Ohio Bioscience Growth Report2015

Ohio Bioscience Growth Report | 2015

IntroductionThe Ohio Bioscience Growth Report is published by BioOhio, the state’s bioscience membership organization, to communicate the progress of Ohio’s bioscience industry and research endeavors, from ideation and commercialization, to expansion and attraction, using the latest data available. The report is also meant to serve as an educational tool to inform the public about the bioscience industry in Ohio.

The Report presents factual findings analyzing the bioscience sector within the state and its six geographic regions. It describes trends in the bioscience industry and each of its six subsectors: Agricultural Biotechnology, Medical & Testing Laboratories, Medical Device & Equipment Manufacturers, Medical Product Distribution, Pharmaceuticals & Therapeutics, and Research & Development.

To present findings that address the full continuum of products and services in the bioscience industry, additional analysis is provided on the Ohio bioscience supply chain, digital health sector, health care providers, and the state’s robust bioscience-related educational institutions.

Data that provides the foundation of the Report is drawn and analyzed from a wide array of recognized industry and government sources, making this a compendium of Ohio bioscience facts and statistics. Industry trend analysis measuring employment, payroll, average wages, number of locations, number of firms, and economic impact statistics are excerpted from a commissioned study conducted quarterly for BioOhio by The University of Cincinnati Economics Center.

The 2015 Ohio Bioscience Growth Report includes analysis of industry sub-sectors not covered in previous editions; therefore direct comparisons between this report and previous publications are not valid. While past reports remain factual resources, with the added content and refined scope, we think that you will find the 2015 Report even more valuable.

A detailed methodology can be found in the appendix. This report may be accessed online at BioOhio.com/Ohio. Visit the Ohio Bioscience Resource Directory (BioOhio.com/Directory) for profiles of companies in sectors covered by this report.

Questions, comments, suggestions or contributions for future Ohio Bioscience Growth Reports may be directed to BioOhio President & CEO, John F. Lewis, Jr., jlewis@bioohio.com.

On the cover: Adare Pharmaceuticals, Assurex Health, Athersys, Battelle, BioHio Research Park, BioOhio Southwest Ohio Career Fair, ChanTest (a Charles River Company), CTI Clinical Trial and Consulting Services, Eastland-Fairfield Career & Technical Schools, Exsurco Medical, Ganeden, Hardy Diagnostics, Interplex Medical, University Hospitals, Medpace, Meridian Bioscience, NAMSA, The Research Institute at Nationwide Children’s Hospital, NIH NHLBI & BioOhio Innovation Conference, The Ohio State University OARDC & Quasar Energy Group, OhioHealth, PharmaForce, PMC Smart Solutions, SafeWhite, STERIS, University of Cincinnati, US Endoscopy, and Valtronic Technologies.

© BioOhio 2016

Frank Samuel was President of VentureOhio, an organization founded in 2013 to advance entrepreneurial business growth in Ohio. Prior to this position, he was Founding President of the Geauga Growth Partnership, a business-led economic development organization. He was Science and Technology Advisor to Ohio Governor Taft from 2000-2007 when he was a principal architect of Ohio’s Third Frontier program. Frank Samuel worked to advance Ohio’s bioscience community as BioOhio’s second President from 1995-2000. He served on the Board of Directors of the Global Cardiovascular Innovation Center at Cleveland Clinic. Frank Samuel was also the second President of the Health Industry Manufacturers Association, now AdvaMed.

Frank Samuel passed away in October 2014.

In Memory of Frank SamuelBioOhio President 1995-2000

Executive Summary On behalf of BioOhio, our Board of Trustees, and our members, thank you for your interest in Ohio’s bioscience industry.

We are proud to announce that Ohio’s bioscience industry is stronger than ever! The markets remain receptive, financing continues to be available for the development of new products and services, and the entrepreneurial spirit thrives right here in the Buckeye State.

Since 1987, BioOhio has been a reliable and objective source of information concerning not only the successful growth of our industry, but also a trusted guide through some of the business challenges that we face. For example, we continue to examine topics such as the appropriate balance of talent for a specific type of company, are consistently on the lookout for new regulatory issues that may impact Ohio companies, and help connect entrepreneurs to the resources necessary to move their idea toward profitable market acceptance. Again, please allow us to thank you for your support of Ohio’s bioscience industry and to present the 2015 Ohio Bioscience Growth Report.

Today in Ohio, at least 2,391 bioscience-related organizations are manufacturing products, providing essential services, or researching the next breakthrough at 3,115 facilities around the state. This is an increase of 384 locations (14%) in the last five years.

Ranging from the large and well known such as Abbott Nutrition, Battelle, Cardinal Health, Ethicon, Midmark and STERIS, to young and growing companies including Assurex Health, Cleveland HeartLab, and Minimally Invasive Devices, Ohio bioscience firms employ over 68,500 workers. Since 2009, Ohio bioscience employment has increased by 1.4%.

Ohio’s bioscience industry generated $4.83 billion of payroll in 2014, a 15% ($631 million) increase since 2009. Bioscience sector jobs in Ohio paid an average wage of $70,481, encompassing a wide variety of occupations, not exclusively scientists and executives. In comparison, the average wage for all industries in Ohio in 2014 was $44,522.

The bioscience industry’s economic impact is felt throughout the state, with bioscience- related companies found in 81 of 88 Ohio counties. Anchored by Cleveland and Akron, northeast Ohio led the state in the number of bioscience locations with 1,234 locations, 40% of the statewide total. The central and southwest regions followed with 624 (20%) and 580 (19%), respectively. Western Ohio is home to 313 locations, 228 in northwest Ohio, and 136 in the southeast region. Since 2009, all six Ohio regions have experienced growth in the number of locations. In terms of employees, northeast and central Ohio are closely aligned at 32% and 29% of the statewide total.

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Bioscience companies continue to expand operations and announce new facilities in the state. 360 Pharma Group, Abbott Nutrition, Alkermes, Assurex Health, AtriCure, Cardinal Health, CoverMyMeds, Enable Injections, Midmark, Quality Electrodynamics, Siemens Healthcare, and STERIS are all among the many companies that continue to grow in Ohio.

Since 2013, 155 new bioscience-related firms began operations in Ohio. These include start-up companies like Abeona Therapeutics, Genetesis, Cleveland Diagnostics, Eccrine Systems, MedaCheck, and Vesco Medical. Also, many existing firms such as Aprecia Pharmaceuticals, Chromocare, Beam Technologies, Aver Informatics, and Quest Medical Imaging chose to locate their facilities in Ohio.

Ohio-based institutions and companies received $701.6 million from the National Institutes of Health (NIH) in 2015, well ahead of the U.S. average of $470.7 million. Five institutions—Case Western Reserve University, The Ohio State University, Cincinnati Children’s Hospital Medical Center, Cleveland Clinic, and University of Cincinnati—were once again among the nation’s top 100 NIH funding recipients.

Ohio companies attracted over $3.1 billion in funding in 2014, from sources including venture capital, exits, angel investors, federal grants, and state initiatives such as the Ohio Third Frontier. Significant acquisition activity propelled 2015 to record breaking levels, with over $19 billion recorded.

In 2014, Ohioans were issued 3,755 total patents, 895 (24%) of which were bioscience related. Ohio ranks 10th nationally in bioscience-related patents, keeping well ahead of the U.S. average of 458.

Bioscience education continues to thrive in Ohio. In 2013, 9,671 bioscience-related degrees and certificates were awarded to students in Ohio, up a full 50% since 2006. The number of schools with bio programs has also increased, from 85 in 2006 to 108 public and private schools directly impacting the industry in Ohio in 2013.

In the following pages, you will find in-depth discussion of these progress indicators and much more.

Photo: CTI Clinical Trial & Consulting Services

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About BioOhioBioOhio is a non-profit membership organization, founded in 1987, focused on accelerating bioscience discovery, innovation, education, research and commercialization, driving economic growth, and improved quality of life in Ohio.

BioOhio represents nearly 400 members that employ over 100,000 Ohioans - from Ohio’s largest employers to emerging start-ups, schools & universities, research institutions, students, and individuals. BioOhio helps members identify partners, attract investment dollars, save money through affinity purchasing programs, build professional networks, promote news and services, tap into talent sources, support educational programs, and advocate in front of federal, state, and local officials. BioOhio is the Ohio affiliate for global bioscience associations Advanced Medical Technology Association (AdvaMed), Biotechnology Innovation Organization (BIO), Medical Device and Manufacturing Association (MDMA), and Pharmaceutical Research and Manufacturers of America (PhRMA).

To boost connectivity and industry education, BioOhio hosts many events throughout the year. These events provide exceptional networking and partnership building opportunities, with significant collaborations forged at these functions. In addition to the networking, events feature knowledgeable and influential industry speakers. BioOhio events include the BioOhio Annual Conference, FDA Regulatory Forum, Women in Bioscience Conference, Statehouse Day, as well as networking socials, career fairs, member driven strategic webinars, and the ongoing Regulatory 101 series.

BioOhio.com houses the Ohio Bioscience Resource Directory, the most comprehensive source for information about Ohio’s bioscience companies, suppliers, and professional service providers. The website is also home to Ohio bioscience news from around the state.

Photo: Valtronic Technologies

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“Ohio has quietly become a great place for bioscience companies to start, nurture and grow. As BioOhio’s Chairman of the Board and President of a start-up, I have a unique perspective about our state. The exceptional business environment in Ohio is one of the main reasons I chose to join a pharmaceutical start-up here in Dayton. I invite all of you to join the state’s bio community and learn why we say it’s all happening right here in Ohio.”

Mike Sieron, BioOhio Board Chair, President & COO, Patients’ & Consumers’ Pharma

BioOhio Membershipbioohio.com/membership

Everything BioOhio does is driven by member requests, feedback, and suggestions. Together, with our members, BioOhio is focused on the growth and acceleration of Ohio’s bioscience industry.

BioOhio members continuously show proven success and innovation in the areas of medical devices, pharmaceuticals, therapeutics, diagnostics, medical imaging, research, healthcare IT, and education.

You will find employees of member organizations working on breakthroughs in the lab, running manufacturing lines, designing new equipment, performing quality testing, preparing product for distribution, meeting with collaborators, and advocating on Capitol Hill. They are raising money, launching new companies, hiring new employees, running clinical trials, receiving FDA clearance, mentoring local students, and breaking ground for new facilities.

Products and services in the bioscience industry exist to improve quality of life and support the environment. BioOhio members rally behind this goal as a community, with a collective desire to achieve success. They know that if success and growth are achieved, the state, the economy, and ultimately, all of our citizens will experience the benefits.

We thank our members for their support, and encourage you to join the member family and help Ohio’s bioscience community continue to rise and excel.

Contact BioOhio if you need assistance, advice, consulting, referrals, introductions, or just need a friend in the industry. All questions and comments are gratefully accepted.

Photo: University of Cincinnati

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BioOhio Staffbioohio.com/about/staff

John F. Lewis, Jr.President & CEO

Jennifer GoldsberryManager, Member Services & Events

Drew CookProject & Technology Manager

We would like to sincerely acknowledge BioOhio Interns Lauren Reitz and David Sypert, from The Ohio State UniversityCollege of Engineering for researchassistance, BioOhio Members for photo contributions, and Nadia McGaughy for assistance with layout and design.

BioOhio Board of Trusteesbioohio.com/about/board

BioOhio is proud to have a board comprised of some of the most influential leaders in Ohio’s bioscience community. From all corners of the state, representing many business elements within the life cycle of a company, this leadership helps BioOhio and the bioscience industry achieve goals that would otherwise be unattainable.

Mike SieronBioOhio Board Chair, President & COO, Patients’ & Consumers’ Pharma

William S. Ball, MDVice President for Research, Vice President for Health Affairs, Dean of the College of Medicine, Professor of Radiology, Biomedical Engineering and Pedriatrics, University of Cincinnati

Tim Biro, RPH MBAChief Operating Officer, On Target Labs

Susan ColbyDirector of Human Resources, Alkermes

Bill DunlevyBioOhio Board Member

John GorskiPresident & CEO, NAMSA

Mike HoovenPresident & CEO, Enable Injections, Enable Medical Technologies

Peter G. KleinhenzManaging Director, CID Capital, Venture Partner, Fletcher Spaght Ventures

John F. Lewis, Jr.President & CEO, BioOhio

John P. Pigott, MD, FACSMedical Director, ProMedica Innovations, Board-Certified Vascular Surgeon, Jobst Vascular Center and The Toledo Hospital

Aaron PittsManaging Director, Biohealth & Agribusiness, Food Processing, JobsOhio

Gerry ReisSenior Vice President, Government Affairs, STERIS

Gordon RosenberryDirector, State Government Affairs for Johnson & Johnson, Ohio SGA Force Chair, PhRMA

Phyllis H. SarkariaVice President, Human Resources, Quidel

David R. Scholl, PhDPast BioOhio Board Chair, Partner, Athenian Venture Partners

Jennifer SimonDirector, Ohio University Innovation Center

Jon J. SnyderPresident & CEO, Neuros Medical

Caroline C. Whitacre, PhDVice President for Research, The Ohio State University

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Ohio Bioscience Growth ReportIntroductionIn Memory of Frank SamuelExecutive SummaryAbout BioOhio & BioOhio MembershipBioOhio Staff & Board of TrusteesTable of ContentsBioscience in OhioBioscience DefinedOhio Bioscience Economic Impact Trends

- Bioscience Employment- Bioscience Expansions and

AttractionsResearch Indicators

- Bioscience Research & Development- Discovery Drives New Company

Growth- NIH Funding- NSF Funding- SBIR/STTR Funding

Investment Indicators- National Venture Indicators- Ohio Venture Indicators- Ohio Bioscience Exits

Ohio Third Frontier- Impact of the Ohio Third Frontier- Select Bioscience Projects Funded by

the Ohio Third FrontierBioscience Education

- Higher Education- Secondary Education

Ohio Healthcare & Clinical Network- Healthcare and Bioscience- Ohio Healthcare Subsectors- National Rankings

Bioscience Suppliers & Professional Service Providers

Bioscience AdvocacyHealthcare & Life Science IT

- Technology & Research- Medical Records- Patient Wellness- Practice Management & Revenue

Bioscience in Ohio’s Six Regions- Central Ohio- Northeast Ohio- Northwest Ohio- Southeast Ohio- Southwest Ohio- Western Ohio

Concluding Remarks

AppendixBioOhio Member ListBioOhio Partners and Resources for Commercialization, Expansion, and AttractionEngage Ohio! Bioscience EventsMethodology of Economic Impact Analysis

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Table of Contents

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Tables and FiguresTable 1: Ohio’s Bioscience & Healthcare EconomyTable 2: Ohio Bioscience Locations by Subsector (2009-14)Table 3: Ohio Bioscience Firms by Subsector (2009-14)Table 4: Ohio Bioscience Employment, Payroll, Average Wage by Subsector (2014)Figure 1: Employment Momentum by Subsector (2014)Table 5: Bioscience-Related Expansions and Attractions, Announced Projects (2005-15)Table 6: Bioscience-Related Expansions and Attractions, Projected Jobs Created (2005-15)Table 7: Bioscience-Related Expansions and Attractions, Announced Investment (2005-15)Table 8: New Bioscience Companies in Ohio (2004-14)Table 9: Top Ohio NIH Funding Recipients (2014-15)Table 10: Ohio NIH Funding by Region (2014-15)Table 11: Ohio NSF Bioscience Grant Funding Recipients (2014-15)Table 12: Ohio SBIR/STTR Funding (2004-14)Table 13: Ohio Companies Receiving Bioscience SBIR/STTR Grants (2013-14)Table 14: Ohio Bioscience FundingTable 15: Private Investment by Ohio Region (2011-15)Table 16: Ohio Bioscience Private Investment Recipients (2014-15)Table 17: Ohio Bioscience Acquisitions and IPOs (2014-15)Table 18: Ohio Bioscience Graduations, 4 Year, 2 Year, Private-for-Profit (2006-2013)Table 19: Ohio Bioscience Post-Secondary Graduations by Region (2006-13)Table 20: The Ohio Healthcare System (2014)Table 21: Ohio Bioscience Resource Directory by Category and RegionTable 22: Ohio Bioscience Employment, Payroll, Average Wage & Locations by Region (2014)Table 23: Ohio Bioscience Employment by Region (2009-14)Table 24: Ohio Bioscience Locations by Region (2009-14)Table 25: Ohio Bioscience Average Wage by Region (2009-14)Figure 2: Ohio Bioscience Employment Momentum by Region – (2014)Table 26: Bioscience Employment, Payroll, Average Wages & Locations in Central Ohio (2014)Table 27: Bioscience Employment in Central Ohio (2009-14)Table 28: Bioscience Locations in Central Ohio (2009-14)Table 29 Bioscience Average Wage in Central Ohio (2009-14)Table 30: Bioscience Employment, Payroll, Average Wages & Locations in Northeast Ohio (2014)Table 31: Bioscience Employment in Northeast Ohio (2009-14)Table 32: Bioscience Locations in Northeast Ohio (2009-14)Table 33: Bioscience Average Wage in Northeast Ohio (2009-14)Table 34: Bioscience Employment, Payroll, Average Wages & Locations in Northwest Ohio (2014)Table 35: Bioscience Employment in Northwest Ohio (2009-14)Table 36: Bioscience Locations in Northwest Ohio (2009-14)

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Table 37: Bioscience Average Wage in Northwest Ohio (2009-14)Table 38: Bioscience Employment, Payroll, Average Wages & Locations in Southeast Ohio (2014)Table 39: Bioscience Employment in Southeast Ohio (2009-14)Table 40: Bioscience Locations in Southeast Ohio (2009-14)Table 41: Bioscience Average Wage in Southeast Ohio (2009-14)Table 42: Bioscience Employment, Payroll, Average Wages & Locations in Southwest Ohio (2014)Table 43: Bioscience Employment in Southwest Ohio (2009-14)Table 44: Bioscience Locations in Southwest Ohio (2009-14)Table 45: Bioscience Average Wage in Southwest Ohio (2009-14)Table 46: Bioscience Employment, Payroll, Average Wages & Locations in Western Ohio (2014)Table 47: Bioscience Employment in Western Ohio (2009-14)Table 48: Bioscience Locations in Western Ohio (2009-14)Table 49: Bioscience Average Wage in Western Ohio (2009-14)Table 50: NAICS Codes Associated with Ohio’s Bioscience SectorTable 51: NAICS Codes Associated with Ohio’s Healthcare SectorTable 52: Bioscience-Related Degree Programs in Ohio (2013)Table 53: Ohio Institutions Awarding Bioscience-Related Degrees/Certificates (2013)Table 54: Ohio Bioscience Graduations by Region, Four Year Schools (2006-13)Table 55: Ohio Bioscience Graduations by Region, Two Year Schools (2006-13)Table 56: Ohio Bioscience Graduations by Region, Private For-Profit Schools (2006-13)Table 57: Ohio Sources of Capital for Bioscience Commercialization and Expansion (2015)Table 58: Ohio Third Frontier Bioscience-Related Awards (2014-15)Table 59: Ohio Bioscience Expansions and Attractions (2014-15)Table 60: Bioscience Company Origins – Spinouts, Licensing & CommercializationTable 61: Ohio Bioscience Patents (2004-14)Table 62: Ohio Bioscience Patent Classifications

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Bioscience in Ohio Ohio is the 7th largest state in the nation and home to 11.5 million people. Just under half of all Ohioans live in the three largest metro areas: Cincinnati, Cleveland and Columbus.

Ohio has one of the Top 5 business climates in the nation and is 2nd in the nation in both total number of new corporate facility projects and most qualifying projects per capita. The state has a balanced budget with a $1.4B budget surplus, high credit rating, pro-business tax climate, and an increasing number of exports that continue to support economic growth. Ohio is within 600 miles of more than half the U.S. and Canadian populations and is within one day’s drive from more than 60 percent of North America’s manufacturing capacity.

Ohio’s bioscience industry has experienced steady growth fueled by strategic state investments, continued availability of financing options, favorable industry trends, and a qualified workforce.

This report focuses on bioscience business and research occurring in Ohio, including, but not limited to, pharmaceuticals & therapeutics, medical device & equipment manufacturers, research & development facilities, medical laboratories, diagnostic imaging centers, digital health products & services, agricultural products, bio-based materials & fuels, and their respective infrastructures.

Bioscience is also part of a bigger picture, that of Ohio’s overall healthcare economy and ecosystem. Ohio bioscience organizations contribute daily to technological advances benefitting the health and well-being of Ohioans, Americans, and citizens of the world. New drugs and devices developed in Ohio are delivered in hospitals, clinics, and physician offices around the globe. Likewise, ideas that originate among entrepreneurs, doctors, nurses, and other care givers are being connected with resources that can translate them into real products. The connection between inventor and provider is becoming even stronger as innovators must show how their products or services will either drive medical costs down or inject new revenue into the system.

Sector Firms Locations Employees Average Wage

Payroll (Annual)

Bioscience 2,391 3,115 68,577 $70,481 $4,833,371,781

Health and Medical Insurance 101 118 13,399 $63,210 $846,950,790

Healthcare Providers 18,898 27,073 757,166 $45,844 $34,478,902,685

Total 21,390 30,306 839,142 $47,857 $40,159,225,256

Table 1: Ohio’s Bioscience & Healthcare Economy

Photo: University of Cincinnati

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Bioscience Defined The biosciences are a diverse and often converging group of industries and activities with a common link – they apply knowledge to develop biological solutions that sustain, restore, and improve the quality of life for humans, plants, and animals in our world. From life-saving therapies and procedures, to healthier foods or cutting-edge research, you have undoubtedly enjoyed a better quality of life because of bioscience.

Within this report, for data related to economic metrics such as jobs, wages, and number of locations, the bioscience industry is defined by six subsectors: Agricultural Biotechnology, Medical & Testing Laboratories, Medical Device & Equipment Manufacturers, Medical Product Distribution, Pharmaceuticals & Therapeutics, and Research & Development.

Additional analysis is provided on the Ohio bioscience supply chain, Health & Life Science IT, Healthcare Providers including Health and Medical Insurance Carriers, and the state’s robust bioscience-related educational institutions.

Agricultural Biotechnology applies life science knowledge, biochemistry, and biotechnologies to the processing of agricultural goods, organic chemicals as well as biofuels and bio-based materials. Examples of products include: ethanol, biodiesel, bio-based polymers & chemicals, fertilizers, pesticides, herbicides, fungicides, biodegradable materials synthesized from plant-based feedstock, sustainable industrial oils and lubricants, biocatalysts, and feed additives and ingredients.

Medical & Testing Laboratories provide critical analytical and medical imaging services for healthcare providers, as well as drug development and analysis work for pharmaceutical companies and research organizations. Laboratories operate throughout Ohio, many as independent facilities and others as part of national health networks.

Medical Device & Equipment Manufacturers deliver a wide range of products including surgical supplies and instruments, orthopedic implants, hospital equipment, advanced diagnostic imaging systems, electromedical devices, mobility aids, laboratory equipment, and much more. Ranging from simple hand tools to highly complex, computerized devices, this sector utilizes materials and techniques that span the entire manufacturing sector.

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Medical Product Distribution delivers finished products to healthcare providers and patients in the clinical, long term care, and residential settings. Durable medical equipment, mobility aids, respiratory equipment, medications, personal care supplies, home safety equipment, and other goods that enhance and maintain patients’ quality of life all enter the market through this sector.

Pharmaceuticals & Therapeutics represents companies developing and manufacturing medicinal, botanical, and biological products for both therapeutic and diagnostic applications. Pharmaceuticals can be found in a variety of forms, some being well established medicines available at pharmacies in every town and others at the highly experimental stage, just entering clinical trials on their way toward regulatory approval.

Research & Development organizations in Ohio work to advance new discoveries and translate research into products, treatments, and services. This sector includes a wide range of organizations and private companies that include contract research organizations, clinical trial facilities, as well as many start-ups and entrepreneurs. Bioscience research is thriving within academic institutions and health systems, with many groundbreaking concepts being developed by teachers, physicians and caregivers.

Bioscience Education Institutions can be found across Ohio, providing instruction at all levels from middle school through advanced degrees. Through intensive STEM education, specialized programs, industry partnerships, and especially the involvement of dedicated teachers, student interest in the biosciences continues to grow.

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Healthcare & Life Science IT companies develop software and technology to expand the capabilities of the bioscience industry, reduce healthcare costs, and improve patient care across the state. BioOhio has identified four categories as focus areas within the field: Technology & Research, Medical Records, Patient Wellness, and Practice Management & Revenue.

Healthcare Providers are a key component of the state’s biomedical infrastructure. While offering both routine and lifesaving care, hospitals and providers around Ohio also participate in cutting edge research through clinical trials and laboratory research that enable new discoveries for patients around the world.

Health and Medical Insurance Carriers are a critical component to the patient-provider relationship by offering plans that cover or supplement patients’ dental, health, and medical expenses. Many insurers also offer wellness programs that encourage healthy lifestyles and reduce the need for medical procedures or readmissions.

Suppliers and Service Providers range from firms that provide key materials or ingredients to those that manufacture, assemble, package, and distribute products—including many that are ISO 13485 certified to manufacture medical devices and equipment. Service oriented companies include firms providing first class resources in the areas of regulatory and reimbursement, pre-clinical and clinical assessment, product design, quality assurance, engineering, sales and marketing, legal counsel, IT, training, and more.

Photos: BioHio Research Park, Chromocare, AtriCure, STERIS Corporation, Athersys, Battelle, University of Cincinnati ProPEL, The Research Institute at Nationwide Children’s Hospital, BioMotiv, Sequent, Criterion Tool

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Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 130 128 123 117 120 126

Medical & Testing Laboratories 981 948 908 820 820 825

Medical Device & Equipment Manufacturers 442 442 469 434 442 453

Medical Product Distribution 991 989 1,017 907 870 855

Pharmaceuticals & Therapeutics 43 41 41 38 31 31

Research & Development 528 525 532 463 450 441

Total 3,115 3,073 3,090 2,779 2,733 2,731

Table2:OhioBioscienceLocationsbySubsector(2009-14)

Ohio Bioscience Economic Impact TrendsBioscience EmploymentTrends were analyzed between the years 2009 and 2014 using five measures: employment, payroll, average wages, number of locations, and number of firms. To conduct the analyses for this report, a data set of Ohio businesses was created by the University of Cincinnati Economics Center using the Quarterly Census of Employment and Wages (QCEW or ES202) database based on BioOhio’s NAICS-based industry definition.

