Okyanos Heart Institute Cardiac Cell Therapy

OKYANOS Heart Institute ©2012 All Rights Reserved

“The stream of that river OKYANOS, whence is risen the seed of all the immortals.”

Homer, Iliad 14.244ff


Evolution of Medicine

Surgery Drugs Devices Stem andRegenerative Cells

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“When someone says they don’t believe in stem cells they don’t understand their own development. We’re walking stem cell products.”

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Epiphany

“You would expect cells that do vascular things to improve blood flow. Bingo, they improve blood flow.”

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Ischemic Conditions

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Stroke

Cardiac

Crohn’s Fistulas

Diabetic Wounds

PVD

Radiation and Other Chronic Wounds


Ischemic Heart Disease

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ADRCs

“Fresh cells from adipose-tissue using the Celution™ system seems to have the most dramatic results of any cell therapy study I have seen in Chronic Ischemic Heart Disease.”

Celution™ is not approved

for use in the U.S.

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PRECISE: Sustained Functional Benefit

MV

O2

(%)

p < 0.05 p < 0.05

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Transplant


Cell Society Feb., 2011

Expected EU-Approval

for No-Option CMI

Providing Cardiac Cell Therapy

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EU Ahead of FDA with Comparable Safety Profile

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EU

FDA

Okyanos Heart Institute ©2012 All Rights Reserved


What Don’t We Know

Optimal # of Treatments

Optimal Delivery Method

Optimal Dosage

Optimal Cell Type

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What We Do Know

Cardiac Cell Therapy is Not (Yet)

a “Cure”

Many Trial Patients Are Living Better &

Longer than Expected

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Patients

Improved

Heart

Function

Reduced

MACCE and

Hospitalization

Better

Quality

of Life

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Center of

Excellence

What Patients Expect

Celution One™

U.S. Surgical Center

Standards

Patient Registry

Hospitality Trained-

Staff

EU-Approved Therapy

(Expected)

State of the Art

Cath Lab

Chief Medical Officer

Next-Gen Catheter

Celution One is not approved in U.S.

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OKYANOS Heart Institute

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First in world to provide an (expected) EU-approved cardiac cell therapy to patients with no-option ischemic heart disease

Autologous Adipose-Derived Stem and Regenerative Cells via intramyocardial injection

Center of Excellence built to OKYANOS specifications and U.S. surgical center standards in Freeport, Bahamas

Expected opening Spring, 2012

OKYANOS Heart Institute

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Okyanos Heart Institute Cardiac Cell Therapy

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