nutraceutical

● Skincare

● Beverage

● Functional Foods


Olea25®

Hydroxytyrosol

Distributor and Wholesale Interest: CLICK HERE

● Medical Professional

● Health Care Practitioner

Provide Contact Information Click Here


http://bit.ly/Olea25



Olea25®

Hydroxytyrosol


Contact Information

Randy Bauer


877-925-8444

http://bauerhealthaction.com/

http://bauerhealthaction.com/

Hydroxytyrosol

REFERENCES:

Visioli F, Bellomo G, Galli C.. Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys Res Commun (1998)247(1):60–4.10.1006/bbrc.1998.8735

Feng, Zhihui et al. "Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: regulatory effects of hydroxytyrosol." Free Radical Biology and Medicine 50.10 (2011): 1437-1446.

Schaffer, Sebastian, and Barry Halliwell. "Comment on hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction." Journal of agricultural and food chemistry 59.19 (2011): 10770-10771.

Hashimoto, Tsuneichi, et al. "An endogenous metabolite of

dopamine, 3, 4-dihydroxyphenylethanol, acts as a unique

cytoprotective agent against oxidative stress-induced injury." Free Radical Biology and Medicine 36.5 (2004): 555-564.


Olea25®

Hydroxytyrosol

REFERENCES:

Munoz-Marin, Javier, et al. "Cytoprotective effect of hydroxytyrosyl alkyl ether derivatives after oral administration to rats in a model of glucose–oxygen deprivation in brain slices." Journal of agricultural and food chemistry 60.31 (2012): 7659-7664.

Farr, Susan A., et al. "Extra virgin olive oil improves learning and memory in SAMP8 mice." Journal of Alzheimer's Disease 28.1 (2012): 81-92.

Zheng, Adi, et al. "Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring." The Journal of nutritional biochemistry 26.2 (2015): 190-199.

Rafehi, Haloom et al. "Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis." Genes & nutrition 7.2 (2012): 343-355.


Olea25®

Olea25® hydroxytyrosol neuroprotect cytoprotect

Health & Medicine

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