Statewide, across all industries including the bioscience sector, Ohio employed 5,110,871 individuals, earning an average wage of $44,522 at 271,510 locations operated by 208,561 unique firms.

The study reveals at least 2,391 bioscience-related firms were operating 3,115 total locations in Ohio through the third quarter of 2014. This is an increase of 384 locations (14%) compared to 2009.

These organizations range from Fortune 500 corporations to entrepreneurial startups. Ohio’s pillar bioscience companies include Abbott Nutrition, Adare Pharmaceuticals, AstraZeneca, Battelle, Cardinal Health, Ethicon, Hikma Pharmaceuticals, Invacare, Lubrizol, Medpace, Meridian Bioscience, Midmark, NAMSA, Parker Hannifin, PharmaForce, Philips Healthcare, PRASCO, Procter & Gamble Health Care, STERIS, TEVA Pharmaceuticals, Vancive Medical Technologies, WIL Research, and many others.

Emergent bioscience organizations in Ohio continue to attract market and investor attention. Among these are Abeona Therapeutics, Assurex Health, Chromocare, Cleveland HeartLab, CoverMyMeds, GenomeNext, HealthSpot, Macrophage Therapeutics, Microbial Robotics, Milo Biotechnology, P&C Pharma, and dozens more. Innovative companies like these are the lifeblood of Ohio’s bioscience industry.

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Subsector Employment Payroll (Annual) Average Wage Locations

Agricultural Biotechnology 7,378 $636,270,026 $86,243 130

Medical & Testing Laboratories 13,239 $667,876,542 $50,448 981

Medical Device & Equipment Manufacturers

11,426 $578,006,330 $50,587 442

Medical Product Distribution 15,201 $1,089,758,802 $71,690 991

Pharmaceuticals & Therapeutics 4,865 $455,625,830 $93,654 43

Research & Development 16,469 $1,405,834,251 $85,364 528

Total 68,577 $4,833,371,781 $70,481 3,115

Table4:OhioBioscienceEmployment,Payroll,AverageWage&LocationsbySubsector(2014)

In 2014, direct employment in Ohio’s bioscience sector was 68,577, an increase of 950 jobs (1.4%) since 2009. It should be noted that from 2013 to 2014, bioscience employment in Ohio dropped by over 1,000 due largely to the closure of Boehringer Ingelheim’s Ben Venue Labs in Bedford, which housed 1,100 employees.

The bioscience sector in Ohio had a payroll of $4.83 billion in 2014, up 15% ($631 million) compared to 2009. Bioscience sector jobs paid an average wage of $70,481 in 2014, encompassing all bioscience subsectors and all occupations, not just scientists and executives. Wages in the bioscience sector have increased by 13.4% compared to 2009. In comparison, the bioscience sector paid, on average, nearly $26,000 more than the statewide average of $44,522.

The total number of bioscience locations increased in five out of six subsectors between 2009 and 2014. The largest gain was in Medical & Testing Laboratories, which opened 156 new locations in the study period. Over 60% of Ohio’s bioscience locations fit into two

Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 101 99 96 90 92 95

Medical & Testing Laboratories 565 564 569 517 514 533

Medical Device & Equipment Manufacturers 409 408 428 396 403 416

Medical Product Distribution 816 807 834 728 710 699

Pharmaceuticals & Therapeutics 42 36 37 35 30 30

Research & Development 458 453 463 396 388 380

Total 2,391 2,367 2,427 2,162 2,137 2,153

Table3:OhioBioscienceFirmsbySubsector(2009-14)

Photo: Interplex Medical

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Figure1:EmploymentMomentumbySubsector(2014,Q3)

3.50%

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1.50%

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-1.00%

-1.50%

-25.00% -20.00% -15.00% - 10.00% - 5.00% 0.00% 5.00% 10.00%

Improving Expanding

Contracting Slipping

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AgriculturalBiotechnology

Medical and Testing Laboratories

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Year over Year Growth

subsectors. Medical Product Distribution companies operated 991 locations (31.8% of total), creating a vital connection between manufacturers and end users, patients and providers. Medical & Testing Laboratories accounted for 981 locations (31.5% of total), putting medical discovery into practice to provide critical analysis for researchers and healthcare providers.

Within the study period, the following subsectors saw an increase in direct employment: Agricultural Biotechnology (391 employees, 5.6%), Medical and Testing Laboratories (308 employees, 2.4%), and Research and Development (637 employees, 4%). Relatively small losses were felt by the Medical Device and Equipment Manufacturers (22 employees, 0.2%) and Medical Product Distribution (96 employees, 0.6%) subsectors. Pharmaceuticals and Therapeutics saw the largest reduction in the study period (268 employees, 5.2%) due largely to the closure of one facility with 1,100 employees.

In 2014, the Research & Development subsector employed the most workers (16,469), which accounted for 24% of Ohio’s total bioscience employment. Next in line was Medical Product Distribution with 15,201 (22%) and Medical and Testing Laboratories with 13,239 (19%).

The Research & Development subsector had the largest payroll ($1.4 billion) while the largest average wage was paid by firms in Pharmaceuticals & Therapeutics ($93,654). Despite having the smallest average wage ($50,448), the Medical and Testing Laboratories subsector still exceeds the statewide average.

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ChanTest (a Charles River Company)

Abeona Therapeutics

Battelle

Valtronic Technologies

LexaMed

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Bioscience Expansions and AttractionsBioscience has been identified as one of the state’s key subsectors. Economic development organizations including JobsOhio, the Ohio Development Services Agency, and regional partners prioritize support for bioscience companies that seek to expand in Ohio or establish facilities in the state.

Expansion and attraction data analyzed in this report is sourced from company information, media announcements, and data released by JobsOhio and the Ohio Development Services Agency. Projected figures related to job growth and capital investment may vary with time as projects move forward.

A significant number of Ohio’s new sites and expansions originate in the bioscience sector. Between 2005 and 2015, 542 bioscience expansions or new facilities have been announced in Ohio. In 2014-15, 77 projects were announced, which together are projected to create 3,239 new jobs, retain an additional 1,972 jobs, and invest $1.1 billion in capital over the next several years.

Ohio continues to be a leading state in business expansion. Since 2006, Ohio has been ranked first or second nationally by Site Selection magazine for having the most new or expanded capital projects.

Inc. magazine’s annual ranking of the fastest-growing private companies in the United States, the Inc. 5000, recognized numerous Ohio bioscience and health IT companies, including: Advocate Radiology Billing, Alpha Imaging, Assurex Health, BioRx, EnviroScience, Bravo Wellness, CoverMyMeds, Echo Health, EnvisionRx, ESD, ExactCare Pharmacy, Hyland Software, Nanotronics Imaging, Quantum Health, Updox, and Wellness IQ.

Below are examples of recent growth with additional details available in the appendix (Table 59).

Abbott Nutrition’s $270 million nutritional product manufacturing facility in Tipp City, just north of Dayton, opened in 2015. Projected to employ 240 workers, the facility produces two of the company’s fastest-growing adult brands, Ensure and Glucerna, at a rate that could approach more than one million bottles a day.

Pennsylvania-based Aprecia Pharmaceuticals announced in early 2015 it would move manufacturing operations to Blue Ash, investing $25M to customize a facility constructed by Forest Pharmaceuticals. Aprecia’s platform technology, ZipDose, is a 3D printed drug delivery product that received its first approval from the FDA in December 2014.

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Cardinal Health, one of Ohio’s largest employers, added 400 new employees in 2014 through organic growth. Headquartered in Dublin, Ohio, Cardinal has also grown through acquisitions; most notably Edgepark Medical Supplies of Twinsburg, Ohio in 2013 for $2B, as well as numerous others around the country including Cordis, Metro Medical Supply, Harvard Drug Group, OutcomesMTM, and naviHealth.

In November of 2015, AtriCure celebrated the grand opening of their new 85,000 square-foot headquarters in Mason, Ohio that will house up to 400 employees with ample room to expand further. In October 2015, the company announced the acquisition of nContact, a North Carolina company developing innovative cardiac ablation solutions that will complement AtriCure’s own atrial fibrillation treatment products.

Aver Informatics and Beam Technologies both chose Central Ohio as their new homes thanks to investment from Columbus-based Drive Capital. Aver Informatics of Green Bay, Wisconsin is a health IT company focused on solutions for the healthcare revenue cycle. Beam Technologies, originally from Kentucky, is a consumer wellness and dental insurance company in market with toothbrushes linked to apps for monitoring oral health.

Bocchi Laboratories of California, a contract manufacturer specialized in personal care products, is opening a $20 million facility projected to bring 300 jobs to New Albany, Ohio in the areas of management, engineering, logistics and production.

Siemens Healthcare announced in late 2014 that it was investing heavily in an increased presence in northeast Ohio. The company plans to move a medical imaging headquarters to the Cleveland area, while also spending $2 million on the creation of a facility to be located in the city’s Global Center for Health Innovation.

Assurex Health, makers of GeneSight, a genetic test that assists healthcare providers personalize patient treatments, has also seen rapid growth in recent years. In April of 2015, Assurex Health announced investment of $15 million in a new headquarters to be located in Mason, Ohio to house more than 300 employees.

Abeona Therapeutics, which went public in 2015, is developing potential cures for the deadly childhood disease Sanfilippo Syndrome, and Columbus-based CoverMyMeds, a benefits investigation provider that helps physicians and pharmacists complete coverage determinations, both announced opening of new offices in the Cleveland area.

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Region Total 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005

Central 100 4 9 3 10 15 17 16 7 4 11 4

Northeast 204 7 15 7 15 31 28 23 31 21 16 10

Northwest 59 3 10 3 6 7 6 6 7 6 5

Southeast 20 1 3 1 4 2 1 3 2 3

Southwest 102 5 12 1 10 19 17 13 7 6 8 4

Western 57 2 6 1 10 4 7 14 4 1 5 3

Total 542 22 55 15 46 79 78 73 55 42 48 29

Table5:Bioscience-RelatedExpansionsandAttractions,AnnouncedProjects(2005-15)

Region Total 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005

Central 6,552 203 905 200 1,069 571 1,142 600 335 874 495 158

Northeast 8,517 301 730 413 836 1,031 1,459 999 858 1,040 621 229

Northwest 1,206 27 228 24 72 85 1 137 383 169 80

Southeast 853 209 96 21 116 70 88 253

Southwest 7,152 370 184 30 412 1,289 841 381 1,805 985 108 747

Western 2,836 15 67 15 525 82 506 625 464 40 385 112

Total 27,116 916 2,323 682 2,842 3,141 4,054 2,722 3,599 3,392 1,866 1,579

Table6:Bioscience-RelatedExpansionsandAttractions,ProjectedJobsCreated(2005-15)

Region Total 2015 2014 2013 2012 2011

Central $1,116.5 1.5 46.2 13.6 94.09 53.54

Northeast $1,139.98 48.75 48.67 58.83 106.24 118.16

Northwest $1,176.32 0.79 88.85 29 93.5

Southeast $829.55 427.65 6.2

Southwest $1,511.35 359.5 68.6 50 37.48 116.78

Western $899.08 4 18.2 5.4 341.5 8.5

Total $6,672.77 414.54 698.17 156.83 579.31 396.67

Table7:Bioscience-RelatedExpansionsandAttractions,AnnouncedInvestment(2005-15)

Region 2010 2009 2008 2007 2006 2005

Central 159.13 343.6 55.2 184.6 149.75 15.3

Northeast 112.72 212.1 105.7 68.78 201.94 58.11

Northwest 134.2 40.9 38.6 522 151.6 76.88

Southeast 10 1.9 122.6 176.6 84.6

Southwest 96.94 39.45 51.64 412.58 44.96 233.43

Western 32.29 90.21 40.57 8.5 341.9 8.01

Total 545.28 728.16 291.69 1,319.06 1,066.74 476.32

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Athersys

Balance (ElectroSonics, Navage)

Meridian Bioscience

Airway Therapeutics

NITTO DENKO Avecia

Jalex Medical

Minimally Invasive Devices

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Research IndicatorsBioscience Research & DevelopmentThrough discovery and innovation, bioscience research is critical to the health and well-being of our state and our nation. It is also an important source of income and job creation. Research programs are in operation throughout the state at a variety of organizations that include universities, health systems, and private companies, all contributing to Ohio’s health and prosperity every day.

To more easily address the vast landscape of the research and development field, BioOhio and key partners have categorized specific groups within the sector: Academic & Non-Profit Institutions, Clinical Trial Facilities, Clinical Research Support, Contract Research Laboratories, Contract Research Organizations, and Device Design & Development. While some organizations operate within multiple sectors, each area of bioscience R&D has unique attributes.

Academic Institutions provide a critical role in Ohio’s bioscience industry by providing education to students entering the field, while also performing research in some of the state’s most advanced facilities. Universities and medical schools often receive grants from private foundations, the National Institutes of Health, and the National Science Foundation, among others, to support research conducted by faculty and postdoctoral researchers. Collaboration between the academic sector and private industry, often encouraged by programs such as the Ohio Third Frontier, has led to much advancement in bioscience. In recent years, many Ohio universities have expanded R&D capabilities with new facilities, technology, and an internal focus on promoting discovery.

Clinical Trial Facilities operate as stand-alone entities focused exclusively on clinical research, as well as embedded programs within existing health systems, hospitals, and clinicsperforming research alongside delivery of care to patients. Clinical trials are sponsored by private researchers, companies, and government agencies with the aim of proving the safety and effectiveness of new discoveries intended to improve quality of life. Clinical Trial Facilities operate in highly regulated conditions with strict adherence to protocols determined by study sponsors, and are often overseen by independent monitors.

Clinical Research Support companies provide professional services to augment and bolster clinical trial efforts being performed by study sponsors, clinical trial facilities, and contract research organizations. Clinical trial/study sponsors seek out firms in this group for assistance with biostatistics, data management, study monitoring & management, protocol development, medical writing, safety reporting, and project management among many other key services.

Contract Research Organizations and Contract Research Laboratories offer outsourced research and development services to companies in the pharmaceutical, medical device, biotech, chemical, agricultural, veterinary, food, and consumer products markets.

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Highly specialized, targeted services are tailored to clients’ needs in such areas as investigational drug development, medicinal chemistry, compound evaluation & synthesis, formulations, biocompatibility, efficacy modeling, toxicity, and safety testing.

Device Design & Development companies provide critical engineering and design services to medical device companies. Inventors turn to companies in this space for specific, technical capabilities that bring their concepts to reality, and, ultimately, to the market. Concept modeling, design for manufacture, prototyping, material & supplier selection, aesthetic development, graphic design, regulatory assistance, quality controls, and risk assessment are just a few of the services typically available from firms in this group.

Ohio’s Hospitals and Healthcare Providers have long been an essential interface between the bioscience industry and implementation of clinical and laboratory research. Many institutions have added to their role in the R&D pipeline by supporting creative ideas developed by doctors, nurses and other employees. Being on the front lines of care delivery, practitioners are ideally suited to explore new methods and technologies to improve patient well-being. Numerous adult and children’s hospitals in Ohio have deployed commercialization programs that seek to market discoveries made by clinicians and create exciting collaborations with private industry.

Discovery Drives New Company GrowthNew bioscience companies, either homegrown or attracted from outside Ohio’s borders, can be found in every region of the state. BioOhio tracks new company formations and attractions from within the scope of the bioscience sectors, as well as emergent companies in health & life science IT, specialized manufacturers, and bioscience focused service providers.

From 2004-2014 at least 1,148 new firms began operations in Ohio’s bioscience industry - an average of 104 each year. These include both start-up companies and those that established their first facilities in Ohio. Significant lag can be experienced in reporting company formations; consequently, figures for the most recent years do not fully reflect growth.

New company growth is seen in each of Ohio’s six regions, the highest number being associated with the northeast region (502), followed by central (274) and southwest (206) Ohio.

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Table8:NewBioscienceCompaniesinOhio(2004-14)Region Total 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004

Central 274 28 18 25 19 32 23 31 18 26 28 26

Northeast 502 27 28 48 37 42 52 69 62 51 42 44

Northwest 206 9 13 15 11 18 33 23 23 19 19 23

Southeast 31 2 3 4 5 6 1 3 4 3

Southwest 68 1 3 6 11 7 6 9 1 9 6 9

Western 67 1 5 9 2 5 7 12 5 9 6 6

Total 1,148 68 67 106 84 109 127 145 112 114 105 111

Many of Ohio’s most innovative bioscience companies have their origin in research performed within the university or healthcare system. In every region of Ohio, forward thinking institutions have encouraged a culture of discovery within their organizations, making the transition from research solely focused on publishing, to a goal of commercializing new technologies.

Existing bioscience companies are also heavily vested in ongoing research and development to advance current products through regulatory approval, create new pipeline products, or build upon platform technologies. Often this research reaches a stage that merits creation of a new company to guide discoveries to market.

Spinouts and technology licensing deals, from academic and commercial sectors, account for at least 300 company starts since 2000. While a detailed look at company origins can be found in the appendix (Table 60), the following are examples of spinouts and licensing in Ohio:

Abeona Therapeutics (Nationwide Children’s Hospital, now publicly traded) Akebia Therapeutics (P&G Pharmaceuticals, now publicly traded) Apollo Medical Devices (Case Western Reserve University) Apto Orthopaedics (Austen BioInnovation Institute in Akron, Akron Children’s Hospital) Assurex Health (Cincinnati Children’s Hospital Medical Center, Mayo Clinic) Biosortia Pharmaceuticals and Biobent Polymers (Univenture) Blue Ash Therapeutics (P&G Pharmaceuticals) Centerline Biomedical (Cleveland Clinic) Compass Biomedical (Arteriocyte) Crystal Diagnostics (Kent State University, NEOMED) Explorys (Cleveland Clinic, acquired by IBM Health) Exsurco Medical (Bettcher Industries) Kinnear Pharmaceuticals (N8 Medical) Minimally Invasive Devices (OhioHealth) Nanofiber Solutions (The Ohio State University) Oralectrics (Biolectrics) OsteoNovus (The University of Toledo) TempTraq (Blue Spark Technologies)

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Creation of new companies is by no means limited to growth from within existing organizations. Numerous company formations also come from independent inventors, researchers, scientists, students, clinicians, and other inspired individuals that become entrepreneurs seeking to commercialize their creations.

Ohio has a strong network of business assistance organizations ready to support and guide entrepreneurs, regardless of their origins, from stealth-stage startup to a well-honed operation positioned for market entry. Business incubators, accelerators, development centers, and industry organizations, all with specific bioscience-related experience, can be found across the state. Details on these resources can be found in “BioOhio Partners andResources for Commercialization, Expansion and Attraction” located in the appendix.

For inventors of newly discovered intellectual property, securing legal protection to prevent others from making, using, selling, or otherwise infringing on their rights is the purview of the United States Patent and Trademark Office (USPTO). In 2014, Ohioans were issued 3,755 total patents, 895 (24%) of which were bioscience related. Ohio ranks 10th nationally in bioscience-related patents, well ahead of the U.S. average of 458. Ohio has recorded 25,519 bioscience-related patents since 1963, the oldest year of data available for this report. Additional detail on bioscience-related patent types and yearly totals can be found in the appendix, (Tables 60 and 61).

NIH FundingFunding from the National Institutes of Health (NIH) has long been essential to research and development in the life sciences, providing support for discoveries at Ohio’s academic research institutions and private companies, that could one day change people’s lives. The NIH is made up of 27 Institutes and Centers, each with a unique research focus. Areas of study include cancer, vision, heart health, genome research, alcohol & drug abuse, infectious diseases, medical imaging, diabetes, environmental health, and much more.

55 Ohio institutions and companies received $633.2 million from the National Institutes of Health in 2014. $701.6 million was awarded in 2015 to 50 Ohio organizations. The national average rose in 2015 to $470.7 million from $431.9 million in the previous year.

Ohio’s NIH awards ranked 10th in the nation in both 2014 and 2015 and Ohio’s top five NIH award recipients have retained their positions among the leading 100 nationally. Among nearby states, Ohio’s 2015 NIH funding surpassed Michigan ($634.6 million) and Indiana ($219.5 million), but trails ninth-ranked ranked Illinois ($753.9 million).

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2014 2015

Region Awards Funding Awards Funding

Central 429 173.64 504 226.3

Northeast 614 268.76 654 286.81

Northwest 51 14.84 41 12.28

Southeast 14 4.37 7 1.98

Southwest 409 163.37 426 165.16

Western 19 8.22 25 9.07

Total 1,536 633.22 1,657 701.59

Table10:OhioNIHFundingbyRegion(2014-15,inmillions)

2014 2015

Organization Awards Funding (millions) Awards Funding

(millions) Region

Case Western Reserve University 348 158.76 366 160.02 Northeast

The Ohio State University 337 131.48 363 136.13 Central

Cincinnati Children's Hospital Medical Center & Research Foundation

257 100.27 261 100.53 Southwest

Cleveland Clinic Lerner College of Medicine, Case Western Reserve University

195 80.95 210 95.45 Northeast

University of Cincinnati 139 59.33 151 60.04 Southwest

Battelle 14 8.22 43 46.03 Central

The Research Institute at Nationwide Children'sHospital

61 25.86 78 31.13 Central

Wright State University 17 7.05 24 8.21 Western

The University of Toledo Health Science Campus 34 9.93 27 7.94 Northwest

Northeast Ohio Medical University (NEOMED) 23 6.7 21 7.24 Northeast

Navidea Biopharmaceuticals 3 2.05 7 4.6 Central

Clinical Research Management 2 0.7 13 3.85 Northeast

International Chemical Workers Union Council 2 2.89 3 3.1 Northeast

Columbus Nanoworks 2 2.99 Central

Miami University 8 2.11 9 2.63 Southwest

The University of Toledo 8 2.58 7 2.37 Northwest

SPR Therapeutics 1 1.53 3 2.32 Northeast

Cleveland Clinic Foundation 1 2.17 Northeast

University of Akron 2 0.71 5 2.06 Northeast

Ohio University 14 4.37 7 1.98 Southeast

Table9:TopOhioNIHFundingRecipients(2014-15)

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NSF FundingThe National Science Foundation’s (NSF) Directorate for Biological Sciences supports research activities that advance the understanding of biological knowledge. The agency operates a variety of programs designed to promote research collaboration and discovery related to biological molecules, cells, tissues, organs, organisms, populations, communities, and ecosystems.

The National Science Foundation’s Directorate of Biological Sciences awarded $11.95 million in grants to Ohio-based organizations in FY2014, down from $15.8 million in FY2013. For the first time since 2006, Ohio’s FY2014 awards fell below the national average of $14.8 million.

Preliminary data for 2015 NSF grants to Ohio bioscience institutions shows a moderate resurgence in funding with $14.6 million directed to research projects in the state. This data shows only 59 awards in 2015, compared to 71 in the previous year.

“Our state relies on NIH grants for a significant amount of its research and development in academic institutions, private industry and small and growing businesses. Without sufficient funding to the NIH, discoveries produced by Ohio’s bioscience sector will suffer, which means the health of every Ohioan and Ohio’s economy will suffer as well.

Yet the NIH continues to face cuts. After remaining more or less steady for a decade, the number of investigators with NIH funding dropped sharply in FY2014 by between 500 to 1,000 researchers and it occurred the same year that the NIH’s budget took a 5% cut. That year, the NIH’s budget plummeted $1.55 billion due to sequestration. As we enter into the appropriations process for FY2016, we encourage lawmakers to consider these dire cuts and how they impact Ohio’s economy, the biosciences sector that fuels so much innovation and job creation for the state, and of course, the medical advancements needed to address cancer, Alzheimer’s, trauma care, paralysis and so many other conditions affecting tens of millions of Americans.”

Excerpt from a BioOhio letter to Ohio’s Congressional Delegation, June 2015 http://www.bioohio.com/bioohio-letter-to-congress-nih-support-june-2015/

Photo: Athersys

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SBIR/STTR FundingThe U.S. Small Business Administration’s Technology Program Office administers the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These competitive programs are open to small, high-tech, and innovative businesses to support their research and development efforts. Many federal departments, such as the NIH, NSF, and Department of Defense, participate in the SBIR and STTR programs.

SBIR and STTR funding is widely considered a leading indicator of the amount of new technology approaching commercialization. Receipt of a grant from the SBIR and STTR also serves as validation that can strengthen a company’s position for future investment from the private sector. Since 2000, the SBIR/STTR program has contributed $239 million to biosci-ence innovation in the state, representing 22% of the state’s $1.09 billion in total grants from the program.

In 2014, Ohio companies collectively received $78 million in grants, of which $20.9 million was bioscience related. While not record-setting, 2014 funding was the fourth highest since 2000 and is much improved over the previous year. In 2013, the total awarded to Ohio companies was only $58.9 million, the lowest level since 2001’s $46 million. For the bioscience sector only, 2013’s $11.5 million was the lowest since 2004 when bioscience companies were awarded $8.66 million.

Table11:OhioNSFBioscienceGrantFundingRecipients(2014-15)2014 2015 (Preliminary)

Organization Funding Awards Funding Awards

The Ohio State University $5,225,000 25 $8,493,000 26

Case Western Reserve University $1,277,000 7 $517,000 2

Miami University $932,000 8 $811,000 6

Oberlin College $693,000 3 $165,000 2

University of Cincinnati $582,000 8 $2,164,000 7

Kent State University $567,000 3 $290,000 3

University of Dayton $527,000 1 $6,000 1

Wright State University $322,000 3

Cleveland Museum of Natural History $306,000 1

The University of Toledo $300,000 1 $357,000 2

University of Akron $296,000 3 $193,000 1

The Research Institute at Nationwide Children's Hospital $255,000 1

Cleveland Clinic Foundation $245,000 1 $433,000 2

Ohio University $243,000 3 $768,000 4

Bowling Green State University $159,000 2 $270,000 1

Denison University $46,000 1

Individual Award $138,000 1

Northeast Ohio Medical University (NEOMED) $21,000 1

Total $11,950,000 71 $14,649,000 59| 27

Table13:OhioCompaniesReceivingBiosienceSBIR/STTRGrants(2013-14)

Affinity Therapeutics Imaging Systems Technology NovelMed Therapeutics

APTO Orthopaedics Integrated Sensors Orbital Research

Arteriocyte LARAD P2D Bioscience

Athersys LeadScope PeriTec Biosciences

Cleveland Medical Devices LEVOS Premix

Columbus Nanoworks Linda and Cameron, Inc. Rashmivu

Core Quantum Technologies Meridian Life Science ReXceptor

Cornerstone Research Group MesoCoat Siloam Biosciences

Faraday Technology Metallopharm SPR Therapeutics

General Innovations and Goods Microbial Robotics Sterionics

GLC Biotechnology MetaMateria Technologies Thermalin Diabetes

Great Lakes Neurotech Nanofiber Solutions Think-A-Move

Guild Associates Navidea Biopharmaceuticals UES

H & N Instruments NeoGene BioSciences

Hyper Tech Research NeuroWave Systems

Year Bioscience Awards Ohio Total Percent Bio

2000 8.49 46.58 18%

2001 5.30 45.98 12%

2002 16.12 59.08 27%

2003 13.32 70.89 19%

2004 8.66 70.64 12%

2005 17.63 85.30 21%

2006 22.13 89.65 25%

2007 14.86 74.00 20%

2008 17.43 74.01 24%

2009 18.64 65.39 29%

2010 14.37 99.99 14%

2011 23.24 83.20 28%

2012 26.98 89.77 30%

2013 11.55 58.87 20%

2014 20.92 77.98 27%

Total 239.65 1,091.33 22%

Table12:OhioSBIR/STTRFunding(2004-14,inmillions)

When possible, awards that are reported by multiple agencies, such asthe NIH, are removed from the figures above to avoid duplication.

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Investments IndicatorsInstitutional, award-based funding avenues that include the Small Business Administration’s SBIR/STTR programs, Ohio Third Frontier, National Science Foundation, National Institutes of Health, Congressionally Directed Medical Research Program, and a variety of private foundations and grant-making organizations have long been a valuable funding resource for Ohio’s bioscience organizations. Strong company growth has also been driven by angel investors, venture funding, and capital from investor exits, liquidation events such as initial public offerings (IPOs) and strategic corporate acquisitions.

Combining both private and public funding sources, over $41.7 billion has been invested in Ohio’s bioscience industry since 2007.

2014 was an excellent year overall, with over $3.1 billion invested across Ohio to accelerate bioscience growth. Significant acquisition activity has propelled 2015 totals to record breaking levels, with over $19 billion recorded.

Table14:OhioBioscienceFunding(inmillions)

Funding Source 2015 2014 2013 2012 2011 Total (2007-15)

Private Investment 410.25 576.76 544.18 310.07 225.24 3,048.35

Exits (Acquisitions & IPOs) 17,961.5 1,642.9 2,074.5 647.90 1,345.3 30,860.98

Ohio Third Frontier (OTF) 16.1 69.11 17.55 21.48 52.94 389.61

OTF Matching Corporate Funds for Biomedical Partnerships

16.1 188.11 17.55 21.48 54.32 527.85

NSF Bioscience Grants 14.65 11.95 15.83 18.65 14.77 143.51

NIH Institutional Grants 701.59 633.2 685.3 707.6 710.99 6,536.16

SBIR/STTR Funded Bioscience Awards

20.9 11.55 26.98 23.24 147.97

Congressionally Directed Medical Research Program

8.26 14.67 7.01 13.15 92.67

Therapeutic Discovery Program 15.91

Total 19,120.19 3,151.18 3,381.13 1,761.17 2,439.95 41,763.01

SBIR/STTR totals exclude awards also found NIH data sets. 2015 NSF, SBA, CDMRP, OTF data unavailable or incomplete. 2015 Exit data includes a significant outlier, the $12.9B acquisition of Omnicare by CVS.

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National Venture IndicatorsAccording to the 2015 Annual U.S. Private Equity Breakdown Report issued by PitchBook1, “Today’s market is founder-friendly. Investors have a healthy amount of capital to use and are putting it to use; the $59 billion invested in 2014 was the highest amount since the dotcom era. Those well-capitalized companies are waiting longer to go public, and in some cases are increasing their burn rates, confident that if they need future financing it will be easily available. To startups and VCs alike, big investments and high burn rates are sometimes necessary in today’s winner-take-all environment…Fewer financings but bigger rounds: 2014 was a watershed year for the U.S. VC industry, particularly for startups…VC capital invested jumped $20 billion from 2013-2014, while the number of financings fell by 16%.

By sector, software accounted for 40% of 2014 activity, up from about 31% in 2009. The two largest healthcare verticals for VCs, healthcare devices & supplies and pharma & biotech, accounted for a little over 10%, which is notable because their combined share was around 20% just five years ago. The comparison between software and healthcare may lend credence to the theory that VCs are paying more attention to shorter-term sectors like software at the expense of longer-term sectors like biotech. While VCs are associated with groundbreaking technologies and miracle cures, those types of breakthroughs take longer to successfully build, hurting returns. Software companies, on the other hand, can be up and running quickly, and can be snapped up just as fast.”

“With seven consecutive quarters of more than $10 billion deployed to the startup ecosystem and more than half of all investment deals now going to seed or early stage companies, it’s a great time to be an entrepreneur in America,” said Bobby Franklin, President and CEO of NVCA. “If there’s anything we learned this quarter, it’s that despite the recent turbulence in the financial markets, venture capitalists remain undeterred and are confident investing in truly innovative companies across all sectors of our economy. At $16.3 billion invested for the quarter and over $47 billion invested for the year, total venture capital dollars deployed to the startup ecosystem in 2015 is on target to be the second highest since the inception of the MoneyTree Report in 1995.” 2

According the October 2015, PwC MoneyTree Report3, “The Software industry continues to receive the highest level of funding of all industries, receiving $5.8 billion going into 412 deals for the quarter, despite being down 21 percent in dollars and 17 percent in deals compared to the second quarter. Although the Biotechnology industry received the second largest amount of venture capital for the quarter, with $2 billion going into 121 deals, dollars invested and number of deals remained relatively flat over the previous quarter. Investments in the Life Sciences sector (Biotechnology and Medical Devices combined) during the third quarter accounted for $2.9 billion going into 194 deals, staying flat in dollars and slightly declining 3 percent in deals. Life Sciences company investments accounted for 18 percent of all venture capital deployed to the startup ecosystem in the third quarter.”

1. Pitchbook, http://pitchbook.com/2015_Annual_U.S._PE_Breakdown_Report.html2. October 16, 2015, MoneyTree™ Report from PricewaterhouseCoopers LLP (PwC) and the National Venture Capital Association (NVCA), http://nvca.org/pressreleases/16-billion-in-venture-capital-deployed-to-startup-ecosystem-in-third-quarter-according-to-the-moneytree-report/3. October 2015, MoneyTree™ Report Q3 2015, PwC, NVCA, https://www.pwcmoneytree.com/Reports/FullArchive/National_2015-3.pdf

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Ohio Venture IndicatorsOhio is home to a strong community of private investors, angel funds, venture capitalists, and leveraged buyout firms. Compared to 12 firms in 2001, in 2015 there were nearly 100 sources of equity capital in Ohio for bioscience commercialization and company growth. Since 2004, 271 sources of funding located in Ohio, elsewhere in the United States, and from various locations globally have contributed to the growth of Ohio’s bioscience industry by investing in 424 companies.

Angel funding (organized groups of high net worth individuals and funds) remains a consistent bright spot for startup investment options in Ohio. Ohio’s largest groups are the Columbus-based Ohio TechAngel Fund (340+ members) and Cleveland-based North Coast Angel Fund (180+ members), both among the largest angel groups in North America. Queen City Angels, located in Cincinnati, is made up of more than 50 investors who provide funding, support and guidance to early-stage companies.

Support from angel groups is, however, only part of the investment ecosystem. Bringing a new medical device or drug to market is an exceptionally expensive process, one which often requires years of research, clinical trials, and regulatory considerations. Traversing this lengthy commercialization pathway will quickly take a company past the capabilities of angel investors. Companies often turn to investment from venture capital (VC) funds to begin or continue clinical research, strengthen quality and regulatory affairs capabilities, enhance marketing outreach, and bolster new product & pipeline development. For companies with a relatively shorter runway to market, such as makers of digital health products, post-angel investment serves to accelerate sales, production and market presence.

In addition to VC funding, many early stage companies have utilized alternative options for much needed capital. Foundations, grant-making organizations, and family offices are active in the life science sector. Often this support is offered in a traditional philanthropic role; however, recently many organizations are investing in companies in support of a cause while also receiving a return on the investment. There are also unique loan programs available in Ohio to supplement funding needs for emerging companies such as the JobsOhio/Ohio Development Services Agency’s Innovation Ohio Loan Fund (IOLF) and Ohio Third Frontier’s Commercial Acceleration Loan Fund (CALF).

VentureOhio, publisher of the 2014 Ohio VentureReport, was formed to be the unified voice for capital sources and other organizations that finance or support high growth companies based in Ohio, and that seek to make Ohio a preferred location for high potential entrepreneurial activity. In their report, VentureOhio’s leadership summarized Ohio’s early stage financial ecosystem this way, “Capital for seed and startup companies continues to flow strongly in Ohio thanks in large part to Ohio’s Third Frontier Program and our active angel investor community. …While Ohio has much to be proud of and excited about, the state’s growing early-stage capital gap has the potential to slow the growth of Ohio’s current and future high potential startup companies.

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VentureOhio’s 2014 survey indicated that 115 of these companies will require $633 million in funding before the end of 2016 to support accelerating growth and job creation…and the capital available from these firms is reported to be well less than half of the need cited above. In summary, while there has never been a better time to launch a startup company in Ohio, the early-stage capital gap continues to be a serious and growth-limiting issue for the eco-system. Ensuring there is abundant capital to support early-stage company growth in Ohio remains VentureOhio’s top priority.”4

BioOhio analysis indicates that at least 68 Ohio bioscience and healthcare-related companies received private investment in 2014 and another 65 in 2013. Investment dollars in 2014 topped $576 million, the highest level in BioOhio’s last decade of deal tracking, seconded only by $544 million in 2013.

Current tracking of 2015 investment indicates that at least 78 companies have received combined private funding in excess of $410 million and $17.9 billion in acquisitions. Northeast Ohio had the highest number of deals and most investment within the state in 2014 and continues to lead in 2015. Central Ohio has brought in its highest amount since 2008 with $113.8 million.

Ohio had the largest total bioscience investment in 2014 when compared to neighboring Midwestern states tracked in the Midwest Healthcare Growth Capital Report published by BioEnterprise, followed by Minnesota ($406M), Illinois ($193M) and Wisconsin ($187M).

4. Ohio VentureReport 2014, published by VentureOhio, www.ventureohio.org

Table15:PrivateInvestmentbyOhioRegion(2011-15,inmillions)Region 2015 2014 2013 2012 2011

Central 113.83 36.65 44.22 12.8 20.86

Northeast 238.78 183.75 392.86 219.31 122.72

Northwest 0.1 0.47

Southeast 0.6 0.1 0.68 3.41

Southwest 33.87 79.85 59.4 62.82 51.93

Western 0.51 0.4 1.89 5.9

Unspecified 22.56 276.01 45.13 8.78 26.33

Total $410.25 $576.76 $544.18 $310.07 $225.24

*Unspecified includes confidential investment amounts that are not assigned to a region

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ClinicalRM

Nanofiber Solutions

University of Cincinnati

Battelle

Interplex Medical

The Research Institute at Nationwide Children’s Hospital

CTI Clinical Trial & Consulting Services

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“We often hear entrepreneurs say, ‘We don’t want east or west coast venture capital money because they will pack up and move us out of Ohio.’ But the fact is we count only a small number of companies that have moved out of Ohio over the past 15 years for that reason. Most actually see their operations grow in Ohio, experiencing an influx of ideas, support, and new jobs.”

John F. Lewis, Jr., President & CEO, BioOhio

Ohio Bioscience Exits The 2014-15 period has been record breaking in the area of exits with over $19.4 billion recorded. With the terms of many deals remaining undisclosed, the actual value of Ohio bioscience assets acquired is much higher.

Foremost among these is the $12.9 billion acquisition of Cincinnati-based Omnicare, a distributor of pharmaceutical products, by the national pharmacy chain CVS completed in August of 2015.

Hikma Pharmaceuticals, a global pharmaceutical company based in Jordan, has entered Ohio’s bioscience community with the acquisition of both Roxane Laboratories (2015, $2.65 billion) and Bedford Labs (2014,$300M) from Boehringer Ingelheim.

Medpace, a global contract research organization headquartered in Cincinnati, was acquired by Cinven in early 2014 for $915 million. Medpace would continue to be featured in the news with announcement of a $100 million development for office and commercial property on the company’s campus.

Envision Pharmaceutical Services, a drug distributor located in Twinsburg, was acquired in 2013 by investment firm TPG, only to make headlines again after being acquired by Rite Aid for $2 billion.

Cleveland medical device company CardioInsight Technologies was acquired for $93 million to become a part of Medtronic’s Atrial Fibrillation Solutions business in the Cardiac Rhythm and Heart Failure division.

Simbionix, a digital health company that has developed an advanced surgical simulator, was acquired by 3D Systems for $120 million in 2014.

ChanTest, provider of ion channel testing, became part of Charles River Laboratories following a $54 million deal that will greatly expand the contract research organization’s reach and services.

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Companies that have publicaly announced investment totaling over $10 million in 2014-15

Abeona Therapeutics ($19M) Aerpio Therapeutics ($22M) Assurex Health ($52M) Athersys ($30M) Aver ($22M) BioMotiv ($75M) Bravo Wellness ($22M) ChanRx ($17M)

Envision Pharmaceutical Services ($58M) HealthSpot ($28M) Juventas Therapeutics ($13M) Language Access Network ($15M) Minimally Invasive Devices ($14M) POCARED Diagnostics ($15M) Sirrus ($17M) ViewRay ($59M)

Photo: University of Cincinnati

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Company Region Company Region

Abeona Therapeutics Northeast HealthPro Brands Southwest

Aeromics Northeast HealthSpot Central

Aerpio Therapeutics Southwest Include Fitness Southwest

Airway Therapeutics Southwest Infinite Arthroscopy Northeast

Ardina Central Intellirod Spine Northeast

Assurex Health Southwest iRxReminder Northeast

Athersys Northeast Ischemia Care Southwest

Aver Central JoeyMedical Southwest

AxioMed Spine Corporation Northeast Juventas Therapeutics Northeast

Beam Technologies Central Language Access Network Central

Bio Wellness Northeast Lumoptik Eye Northeast

BioGreenChoice West Macrophage Therapeutics Central

BioMotiv Northeast MedaCheck Southwest

Biosortia Pharmaceuticals Central Minimally Invasive Devices Central

Bjond Central Movband Northeast

Blue Spark Technologies Northeast Myomo Northeast

Bravo Wellness Northeast NanoStatics Central

Cardiox Central Nanotronics Imaging Northeast

Centerline Biomedical Northeast Navage Northeast

CerviLenz Northeast Navidea Biopharmaceuticals Central

ChanRx Northeast OnShift Northeast

Checkpoint Surgical Northeast OtoKinetics Southwest

Cleveland Diagnostics Northeast P&C Pharma West

Cleveland HeartLab Northeast POCARED Diagnostics Central

Complion Northeast Quantum Health Central

CoverMyMeds Northeast Sanuthera Southeast

CrossChx Central Sermonix Pharmaceuticals Central

Eccrine Systems Southwest Sirrus Southwest

Enable Injections Southwest Socrates Analytics Northeast

Endosphere Central SpineForm Southwest

Envision Pharmaceutical Services Northeast SPR Therapeutics Northeast

EnzymeBioSystems Northeast Sujana Biotech Northeast

FMI Medical Systems Northeast Sulfagenix Northeast

Future Path Medical Holding Northeast Thermalin Diabetes Northeast

GenomOncology Northeast ViewRay Northeast

Health Data Intelligence Central Western Oncolytics Northeast

Table16:OhioBiosciencePrivateInvestmentRecipients(2014-15)

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Table17:OhioBioscienceAcquisitionsandIPOs(2014&2015)

Name Acquirer Year Amount (millions) Region Industry Sector

Abeona TherapeuticsPlasmaTech

Biopharmaceuticals2015 Undisclosed Northeast

Pharmaceuticals & Therapeutics

Beacon Partners KPMG 2015 Undisclosed NortheastHealthcare &

Life Science IT

Boehringer Ingelheim Roxane Laboratories

Hikma Pharmaceuticals

2015 $2,650 CentralPharmaceuticals &

Therapeutics

CardioInsight Technologies

Medtronic 2015 $93 NortheastElectromedical

Devices

DNA Diagnostics Center, The

GHO Capital Partners 2015 $118 SouthwestMedical &

Testing Laboratories

Envision Pharmaceutical Services

Rite Aid 2015 $2,000 NortheastPharmaceutical

Distribution

Explorys IBM 2015 Undisclosed NortheastHealthcare &

Life Science IT

Health Care DataWorks

Health Catalyst 2015 Undisclosed CentralHealthcare &

Life Science IT

Invacare Outcomes Management / Dynamic Medical Systems

Undisclosed 2015 $15.5 NortheastMedical Device

Distribution / Medical Devices

Mound Laser & Photonics Center

Resonetics 2015 Undisclosed WesternMedical Device

Supplier

National Biochemicals VWR International 2015 Undisclosed NortheastPharmaceutical

Supplier

Omnicare CVS Health 2015 $12,900 SouthwestPharmaceutical

Distribution

Rapid MR International FASTRON Group 2015 Undisclosed CentralElectromedical

Devices

X-Spine Systems Bacterin International 2014 $88 WesternImplantable Medical

Devices

Accutek Testing Laboratory

Element Materials Technology

2014 Undisclosed SouthwestQuality Assurance & Testing Laboratories

Akebia Therapeutics IPO 2014 $106.9 SouthwestPharmaceuticals &

Therapeutics

AxioMed Spine Undisclosed 2014 Undisclosed NortheastImplantable Medical

Devices

Boehringer Ingelheim Bedford Labs

Hikma Pharmaceuticals

2014 $300 NortheastPharmaceuticals &

Therapeutics

Cardinal Health (Physician Focused Division)

Henry Schein Medical Group

2014 Undisclosed CentralMedical Device &

Pharmaceutical Distribution

CareWorksYork Risk Services

Group, Inc.2014 Undisclosed Central

Healthcare & Life Science IT

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Name Acquirer Year Amount (millions) Region Industry Sector

ChanTestCharles River Laboratories

2014 $54 NortheastContract Research

Laboratories

Devicor Medical Products (Mammotome)

Danaher Corporation’s

Leica Biosystems2014 Undisclosed Southwest Medical Devices

Directed Medical Systems

COMS Interactive 2014 Undisclosed NortheastHealthcare &

Life Science IT

Goodwyn Institutional Review Board

Chesapeake IRB 2014 Undisclosed SouthwestResearch &

Development

Healthcare Colloquium Battelle 2014 Undisclosed CentralHealthcare &

Life Science IT

MedData MEDNAX 2014 Undisclosed NortheastHealthcare &

Life Science IT

Medpace Cinven 2014 $915 SouthwestContract Research

Organization

Pilus Energy Tauriga Sciences 2014 $2 Southwest

Agricultural Biotechnology,

BioFuels, Environmental Services

Ricerca Biosciences Main Market Partners 2014 Undisclosed NortheastContract Research

Organization

Simbionix USA 3D Systems 2014 $120 NortheastHealthcare &

Life Science IT

Table17:OhioBioscienceAcquisitionsandIPOs(2014&2015,continued)

Photo: ChanTest (a Charles River Company)

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AtriCure

VentureMed Group

Medpace

PharmaForce

Smithers Rapra

Global Cardiovascular Innovation Center

Assurex Health

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Ohio Third FrontierImpact of the Ohio Third FrontierToday, more than ever before, there is a strong cultural expectation that ground-breaking bioscience research, discovery, and innovation can be developed and commercialized in Ohio, by Ohio entrepreneurs. Historically, the Ohio Third Frontier (OTF) program has proven to be a game-changing resource for the Ohio bioscience industry over the past decade and has changed the growth trajectory for those participating in it.

Ohio’s 10-year, $2.3 billion innovation project launched in February 2002 was extended by voters in 2010 with an additional $700 million over four years starting in 2012. The expansion helps fund “Innovation Centers” at state universities and invests in start-up companies involved in biomedical, alternative energy and other high-tech fields, with the expectation that these investments will continue to grow and develop quality jobs.

Broadly, more than $1 billion from the OTF has been leveraged alongside private funds (10:1 or more in many cases) to drive an enterprise-shift among Ohio researchers, innovators, entrepreneurs, universities, and large to mid-size companies. A relatively large portion of these investments has been deployed within the bioscience community.

Viewed in the context of a collective strategy, the aim of OTF initiatives has evolved smartly to combine the development of proprietary bioscience research excellence and innovators with strong collaborative partners, and sustainable regional infrastructure thatpromotes capital formation, start-up business services, and talent development. As currently integrated and aligned with well-managed incubator facilities and strong mentorship programs, the interests and efforts of multiple key stakeholders converge.

“Inventors, founders, private co-investors and thousands of skilled technology people employed share a common pursuit within hundreds of new Ohio-based companies supported by Ohio Third Frontier (OTF) programs.

They all contribute to an enterprise goal of innovating, expanding product pipelines, driving newrevenue, and recruiting the best talent - create improved health outcomes for consumers - and deliver a favorable impact to their local community of higher paying jobs, improved quality of life, and fuel to an industry presence and infrastructure that will support sustained growth.

The OTF program has, and continues to provide a major in-vestment in Ohio’s bioscience com-munity. The industry as a whole benefits and Ohio’s bioscience entrepreneurs operating in the space are clearly better positioned to experience success and expanded economic growth over the next decade as a result.”

David R. Scholl, Ph.D., Past Board Chair, BioOhio / Commissioner, Ohio Third Frontier ProgramFounder, Diagnostic Hybrids (acquired by Quidel)

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By encouraging collaborations and private industry funding support, the program has created many productive partnerships between academic research institutions and high-tech Ohio companies. Since 2002, more than 262 diverse bioscience-related projects have been funded with $1.8 billion in collective state and corporate matching investments. From 2014-15, 72 bioscience-related projects were funded by the Ohio Third Frontier, totaling $85.2 million and matched by more than $204 million in private funding.

The current focus of OTF is on start-up and early-stage companies with the following programs currently available through the Ohio Third Frontier in 2015.

Entrepreneurial Signature Program to establish robust networks of entrepreneurial services and capital within six geographies to accelerate the growth of early-stage Ohio technology companies.

Open Innovation Incentive to assist Ohio middle market companies that are new to Open Innovation, leading to an accelerated time to market of Ohio technology products, processes, or services, and increasing national and global competitiveness of Ohio industry.

Technology Validation and Start-up Fund to create greater economic growth in Ohio based on start-up companies that commercialize technologies developed by Ohio research institutions.

Open Pre-Seed Fund Capitalization Program to increase the availability of professionally managed capital and associated services to accelerate the growth of early-stage Ohio technology companies.

Commercial Acceleration Loan Fund to support Ohio for-profit companies addressing the technical and cost barriers to commercialization in Ohio of high-tech products and processes.

Select Bioscience Projects Funded by the Ohio Third FrontierThe Ohio State University was awarded $21 million to support the Neurotechnology Innovations Translator (NIT). The NIT brings together proven business development leaders, medical device industry leaders, entrepreneurs, venture capitalists, and world-class neuroscience and neurotechnology engineers, scientists, and clinicians. This translational center is designed to commercialize technology solutions in the high-growth frontier of neurotechnology and to establish Ohio as a global leader and epicenter for neurotechnology development.

University Hospitals Health Systems was awarded $25 million to support the Harrington Discovery Institute Innovation Support Center (ISC). The ISC assists in creating detailed development plans for pharmaceutical projects, conducts business and market assessments, strengthens intellectual property positions, and provides support for pursuing additional

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funding. Through the ISC, and partner organization BioMotiv, new relationships between inventors and industry experts, their institutions, and commercialization partners will be forged to establish Ohio as a leading center of pharmaceutical development.

Eccrine Systems, a start-up working with Wright Patterson Air Force Base to develop technology from the University of Cincinnati, was awarded a $1 million commercialization loan. Eccrine Systems is developing non-invasive, disposable, electronic patches that measure and transmit real-time data about human perspiration. This technology can be utilized in a variety of fields across bioscience, such as medication adherence, treatment effectiveness, clinical trials monitoring, diagnostics, industrial toxicity & workforce safety, and performance optimization & human performance monitoring in military, emergency response, and athletic fields.

Homeward Health of Toledo was awarded a $1 million loan to launch Health IT software to identify patients’ risk of readmission, with the goal of reducing costs for the healthcare system. This mobile app helps medical staff better communicate with their patients and make more informed decisions about treatment and discharge. By alerting care management of high-risk patients, they are able to focus on patients who need the most support and provide better outcomes at a lower cost.

Red5 Pharmaceuticals was awarded $60,000 to further develop a sensor kit to predict whether or not a patient’s leukemia or brain cancer will respond to a specific chemotherapy regimen prior to starting treatment. Based on technology developed at Case Western Reserve University, Red5 Pharmaceuticals performs the chemical synthesis and pharmaceutical testing of non-natural nucleosides as novel anti-cancer agents against hematological cancers and solid tumors.

Centerline Biomedical, a Cleveland Clinic spin-off, was awarded $100,000 to commercialize an imaging system for certain minimally invasive surgical procedures, improving the accuracy of the procedure, and reducing the patient’s and doctor’s exposure to radiation and contrast dye usage. The Intra-Operative Positioning System navigates proprietary, sensor equipped catheters and guide wires (and ultimately devices) in the 3D anatomy of vascular disease patients. This delivers real-time guidance to surgeons, making endovascular procedures safer, more efficient, and with fewer complexities.

The University of Akron was awarded $3 million in collaboration with PolyOne, Lubrizol, SNS NanoFiber, Viscus Biologics, and the Austen BioInnovation Institute in Akron. This partnership will enable the development of numerous products including novel polymers, X-ray shielding materials, protective coatings for medical devices and catheters, and antimicrobial materials for wound healing.

Additional detail on awards can be found in the appendix (Table 58). For more information, metrics, and current funding platforms offered by the OTF, visit development.ohio.gov/bs_thirdfrontier.

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Bioscience Education A skilled and available workforce is integral to the growth of Ohio’s bioscience industry. In recent years, this diverse industry has made great strides in forming, attracting, and growing companies. Ohio high schools, technical career centers, two-year, four-year, graduate, and advanced degree programs deliver a workforce pipeline necessary to supply Ohio’s growing economy.

Higher EducationOhio has at least 360 post-secondary institutions serving all industries and walks of life, from universities and community colleges to specialized job training centers and vocational schools. BioOhio has reviewed thousands of degrees and programs offered at these institutions to identify a subset directly related to bioscience employment preparation or advancement.

“Education has a special importance for us at BioOhio,” said Drew Cook, Project & Technology Manager at BioOhio. “Supported by dedicated teachers and institutions, the year to year increase in young adults following a pathway to a bioscience career illustrates that science is alive and well in the minds of Ohio’s students.”

In 2013, 9,671 bioscience-related degrees and certificates were awarded to students in Ohio, up a full 50% since 2006. Degrees awarded in 2013 included 1,571 certificates or associates degrees, 5,897 bachelor’s degrees, and 2,203 post-bachelor’s, master’s, or doctoral degrees. While complete 2014 data is not available, preliminary data indicates the upward trend is continuing.

Year Total Bioscience Graduates 4 Year Schools 2 Year Schools Private-for-Profit

Schools

2006 6,437 5,673 512 252

2007 6,788 5,986 537 265

2008 7,178 6,293 472 413

2009 7,696 6,667 507 522

2010 8,094 6,863 610 621

2011 8,824 7,488 736 600

2012 9,604 8,055 739 810

2013 9,671 8,211 747 713

Total 64,292 55,236 4,860 4,196

Table18:OhioBioscienceGraduations,4Year,2Year,Private-for-Profit(2006-2013)

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It is not only the number of graduates that has risen; the number of schools with bioscience programs has also increased. In 2006 there were 85 institutions awarding bioscience degrees & certificates, but by 2013 the number rose to 108 public and private schools directly impacting bioscience in Ohio. The five schools with the most awarded degrees include:

The Ohio State University (2,018) University of Cincinnati (973) The University of Toledo (658) Case Western Reserve University (565) Miami University (397)

Institutions in Ohio are building capacity and improving technology to support the increase in student demand and market need.

The Ohio State University celebrated completion of the 225,000 square foot, LEED certified, Chemical and Biomolecular Engineering and Chemistry Building, home to a community of scientists, engineers, postdoctoral fellows, graduate students, and technical staff.

Butler Tech recently opened the Butler Tech Bioscience Center, a $16 million, 32,815 square-foot facility in West Chester to house high school and adult education programs.

Wright State University has constructed a cutting-edge Neuroscience Engineering Collaboration Building to house engineers, neuroscientists, neurologists, postdoctoral fellows, and medical students working and learning collaboratively.

North Central State College officially opened a new learning laboratory built specifically to support bioscience programs.

Cedarville University is growing with a $5 million project to construct a new building that will house additional laboratories for chemistry, biology and research.

NEOMED implemented The Research, Entrepreneurship, Discovery and Innovation Zone (REDIzone) program to foster innovation and technology commercialization.

“It is encouraging that post-secondary programs in Ohio are producing more bio-related degrees. We, as a state, must continue to engage our primary and secondary students with hands-on programming to cultivate their interest in this career path. As the industry continues to grow, we need an even greater number of skilled students entering the workforce to fill these highly technical careers and support the innovation taking place in Ohio.”

Stephen J. McConoughey, Ph.D.CEO, The Ohio Academy of Science

“Within the College of Engineering at Ohio State alone, we’ve seen prolific growth in the number of students interested in and pursuing bio-related degrees. And they’re not limited to just the biomedical engineering program, which has been at full capacity since its inception 8 years ago. Undergrads and grad students in many engineering disciplines—including electrical, environmental, materials, chemical and biomolecular, industrial and systems, mechanical and computer science—have numerous opportunities to apply their learning and research to health-care challenges. I don’t see that growth slowing any time soon.”

David Tomasko, Associate Dean for Undergraduate Education and Student Services, The Ohio State University College of Engineering

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The University of Toledo is striving to support innovation through the UT-Interprofessional Immersive Simulation Center (IISC), a $36 million training center using simulation models, simulated clinical settings, and 3D virtual immersive environments.

Kent State University broke ground in October 2015 on the new Integrated Sciences Building, a $37.5 million, 57,000 square foot facility to house the Chemistry, Biochemistry, Biological Sciences, and Physics departments.

In 2013, the top ten bioscience pipeline degrees were:

Biology & Biological Sciences (2,259) Pharmacy (857) Chemistry (761) Chemical Engineering (540) Veterinary, Animal Health Technology (532) Zoology, Animal Biology (505) Bioengineering and Biomedical Engineering (416) Pharmacy Technician & Assistant (347) Biochemistry (291) Clinical Laboratory Science, Medical Technology (244)

Graduation figures for selected bioscience-related programs were analyzed by BioOhio using data from the National Center for Education Statistics, in cooperation with the Ohio Board of Regents.

A complete list of bioscience-related programs, awarding institutions, and regional graduation data can be found in the appendix (Tables 52-56).

RegionCumulative

Total(2006-2013)

2006 2007 2008 2009 2010 2011 2012 2013PercentChange

2006 to 2013

Central 18,241 1,820 1,925 2,156 2,322 2,410 2,472 2,613 2,523 39%

Northeast 18,130 1,758 1,875 1,865 2,118 2,254 2,535 2,798 2,927 66%

Northwest 9,285 946 1,000 1,081 1,139 1,156 1,289 1,329 1,345 42%

Southeast 3,038 418 379 317 328 361 412 405 418 0%

Southwest 10,400 954 1,098 1,210 1,240 1,266 1,379 1,620 1,633 71%

Western 5,198 541 511 549 549 647 737 839 825 52%

Total 64,292 6,437 6,788 7,178 7,696 8,094 8,824 9,604 9,671 50%

Table19:OhioBiosciencePost-SecondaryGraduationsbyRegion(2006-13)

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Secondary EducationEducation in science, technology, engineering, and mathematics (STEM) is imperative for the future of Ohio’s workforce and economy. The disciplines within STEM are found in a diverse range of applications across daily life including roadways, electronics, advanced polymers, and aerospace. In bioscience, STEM skills create the products and techniques that save and improve lives, and sustain and protect our environment. Students learn concepts that prepare them to confront the challenges of today’s world, such as medical emergencies, food shortages, and critical demand for sustainable energy sources.

In addition to the core components of STEM education, a number of schools are incorporating new disciplines into this valuable curriculum. STEMM, or STEM+M, brings aspects of the medical field into the classroom. Nationally, some districts have added arts and reading to STEM, creating programs known as STEAM and STREAM.

The Ohio Department of Education (ODE) identified sixteen career fields based on common characteristics within industries to align content standards and curriculum with national efforts, and the needs of industry and job-seekers alike. Three fields of professional and technical level careers directly relate to the skills found in the bioscience sector:

Agricultural and Environmental Systems includes animal and crop production, agricultural services and engineering, food processing, horticulture, natural resource management, environmental services, agricultural and environmental education, communications, and research.

Engineering and Science Technologies includes planning, managing, and providing scientific research services. Applications include laboratory testing, research & development, product design, and process development in fields such as electrical & industrial engineering, materials science, nanofabrication, fuel cell technology and robotics.

“Since beginning this program, I have been able to instruct students in the manner in which they were intended to learn: hands-on and immersive. This allows students to learn and grow in unbelievable ways. I have seen my students do things that boggle the mind. I am so privileged to be able to teach these young adults and help usher in the next generations of the bioscience workforce. The overwhelming success of our biotech program is allowing us to explore additional STEM pathways for our students.”

Jamie Allison, Biotechnology Teacher, Loveland High SchoolManager, Southwest Ohio Bioscience Education Consortium,BioOhio Workforce & Education Consultant

“As programs grow at our school, and around Ohio, there is a need for more local businesses to provide students with relevant experiences in the biotech fields. This can be as a speaker for the class, a single day shadowing for a student, mentors for senior projects or something more long term such as a paid internship. These interactions can have a lifelong impact on a student’s career.”

Kelly Lewis, Bioscience Technologies Instructor, Eastland-Fairfield Career & Technical Schools

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Health Science includes planning, managing and providing therapeutic services, diagnostic services, health informatics, support services, and biotechnology research & development.

In the state of Ohio, the Ohio STEM Learning Network (OSLN), Project Lead the Way (PLtW), and numerous Career-Tech programs provide opportunities for students to attain the skills needed for a successful career.

The OSLN is a network that assists in starting STEM schools within the state as well as leveraging existing STEM schools and programs to spread effective practices and tools across the state and nation. The network includes 23 schools across the state.

PLtW is a national non-profit organization dedicated to increasing the quality and quantity of science and technology graduates in the United States. Currently, nearly 300 Ohio schools implement some form of PLtW STEM curriculum, including pre-engineering, biomedical science, gateway to technology, and elementary STEM lessons, as well as summer STEM academies.

Career-Tech programs around Ohio offer educational pathways that leverage ODE’s health, agriculture, engineering and manufacturing fields, with intense bioscience specialization. Students are instructed in essential skills used every day at real-world workplaces, many in cooperation with local businesses and industry organizations. Depending on the pathway, instruction of these skills takes on a different context, such as specific tasks performed in the health or agricultural settings with relevant topics and goals for each. These programs are immersing students in a hands-on exploration of bioscience skills, and delivering students that are college and career ready.

Ohio’s bioscience curriculum has also benefited from the efforts of GrowNextGen, a teacher driven organization formed to bring scientific, agriculture focused content into the classroom in partnership with industry leaders. Operating with support from the Ohio Soybean Council and farmers across the state, the group works to bring real world experiences and insights to students studying modern agricultural careers.

Considering the continued increase of post-secondary bioscience-related graduates in Ohio, and the steady growth of the bioscience industry as a whole, Ohio is primed for the formalization of middle and high school level pathways specifically suited to support bioscience education and prepare students for a career in the bioscience sector, including jobs in medical device and pharmaceutical manufacturing, agricultural biotechnology, and research & development.

The accomplishments of Ohio’s secondary schools far exceed the space available in this report. The following are just a few examples of STEM programs around Ohio.

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Akron STEM High School (Akron) works in partnership with the University of Akron, Invent Now, the Greater Akron Chamber, and Akron Tomorrow to allow students to gain real-world experiences.

Bio-Med Science Academy (Rootstown) is located on the campus of Northeast Ohio Medical University (NEOMED) and provides students with a STEM education rich with medical curriculum.

Carroll High School STEMM (Dayton) offers the opportunity to explore theoretic math and science as well as applied disciplines such as engineering, robotics, clinical medicine, applied statistics and architecture.

Eastland-Fairfield Career & Technical Schools (Groveport) offers students a wide range of skills and access to unique partnerships with area businesses, preparing students to excel in their workplace or post-secondary paths.

Global Impact STEM Academy (Springfield) focuses students on core STEM curriculum and specialized gateways including food science, biotechnology, energy, and environmental studies.

Health Sciences & Human Services Academy (Reynoldsburg) is one of two Ohio- designated STEM schools specializing in medical fields, encouraging students to explore a future in healthcare.

Hughes STEM High School (Cincinnati) immerses students in pathway programs at the advent of their junior year, including engineering futures, informational technology, health sciences, or animal and plant sciences.

Loveland High School (Loveland) offers a two year biotech program applying the principles of engineering and technology to life sciences through discovery-based laboratory practice.

Metro Early College High School (Columbus) enables students to become full-time Ohio State University students as they complete core graduation requirements.

Northwestern Local School District (West Salem) delivers award winning education through project-based learning, capstone courses, agri-science programs, and STEM programs.

Putnam County ESC STEMM Platform (Ottawa) uses distance learning practices to collaborate education between nine school districts, simultaneously providing STEMM education to a large population of students.

STEM Academy of Lawrence County (Chesapeake) offers dual credit through Collins Career Technical Center toward degrees that include RN licensure and an associate degree in medical laboratory technology.

“Ever since I was a little girl, I was always fascinated with how the universe worked. Living in an environment drastically impacted by human activity, I could not help but choose a path of life that would help replenish and sustain the world. The biosciences help us to not only understand our purpose in life, but also what we can do to help others. It is truly one of the most rewarding career paths!”

Madeleine Gagne, High School Junior/Founder, The Collins-Miller Project

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University of Cincinnati

The Ohio State University College of Engineering, OncoFilter

Camargo Pharmaceutical ServicesPMC SMART Solutions

Quidel

Eastland-Fairfield Career & Technical Schools

SmartShape Design

Chromocare

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Ohio Healthcare &Clinical NetworkHealthcare and BioscienceIn Ohio, the healthcare sector provides medical services and products to the seventh largest population in the United States, while working simultaneously with the state’s bioscience industry to develop improved treatment options through cutting edge research in clinical trials and laboratory research that enable new discoveries for patients around the world.

Ohio hosts 15% of active clinical trials conducted in the nation. As of September 2015, a total of 4,733 clinical trials were in progress or actively recruiting patients in Ohio. In terms of total study activity, Ohio ranks sixth among all states and first in the Midwest in this important indicator.

A majority of these trials are in either Phase II (29%) or Phase III (30%), indicating that Ohio is a vital location for validating bioscience research as it approaches commercialization. Of the active phase I-IV studies being conducted in Ohio, 26% have been funded in whole or in part by the National Institutes of Health.

While the economic impact definition of bioscience does not include the healthcare sector, it is of critical importance to the industry, both in the pre-market and patient focused environments. To further understand the full continuum of products and services related to the bioscience industry, BioOhio commissioned an additional study, also performed by the University of Cincinnati Economics Center, on Ohio’s healthcare providers for the years 2013 and 2014.

BioOhio assigned subsectors to providers and related organizations based on their activities, specifically: Consumer Health, Extended Care, Health and Medical Insurance Carriers, Hospitals, Outpatient Care, Physicians and Additional Health-Related Fields. Table 51, located in the appendix, provides a detailed look at the relevant NAICS codes and how they are grouped for the purposes of this report.

“Clinical trials are a vital component of biomedical research taking place in Ohio. To further advance and promote Ohio’s capabilities in the area of translational science and clinical research, The Ohio Clinical Trials Collaborative, founded by the NIH Clinical and Translational Sciences Award Centers at Case Western Reserve University, The Ohio State University, and the University of Cincinnati, has built a network connecting thirteen health systems and five research universities around the state. Through streamlined access to leading academic translational science researchers, clinical investigators, clinical trial sites, and governmental resources, pharmaceutical, biotechnology and medical device companies seeking to develop products more efficiently will experience fewer barriers and bureaucracy, leading to faster access to study participants and ultimately smoother commercialization pathways.”

John R. Peterson, Ph.D.Executive Director Global Business DevelopmentOhio Clinical Trials Collaborative

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Based on the commissioned study, in 2014, Ohio’s Healthcare sector employed 770,565 at 27,191 locations operated by 18,999 unique firms, with a total payroll of $35.3 billion providing an average wage across the sector of $45,844. These figures are steady compared to 2013 data. Physician’s offices lead the subsector in terms of number of locations (16,880), unique firms (13,875) and average wage ($65,022). Hospitals lead in terms of employees (277,962) and payroll ($14.7 billion).

Data indicates that the state as a whole employed 5,110,871 individuals in 2014 (Q3), meaning that fully 15% of Ohio’s workforce is represented by the healthcare sector. In terms of wages, the healthcare sector earned 15.5% of the state’s $227.5 billion total payroll.

Ohio Healthcare SubsectorsWithin the seven subsectors used in this analysis, there are a wide range of healthcare providers, organizations and companies. Below is a summary of some of those fields along with relevant metrics.

Consumer Health includes pharmacies, drug stores, providers of optical goods, and food & health supplement stores. This largely retail subsector addresses consumers’ needs for prescription products, health & wellness supplements, and also non-prescription medicines, medical supplies, and personal care products. Within Consumer Health, the Pharmacies & Drug Stores group is the largest in all measures, with 25,580 employees earning an average wage of $35,204 at 2,079 locations operated by 445 unique firms.

Extended Care providers include residential, retirement, and assisted living communities. Examples include skilled nursing facilities, residential mental health and substance abuse facilities, continuing care retirement communities, and developmental disability facilities. This category provides comforting, community-style care to a variety of people with varying

Table20:TheOhioHealthcareSystem(2014)

Ohio Healthcare Sector Firms Locations Employees Payroll(annual)

Average Wage

Consumer Health 721 2,734 28,979 $987,684,472 $34,083

Extended Care 1,666 3,565 174,798 $4,513,681,496 $25,822

Health and Medical Insurance 101 118 13,399 $846,950,790 $63,210

Hospitals 224 336 277,962 $14,741,362,768 $53,034

Outpatient Care 2,170 3,202 105,583 $3,310,549,285 $31,355

Physicians 13,875 16,880 161,880 $10,525,772,936 $65,022

Additional Health-Related Fields 242 356 7,964 $399,851,728 $50,210

Total 18,999 27,191 770,565 $35,325,853,475 $45,844| 51

medical conditions. Nursing Care Facilities / Skilled Nursing Facilities is the largest group, with 99,899 employees earning an average wage of $27,033 at 1,069 locations operated by 692 firms. While larger, this group’s average wage lagged behind Residential Mental Health & Substance Abuse Facilities ($27,661) and Other Residential Care Facilities ($28,456), both representing the smallest groups in terms of employees and number of locations.

Health and Medical Insurance Carriers are a critical component to the patient-provider relationship by offering plans that cover or supplement patients’ dental, health, and medical expenses. The insurance sector is a vast network of services that include underwriters, brokers, processors, and claims management firms just to name a few. In 2014, this subsector employed 13,399 with an average wage of $63,210, second highest in the Ohio Healthcare sector, at only 118 locations, operated by 101 unique firms.

Hospitals include facilities with a skilled staff of physicians and medical professionals that provide diagnostics and medical treatment to a wide variety of medical conditions. Examples include medical, surgical, and children’s hospitals, psychiatric and substance abuse hospitals, and other locations that treat a specific type of disease or medical condition. These facilities also provide outpatient services, clinical laboratory analysis, and pharmacy services. Hospitals represent the largest group in the entire Ohio Healthcare sector in terms of employment (277,962) and total annual payroll ($14.2 billion). The largest group in this area is General Medical, Surgical, and Children’s Hospitals which employed 267,190 with an average wage of $53,320, working at 258 locations operated by 169 unique firms.

Outpatient Care comprises establishments that provide a range of diagnostic, consultation, treatment, or rehabilitation services to patients without being admitted overnight, with many offering services performed at patients’ homes. Examples include outpatient community health centers, family planning centers and fertility clinics, alcoholism and drug addiction treatment centers, mental health clinics, dialysis centers, freestanding ambulatory and emergency medical centers, and health screening service centers. The largest group in this subsector is Home Health Care Services, employing 61,709 that earn an average wage of $24,467 at 1,526 locations operated by 1,246 unique firms. Outpatient Mental Health and Substance Abuse Centers is the second largest group with 11,601 employees, an average wage of $34,502 at 385 locations operated by 205 firms. The highest average wage of $59,636 is paid by the Freestanding Ambulatory Surgical and Emergency Centers group.

Physicians include independent health practitioners, such as practices of dentists, dermatologists, cardiologists, optometrists, chiropractors, pediatricians, clinical psychologists, and social workers. Physicians offer individualized practice of general or specialized treatments, and their offices exist in either their own private facility or within other establishments such as hospitals or outpatient care centers. Among the ten groups in this subsector, Offices of Physicians is the largest, employing 85,701 with an average wage of $87,140 at 6,639 locations operated by 4,689 firms. This category leads the entire Healthcare sector in terms of average wage, and number of locations and firms.

Additional Health-Related Fields includes three groups of specialized professional and administrative services: Administration of Public Health Programs, Voluntary Health Organizations, and Health and Welfare Funds. Public Health Management covers government

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establishments that facilitate improving public health, such as immunization services, environmental health activities, mental health programs, and health-related inspections. This is the largest of this group with 6,540 employees at 244 locations operated by 167 firms, paying an average wage of $51,269. Voluntary Health Organizations consists of companies that raise research funds, including disease and cancer prevention, and health education. Health and Welfare Funds focus on managing employee benefits, health plans, and general health-related funds.

National RankingsU.S. News & World Report4 examined nearly 5,000 medical centers across America in 2015, of which 17 Ohio facilities were ranked among the top 227 hospitals in a variety of adult and pediatric specialties.

Of Ohio’s eleven adult hospitals included in the 2015 rankings, Cleveland Clinic maintained the highest position at fourth overall in the nation. In addition, Cleveland Clinic’s Heart Center was named the nation’s best for cardiac care for the 20th consecutive year. The publication also ranked 14 Cleveland Clinic specialty care areas among the nation’s best.

Ohio hospitals earning recognition in several disciplines included University Hospitals Case Medical Center of Cleveland, with 12 top 50 specialty areas, TriHealth Bethesda North Hospital with 7, and The Ohio State University Wexner Medical Center with 5.

The 2015 U.S. News & World Report “America’s Best Children’s Hospitals” study revealed that 5 Ohio pediatric hospitals were ranked in the top 25 of 184 hospitals in at least one of the following areas: pediatric oncology, cardiology & heart surgery, diabetes & endocrinology, gastroenterology & GI surgery, neonatology, nephrology, neurology & neurosurgery, orthopedics, pulmonology and urology. Cincinnati Children’s Hospital Medical Center ranked first nationally in pediatric pulmonology, and second in both pediatric oncology and nephrology.

Ohio Hospitals ranked by U.S. News & World Report, “America’s best hospitals”

Akron Children’s Hospital Akron General Medical Center Christ Hospital (Cincinnati) Cincinnati Children’s Hospital Medical

Center Cleveland Clinic Cleveland Clinic Children’s Hospital Metro Health Medical Center (Cleveland) Nationwide Children’s Hospital (Columbus)

The Ohio State University Wexner Medical Center (Columbus)

OhioHealth Riverside Methodist Hospital (Columbus)

Summa Akron City and St. Thomas Hospitals

TriHealth Bethesda North Hospital (Cincinnati)

TriHealth Good Samaritan Hospital (Cincinnati)

4. U.S. News & World Report, http://health.usnews.com/best-hospitals/rankings

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University Hospital’s Rainbow Babies & Children’s Hospital (Cleveland)

University Hospitals Case Medical Center (Cleveland)

University of Cincinnati Medical Center

Bioscience Suppliers & Professional Service Providers bioohio.com/directory

Ohio’s bioscience industry develops and manufactures therapeutics, medical devices, and advanced agricultural products, for use locally and around the globe. Moving these ideas from concept through commercialization and into the marketplace takes a tremendous amount of resources and skills. In many cases, the market facing company may not have the required capabilities, equipment or workforce to perform every aspect of production in-house.

The Ohio Bioscience Resource Directory (bioohio.com/directory) is the most comprehensive collection of Ohio companies, organizations, and research centers involved in the biosciences. Originally launched in 1988 as a printed text entitled The Directory of Ohio Biomedical and Biotechnology Companies, BioOhio’s first volume included a mere 170 entries. Eventually transitioning to a digital platform in 2006, today’s Directory includes profiles of over 3,000 bioscience, supplier, service provider, and educational facilities. In addition to the published entries, over 800 laboratory facilities are cataloged offline.

BioOhio has identified more than 1,500 Ohio facilities that provide equipment & supplies, contract manufacturing, and professional services to the state’s bioscience sector. Suppliers offer key ingredients, materials, machinery, and production services including manufacturing, assembly, packaging, and distribution of products. At least 60 companies in Ohio are ISO 13485 certified to manufacture medical devices and equipment. Service-oriented companies include firms providing first class resources in the areas of regulatory and reimbursement consulting, pre-clinical and clinical assessment, product design, quality assurance, engineering, sales and marketing, legal counsel, IT services, training, and more.

The Ohio Bioscience Resource Directory uses the following categories to organize companies and organizations in the service and supply fields.

Contract Manufacturers & SuppliersMetalworkingPolymer ProductsDevice Materials & Process EquipmentMedical Equipment Repair & Service

Pharmaceutical SuppliersPharmaceutical Process EquipmentRaw Materials & IngredientsElectronics

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Professional Services / Business AssistanceArchitecture & ConstructionBusiness IncubatorsCommunications / MarketingConsultingEconomic DevelopmentFDA Medical Device AgentFinancial / Capital Investment

InsuranceLegal / IPTalentRegulatory AffairsReimbursement & RevenueService ITAssociations & Non-Profit Groups

The following table represents a comprehensive view of the companies and organizations contained in the Directory, including the broad range of Ohio suppliers and service providers that enable market-facing bioscience companies to innovate and thrive.

Table21:OhioBioscienceResourceDirectorybyCategoryandRegionDirectory Category Total Central Northeast Northwest Southeast Southwest Western

Medical Devices 553 94 279 29 24 86 41

Pharmaceuticals & Therapeutics

201 46 76 5 7 53 14

Contract Manufacturers & Suppliers

812 100 378 69 21 148 96

Consumer Products

98 17 43 12 23 3

Research & Development

420 100 154 19 11 87 49

Professional Services / Business Assistance

726 175 319 29 17 138 48

Education / Workforce Development

195 29 70 23 18 27 28

Healthcare & Life Science IT

235 69 95 7 4 45 15

Laboratories 877 196 288 109 28 136 120

Distribution & Packaging

581 94 226 70 34 111 46

Agricultural Biotechnology

190 33 70 33 10 23 21

Companies profiled in this data may operate in more than one category or region.

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Bioscience Advocacybioohio.com/advocacy

Throughout BioOhio’s twenty-eight year history, the organization has worked with local, state and federal agencies, officials and representatives to promote Ohio’s bioscience industry, BioOhio members, and the health and prosperity of Ohio. BioOhio also proudly serves as the Ohio affiliate of national industry groups Advanced Medical Technology Association (AdvaMed), Biotechnology Innovation Organization (BIO), Medical Device and Manufacturing Association (MDMA), and Pharmaceutical Research and Manufacturers of America (PhRMA).

Purpose of Advocacy, Government Relations and Public Policy: Educate, Engage, & Change

Public officials make decisions every day about funding, regulatory rulings, and a myriad of other policy initiatives that have substantial impact on Ohio’s bioscience community. The voice of Ohio’s bioscience community is a crucial component of that conversation. Legislators rely on industry leaders and constituents for on-the-ground, real-time understanding of the industry. An effective advocacy campaign can:

Educate elected officials – most are not industry experts and value constituent guidance Influence regulations within executive agencies Shape legislative process and policies – industry has the unique experiences and job-

creating power that make bioscience issues a top priority Affect elections, polling, and the media – ensure support of decision-makers who champion

constituents’ causes Lead to active partnerships across the bioscience business community

2015 Legislative Update on State and Federal Policies Impacting Ohio’s Bioscience Industry

Access to capital remains one of the key issues facing Ohio’s bioscience industry, and BioOhio has brought it to the forefront of its advocacy agenda on the Hill and in the Statehouse. BioOhio is planning a new state initiative with legislators to address this challenge and wants the bioscience community to be engaged.

Small business tax cuts were a central focus in this year’s state biennial budget. Governor John Kasich and the legislature recently signed into law the budget bill for FY 2016-2017, which grants tax relief for most Ohioans. Though the intent of policy-makers was to lower taxes for Ohio’s small businesses, Ohio Department of Taxation has confirmed that there may be a bump in taxation for small businesses and self-employed individuals earning up to $270,000 during the first year of the new formula’s implementation.

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Medical Device Tax repeal legislation recently passed the U.S. House and awaits Senate action later in 2015. BioOhio has championed the repeal of this 2.3% tax and this issue remains an ongoing concern worthy of member engagement.

The 21st Century Cures Act, which passed the house in early July, would increase NIHfunding and provide additional tools to the FDA in order to streamline the process of bringing new prescription drugs to market. BioOhio championed the Ohio dialogue on this issue with Congressman Bill Johnson (OH District 6) and Congressman Bob Latta (OH District 5), and will continue to advocate for ways to accelerate bringing innovation to market.

Why Constituents MatterOne of the strongest guiding forces behind state and federal policy is the position of lawmakers’ constituents. Many lawmakers refer to their constituents as their boss. Individual voices matter because they have the power to influence representatives in the following ways:

Increase their credibility with the community Employ other constituents Help with fundraising and re-election efforts Secure local media coverage to highlight

activities in their district Mark the district and the state of Ohio as

nationwide leaders in advancements within the bioscience field

As individuals, or representatives of companies and organizations, constituents can engage with state and federal legislators, communicate with them on issues that impact their company or institution, educate these officials with facts versus opinions, and be part of the process to effect change.

Having worked for two of Ohio’s largest bioscience innovation firms and having guided several biopharmaceutical startups, I understand different policy issues often confront large and small companies. Yet, the impact of those different policy issues can be as equally profound on both companies. In my interactions with Ohio legislators and administrators, Ohio’s bioscience industry possesses a very strong value proposition for the State of Ohio. Our government leaders are very receptive to our industry, once they understand our issues and our perspectives. Our challenge is one of awareness; we absolutely must communicate more frequently with the State of Ohio.

Michael Triplett, Ph.D.Bioscience Entrepreneur, Partner, Carmen Partners, Co-chair, BioOhio Advocacy Committee

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AboutourPartners

AdvaMed is a trade association that leads the effort to advance medical technology in order to achieve healthier lives and healthier economies around the world. AdvaMed.org

BIO is the world’s largest biotechnology trade association, providing advocacy, business development, and communications services for more than 1,100 members worldwide. BIO.org

MDMA is a national trade association that provides educational and advocacy assistance to innovative and entrepreneurial medical technology companies. MedicalDevices.org

PhRMArepresents leading biopharmaceutical researchers and biotechnology companies committed to finding cures and treatments for some of the most serious diseases. PhRMA.org

G2G Consulting is BioOhio’s partner in building and maintaining relationships with Ohio’s elected officials, working with BioOhio members to address issues that directly affect bioscience business in the state. G2GConsulting.com

Photo: STERIS Corporation

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Richard Desich SMART Commercialization Center for Microsystems

E-BEAM Services

CARON Products & Services

NAMSA

U.S. Endoscopy (a STERIS Company)

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Healthcare & Life Science ITWith all the new technologies being used by the bioscience industry today, the storage,sharing, and analysis of health information has never been more scrutinized. Whether it is an electronic system that stores patient health records at the hospital or an app that tracks your wearables data from your smartphone, the health information technology (HIT) and digital health industries strive to enhance patient wellness and improve efficiency and productivity. HIT and digital health continue to produce significant jobs in Ohio that look to expand the capabilities of the bioscience industry, reduce healthcare costs, and improve patient care across the state.

The growth of the digital health sector in Ohio is supported through a variety of institutions across the state, including Ohio’s universities, medical centers, and children’s hospitals. Significant impact has also been made by the Healthcare Information and Management Systems Society (HIMSS) Innovation Center, the Ohio Health Information Partnership, Healthbridge, Innov8 for Health, and other private organizations.

Startups and established businesses have also joined Ohio’s high-tech growth by taking advantage of the existing infrastructure and resources committed to managing the toughest healthcare concerns of the 21st century. They are developing robust informatics solutions for clinical trials management, genomic testing, personalized medicine, and other areas of health data development which will revolutionize the practice of medicine.

Since 2014, over $200 million worth of private investment has been directed into Ohio’s digital health companies, including: Aver Informatics, Beacon Partners, Beam Technologies, Bio Wellness, Bjönd, Bravo Wellness, Complion, CoverMyMeds, CrossChx, Eccrine Systems, Health Care DataWorks, Health Data Intelligence, HealthSpot, MedaCheck, Movband, OnShift, Quantum Health, and Simbionix.

Economic impact analysis of the digital health sector has not been performed due to the nature of that sector’s NAICS codes. Currently digital health is contained within the same codes that represent software and computer companies from all industries, with no viable method to isolate only those involved in digital health.

BioOhio has identified over 200 companies and organizations currently operating in one or more of the following four areas of digital health: Technology & Research, Medical Records, Patient Wellness, and Practice Management & Revenue. The following are summaries of these areas, with examples of organizations working in each field.

Technology & ResearchThe Technology & Research category uses software engineering to support and advance research & development efforts of academic institutions, medical device companies, and pharmaceutical organizations, while also providing personalized medical solutions to patients.

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Using imaging technologies, online search databases, genetic testing tools, and data capture software, companies are doing their part to streamline processes for researchers and personalize the care of patients.

Explorys – A Cleveland Clinic spinoff developing an online search database for researchers to easily and efficiently access medical data to promote research, discovery, and ultimately enhance patient care. Explorys has grown rapidly and was acquired by IBM Watson Health in April, 2015.

GenomeNext - A bioinformatics company utilizing technology licensed from Nationwide Children’s Hospital, focused on genomic analysis workflows designed to significantly advance medical research and expand understanding of the basis, treatment, and prevention of complex diseases by aggregate population scale analysis.

ImageIQ – An Imaging Contract Research Organization, spun out of Cleveland Clinic, provides image management software, image analysis capabilities, and professional services for imaging in drug and device clinical trials. ImageIQ recently launched an online quantitative image analysis service for preclinical research.

Medical RecordsMuch of digital health first emerged when the healthcare industry began the transition from manila folders to digital medical records. Balancing the connectivity, security, portability, and usability of records, while maintaining HIPAA compliance, is critical in this space. The Medical Records category is dedicated to using localized and cloud-based software to remove complexities in medical records for patients, streamlining the sharing of medical images, accelerating the collection of clinical trial data, and ultimately making the patients feel safe that their medical information is in the right hands.

CrossChx – A patient identification company that develops and deploys real-time biometric solutions to prevent medical identity fraud, improve health outcomes, and enable nationwide health information exchange by scanning a patient’s fingerprint. CrossChx recently closed a $15 million funding round and plans to triple its staff.

Intelemage – Designers of a HIPAA compliant, web-based medical imaging sharing system designed for medical providers as well as pharmaceutical and medical device companies to further medical collaboration, research & development, and patient care.

Olah Healthcare – A healthcare software and services organization helping hospitals reduce costs and complexities in medical record storage, sharing, and retention. Olah Healthcare has serviced more than 200 hospitals and institutions across the country and processed more than 10 million medical and imaging records.

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Patient WellnessThe category of digital health that has been the most impacted by bioscience research and technology advancements of the past decade is Patient Wellness. From apps reminding patients to take their medicines, technology that allows people to visit a healthcare professional via video screen, and fully integrated workplace wellness programs, the mission of Patient Wellness companies is to make it easier for people to stay healthy.

Beam Technologies – The designer and developer of the Beam Brush, a wirelessly connected toothbrush that offers consumers the ability to track and monitor brushing habits with a smart phone app. Beam Technologies moved their headquarters to Ohio in 2014 and has recently entered the dental insurance market.

iRxReminder – A mobile health application developer focused on real-time medication adherence, care compliance, patient activation and data capture in care delivery or research settings. The app is a customizable, bidirectional tool used to conduct patient care or intervention studies as well as produce improved outcomes and reduce costs.

TempTraq – Makers of a 24-hour wireless thermometer patch, initially targeted to the pediatric market, designed for continuous monitoring and capture of data by a mobile device such as a cell phone. The product was recently launched by parent Blue Spark Technologies for sales in the United States.

Practice Management & RevenueWhile the mission of Patient Wellness companies is to make patients’ lives easier, organizations in the Practice Management and Revenue space concentrate on healthcare providers. By finding ways to optimize the performance of their clients, Practice Management and Revenue companies are able to simplify processes for physicians and pharmacists, cut costs for patients, and improve the services of healthcare providers. From shortening the time for coverage determinations for patients, to providing a secure bridge of communication when transferring digital files between practitioners, Practice Management and Revenue companies streamline the workflow of healthcare providers, allowing them to better care for patients.

CoverMyMeds – A benefits investigation provider that works with electronic health record systems, health plans, pharmacy systems, and prescribers to initiate, transmit, and track the status of prior authorizations within the clinical workflow. CoverMyMeds has doubled in size each of the past two years.

Health Care DataWorks – HCD delivers financial and operational performance solutions to healthcare providers and offers an innovative approach in tracking, alerting, and report-ing an organization’s strategic and operation performance. Health Care DataWorks was acquired by Health Catalyst in July, 2015.

Updox – A web-based subscription service that allows physician practices and practitioners to securely receive and review reports, file patient records, comment on documents and images, and send notes to labs, pharmacies and other physicians.

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Valtronic Technologies

University Hospitals

Brixey & Meyer

BioEnterprise

OsteoSymbionics

Skoda MinottiBioHio Research Park

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Bioscience in Ohio’s Six RegionsThe bioscience industry’s economic impact is felt throughout the state, with bioscience- related companies found in 81 of 88 Ohio counties. Based on boundaries defined by the Ohio Development Services Agency, the six regions of Ohio include central, northeast, northwest, southeast, southwest, and western.

Economic development in terms of retention, attraction, and expansion of businesses across the state and within each of Ohio’s six regions is overseen by JobsOhio, a private, non-profit organization formed to drive job creation and new capital investment in Ohio. The organization operates in partnership with regional economic development organizations that make up the JobsOhio Network, which includes Appalachian Partnership for Economic Growth (southeast), Columbus 2020 (central), Dayton Development Coalition (western), REDI Cincinnati (southwest), Regional Growth Partnership (northwest), and Team NEO/Cleveland+ (northeast).

Supported by the Ohio Third Frontier program and the Ohio Development Services Agency, Ohio’s Entrepreneurial Signature Program (ESP) delivers a coordinated network of high-value services that is easily accessible to technology-based entrepreneurs and small tech-based companies, many operating in the bioscience field. The ESPs provide an approach that tightly integrates sources of deal flow, entrepreneurial support, and capital to effectively commercialize innovative new products and services. Ohio’s regional ESPs include CincyTech (southwest), JumpStart (northeast), Rev1 Ventures (central), Rocket Ventures (northwest), and TechGROWTH Ohio (southeast). The Dayton Development Coalition assists businesses in the western Ohio region.

Anchored by Cleveland and Akron, northeast Ohio led the state in the number of bioscience locations with 1,234 locations, 40% of the statewide total. The central and southwest regions followed with 624 (20%) and 580 (19%), respectively. Western Ohio is home to 313 locations, 228 in northwest Ohio, and 136 in the southeast region. Since 2009, all six Ohio regions have experienced growth in the number of locations.

In terms of total employment, northeast and central Ohio are closely aligned as leaders with 32% and 29% of the statewide total (21,810 and 20,028 respectively). The central region recorded the largest increase in employees within the study period, adding 2,469, a 14% gain. Southeast Ohio marked the largest percentage increase, gaining 400 individuals, up 23% compared to 2009. While employment grew in five of six regions, northeast Ohio lost employees due largely to the recent closure of Boehringer Ingelheim’s Ben Venue Labs in Bedford, which housed 1,100 employees.

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2014 2013 2012 2011 2010 2009

Central 20,028 19,827 18,954 18,377 18,348 17,559

Northeast 21,810 23,207 24,044 24,147 23,959 24,100

Northwest 4,512 4,474 4,321 4,081 4,134 4,153

Southeast 2,132 2,053 1,940 1,925 1,888 1,732

Southwest 13,244 13,431 12,820 13,091 13,150 13,094

Western 6,851 6,879 6,602 6,814 6,909 6,990

Total 68,577 69,871 68,681 68,435 68,389 67,627

Table23:OhioBioscienceEmploymentbyRegion(2009-2014)

Region Employment Payroll Average Wage Locations

Central 20,028 $1,588,311,514 $79,306 624

Northeast 21,810 $1,501,960,546 $68,866 1,234

Northwest 4,512 $236,040,880 $52,310 228

Southeast 2,132 $104,892,943 $49,207 136

Southwest 13,244 $958,382,838 $72,362 580

Western 6,851 $443,783,060 $64,773 313

Total 68,577 $4,833,371,781 $70,481 3,115

Table22:OhioBioscienceEmployment,Payroll,AverageWage&LocationsbyRegion(2014)

2014 2013 2012 2011 2010 2009

Central 624 600 586 532 499 499

Northeast 1,234 1,215 1,272 1,132 1,119 1,105

Northwest 228 232 232 212 223 223

Southeast 136 132 117 108 107 106

Southwest 580 578 557 498 492 494

Western 313 316 326 297 293 304

Total 3,115 3,073 3,090 2,779 2,733 2,731

Table24:OhioBioscienceLocationsbyRegion(2009-2014)

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2014 2013 2012 2011 2010 2009

Central $79,306 $73,931 $72,729 $75,153 $70,550 $70,215

Northeast $68,866 $66,500 $70,629 $70,325 $63,620 $61,744

Northwest $52,310 $50,130 $50,305 $53,300 $52,920 $50,681

Southeast $49,207 $48,107 $44,607 $46,492 $43,313 $45,152

Southwest $72,362 $65,862 $66,643 $66,316 $61,431 $60,087

Western $64,773 $62,933 $63,369 $62,680 $59,429 $58,058

Statewide Average $70,481 $66,546 $67,753 $68,408 $63,428 $62,137

Table25:OhioBioscienceAverageWagebyRegion(2009-2014)

Figure2:OhioBioscienceEmploymentMomentumbyRegion(2014)

3.50%

3.00%

2.50%

2.00%

1.50%

1.00%

0.50%

0.00%

-0.50%

-1.00%- 10.00% - 8.00% -6.00% -4.00% -2.00% 0.00% 2.00% 4.00% 6.00% 8.00% 10.00%

Improving Expanding

Contracting Slipping

3 M

onth

Gro

wth

Southwest Region

Central Region

Western Region

Southeast Region

Northwest Region

Northeast Region

Ohio

Year over Year Growth

In compliance with federal privacy laws protecting the privacy of companies included in this study, certain information presented within this report’s regional analysis is suppressed. To accommodate both privacy concerns and the need for accurate data, within the central, northeast, southwest and western regions, the Pharmaceuticals & Therapeutics subsector was combined with Research & Development. For data on the northwest and southeast regions, the Medical Device & Equipment Manufacturers subsector was combined with Pharmaceuticals & Therapeutics and Research & Development.

In some cases, Metropolitan Statistical Areas may extend outside of Ohio when a city lies near a border with a neighboring state; however, only data on Ohio companies is included in this report.

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Central OhioThe central region encompasses the entire Columbus Metropolitan Statistical Area (MSA) including the cities of Delaware, Dublin, New Albany, and Newark, and is comprised of 11 counties: Delaware, Fairfield, Franklin, Knox, Licking, Logan, Madison, Marion, Morrow, Pickaway, and Union.

Bioscience employment in the central region was 20,028 in 2014, the second highest in the state with 29.2% of total employees. Employment increased by 14% compared to 2009. The number of bioscience locations in the central region in 2014 was 624. The region had a net gain of 125 locations from 2009 to 2014, an increase of 25%.

Payroll in the central region was $1.59 billion in 2014, reflecting an increase of 28.8% over 2009. The average wage of bioscience employees in the central region was $79,306 in 2014, an increase of 12.9% over the study period.

Subsector Employment Payroll Average Wage Locations

Agricultural Biotechnology 1,622 $174,322,539 $107,496 21

Medical & Testing Laboratories 3,015 $154,273,289 $51,163 208

Medical Device & Equipment Manufacturers

1,704 $72,640,898 $42,638 68

Medical Product Distribution 5,733 $478,980,029 $83,548 213

Pharmaceuticals & Therapeutics and Research & Development

7,954 $708,094,759 $89,024 114

Total 20,028 $1,588,311,514 $79,306 624

Table26:BioscienceEmployment,Payroll,AverageWages&LocationsinCentralOhio(2014)

Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 1,622 1,533 1,664 1,587 1,677 1,694

Medical & Testing Laboratories 3,015 2,975 2,643 2,756 2,678 2,555

Medical Device & Equipment Manufacturers

1,704 1,592 1,492 1,614 1,475 1,395

Medical Product Distribution 5,733 6,006 5,639 5,372 5,225 4,749

Pharmaceuticals & Therapeutics and Research & Development

7,954 7,722 7,516 7,048 7,293 7,166

Total 20,028 19,827 18,954 18,377 18,348 17,559

Table27:BioscienceEmploymentinCentralOhio(2009-14)

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Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 21 22 21 20 21 24

Medical & Testing Laboratories 208 195 179 161 152 146

Medical Device & Equipment Manufacturers

68 67 65 66 61 63

Medical Product Distribution 213 214 217 192 178 178

Pharmaceuticals & Therapeutics and Research & Development

114 102 104 93 87 88

Total 624 600 586 532 499 499

Table28:BioscienceLocationsinCentralOhio(2009-14)

Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology $107,496 $92,011 $91,452 $115,041 $106,108 $105,127

Medical & Testing Laboratories $51,163 $48,176 $48,695 $45,047 $45,385 $46,846

Medical Device & Equipment Manufacturers

$42,638 $43,262 $45,639 $43,654 $43,763 $51,991

Medical Product Distribution $83,548 $72,275 $67,663 $68,643 $61,980 $57,314

Pharmaceuticals & Therapeutics and Research & Development

$89,024 $87,874 $86,213 $90,114 $83,177 $82,392

Total $79,306 $73,931 $72,729 $75,153 $70,550 $70,215

In compliance with federal privacy laws protecting the privacy of companies included in this study, certain information presented within this report’s regional analysis is suppressed. To accommodate both privacy concerns and the need for accurate data, the Pharmaceuticals & Therapeutics subsector has been combined with Research & Development.

Table29:BioscienceAverageWageinCentralOhio(2009-14)

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Table30:BioscienceEmployment,Payroll,AverageWages&LocationsinNortheastOhio(2014)Subsector Employment Payroll Average Wage Locations

Agricultural Biotechnology 2,847 $267,180,131 $93,846 51

Medical & Testing Laboratories 3,768 $204,017,942 $54,145 351

Medical Device & Equipment Manufacturers

6,307 $332,421,648 $52,704 223

Medical Product Distribution 4,580 $279,071,625 $60,928 413

Pharmaceuticals & Therapeutics and Research & Development

4,307 $419,269,200 $97,338 196

Total 21,810 $1,501,960,546 $68,866 1,234

Table31:BioscienceEmploymentinNortheastOhio(2009-14)Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 2,847 2,819 2,765 2,730 2,603 2,510

Medical & Testing Laboratories 3,768 3,902 4,146 4,190 4,217 4,339

Medical Device & Equipment Manufacturers

6,307 6,547 6,655 6,434 6,374 6,404

Medical Product Distribution 4,580 4,470 4,687 5,040 5,018 5,178

Pharmaceuticals & Therapeutics and Research & Development

4,307 5,469 5,790 5,753 5,746 5,669

Total 21,810 23,207 24,044 24,147 23,959 24,100

Northeast OhioThe northeast region includes the cities of Cleveland, Akron, Canton, and Youngstown, and is made up of 18 counties: Ashland, Ashtabula, Columbiana, Cuyahoga, Erie, Geauga, Huron, Lake, Lorain, Mahoning, Medina, Portage, Richland, Stark, Summit, Trumbull, Tuscarawas, and Wayne. Included in the northeast region are the following Metropolitan Statistical Areas (MSAs): Akron, Cleveland-Elyria-Mentor, Mansfield, Sandusky, and Youngstown-Warren-Boardman (Ohio counties only). This region also includes one-half of the Canton-Massillon MSA (Stark County).

Bioscience in the northeast region led the state with 21,810 employees, 31.8% of the state’s total. Northeast Ohio also led in the number of locations, with 1,234 (40%). Employment declined by 9.5% from 2009 to 2014 while the region experienced a net gain of 129 locations in the same period.

Payroll in the northeast region was $1.5 billion in 2014, down slightly (0.9%) over the study period. The average wage of bioscience employees in the northeast region was $68,866 in 2014, an increase of 11.5% compared to 2009.

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Table32:BioscienceLocationsinNortheastOhio(2009-14)Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 51 50 51 49 50 50

Medical & Testing Laboratories 351 339 344 318 327 317

Medical Device & Equipment Manufacturers

223 218 233 210 215 220

Medical Product Distribution 413 408 429 373 355 348

Pharmaceuticals & Therapeutics and Research & Development

196 200 215 182 172 170

Total 1,234 1,215 1,272 1,132 1,119 1,105

Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology $93,846 $96,678 $136,125 $146,428 $107,615 $91,695

Medical & Testing Laboratories $54,145 $57,110 $55,465 $55,254 $52,771 $53,536

Medical Device & Equipment Manufacturers

$52,704 $50,375 $53,198 $49,691 $47,513 $47,638

Medical Product Distribution $60,928 $63,057 $67,505 $66,615 $66,465 $66,264

Pharmaceuticals & Therapeutics and Research & Development

$97,338 $79,764 $72,771 $71,509 $67,034 $66,572

Total $68,866 $66,500 $70,629 $70,325 $63,620 $61,744

In compliance with federal privacy laws protecting the privacy of companies included in this study, certain information presented within this report’s regional analysis is suppressed. To accommodate both privacy concerns and the need for accurate data, the Pharmaceuticals & Therapeutics subsector has been combined with Research & Development.

Table33:BioscienceAverageWageinNortheastOhio(2009-14)

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Table34:BioscienceEmployment,Payroll,AverageWages&LocationsinNorthwestOhio(2014)Subsector Employment Payroll Average Wage Locations

Agricultural Biotechnology 712 $40,116,514 $56,370 19

Medical & Testing Laboratories 1,519 $70,409,113 $46,362 70

Medical Product Distribution 1,067 $50,207,641 $47,055 68

Pharmaceuticals & Therapeutics, Research & Development, and Medical Device and Equipment Manufacturers

1,215 $75,307,612 $61,982 71

Total 4,512 $236,040,880 $52,310 228

Table35:BioscienceEmploymentinNorthwestOhio(2009-14)Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 712 791 715 660 698 687

Medical & Testing Laboratories 1,519 1,482 1,379 1,252 1,242 1,148

Medical Product Distribution 1,067 1,057 1,057 980 946 943

Pharmaceuticals & Therapeutics, Research & Development, and Medical Device and Equipment Manufacturers

1,215 1,144 1,170 1,189 1,249 1,375

Total 4,512 4,474 4,321 4,081 4,134 4,153

Northwest OhioThe northwest region includes the cities of Toledo, Bowling Green, Findlay, Lima, and the Toledo and Lima MSAs. It is made up of these 17 counties: Allen, Crawford, Defiance, Fulton, Hancock, Hardin, Henry, Lucas, Ottawa, Paulding, Putnam, Sandusky, Seneca, Van Wert, Williams, Wood, and Wyandot.

Bioscience employment in the northwest region was 4,512 in 2014, an increase of 8.7% over 2009. The number of bioscience locations in the region in 2014 was 228, an increase of 2.2% in the study period.

Payroll in the northwest region was $236 million in 2014, an increase of 12.2% from 2009 to 2014. The average wage of bioscience employees in the northwest region was $52,310 in 2014, up 3.2% compared to 2009.

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Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology $56,370 $52,006 $55,427 $60,767 $59,493 $53,589

Medical & Testing Laboratories $46,362 $46,011 $45,408 $48,619 $46,399 $46,594

Medical Product Distribution $47,055 $46,855 $45,538 $46,762 $53,816 $51,112

Pharmaceuticals & Therapeutics, Research & Development, and Medical Device and Equipment Manufacturers

$61,982 $57,195 $57,254 $59,474 $55,051 $52,344

Total $52,310 $50,130 $50,305 $53,300 $52,920 $50,681

In compliance with federal privacy laws protecting the privacy of companies included in this study, certain information presented within this report’s regional analysis is suppressed. To accommodate both privacy concerns and the need for accurate data, the Medical Device & Equipment Manufacturers, Pharmaceuticals & Therapeutics, and Research & Development subsectors have been combined.

Table37:BioscienceAverageWageinNorthwestOhio(2009-14)

Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 19 18 19 17 16 16

Medical & Testing Laboratories 70 76 78 69 75 78

Medical Product Distribution 68 64 66 58 63 64

Pharmaceuticals & Therapeutics, Research & Development, and Medical Device and Equipment Manufacturers

71 74 69 68 69 65

Total 228 232 232 212 223 223

Table36:BioscienceLocationsinNorthwestOhio(2009-14)

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Table39:BioscienceEmploymentinSoutheastOhio(2009-14)Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 569 483 341 338 328 303

Medical & Testing Laboratories 319 318 308 313 300 309

Medical Product Distribution 260 246 281 260 239 225

Pharmaceuticals & Therapeutics, Research & Development, and Medical Device and Equipment Manufacturers

984 1,007 1,010 1,013 1,021 895

Total 2,132 2,053 1,940 1,925 1,888 1,732

Table38:BioscienceEmployment,Payroll,AverageWages&LocationsinSoutheastOhio(2014)

Subsector Employment Payroll Average Wage Locations

Agricultural Biotechnology 569 $34,615,389 $60,800 11

Medical & Testing Laboratories 319 $12,390,745 $38,883 51

Medical Product Distribution 260 $9,221,199 $35,466 40

Pharmaceuticals & Therapeutics, Research & Development, and Medical Device and Equipment Manufacturers

984 $48,665,610 $49,474 34

Total 2,132 $104,892,943 $49,207 136

Southeast Ohio The southeast region includes the cities of Athens, Marietta, Portsmouth, and Chillicothe, and is comprised of 25 counties: Adams, Athens, Belmont, Carroll, Coshocton, Gallia, Guernsey, Harrison, Highland, Hocking, Holmes, Jackson, Jefferson, Lawrence, Meigs, Monroe, Morgan, Muskingum, Noble, Perry, Pike, Ross, Scioto, Vinton, and Washington. The region includes one county in each of the following MSAs: Canton-Massillon, OH; Steubenville-Weirton, OH-WV; Huntington-Ashland, WV-KY-OH; Parkersburg-Marietta-Vienna, WV-OH; and Wheeling, WV-OH.

Bioscience employment in the southeast region was 2,132 in 2014, reflecting thestrongest percentage growth in the state with a 23.1% gain since 2009. The number of bioscience locations in the southeast region in 2014 was 136, a net gain of 30 locations in the study period.

Payroll in the southeast region was $104.9 million in 2014, an increase of over 34% since 2009. The average wage of bioscience employees in the southeast region was $49,207 in 2014, growing 9% compared to 2009.

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Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology $60,800 $63,371 $53,172 $52,204 $51,216 $53,773

Medical & Testing Laboratories $38,883 $40,595 $44,734 $44,254 $42,429 $41,794

Medical Product Distribution $35,466 $32,945 $31,951 $30,975 $30,880 $31,422

Pharmaceuticals & Therapeutics, Research & Development, and Medical Device and Equipment Manufacturers

$49,474 $46,854 $45,197 $49,265 $43,943 $46,836

Total $49,207 $48,107 $44,607 $46,492 $43,313 $45,152

In compliance with federal privacy laws protecting the privacy of companies included in this study, certain information presented within this report’s regional analysis is suppressed. To accommodate both privacy concerns and the need for accurate data, the Medical Device & Equipment Manufacturers, Pharmaceuticals & Therapeutics, and Research & Development subsectors have been combined.

Table41:BioscienceAverageWageinSoutheastOhio(2009-14)

Table40:BioscienceLocationsinSoutheastOhio(2009-14)Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 11 9 7 7 7 7

Medical & Testing Laboratories 51 48 44 37 37 37

Medical Product Distribution 40 44 38 35 33 31

Pharmaceuticals & Therapeutics, Research & Development, and Medical Device and Equipment Manufacturers

34 31 28 29 30 31

Total 136 132 117 108 107 106

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Table42:BioscienceEmployment,Payroll,AverageWages&LocationsinSouthwestOhio(2014)Subsector Employment Payroll Average Wage Locations

Agricultural Biotechnology 895 $70,468,838 $78,736 18

Medical & Testing Laboratories 3,174 $158,776,333 $50,029 195

Medical Device & Equipment Manufacturers

1,370 $73,000,210 $53,285 61

Medical Product Distribution 2,847 $229,504,574 $80,613 191

Pharmaceuticals & Therapeutics and Research & Development

4,959 $426,632,883 $86,038 115

Total 13,244 $958,382,838 $72,362 580

Table43:BioscienceEmploymentinSouthwestOhio(2009-14)Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 895 925 1,017 1,032 1,065 1,134

Medical & Testing Laboratories 3,174 3,094 2,932 2,972 2,956 2,896

Medical Device & Equipment Manufacturers

1,370 1,433 1,281 1,301 1,344 1,348

Medical Product Distribution 2,847 3,474 3,233 3,472 3,485 3,378

Pharmaceuticals & Therapeutics and Research & Development

4,959 4,505 4,357 4,315 4,300 4,339

Total 13,244 13,431 12,820 13,091 13,150 13,094

Southwest OhioThe southwest region includes the greater Cincinnati area, including the cities of Blue Ash, Mason, and West Chester, and consists of 5 counties: Brown, Butler, Clermont, Hamilton, and Warren.

Bioscience employment in the southwest region was 13,244 in 2014, an increase of 1.1% fom 2009 to 2014. The number of bioscience locations in the southwest region in 2014 was 580, reflecting a net gain of 86 locations (14.6%) in the study period.

Payroll in the southwest region was $958 million in 2014, an increase of 21.8% since 2009. The average wage of bioscience employees in the southwest region was $72,362 in 2014, marking the strongest percentage increase in the state with 20.4% improvement over 2009 figures.

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Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology $78,736 $76,256 $80,601 $83,228 $78,831 $75,636

Medical & Testing Laboratories $50,029 $44,547 $43,904 $42,338 $40,884 $40,008

Medical Device & Equipment Manufacturers

$53,285 $50,102 $49,978 $50,879 $46,507 $45,171

Medical Product Distribution $80,613 $71,448 $71,255 $68,593 $65,687 $65,501

Pharmaceuticals & Therapeutics and Research & Development

$86,038 $79,076 $80,166 $81,607 $72,459 $69,844

Total $72,362 $65,862 $66,643 $66,316 $61,431 $60,087

In compliance with federal privacy laws protecting the privacy of companies included in this study, certain information presented within this report’s regional analysis is suppressed. To accommodate both privacy concerns and the need for accurate data, the Pharmaceuticals & Therapeutics subsector has been combined with Research & Development.

Table45:BioscienceAverageWageinSouthwestOhio(2009-14)

Table44:BioscienceLocationsinSouthwestOhio(2009-14)Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 18 18 15 14 14 15

Medical & Testing Laboratories 195 192 163 142 136 143

Medical Device & Equipment Manufacturers

61 61 63 55 59 58

Medical Product Distribution 191 191 201 188 185 181

Pharmaceuticals & Therapeutics and Research & Development

115 116 115 99 98 97

Total 580 578 557 498 492 494

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Table47:BioscienceEmploymentinWesternOhio(2009-14)Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 733 716 707 651 705 658

Medical & Testing Laboratories 1,445 1,388 1,423 1,518 1,530 1,685

Medical Device & Equipment Manufacturers

1,045 1,083 1,132 1,125 1,148 1,150

Medical Product Distribution 714 700 642 790 785 825

Pharmaceuticals & Therapeutics and Research & Development

2,915 2,992 2,698 2,730 2,741 2,672

Total 6,851 6,879 6,602 6,814 6,909 6,990

Table46:BioscienceEmployment,Payroll,AverageWages&LocationsinWesternOhio(2014)Subsector Employment Payroll Average Wage Locations

Agricultural Biotechnology 733 $49,566,615 $67,622 10

Medical & Testing Laboratories 1,445 $68,009,120 $47,076 106

Medical Device & Equipment Manufacturers

1,045 $54,566,076 $52,200 42

Medical Product Distribution 714 $42,773,734 $59,935 66

Pharmaceuticals & Therapeutics and Research & Development

2,915 $228,867,515 $78,523 89

Total 6,851 $443,783,060 $64,773 313

Western OhioThe western region is made up of 12 counties: Auglaize, Champaign, Clark, Clinton, Darke, Fayette, Greene, Mercer, Miami, Montgomery, Preble, and Shelby. This region encompasses the entirety of both the Dayton and Springfield MSAs and includes the cities of Troy and Xenia.

Bioscience employment in the western region was 6,851 in 2014, a decrease of 2% compared from 2009 to 2014. The number of bioscience locations in the western region was 313, a 3% increase in the study period.

Payroll in the western region was $443.8 million in 2014, an increase of 9.3% since 2009. The average wage of bioscience employees in the western region was $64,773 in 2014, reflecting an increase of 11.6% since 2009.

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Table48:BioscienceLocationsinWesternOhio(2009-14)Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology 10 11 10 10 12 14

Medical & Testing Laboratories 106 98 100 93 93 104

Medical Device & Equipment Manufacturers

42 48 58 51 53 55

Medical Product Distribution 66 68 66 61 56 53

Pharmaceuticals & Therapeutics and Research & Development

89 91 92 82 79 78

Total 313 316 326 297 293 304

Subsector 2014 2013 2012 2011 2010 2009

Agricultural Biotechnology $67,622 $66,725 $66,734 $74,698 $62,660 $60,852

Medical & Testing Laboratories $47,076 $45,967 $47,180 $44,854 $46,115 $44,259

Medical Device & Equipment Manufacturers

$52,200 $51,805 $49,912 $51,360 $49,662 $48,469

Medical Product Distribution $59,935 $57,064 $55,282 $46,891 $46,719 $45,314

Pharmaceuticals & Therapeutics and Research & Development

$78,523 $75,297 $78,592 $78,955 $73,760 $74,133

Total $64,773 $62,933 $63,369 $62,680 $59,429 $58,058

In compliance with federal privacy laws protecting the privacy of companies included in this study, certain information presented within this report’s regional analysis is suppressed. To accommodate both privacy concerns and the need for accurate data, the Pharmaceuticals & Therapeutics subsector has been combined with Research & Development.

Table49:BioscienceAverageWageinWesternOhio(2009-14)

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Assurex Health

Airway Therapeutics

NanoDetection Technology

Stress Engineering Services

Bionix

Cardiox

Stirling Ultracold

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Concluding RemarksBioscience Growth, More than NumbersOur industry has many faces – medical devices, pharmaceuticals, lab equipment, regenerative medicine, agricultural compounds, alternative fuels, medical testing services, wellness products, life science software technologies, clinical research, digital health, wearables, product development, and more. All of these sectors have a common goal, to improve the quality of life for our community.

The Ohio Bioscience Growth Report presents facts and background to illustrate the strengths and assets of Ohio’s bioscience industry. We believe the comprehensive scope of this report makes it an essential tool for Ohio’s bioscience business leaders, educators, and economic development professionals, and serves as a benchmark for local, state, and federal lawmakers. This report is also a valuable resource for anyone interested in learning more about bioscience.

Tracking of investment, average wages, research funding, expansions, new company growth, and other important metrics serves as a gauge of the industry. These figures, however, simply illustrate the mechanisms behind the companies and organizations. The work being done by Ohio’s bioscience community is so much more important than any of these metrics can convey.

Ohioans are curing debilitating pediatric diseases, creating less invasive surgical tools, formulating cleaner and more efficient biofuels, programming highly accurate diagnostic imaging techniques, improving provider processes to reduce patient costs, and personalizing medication delivery for individual patients.

These are just a few examples of what Ohio’s bioscience companies are doing each day across the state. BioOhio is proud to support and salute their efforts.

Similar to the organic nature of biology itself, much of the content in this report is constantly changing as new companies form, existing companies expand or secure funding, new discoveries are made, and partnerships are forged. We look forward to updating this report alongside our industry’s growth in the years to come.

This report, which will be updated quarterly, may be accessed online at BioOhio.com/Ohio. Questions, comments, or contributions for a future Ohio Bioscience Growth Report may be directed to John F. Lewis Jr., BioOhio President and CEO, jlewis@bioohio.com.

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Appendix

BioOhio Members bioohio.com/membership

“BioOhio’s work is made possible by continuous support and leadership from our members. We thank our members for their support, and encourage you to join the member family and help Ohio’s bioscience community continue to rise and excel.” - Jennifer Goldsberry, Manager, Member Services & Events, BioOhio

LeadershipMembers

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BioOhioMembers(December2015)

CoreAbbott NutritionAbeona TherapeuticsAdare PharmaceuticalsAdvanced Testing LaboratoryAeromicsAerpio TherapeuticsAffymetrixAirway TherapeuticsAlkermesAmerican Medical EquipmentAmgenAMRESCOAoki Manufacturing Columbus (AMC)Applied Biomolecular TechnologiesAprecia PharmaceuticalsArteriocyteAssurex HealthAstraZenecaAstro Manufacturing and DesignAthersysAtriCureAusten BioInnovation Institute in AkronAxioMed Spine CorporationBalanceBattelleBeagle BioproductsBioLectricsBioMotivBionix Development CorporationBiosortia PharmaceuticalsBiotechnology Innovation Organization (BIO)C.R. BardCamargo Pharmaceutical ServicesCardinal HealthCardioInsight TechnologiesCardiox CorporationCARON Products & ServicesCAS (Chemical Abstracts Service)Cellular TechnologyChanTest (a Charles River Company)Charles River LaboratoriesCheckpoint SurgicalChemsultants InternationalChromocareCleveland FES CenterCleveland HeartLab

Cleveland Medical DevicesClinicalRMCriterion ToolCrystal DiagnosticsCTI Clinical Trial and Consulting ServicesDapcelDavis MedicalDesign CentralDIRAmedDragonIDE-BEAM ServicesEccrine SystemsEDDR-InformaticsEG-GILEROEli LillyEnable InjectionsEndoSphereEnduricaEnlytonEthicon Endo-SurgeryEXCMRExplorysExsurco MedicalFirefly DiagnosticsFlocelFluence TherapeuticsFrantz Medical GroupFreedom MeditechFulcrum FactorGanedenGebauer CompanyGenentechGenetesisGEOAnalyticalGFS ChemicalsGlobal Cardiovascular Innovation Center (GCIC)G-M-IGojira Fine ChemicalsGold ThreadGreat Lakes NeurotechHardy DiagnosticsHelix Linear TechnologiesHyper Tech ResearchImageIQInfraRed Imaging Systems (INRIS)Innovative Medical EquipmentIntellirod SpineInterplex Medical

Ischemia CareThe Jackson LaboratoryJALEX MedicalJoeyMedicalKaleidoscopeLab-AllyLeadScopeLee Plastic CompanyMANEMedical Device Manufacturers Association (MDMA)MedpaceMeridian BioscienceMicrobial RoboticsMidmark CorporationMinimally Invasive DevicesMinnetronixMolecular Technologies LaboratoriesMound Laser & Photonics CenterN8 MedicalNAMSA (North American Science Association)NanoDetection TechnologyNanofiber SolutionsNanoLogixNanotronics ImagingNavidea BiopharmaceuticalsNDI MedicalNeoProteomicsNeuros MedicalNeuroWave SystemsNITTO DENKO AveciaNorth Coast Clinical LaboratoryNovella ClinicalNovo NordiskOakwood LaboratoriesOnikoLabsOrbital ResearchOsteoNovusOsteoSymbionicsOxyraseP&C PharmaPathfinder BiotechPercuVisionPfizerPhageVaxPharmaForcePhylogenyPMC SMART Solutions

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Pocared DiagnosticsPolymer ConceptsPPDProxy BiomedicalQTest LabsQuality Electrodynamics (QED)Quanta BioDesignQuidelRAPID MR InternationalREA IncorporatedRemington-DavisRenovo NeuralRicerca BiosciencesRichard Desich SMART Commercialization Center for MicrosystemsRSB SpineS&S Medical ProductsSafeWhiteSara Wood PharmaceuticalsSiloam BiosciencesSironRX TherapeuticsSmartShape DesignSmithers RapraSNS Nano Fiber TechnologySound HealthSparton Medical SystemsSpineFormSPR TherapeuticsStemLutionsSTERIS CorporationStirling UltracoldStress Engineering ServicesSurgical TheaterSur-SealSYMARKSynergy HealthTheraVascThermalin DiabetesThermedxTremorXTRIM-edicineTSS TechnologiesValtronic Technologies (USA)VentureMed GroupViscus BiologicsVisioneering Bio DesignVista OcularWIL Research Laboratories

Associate889 Global SolutionsAccelerant / Dayton Development CoalitionAffordable Language ServicesAmeriLab ScientificAthens Area Chamber of CommerceAtwood & AssociatesAuditgraphAvatar BrokersBeijing Fuxinghua GroupBioEnterpriseBioMediaThe Blackwell HotelBraintree Business Development CenterBricker & Eckler LLPBritton GallagherBrixey & MeyerCalfee, Halter & Griswold LLPThe Center for Professional Innovation & EducationCGK ConsultantsCharter Life SciencesChubb Group of Insurance CompaniesCincinnati USA Regional ChamberCincyTechUSACity of BeachwoodCity of DublinCity of MasonColby & CompanyColumbus 2020Columbus Chamber of CommerceCygnus RegulatoryDardenLentzDATATRAK InternationalDiaPharma GroupDrug Discovery NewsEarly Stage PartnersEdison Biotechnology InstituteEdoc ServiceFathom SEOFrost Brown ToddG2G ConsultingGBQ PartnersGiraffeGrant Thornton LLPGSW

Hahn Loeser & Parks LLPHicks PartnersHIMSS Innovation CenterThe Hoffman GroupHylant GroupIce Miller LLPIMARC ResearchIQ Inc.JAAS SystemsJLP CPA’sJobsOhioKegler, Brown, Hill & RitterKelly Scientific ResourcesKeyser Technical SolutionsKulis Freeze DryKuss FiltrationLaura Green, LLCLaw Office of Jeffrey P. JonesLexaMedMatrix Medical DevicesMcFlusionMcNees Wallace & NurickMeditech GlobalMontgomery CountyThe Montrose GroupOffenberger & White (OffWhite)Ohio Chamber of CommerceOhio Supercomputer CenterOswald CompaniesPellucid AdvantagePharmagilityPorter, Wright, Morris & ArthurPraxairPraxis Packaging SolutionsQuality System ArchitectsQUARA InnovationsRanchod Life SciencesR&Q (Regulatory and Quality Solutions)Rev1 VenturesRidgeback Business DevelopmentRocket VenturesSchauer GroupSequentSiemens IndustrySkoda MinottiSlone PartnersStandley Law Group LLPState and Federal Communications

BioOhioMembers(December2015,continued)

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BioOhioMembers(December2015,continued)

STATKING Clinical ServicesStrategic Regulatory ConsultingTaft, Stettinius & Hollister LLPtaylor strategy partnersTeam NEOThompson Hine LLPTriathlon Medical Venture PartnersUlmer & Berne LLPUPS, Healthcare DivisionVorys, Sater, Seymour and Pease LLPVWR InternationalWestern Reserve Water SystemsWood, Herron & Evans, LLPWorld CourierWright Brothers Global Gas

Universities,Colleges,ResearchInstitutions&HospitalsAshland UniversityBryant & Stratton CollegeCase Western Reserve UniversityCedarville University School of PharmacyCincinnati Children’s Hospital Medical CenterCleveland ClinicCleveland State UniversityDayton Children’s HospitalMiami UniversityThe Research Institute at Nationwide Children’s HospitalNortheast Ohio Medical University (NEOMED)Ohio Aerospace InstituteOhio Northern UniversityOhio UniversityOhioHealth Research and Innovation InstituteProMedicaSinclair Community CollegeSumma Health SystemThe Ohio State UniversityUniversity Hospitals of ClevelandUniversity of CincinnatiThe University of ToledoWright State University

PatientAdvocacy,AcademicSocieties,K-12Schools&CareerCentersAshland County-West Holmes Career CenterBioHio Research ParkButler TechCarroll High SchoolCentral Ohio Men Against Prostate CancerCollins-Miller Project, The Delaware Area Career CenterEastland-Fairfield Career & Technical SchoolsGlobal Enteral Device Supplier Association (GEDSA)Loveland High SchoolNorthwestern Local School DistrictThe Ohio Academy of SciencePhRMAReynoldsburg City School DistrictScience United

IndividualMembersDavid BaldwinChristopher BasilTim BiroHassan BortehFernando ColonJoe DeakTony DennisWilliam DunlevyNicholas GantenbergBecky GrahamEric GuttagSarah HendersonRichard HitchcockJim JolyPeter KleinhenzHenry LabodaMichael LanzilottiMarc LemaitreSheila LynchSteven MayherTony MirandoDon OsborneChrista Pawlowski

Jyothi PisipatiLakshmi SamiduraiDavid SchollIsaiah ShalwitzMike SieronP. Roy SnipesBill TaconNicole TesarBrittany TroutSabine Zacate

StudentMembers Richard AgansRazi AnwerRachel BrockhageKristine-Ann BuelaApril DaubenspeckAnna DikinaZoe HespNelson HsiehJeShaune JacksonEmily NordquistAmruta PradhanRichard PyeHolly ReichertLauren ReitzCraig RozarioShamili SammohiAli ShawkiWendy SloneAndrew SylvesterDavid SypertDeekshith VanamalaWesley WolfRyan Yoakum

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BioOhio Partners and Resources for Commercialization, Expansion, and AttractionBioOhio is proud to work with a wide range of partners across our great state. Our partners include incubators, accelerators, subject matter experts, regional economic development organizations, and more. These entities offer services that include start-up assistance, technology commercialization, access to capital, business acceleration, facility expansion consulting, regional and statewide economic development incentives, workforce development, and industry growth across Ohio.

The following is a listing of many of these resources, as well as national entities covered in this report.

National Resources

AdvaMed | advamed.orgBIO | bio.orgBioMotiv | biomotiv.comClinical Trials Database | clinicaltrials.govCoalition of State Bioscience Institutes | csbinstitutes.orgCongressionally Directed Medical Research Programs | cdmrp.army.milMDMA | medicaldevices.orgNational Institutes of Health Award Data | report.nih.govNational Science Foundation Directorate for Biological Sciences | nsf.govPhRMA | phrma.orgState Science & Technology Institute | ssti.orgU.S. Patent and Trademark Office | uspto.govU.S. Population Statistics & NAICS database | census.govU.S. Small Business Administration, Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs | sbir.gov

Educational Resources

GrowNextGen | grownextgen.org National Center for Education Statistics | nces.ed.govOhio Academy of Science | ohiosci.orgOhio Board of Regents | ohiohighered.orgOhio Department of Education | education.ohio.govOhio Stem Learning Network (OSLN) | osln.orgProject Lead the Way (PLtW) | pltwohio.org

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Accelerators and Incubators

Statewide OrganizationsBioHio Research Park | biohioresearchpark.orgCenter for Innovative Food Technologies (CIFT) | ciftinnovation.orgEdison Welding Institute (EWI) | ewi.orgGlobal Cardiovascular Innovation Center | gcic.org HIMSS Innovation Center | himssinnovationcenter.org JobsOhio | jobs-ohio.comMAGNET (Manufacturing Advocacy & Growth Network) | manufacturingsuccess.orgMinority Business Assistance Centers (MBAC) | development.ohio.gov/bs/bs_mbac.htmOhio Clinical Trials Collaborative | ohioclintrials.orgOhio Development Services Agency | development.ohio.govOhio Health Information Partnership | clinisync.orgOhio Manufacturing Extension Partnership, The (Ohio MEP) | development.ohio.gov/ bs_thirdfrontier/mep.htmOhio Small Business Development Centers Network | ohiosbdc.ohio.govOhio Third Frontier | development.ohio.gov/bs_thirdfrontierOhio Woman’s Business Program | development.ohio.gov/bs/bs_wbp.htmPolymerOhio | polymerohio.orgState Science & Technology Institute (SSTI) | ssti.orgTechSolve | techsolve.orgVentureOhio | ventureohio.org

Central Ohio Columbus 2020 | columbusregion.comDublin Entrepreneurial Center (DEC) | decindublin.comEdison Welding Institute (EWI) | ewi.orgInnovate New Albany | innovatenewalbany.orgPolymerOhio | polymerohio.org Rev1 Ventures, an Ohio ESP | rev1ventures.com

Northeast Ohio Akron Global Business Accelerator | akronaccelerator.comAusten BioInnovation Institute in Akron | abiakron.orgBeachwood Business Development Center | beachwood.orgBioEnterprise | bioenterprise.comBioHio Research Park | biohioresearchpark.orgBraintree Business Development Center | braintreepartners.orgCleveland Clinic Innovations | innovations.clevelandclinic.org

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GLIDE (Great Lakes Innovation & Development Enterprise) | glideit.orgGlobal Cardiovascular Innovation Center Incubator | gcicincubator.orgJumpStart, an Ohio ESP | jumpstartinc.orgMAGNET (Manufacturing Advocacy & Growth Network) | manufacturingsuccess.orgOhio Clinical Trials Collaborative | ohioclintrials.orgREDIzone at NEOMED | neomed.edu/research/redizoneShaker LaunchHouse | launchhouse.comTeam NEO / Cleveland+ | clevelandplusbusiness.comYoungstown Business Incubator | ybi.org

Northwest Ohio Agricultural Incubator Foundation | agincubator.orgCenter for Innovative Food Technologies (CIFT) | ciftinnovation.orgLaunchPad at the University of Toledo | utoledo.edu/incubatorProMedica Innovations | promedica.org/innovationsRegional Growth Partnership | rgp.orgRocket Ventures, an Ohio ESP | rocketventures.org

Southeast Ohio Appalachian Partnership for Economic Growth | apeg.comEdison Biotechnology Institute | ohio.edu/research/biotechOhio University Innovation Center | ohio.edu/research/innovationTechGROWTH Ohio, an Ohio ESP | techgrowthohio.com

Southwest Ohio CincyTech, an Ohio ESP | cincytechusa.comCintrifuse | cintrifuse.comHCDC Business Center | hcdc.comREDI Cincinnati | redicincinnati.comTechSolve | techsolve.orgUniversity of Cincinnati Technology Accelerator | uc.eduVora Technology Park | voraventures.com

Western Ohio Ascend Innovations | ascend-innovations.comDayton Development Coalition | daytonregion.comEntrepreneurs Center, The (TEC Dayton) | tecdayton.comFASTLANE | fastlane-mep.orgInstitute for Development and Commercialization of Advanced Sensor Technology (IDCAST) | idcast.com

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Engage Ohio!Bioscience Eventsbioohio.com/events

BioOhio sends an annual survey to our members in order to understand what they value, which helps us plan for the future. The response is consistent each year with events and networking being the most valuable and desired service. BioOhio events gather our community together for industry education, networking and connectivity, idea sharing and collaboration, career exploration, and more.

Our events are made possible and are successful because of knowledgeable speakers, generous sponsors, promotion advocates, and of course, attendees. We hear of many partnering and business deals as a result of our events, and we are excited to continue in our role of supporting these important activities.

We also encourage Ohio’s bioscience community to take an active role in other eventsaround the state, region and country. BioOhio attends, promotes, and endorses these quality functions.

Annual Ohio EventsAdvanced Materials in Healthcare Conference, presented by the American Chemical SocietyBioOhio Annual ConferenceBioOhio FDA Regulatory ForumBioOhio Investment & Capital SeminarBioOhio Leadership DinnerBioOhio Networking SocialsBioOhio Regulatory 101 SeriesBioOhio Statehouse DayCase Western Reserve University Innovation SummitCincyBioCleveland Clinic Innovations Medical Innovation SummitCleveland HeartLab Symposium

Combination Products Summit presented by Xavier HealthMedCon, presented by Xavier HealthMSC2016, presented by Case Western Reserve University National Center for Regenerative MedicineOhio Biomedical & Pharmaceutical Career & Internship Fairs presented by BioOhioOhio Bioscience Supplier ExpoOVALSPharmaLink Conference, presented by Xavier HealthPlastics in Medical DevicesProMedica Innovation ConferenceWomen in Bioscience Conference, presented by BioOhio

Global, National & Regional Events3 Rivers Venture FairAdvaMed Annual ConferenceBIO International ConventionBioIT World Conference and ExpoBioMed IsraelHealthcare Businesswomen’s Association Annual ConferenceHIMSS Annual Conference & ExhibitionJP Morgan Healthcare Conference

MD&M (Medical Design and Manufacturing)MDMA Annual ConferenceMEDICAMidAmerica Healthcare Venture ForumPittConRadiological Society of North America (RSN&A) Annual MeetingRegulatory Affairs Professionals Society Regulatory Convergence

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MethodologyThis report analyzes the bioscience industry and its six subsectors both in Ohio as a whole and in six distinct geographic regions: central, northeast, northwest, southeast, southwest, and western. The regions are based on commonly used definitions created by Ohio’s Development Services Agency and JobsOhio.

To conduct the analyses for this report, a data set of Ohio businesses was created by the University of Cincinnati Economics Center using the Quarterly Census of Employment and Wages (QCEW or ES202) database for the years 2009 through 2014, based on BioOhio’s NAICS based industry definition.

OhioRegionalMap

O�awa

Sandusky

Seneca

CrawfordWyandot

Hardin

Allen

HancockPutnam

Van Wert

Williams

Defiance WoodHenry

LucasFulton

Paulding

PickawayFairfield

Licking

DelawareUnion

Logan

Marion

MorrowKnox

Madison

Franklin

Preble

Darke

Clinton

Greene

Clark

ChampaignMiami

Shelby

Auglaize

Faye�eMon

tgom

ery

Mercer

Hamilton

Cle

rmon

t

Butler Warren

Brown

Muskingum

MonroeNobleMorgan

Athens

Meigs

Gallia

Lawrence

JacksonPike

Highland

SciotoAdams

Ross

Hocking

Vinton

Perry

BelmontGuernsey

Harrison

Carroll

Coshocton

Holmes

Jeffe

rson

Tusc

araw

as

Washington

ColumbianaStarkWayne

Ash

land

Rich

land

Mahoning

Trumbull

GeaugaCuyahogaErie

Huron

Lorain

PortageSummitMedina

AshtabulaLake

Central Northeast Northwest Southeast Southwest Western

About the Economics Center

“The Research and Consulting division of the Economics Center at the University of Cincinnati provides the knowledge building blocks that help clients make better policy and economic development decisions. Our dynamic approach and critical data analysis empower leaders to respond to changing economic conditions, strengthen local economies and improve the quality of life for their communities.”

Michael Jones, Ph.D.,Director of Research, University of Cincinnati Economics Center

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This study uses six subsectors to define and measure Ohio’s bioscience sector. These subsectors are Agricultural Biotechnology, Medical & Testing Laboratories, Medical Device & Equipment Manufacturers, Medical Product Distribution, Pharmaceuticals & Therapeutics, and Research & Development. Each subsector is comprised of a collection of bioscience- related NAICS codes that reflect the industries included.

The North American Industry Classification System (NAICS) is the standard used by federal and private statistical agencies in classifying businesses for the purpose of collecting, analyzing, and publishing economic data. The codes used in this report, and their respective industry sectors can be found in Table 50. Learn more at the U.S. Census website, www.census.gov/eos/www/naics.

In 2012, the NAICS system was revised and a number of codes used in previous Ohio Bioscience Growth Reports were reclassified. 311222 Soybean Processing and 311223 Oilseed Processing were combined into 311224 Soybean and Other Oilseed Processing. 325221 Cellulosic Organic Fiber Manufacturing was merged into 325220 Artificial and Synthetic Fibers and Filaments Manufacturing. 339111 Laboratory Apparatus and Furniture Manufacturing was a 2002 code that has since been merged into other Medical Device codes in the 3391 group.

Economic impact analysis of the Health & Life Science IT sector has not been performed due to the nature of that sector’s NAICS codes. Currently, digital health is contained within the same codes that represent software and computer companies from all industries, with no viable method to isolate only those involved in digital health. In some cases, however, companies operating in the digital health market also operate in one or more of the bioscience subsectors – such as a wearables developer that also produces an electromedical device. In these cases, the company would be included in the bioscience data based on the relevant NAICS code.

Generally speaking, digital health companies can be found within these broad industry codes:

511210 | Software Publishing, Licensing, and Sales541511 | Custom Computer Programming Services, Software Development541512 | Computer Systems Design Services 541519 | Other Computer Related Services518210 | Data Processing, Hosting, and Related Services

To further understand the full continuum of products and services related to the bioscience industry, BioOhio commissioned an additional study, also performed by the University of Cincinnati Economics Center, on Ohio’s healthcare providers for the years 2013 and 2014. BioOhio assigned a number of subsectors to providers and related organizations based on their activities, specifically: Consumer Health, Extended Care, Health and Medical Insurance Carriers, Hospitals, Outpatient Care, Physicians, and Additional Health Related Fields.

90 |

Table 51 provides a detailed look at the relevant NAICS codes and how they are grouped for the purposes of this report.

Regarding Health and Medical Insurance Carriers (524114), within the NAICS structure, much like the Health & Life Science sector, it is not possible to examine the entire scope of companies working in the medical space. The Health and Medical Insurance Carriers is the only code that is specific to the healthcare industry, and therefore the only one included for analysis in this report.

Regarding employment, location, firm, and wage data in the Research & Development category, while research programs are in operation throughout the state at a variety of organizations such as universities and health systems, the NAICS structure only allows analysis of data from organizations identified with the 541711 and 541712 codes. If the research is being performed at a university, for example, it will not be reflected in the R&D sector of this report because the organization would be submitting their employment data under an educational NAICS code. This employment data would reflect the entire workforce data from the university, with no reasonable method for extracting only the bioscience- related research portion.

Employment and wage data on companies in the NAICS defined groups include all the workers at each business identified, regardless of their occupation. Analysis of employment trends provides information on local jobs without differentiation between part-time and full-time employment or between entry level and executive positions. Five measures of economic activity are used for the trend analysis: employment, payroll, average wage, number of locations, and number of firms.

Analysis of payroll/wage trends describes the scale of the bioscience sector in different economies. Although payroll does not measure gross regional product, it can be viewed as a proxy for value-added output. The number of locations counts the individual locations of businesses and captures the different functionalities that firms have at different sites. Average wage is calculated as payroll per employee and estimates the annual average wage in each industry and region.

The QCEW is managed, maintained, and edited by the University of Cincinnati Economics Center, which receives quarterly updates of this data from the Ohio Department of Jobs and Family Services. The QCEW includes information such as company name, address, city, county, NAICS code, employment, and wages on most locations with paid employees in Ohio. Although the database includes company-level information, only industry level data can be reported due to confidentiality restrictions. As a result, information is suppressed for some industries, primarily small industries in small geographic areas of the state.

To accommodate privacy concerns and the need for accurate regional analysis within the central, northeast, southwest and western regions, the Pharmaceuticals and Therapeutics subsector was combined with Research and Development. For data on the northwest and southeast regions, three subsectors were combined; Medical Device and Equipment Manufacturers, Pharmaceuticals and Therapeutics, and Research and Development.

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NAICS Codes Associated with Ohio’s Bioscience Sector

NAICS Code Description

Agricultural Biotechnology

311221 Wet Corn Milling

311224 Soybean and Other Oilseed Processing

325193 Ethanol / Ethyl Alcohol Manufacturing

325199 Basic Organic Chemical Manufacturing, Bio-based Fuel Manufacturing (except Ethanol)

325220 Artificial and Synthetic Fibers and Filaments Manufacturing

325311 Nitrogenous Fertilizer Manufacturing

325312 Phosphatic Fertilizer Manufacturing

325314 Fertilizer Manufacturing (Mixing Only)

325320 Pesticide and Other Agricultural Chemical Manufacturing

Medical & Testing Laboratories

541380 Testing Laboratories

621511 Medical Laboratories

621512 Diagnostic Imaging Centers

Medical Device & Equipment Manufacturers

333314 Optical Instrument and Lens Manufacturing

334510 Electromedical, Electrotherapeutic, and Medical Imaging Apparatus Manufacturing

334516 Analytical Laboratory Instrument Manufacturing

334517 Irradiation Apparatus Manufacturing, Including Diagnostic Medical Equipment

339112 Surgical and Medical Instrument Manufacturing

339113 Surgical Appliance and Supplies Manufacturing

339114 Dental Instruments, Equipment and Supplies Manufacturing

339115 Ophthalmic Goods and Supplies Manufacturing (including lens coating, grinding, etc.)

339116 Dental Laboratories (Manufacturing of Bridges, Dentures, Teeth, Orthodontic Appliances, etc.)

Medical Product Distribution

423450 Medical, Dental, and Hospital Equipment and Supplies Wholesaler / Distributor

423460 Ophthalmic Goods Wholesaler / Distributor

424210 Pharmaceuticals, Medication and Supplies Wholesaler / Distributor

532291 Home Health and Durable Medical Equipment Rental

Pharmaceuticals & Therapeutics

325411 Medicinal and Botanical Product Manufacturing

325412 Pharmaceutical Preparation Manufacturing

325413 In-Vitro Diagnostic Substance Manufacturing

325414 Biological Product Manufacturing (except Diagnostic)

Research & Development

541711 Research and Development in Biotechnology

541712 Research and Development in the Physical, Engineering, and Life Sciences

Table50:NAICSCodesAssociatedwithOhio’sBioscienceSector

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NAICS Codes Associated with Each Subsector of the Healthcare Sector

NAICS Code Description

Consumer Heatlh

446110 Pharmacies and Drug Stores

446130 Optical Goods Stores

446191 Health Food & Supplement Stores

Extended Care

623110 Nursing Care Facilities (Skilled Nursing Facilities)

623210 Residential Intellectual and Developmental Disability Facilities

623220 Residential Mental Health and Substance Abuse Facilities

623311 Continuing Care Retirement Communities

623312 Assisted Living Facilities for the Elderly

623990 Other Residential Care Facilities

Health and Medical Insurance Carriers

524114 Direct Health and Medical Insurance Carriers

Hospitals

622110 General Medical, Surgical and Children's Hospitals

622210 Psychiatric and Substance Abuse Hospitals

622310 Specialty Hospitals (except Psychiatric and Substance Abuse)

Outpatient Care

621410 Family Planning Centers

621420 Outpatient Mental Health and Substance Abuse Centers

621491 HMO Medical Centers

621492 Kidney Dialysis Centers

621493 Freestanding Ambulatory Surgical and Emergency Centers

621498 All Other Outpatient Care Centers

621610 Home Health Care Services

621910 Ambulance Services

621991 Blood, Organ and Tissue Banks

621999 All Other Miscellaneous Ambulatory Health Care Services

Table51:NAICSCodesAssociatedwithOhio’sHealthcareSector

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NAICS Codes Associated with Each Subsector of the Healthcare Sector

NAICS Code Description

Physicians

621111 Offices of Physicians (except Mental Health Specialists)

621112 Offices of Physicians, Mental Health Specialists

621210 Offices of Dentists

621310 Offices of Chiropractors

621320 Offices of Optometrists

621330 Offices of Mental Health Practitioners (except Physicians)

621340 Offices of Physical, Occupational and Speech Therapists, and Audiologists

621391 Offices of Podiatrists

621399 Offices of All Other Health Practitioners

541940 Veterinary Services

Additional Health Related Fields

525120 Health and Welfare Funds

813212 Voluntary Health Organizations

923120 Administration of Public Health Programs

Table51:NAICSCodesAssociatedwithOhio’sHealthcareSector(continued)

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Table52:Bioscience-RelatedDegreeProgramsinOhio(2013)

Agricultural EngineeringAgronomy and Crop ScienceAnatomyAnimal GeneticsAnimal PhysiologyAnimal SciencesAquacultureBiochemistryBiochemistry - Biophysics and Molecular BiologyBiochemistry and Molecular BiologyBioengineering and Biomedical EngineeringBioethics/Medical EthicsBioinformaticsBiological and Biomedical SciencesBiological and Physical SciencesBiology Technician/Biotechnology Laboratory TechnicianBiology/Biological SciencesBiomathematics, Bioinformatics, and Computational BiologyBiomedical SciencesBiomedical Technology/TechnicianBiophysicsBiopsychologyBiostatisticsBiotechnologyBotany/Plant BiologyCardiovascular ScienceCardiovascular Technology/ TechnologistCell PhysiologyCell/Cellular and Molecular BiologyCell/Cellular Biology and Anatomical SciencesCell/Cellular Biology and HistologyChemical EngineeringChemical PhysicsChemical Technology/TechnicianChemistryClinical Laboratory Science/ Medical Technology/TechnologistClinical/Medical Laboratory AssistantClinical/Medical Laboratory TechnicianComputational Biology

Conservation BiologyCytotechnology/CytotechnologistDairy ScienceDental Laboratory Technology/ TechnicianDevelopmental Biology and EmbryologyEcologyElectroneurodiagnostic/ Electroencephalographic Technology/TechnicianEntomologyEnvironmental BiologyEnvironmental HealthEnvironmental ToxicologyEpidemiologyEvolutionary BiologyExercise PhysiologyFood ScienceFoods, Nutrition, and Related ServicesFoods, Nutrition, and Wellness StudiesForensic Science and TechnologyGene/Genetic TherapyGeneticsHematology Technology/TechnicianHistologic TechnicianHorticultural ScienceHuman NutritionHuman/Medical GeneticsImmunologyIndustrial and Physical Pharmacy and Cosmetic SciencesMarine Biology and Biological OceanographyMedical InformaticsMedical Microbiology and BacteriologyMedical Scientist (MS - PhD)Medicinal and Pharmaceutical Chemistry (MS - PhD)MicrobiologyMolecular BiologyMolecular GeneticsMolecular MedicineNeurobiology and NeurophysiologyNeuroscience

Nutrition SciencesOncology and Cancer BiologyPathology/Experimental PathologyPharmaceutical Marketing and ManagementPharmaceutical SciencesPharmaceutics and Drug Design (MS - PhD)Pharmacology and ToxicologyPharmacyPharmacy Administration and Pharmacy Policy and Regulatory Affairs(MS,PhD)Pharmacy Technician/AssistantPharmacy, Pharmaceutical Sciences, and AdministrationPhysiologyPhysiology, Pathology, and Related SciencesPlant Pathology/PhytopathologyPlant SciencesPolymer ChemistryPsychopharmacologyRadiation Biology/RadiobiologySoil Science and AgronomySterile Processing Technology/ TechnicianTheoretical ChemistryToxicologyVeterinary/Animal Health Technology/Technician/Veterinary AssistantVirologyVision Science/Physiological OpticsWildlife BiologyZoology/Animal Biology

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Table53:OhioInstitutionsAwardingBioscience-RelatedDegrees/Certificates(2013)

Ashland UniversityBaldwin-Wallace UniversityBluffton UniversityBowling Green State University Bradford School Brown Mackie CollegeCapital University Case Western Reserve UniversityCedarville UniversityCentral Ohio Technical CollegeCentral State University Cincinnati State Technical & Community CollegeClark State Community CollegeCleveland State UniversityCollege of Mount St. JosephCollege of WoosterColumbus State Community College Cuyahoga Community College Daymar College Defiance College Denison UniversityDeVry University Eastern Gateway Community College Edison State Community College Fortis College Franciscan University of Steubenville Heidelberg University Herzing University Hiram College Hocking Technical College John Carroll University

Kent State UniversityKenyon College Lake Erie College Lakeland Community College Lorain County Community College Lourdes College Malone University Marietta College Marion Technical College Mercy College of Ohio Miami University Miami-Jacobs Career College Mount Vernon Nazarene UniversityMuskingum University National College North Central State College Northeast Ohio Medical UniversityNotre Dame College Oberlin College Ohio Dominican University Ohio Northern University The Ohio State University Ohio University Ohio Wesleyan University Otterbein University Owens State Community CollegeRemington College Ross College Sanford-Brown College Shawnee State University Sinclair Community College Southern State Community College Stark State College of TechnologyStautzenberger College

Terra State Community College Tiffin University University of Akron University of Cincinnati University of Dayton University of Findlay University of Mount Union University of Northwestern OhioUniversity of Rio Grande & Rio Grande Community College University of Toledo Urbana University Ursuline College Walsh University Washington State Community College Wilberforce University Wilmington College Wittenberg University Wright State University Xavier University Youngstown State University Zane State College Some institutions have multiple facilities in Ohio

96 |

Table55:OhioBioscienceGraduationsbyRegion,TwoYearSchools(2006-13)

Region Cumulative Total 2006 2007 2008 2009 2010 2011 2012 2013

Percent Change

2006 to 2013

Central 1,099 128 133 134 128 136 143 142 155 21%

Northeast 1,661 128 197 168 170 201 257 243 297 132%

Northwest 190 21 10 10 28 25 30 28 38 81%

Southeast 291 92 52 20 25 24 32 30 16 -83%

Southwest 840 83 81 67 94 96 138 138 143 72%

Western 779 60 64 73 62 128 136 158 98 63%

Total 4,860 512 537 472 507 610 736 739 747 46%

Table56:OhioBioscienceGraduationsbyRegion,Private-For-ProfitSchools(2006-13)

Region Cumulative Total 2006 2007 2008 2009 2010 2011 2012 2013

Percent Change

2006 to 2013

Central 1,196 39 57 208 231 291 173 98 99 154%

Northeast 1,597 85 89 114 153 235 222 386 313 268%

Northwest 429 51 49 25 25 45 69 85 80 57%

Southeast 23 9 14 n/a

Southwest 582 58 58 46 84 49 74 125 88 52%

Western 369 19 12 20 29 1 62 107 119 526%

Total 4,196 252 265 413 522 621 600 810 713 183%

Table54:OhioBioscienceGraduationsbyRegion,FourYearSchools(2006-13)

Region Cumulative Total 2006 2007 2008 2009 2010 2011 2012 2013

Percent Change

2006 to 2013

Central 15,946 1,653 1,735 1,814 1,963 1,983 2,156 2,373 2,269 37%

Northeast 14,872 1,545 1,589 1,583 1,795 1,818 2,056 2,169 2,317 50%

Northwest 8,666 874 941 1,046 1,086 1,086 1,190 1,216 1,227 40%

Southeast 2,724 326 327 297 303 337 380 366 388 19%

Southwest 8,978 813 959 1,097 1,062 1,121 1,167 1,357 1,402 72%

Western 4,050 462 435 456 458 518 539 574 608 32%

Total 55,236 5,673 5,986 6,293 6,667 6,863 7,488 8,055 8,211 45%

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Table57:OhioSourcesofCapitalforBioscienceCommercializationandExpansion

Name City Name City

23Bell Cleveland Draper Triangle VenturesCleveland, Cincinnati

Accelerant Fund Dayton Drive Capital Columbus

Akron ArchAngels Network Akron Early Stage Partners Cleveland

Akron BioInvestments Funds Akron East Central Ohio TechAngel Fund Columbus

Allos Ventures Cincinnati Edgewater Capital Partners Cleveland

American Financial Group Cincinnati Everett Partners Akron

Arboretum Ventures Cleveland Fast Switch Ventures Dublin

Arsenal Venture Partners Cleveland Fifth Third Capital Cincinnati

Athenian Venture Partners Athens Fir Hill Akron

Baird Capital Partners Cincinnati First Fifty Fund Columbus

Battelle Ventures Columbus FlashStarts Cleveland

Bizdom Cleveland Fletcher Spaght Ventures Columbus

Blue Chip Validation Fund Cincinnati Fort Washington Capital PartnersCincinnati,

Columbus & Cleveland

Blue Chip Venture Company Cincinnati Foundation Medical Partners Cleveland

Blue Point Capital Cleveland Frantz Medical Ventures Cleveland

Bridge Investment Fund Cleveland Glengary Ventures Beachwood

Cardinal Health DublinGlobal Cardiovascular Innovation Center

Cleveland

Carleton Advisors ClevelandHealth Foundation of Greater Cincinnati, The

Cincinnati

Case Technology Ventures Cleveland Hopen Life Science Ventures Cleveland

Charter Life Sciences Cincinnati Innovation Ohio Fund Columbus

CID Capital Columbus JumpStart Cleveland

Cincinnati Children's Hospital Medical Center

Cincinnati LCCC GLIDE Fund / Innovation Fund Cleveland

CincyTech Cincinnati Linkage Ventures Mason

Cintrifuse Cincinnati Luxemburg Capital Cleveland

Cleveland Clinic Innovations Cleveland Medical Growth Fund Cleveland

Cleveland Clinic Ohio BioValidation Fund

Cleveland Miami Valley Ventures Dayton

Dayton Region Signature Fund Dayton Morgenthaler Ventures Cleveland

Deaconess Associations Foundation Cincinnati Mutual Capital Partners Cleveland

98 |

Name City Name City

Myrian Capital Dayton Rocket Ventures Toledo

Nationwide Children's Technology Development Fund

Columbus Roulston Ventures Chagrin Falls

Nationwide Mutual Insurance Company

Columbus SaaS Capital Cincinnati

NCT Ventures Columbus Second Generation Cleveland

NDI Healthcare Fund Cleveland Shaker LaunchHouseShaker

Heights

North Coast Angel Fund Cleveland SOCC Fund Cincinnati

Ohio TechAngels Fund Columbus Soin International Dayton

Physician Investment Group Dayton Sun Bridge Partners Beachwood

Piper Jaffray & Co. Cleveland Talisman Capital Partners Columbus

Portal Capital Beachwood TechGROWTH Ohio Athens

Primus Capital Cleveland Tower Wealth Management Cleveland

Queen City Angels Cincinnati Triathlon Medical Venture Partners Cincinnati

Radius Ventures Cleveland Tri-State Growth Capital Cincinnati

Regional Growth Partnership Toledo University Hospitals Cleveland

Reservoir Venture Partners Columbus West Capital Advisors Cincinnati

Rev1 Ventures Columbus Western Reserve Partners Fund Cleveland

RIK Enterprises Beachwood X Squared Angels Columbus

River Cities Capital Funds Cincinnati Zapis Capital Group Cleveland

Rivervest Venture Partners Cleveland

Table57:OhioSourcesofCapitalforBioscienceCommercializationandExpansion(continued)

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Table58:OhioThirdFrontierBioscience-RelatedAwards(2014-15)

Project Participants Award(millions)

Corporate Matching

Funds (millions)

Tomorrow Fund II (significant bioscience focus) Cincinnati Children’s Hospital Medical Center & CincyTech $2 $2

Ohio BioValidation Fund IV (significant bioscience focus)

The Cleveland Clinic, North Coast Angel Fund, Foundation Medical Partners, JumpStart, Parker Hannifin, TechColumbus, Case Western Reserve University, and BioEnterprise

$2 $2

JumpStart Evergreen Fund Continuation Proposal (significant bioscience focus)

JumpStart, BioEnterprise, KeyBank Foundation, Key Corporation, JS Fund I, Burton D. Morgan Foundation, Barberton Community Development Organization, Fund for our Economic Future, The Cleveland Foundation, Panther Expedited Services, and Plasticolors

$2 $2

INNOVATION FUND (significant bioscience focus)

Lorain County Community College, in collaboration with Cleveland State University, GLIDE, University of Akron, Youngstown State University, Youngstown Business Incubator, JumpStart Entrepreneurial Network, Northeast Ohio Universities Colleges of Medicine and Pharmacy, and Stark State College

$2 $2

NDI Healthcare Fund Capitalization Project(significant bioscience focus)

NDI, JumpStart, BioEnterprise, Case Western Reserve University, Cleveland FES Center, NDI Medical, Ogilvy Government Relations, Kichler Lighting, Fourman Limited Partners, Duke University, Check-point Surgical, Greensboro Ophthalmology, the Cleveland Clinic, A-D Technologies, and CFD Trust No. 8

$2 $2

CincyTech Fund II, LLC (significant bioscience focus)

Cincinnati USA Regional Chamber/CincyTech in collaboration with the Greater Cincinnati Foundation, Health Foundation of Greater Cincinnati, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, BIOSTART, Castellini Foundation, The Circuit, Fort Washington Capital, Haile/US Bank Foundation, and the Hamilton County Business Center

$2 $2

North Coast Angel Fund II (significant bioscience focus)

JumpStart, BioEnterprise, CCF Innovations, Case Western Reserve University, University of Akron, Akron Regional Change Angels, TechColumbus, Ohio TechAngel Fund, Queen City Angels, Core Network, Early Stage Partners, Glengary LLC, Portal Capital, East Ohio TechAngel Fund, Porter Wright Morris & Arthur LLP

$2 $2

TechGROWTH Ohio Fund II Pre-Seed Capitalization Program Fund (significant bioscience focus)

Ohio University with Woodland Ventures Management $1 $1

TechColumbus Pre-Seed Fund IV (significant bioscience focus)

City of Columbus, City of Dublin, City of Gahanna, City of Upper Arlington, City of Westerville, Village of New Albany, Franklin County, The Ohio State University, Battelle, North Coast Angel Fund, Draper Triangle Ventures, Margaux Ventures, Queen City Angels, OhioHealth Research Institute, SBDC at Columbus State Community College, Reservoir Venture Partners, CCF Innovations, The Research Institute at Nationwide Children’s Hospital, Fort Washington Investment Advisors, NCT Ventures, Ohio TechAngels Fund, CID Capital, Fletcher Spaght, and BioOhio

$2 $2

BioStart Ohio Continuity Proposal Cincinnati USA Regional Chamber/CincyTech in collaboration with BIOSTART, the University of Cincinnati, and Meridian Biosciences $0.25 $0.25

JumpStart Entrepreneurial Network, the Northeast Ohio Entrepreneurial Signature Program (significant bioscience focus)

In Collaboration with BioEnterprise, MAGNET, GLIDE, Akron Global Business Accelerator, Braintree Business Development Center,Youngstown Business Incubator, Ohio Aerospace Institute, Abington Foundation, Barberton Community Development Corporation, Barberton Community Foundation, Burton D. Morgan Foundation, North Coast Angel Fund, Case Western Reserve University, the Cleveland Clinic, Austen BioInnovation Institute, University Hospitals of Cleveland, NorTech, KeyBank Foundation, Morgenthaler Ventures, William J. and Dorothy K. O’Neill Foundation, Sherwick Fund, Raymond John Wean Foundation, Greater Cleveland Partnership, Fred A. Lennon Charitable Trust, Calfee, Halter & Griswold LLP, Charter One Foundation, the Cleveland Foundation, Cuyahoga County New Product Development & Entrepreneurship Loan Fund, North Coast Opportunities Fund, Eaton Corporation, Fund for our Economic Future, Fir Hill, Lorain County Community College

$4.7 $4.7

100 |

Project Participants Award(millions)

Corporate Matching

Funds (millions)

TechGROWTH Ohio Continuity Program (significant bioscience focus)

Ohio University, The Ohio State University’s South Centers, Muskingum County Business Incubator, and Woodland Ventures Management $2 $2

TechColumbus Continuity Initiative (significant bioscience focus)

In collaboration with City of Upper Arlington, City of Dublin, City of Columbus, Columbus Chamber of Commerce, SBDC at Columbus State Community College, and BioOhio

$1.45 $1.45

Development and Commercialization of Hematopoietic Stem CellExpansion for Clinical Applications

Arteriocyte and The Ohio State University $0.999969 $0.999969

Development and Commercialization of a Minimally Invasive Left Appendage Exclusion System

AtriCure in collaboration with Good Samaritan Hospital, the University of Cincinnati, Battelle, and The Ohio State University Medical Center $1 $2.002422

Bettcher Medical Debridement Technologies Bettcher Industries, in collaboration with Community Tissue Services $1 $1

Development and Commercialization of Novel Biomaterials Therapy for Stress Urinary Incontinence

Case Western Reserve University, in collaboration with Proxy Biomedi-cal and the Cleveland Clinic Lerner Research Institute $0.982768 $0.99

Pocket Plating System OrthoHelix Surgical Designs, Inc, in collaboration with Hudak, Shunk & Farine $1 $1.088006

DirectVision® Commercialization PercuVision, LLC, in collaboration with the OhioHealth Research and Innovation Institute and Scott and White Hospitals $1 $1

Advanced Urological Diagnostic and Therapeutic Accessories Project U.S. Endoscopy, in collaboration with University Hospitals $1 $1

Vibrating Tip Guidewire System for Penetrating Chronic Occlusions

VasoStar, Inc, in collaboration with Frantz Medical, Interplex and the Cleveland Clinic $1 $1

Commercialization of an Innovative Medical Imaging System for Early Cancer Detection

Imalux Corporation, GVI Medical Devices and the Cleveland Clinic $0.987 $1.1654

SDF-1 Treatment to Induce Vascular and Epithelial Regeneration after Cardiovascular Surgery

SironRX Therapeutics and the Cleveland Clinic $0.991788 $1.093207

Development and Commercialization of a Novel Imaging System to Determine Organ Viability

Quality Electrodynamics in collaboration with Glickman Urological Institute of the Cleveland Clinic, Case Western Reserve University, Toshiba Medical Systems, and Canon

$1.0 $1.002

Positron Mammographic Imaging Case Western Reserve University in collaboration with Philips Healthcare and University Hospitals $0.999649 $1.000613

Water Purification using Nano-Enabled Solutions

MetaMateria Technologies in collaboration with Wright State University, Streamside Environmental LLC, PRD Tech, and Consolidated Treatment Systems

$1 $1

Accelerating the Commercialization of a Novel Bio Resource Resin (BR2) for Agricultural, Construction, and Industrial Applications

NuVention Solutions in collaboration with the Ohio BioProducts Innovation Center, The Ohio State University – Ohio Agricultural Research and Development Center, Owens-Corning, The Garland Company, Momentum Technology, Inc., Kokosing Materials, Inc., Turf Care Supply Company, Royal Chemical Company, Innoventor, Inc., JumpStart, and the Ohio Soybean Council

$0.998 $0.998

Cardiac Perfusion with Computed Tomography

Case Western Reserve University in collaboration with Philips Healthcare and University Hospitals $1.580 $1.581858

Table58:OhioThirdFrontierBioscience-RelatedAwards(2014-15,continued)

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Table59:OhioBioscienceExpansionsandAttractions(2014-15)

Company Year City Region

Projected New &

Retained Job

Announced Investment

(millions)Sector

Accutek Testing Laboratory (an Element Materials Technology Company) 2014 Fairfield Southwest 10 $2.3 Laboratories

Advanced Biological Marketing (ABM) 2014 Van Wert Northwest 30 $14 AgBio

Andersons 2014 Upper Sandusky Northwest $3.5 AgBio

Applied Medical Technology 2014 Brecksville Northeast 185 Medical Device

Assurex Health 2014 Mason Southwest 48 $0.7 Laboratories

AtriCure 2014 Mason Southwest 230 $12.8 Medical Device

Austen BioInnovation Institute in Akron 2014 Akron Northeast $13 R&D

Aver Informatics 2014 Columbus Central 30 Health IT

Beam Technologies 2014 Columbus Central 6 Medical Device

BioRx 2014 Blue Ash Southwest 136 $1.5 Distribution

Bocchi Laboratories Ohio 2014 New Albany Central 300 $20 Supplier

Braun Industries 2014 Van Wert Northwest 30 $1 Medical Device

Camargo Pharmaceutical Services 2014 Blue Ash Southwest $1.3 R&D

Cardinal Health 2014 Dublin Central 400 Distribution

Chromocare 2014 New Albany Central 3 Laboratories

CoorsTek Medical 2014 Vandalia Western $1 Medical Device

Cosmax USA 2014 Solon Northeast 135 $16.6 Consumer Health

CoverMyMeds 2014 Columbus Central 116 $3 Health IT

CTI Clinical Trial & Consulting Services 2014 Cincinnati Southwest 50 R&D

Devicor Medical Products 2014 Blue Ash Southwest Medical Device

DRT Medical 2014 West Chester Township Southwest 10 $4 Supplier

Dual Therapeutics 2014 Cleveland Northeast Pharmaceuticals

Enviroflight 2014 Yellow Springs Western 12 $3 AgBio

Express Scripts 2014 Mason Central $3.2 Distribution

Forest Pharmaceuticals 2014 Blue Ash Southwest 125 $45 Pharmaceuticals

General Data Company 2014 Union Township Southwest $1 Distribution

GOJO Industries 2014 Brecksville Northeast 37 $12 Consumer Health

Hamlet Protein 2014 Findlay Northwest 3 $7.1 AgBio

HealthPro Brands 2014 Cincinnati Southwest Consumer Health

Hyland Software 2014 Westlake Northeast 200 Health IT

iHealth Solutions 2014 South Point Southeast 75 $0.646 Health IT

IntelliHARTx 2014 Findlay Northwest 50 $0.75 Health IT

Kalmbach Feeds 2014 Upper Sandusky Northwest 18 $12 AgBio

KDC Columbus 2014 New Albany Central 60 $15.6 Consumer Health

Lubrizol Advanced Materials 2014 Brecksville Northeast 73 Supplier

Lubrizol Advanced Materials 2014 Chester Township Northeast 20 $1.9 Supplier

Masters Pharmaceutical 2014 Moraine Western Distribution

MedInvent 2014 Medina Northeast $0.913 Medical Device

Movband 2014 Brecksville Northeast 31 $1.1 Health IT

Natural Essentials 2014 Aurora Northeast Consumer Health

Norwood Medical 2014 Dayton Western 50 $13.5 Supplier

Orchem Corporation 2014 Norwood Southwest 10 Consumer Health

102 |

Company Year City Region

Projected New &

Retained Job

Announced Investment

(millions)Sector

ProMedica Innovations 2014 Toledo Northwest 700 $40 R&D

Roxane Laboratories 2014 Columbus Central $4.4 Pharmaceuticals

SGP Biofuels 2014 South Point Southeast 100 $400 AgBio

Siemens Healthcare 2014 Mayfield Village Northeast $2 Medical Device

Siemens Healthcare 2014 Cleveland Northeast 24 Medical Device

Smithers Rapra 2014 Akron Northeast 10 $1.157 Laboratories

STERIS Corporation 2014 Mentor Northeast 200 Medical Device

Tark 2014 Dayton Western 20 $0.7 Supplier

Three Rivers Energy 2014 Coshocton Southeast 34 $27 AgBio

Walgreens 2014 Perrysburg Northwest 75 $9.5 Distribution

360 Pharma Group 2015 Mason Southwest 325 $16 Distribution

Abeona Therapeutics 2015 Cleveland Northeast 22 $5.75 Pharmaceuticals

AC Lens 2015 Columbus Central 50 Distribution

Aeroscena 2015 Cleveland Northeast Consumer Health

Aprecia Pharmaceuticals 2015 Blue Ash Southwest 150 $25 Pharmaceuticals

Assurex Health 2015 Mason Southwest 240 $15 Laboratories

BriskHeat 2015 Columbus Central 103 $1.5 Distribution

Daavlin Distributing Company 2015 Bryan Northwest 25 $0.04 Medical Device

DASCO Home Medical Equipment 2015 Westerville Central 50 Distribution

Enable Injections 2015 Cincinnati Southwest 150 $3.5 Medical Device

GEMCITY Engineering Company 2015 Dayton Western $4 Supplier

GOJO Industries 2015 Wooster Northeast 240 $43 Consumer Health

Hamlet Protein 2015 Findlay Northwest 2 $0.75 AgBio

Organic Technologies 2015 Coshocton Southeast AgBio

OsteoNovus 2015 Toledo Northwest Medical Device

Population Genetics Technologies 2015 Cleveland Northeast 25 Medical Device

Procter & Gamble Beauty Innovation Center 2015 Mason Southwest $300 Consumer Health

Quality Electrodynamics (QED) 2015 Mayfield Village Northeast 130 Medical Device

Quest Medical Imaging 2015 Akron Northeast 16 Medical Device

Vistek Medical (GEMCITY Engineering) 2015 Dayton Western 15 Supplier

Table59:OhioBioscienceExpansionsandAttractions(2014-15,continued)

| 103

Table 60: BioscienceCompanyOrigins–Spinouts,Licensing&CommercializationCompany Name Origin Region Year Sector

3Bar Biologics The Ohio State University Central 2013 AgBio

Abeona Therapeutics Nationwide Children's Hospital Northeast 2013 Pharmaceuticals

Accelerated Healing University of Toledo Northwest 2007 Pharmaceuticals

ADEO Cleveland Clinic Northeast 2014 Health IT

ADS Biotechnology University of Toledo Northwest 2008 Pharmaceuticals

Aeromics Case Western Reserve University Northeast 2007 Pharmaceuticals

Aerpio Therapeutics Akebia Therapeutics Southwest 2012 Pharmaceuticals

Affinity Therapeutics Case Western Reserve University Northeast 2010 Medical Device

Airway Therapeutics Cincinnati Children's Hospital Southwest 2008 Pharmaceuticals

Akebia Therapeutics P&G Pharmaceuticals Southwest 2007 Pharmaceuticals

Akron Medical Innovations University of Akron Northeast 2007 R&D

Akron Medvision University of Akron Northeast 2006 Medical Device

Akrotome Imaging Case Western Reserve University Northeast 2008 Pharmaceuticals

Allostatix The Ohio State University Southwest 2007 Laboratories

Anexis Case Western Reserve University Northeast 2012 Pharmaceuticals

AngioQuest Cleveland Clinic Northeast 2007 Pharmaceuticals

Apollo Medical Devices Case Western Reserve University Northeast 2014 Medical Device

Apoptrol Wright State University Western 2007 Pharmaceuticals

APTO Orthopaedics Austen BioInnovation Institute in Akron, Akron Children's Hospital Northeast 2012 Medical Device

Arteriocyte Case Western Reserve University Northeast 2004 Medical Device

Arteriovations The Ohio State University Central 2009 Pharmaceuticals

Assurex Health Cincinnati Children's Hospital, Mayo Clinic Southwest 2006 Laboratories

AtriCure Enable Medical Corporation Southwest 2000 Medical Device

Ausio Pharmaceuticals Cincinnati Children's Southwest 2006 Pharmaceuticals

AxioMed Spine Cleveland Clinic Northeast 2004 Medical Device

Bexion Pharmaceuticals Cincinnati Children Hospital Southwest 2006 Pharmaceuticals

Biobent Univenture Central 2012 AgBio

BioInvision Case Western Reserve University Northeast 2005 Medical Device

BioMotiv University Hospitals, Harrington Discovery Institute Northeast 2010 Pharmaceuticals

Biosortia Pharmaceuticals Univenture Central 2008 Pharmaceuticals

Blue Ash Therapeutics P&G Pharmaceuticals Southwest 2009 Pharmaceuticals

Buckeye Surgical Optimizations The Ohio State University Central 2013 Medical Device

ButylFuel The Ohio State University Central 2007 AgBio

CardioCeption University of Cincinnati Southwest 2009 Pharmaceuticals

CardioInsight Technologies Case Western Reserve University Northeast 2006 Medical Device

CardioNomic Cleveland Clinic Northeast 2007 Medical Device

CardioStar Frantz Medical Group Northeast 2009 Medical Device

Carenection Language Access Network Central 2015 Health IT

Centerline Biomedical Cleveland Clinic Northeast 2014 Medical Device

ChanRx ChanTest Northeast 2008 Pharmaceuticals

Cleveland Diagnostics Analiza / AnalizaDx, Cleveland Clinic Innovations Northeast 2013 Laboratories

Cleveland HeartLab Cleveland Clinic Northeast 2009 Laboratories

Cleveland Medical Polymers Ovation Polymers Northeast 2009 Medical Device

104 |

Company Name Origin Region Year Sector

CleveX Cleveland Clinic Central 2003 Medical Device

Columbus Healthcare Products Columbus Canvas Products Central 2011 Medical Device

Compass Biomedical Arteriocyte Northeast 2014 Pharmaceuticals

Corceuticals Nephroceuticals Western 2010 Pharmaceuticals

Core Quantum Technologies The Ohio State University Central 2012 Pharmaceuticals

Crystal Diagnostics Kent State University, Northeast Ohio Medical University Northeast 2008 Medical Device

Custom Orthopaedic Solutions Cleveland Clinic Northeast 2011 Health IT

Daylight Medical Codonics Northeast 2009 Distribution

DiAthegen Ohio University Southeast 2001 Pharmaceuticals

Dual Therapeutics University Hospitals of Cleveland Northeast 2012 Pharmaceuticals

Enable Injections Cincinnati Children's Hospital Medical Center Southwest 2010 Medical Device

EndoRetics The Ohio State University Central 2010 Medical Device

Endosphere Spine University of Toledo Northwest 2012 Medical Device

Enforcer eCoaching Cleveland Clinic Northeast 2011 Health IT

Enlyton The Ohio State University Central 2004 Pharmaceuticals

Epico OhioHealth Central 2007 Medical Device

Estrocept Diagnostics Abbott Laboratories Southwest 2004 Medical Device

EXCMR The Ohio State University Central 2008 Medical Device

Explorys Cleveland Clinic Northeast 2009 Health IT

Exsurco Medical Bettcher Industries Northeast 2010 Medical Device

First BioTech Nationwide Children's Hospital Central 2009 Medical Device

FlexLife Health Cleveland Clinic, NASA Northeast 2006 Medical Device

Fluence Therapeutics University Hospitals Case Medical Center, CWRU Northeast 2010 Medical Device

Folio Biosciences Phylogeny Central 2011 R&D

Forensic Bioinformatics Wright State University Western 2002 Health IT

Freedom Meditech University of Toledo Northeast 2007 Medical Device

Gamma Spine University of Toledo Northwest 2009 Medical Device

Gen2Agro The Ohio State University Central 2010 AgBio

GenomOncology Lucidyx Northeast 2012 Health IT

GIDx Cincinnati Children's Hospital Medical Center Southwest 2012 Medical Device

Gnome Diagnostics Phylogeny Central 2013 R&D

Great Lakes Neurotech Cleveland Medical Devices Northeast 2011 Medical Device

Great Lakes Pharmaceuticals Ricerca, Case Western Reserve University Northeast 2005 Pharmaceuticals

Health Care DataWorks The Ohio State University Medical Center Central 2008 Health IT

Heliotronic Energy Systems University of Cincinnati Southwest 2010 AgBio

Homeward Health University of Toledo Northwest 2013 Health IT

ImageIQ Cleveland Clinic Northeast 2011 Health IT

Include Fitness University of Cincinnati Southwest 2009 Medical Device

InfraRed Imaging Systems Air Force Research Labs at Wright-Patterson AFB Central 2010 Medical Device

IntElect Medical Cleveland Clinic Northeast 2005 Medical Device

IRISense University of Toledo Northwest 2011 Medical Device

Ischemia Care Gerard Biotech Southwest 2011 Pharmaceuticals

iVHR Cleveland Clinic Northeast 2013 Health IT

Table 60: BioscienceCompanyOrigins–Spinouts,Licensing&Commercialization (continued)

| 105

Company Name Origin Region Year Sector

Jalex Medical Thogus Products Company Northeast 2012 R&D

Joint Vue OhioHealth Central 2008 Medical Device

Juventas Therapeutics Cleveland Clinic Northeast 2007 Pharmaceuticals

Kencak University of Akron Northeast 2008 Medical Device

Kinnear Pharmaceuticals N8 Medical Central 2015 Pharmaceuticals

LARAD The Ohio State University Northeast 2013 Pharmaceuticals

Lattice Biotech Nationwide Children's Hospital Central 2014 Pharmaceuticals

LeadScope Chemical Abstract Service Central 2000 Health IT

Life Capsules The Ohio State University Central 2012 Pharmaceuticals

Linebacker OhioHealth Central 2011 Medical Device

Macrophage Therapeutics Navidea Biopharmaceuticals Central 2014 Pharmaceuticals

Mammotome Ethicon EndoSurgery Southwest 2010 Medical Device

Merlot OrthopediX Cleveland Clinic Northeast 2005 Medical Device

Metallopharm The Ohio State University Central 2003 R&D

MetaMol Theranostics University of Cincinnati Southwest 2008 Pharmaceuticals

Miach Medical Innovation Case Western Reserve University Northeast 2011 Medical Device

Milo Biotechnology Nationwide Children's Hospital Northeast 2011 Medical Device

Minimally Invasive Devices OhioHealth Central 2006 Medical Device

Nanofiber Solutions The Ohio State University Central 2009 Medical Device

NanoMed Systems Frantz Medical Group, The Ohio State University Northeast 2008 Medical Device

NDI Medical Case Western Reserve University Northeast 2002 Medical Device

NeoProteomics Case Western Reserve University Northeast 2005 R&D

Neuros Medical Case Western Reserve University Northeast 2008 Medical Device

NeuroTherapia Cleveland Clinic Northeast 2015 Pharmaceuticals

NeuroWave Systems Cleveland Medical Devices Northeast 2003 Medical Device

Oculatek Valtronic Technologies Northeast 2006 Medical Device

Ohio Health Information Partnership BioOhio Central 2009 Health IT

OncoFilter The Ohio State University Central 2014 Medical Device

OncoImmune The Ohio State University Central 2005 Pharmaceuticals

Oncothera Ohio University Southeast 2009 Pharmaceuticals

Optimum Therapeutics The Ohio State University Central 2003 Pharmaceuticals

OptoQuest Corporation Cleveland Clinic Northeast 2008 Medical Device

Oralectrics Biolectrics Northeast 2013 Medical Device

OsseoCap University of Toledo Northwest 2011 Medical Device

OsteoDynamics University of Cincinnati Central 2010 Medical Device

OsteoNovus University of Toledo Northwest 2013 Medical Device

P2D Bioscience University of Cincinnati Southwest 2004 Pharmaceuticals

PeriTec Biosciences Cleveland Clinic Northeast 2002 Medical Device

Persepsys Biomedical Cincinnati Children's Hospital Medical Center Southwest 2013 Pharmaceuticals

PharynMed Miami University Southwest 2011 Medical Device

Pilus Energy University of Cincinnati Southwest 2012 AgBio

Poly MedTech University of Akron Research Foundation Northeast 2012 Medical Device

Promiliad BioPharma Ohio University Southeast 2005 Pharmaceuticals

ProteoSense The Ohio State University Central 2012 Medical Device

Table 60: BioscienceCompanyOrigins–Spinouts,Licensing&Commercialization (continued)

106 |

Company Name Origin Region Year Sector

Protimage Diagnostics Case Western Reserve University Northeast 2013 Medical Device

QI Healthcare Systems Cincinnati Children's Hospital Medical Center Southwest 2011 Health IT

Rekovo The Ohio State University Central 2014 Health IT

Renovo Neural Cleveland Clinic Northeast 2008 Pharmaceuticals

ReXceptor Case Western Reserve University Northeast 2011 Pharmaceuticals

Sanuthera Ohio University Southeast 2009 Medical Device

Shield Biotech Cleveland Clinic Innovations Northeast 2013 Pharmaceuticals

Sight4All The Ohio State University Central 2014 Health IT

Siloam Biosciences University of Cincinnati Southwest 2002 Medical Device

Sirona Therapeutics Venture Therapeutics, The Ohio State University, University of Michigan Central 2014 Pharmaceuticals

SironRX Therapeutics Juventas Therapeutics Northeast 2011 Pharmaceuticals

SpineForm Cincinnati Children's Hosptial Southwest 2004 Medical Device

SPR Therapeutics NDI Medical Northeast 2009 Medical Device

Sujana Biotech Case Western Reserve University Northeast 2015 Pharmaceuticals

Surgery Navigator Nationwide Children's Hosptial Central 2010 Health IT

Symplmed Pharmaceuticals Xoma Corporatoin Southwest 2013 Pharmaceuticals

Synapse Biomedical Case Western Reserve University, University Hospi-tals Case Medical Center Northeast 2002 Medical Device

Talis Clinical Cleveland Clinic Northeast 2012 Health IT

Telkesis University of Akron Northeast 2012 Medical Device

TempTraq Blue Spark Technologies Northeast 2014 Medical Device

Thermalin Diabetes Case Western Reserve University Northeast 2009 Pharmaceuticals

Tolera Therapeutics Cleveland Clinic Northeast 2006 Pharmaceuticals

TransChart The Ohio State University Central 2006 Health IT

Turning Point of Ohio University of Toledo Northwest 2010 Medical Device

VentureMed Group Jobst Vascular Institute Toledo Ohio Northwest 2000 Medical Device

Viscus Biologics Proxy Biomedical Western 2012 Pharmaceuticals

Xanthostat Diagnostics University of Cincinnati Southwest 2005 Medical Device

Table 60: BioscienceCompanyOrigins–Spinouts,Licensing&Commercialization (continued)

| 107

Table62:OhioBiosciencePatentClassificationsPatent Class Description

71 Chemistry: Fertilizers

99 Foods and Beverages: Apparatus

128 Surgery (includes Class 600)

351 Optics: Eye Examining, Vision Testing and Correcting

378 X-Ray or Gamma Ray Systems or Devices

422 Chemical Apparatus and Process Disinfecting, Deodorizing, Preserving, or Sterilizing

424 Drug, Bio-Affecting and Body Treating Compositions (includes Class 514)

426 Food or Edible Material: Processes, Compositions, and Products

430 Radiation Imagery Chemistry: Process, Composition, or Product Thereof

433 Dentistry

435 Chemistry: Molecular Biology and Microbiology

436 Chemistry: Analytical and Immunological Testing

504 Plant Protecting and Regulating Compositions

520 Synthetic Resins or Natural Rubbers (includes Classes 520-528)

530 Chemistry: Natural Resins or Derivatives; Peptides or Proteins; Lignins or Reaction Products Thereof

532 Organic Compounds (includes Classes 532-570)

601 Surgery: Kinesitherapy

602 Surgery: Splint, Brace, or Bandage

604 Surgery (Medicators and Receptors)

606 Surgery (Instruments)

607 Surgery: Light, Thermal, and Electrical Application

623 Prosthesis (i.e., Artificial Body Members), Parts Thereof, or Aids and Accessories Therefor

800 Multicellular Living Organisms and Unmodified Parts Thereof and Related Processes

Table61:OhioBiosciencePatents(2004-2014)2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 Total

Bio-science 499 357 433 364 330 419 677 685 771 906 895 6,336

All Fields 2,889 2,319 2,630 2,255 2,227 2,341 3,230 3,177 3,387 3,688 3,755 31,898

% Bio 17% 15% 16% 16% 15% 18% 21% 22% 23% 25% 24% 20%

108 |

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