Odin Tech Summary_ksa v07

8/6/2019 Odin Tech Summary_ksa v07

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ODIN Industries is a molecular engineering company specialized in

macrocycle R&D, technology assessment, new product pipelinedevelopment, and manufacturing. The company’s proprietary technology

gives individuals, institutions and companies the ability to exploit vast,

undeveloped chemical space, establish strong patent protection, and deliver

big profit margins on molecules that, until now, have had little or no

commercial viability. Through internal and external programs, licensing,

and partnerships, ODIN is working to drive the discovery and development

of new pharmaceuticals, advanced materials, renewable energy, water

purification, and other important technologies that use macrocycles as key

components.

About ODIN



High-tech manufacturing is an important wealth-

and job-producing sector of the economy.



High-Tech manufacturing not only decreases cost,

it drives innovation.

1911 1950 2010



And provides important material support

for national infrastructure and for national defense.

Agriculture

Energy

Clean Water

Healthcare and Pharmaceuticals



But where are all of these new technologies, and why is theregrowing concern that many of these laboratory discoveries may

never reach the consumer?

"Prices on electric cars will continue to drop until they're

within reach of the average family."

Washington Post, 1915



The technology pipeline isn’t dry,it’s just missing a key piece!

Research ManufacturingDevelopment Products

Innovation

… but the well is full !

This portion has not been

developed so the pipeline has

yet to deliver on the promise

of emerging technologies

This area is known asthe Valley of Death



But What is this Missing Piece?-mass production of interchangeable parts-

Imagine what our forefathers wouldhave done with just one wheel!



In 1907, Henry Ford announced his goal for the Ford Motor

Company: to create "a motor car for the great multitude." At

that time, automobiles were expensive, custom-mademachines.

In order to do so, Ford would re-discover four principles that

had certainly been invented and lost many times throughoutthe history of mankind. Those principles are:

Re-Invention of a Time Tested Process

• interchangeable parts,

• continuous flow,

• division of labor, and

• reducing wasted effort.



Interchangeable Parts

Using interchangeable parts meant making

the individual pieces of the car the same

every time. That way any valve would fit

any engine, any steering wheel would fit

any chassis.

This meant improving the machinery and

cutting tools used to make the parts. But

once the machines were adjusted, a low-

skilled laborer could operate them, replacing

the skilled craftsperson who formerly made

the parts by hand.



Other Historically SignificantInterchangeable Parts

• Language

• The Wheel

• Mathematics

• Clothing• Arrows

• Sailing Blocks

• Nails and Screws

• Batteries

• Magnets

• Light bulbs

• Bullets• The Electric Motor

• Blood Plasma

• The Microchip



If someone can standardize and scale up the

manufacture of these new high-tech parts, where is

the current opportunity?

• Pharmaceuticals• Human Health

• Biotechnology

• Solar Energy

• Fuel Cells

• Batteries

• Advanced Plastics

• Nanotechnology

• Bioremediation

• Anti-Corrosive Paints

• Water Purification• Pest Control

• Animal Health

• Crop Science

• Transportation

• Aerospace

• Defense

• Synthetic Rubber

• Packaging

• CO2 Sequestration



What do cutting-edge medical treatments, solar cells, advanced

plastics, hydrogen fuel cells, and a new nose have in common?



They are all constructed using a tiny

interchangeable part called the macrocycle.

Chlorophyll (seen above) is a

naturally occurring macrocycle



Introduction to MacrocyclesMacrocycles are arguably the most diverse class of molecules.

Macrocycles are small to medium sized natural, semi-natural, or

artificial molecules where the atoms are connected in a fashionsuch that they form a ring.

C

C

C

CC

C C

C

C C

C

C

C

C

C

C

C

C

linear cycle macrocycle

C

C

C

C

C

C

CC

C

C

C

C

C

C

C

C

C

bicycle



ODIN Industries has developed and patented a

revolutionary new platform technology that dramatically

improves the ‘machinery and cutting tools’ used to make

these highly sought-after parts called the macrocycles.

From Lab to Life



The timing of this breakthrough has created a veryunique opportunity - one that occurs very rarely in

history. Unlike most innovations that have a particular

rhythm as the new technology is born, develops,

matures, and then balloons, ODIN’s technologyprovides a platform to bring an immense back-log of

products from the laboratory to life.

Set Your Own Rhythm



ODIN’s patented platform technology, called

Dynamic Oligomer Control Cyclization or DOCC,enables the scale-up and manufacture of highly

sought-after components that are essential to the

development of innovative products from more than

eight (8) different industries.

Market-ready proto-types, which currently teeter on

the edge of success, will rapidly emerge from the

pipeline with ODIN’s macrocycles inside.



DOCC

cleancoal

aerospacebio-tech

fuelcells

automotiveparts

lubricants

CO2

sequestration

defense

anticorrosivepaint

soapsadditives

detergents

synthetic

rubber

advanced

plastics

disease

detection

health

care

flavors &

fragrances

dyes

more to come !

solarenergy

biosensors

With many

waterpurification

pharmacuticals

greenchemistry“ODIN Inside”



Just Added

Oil Bio-Remediation



Just Added

Prebiotics



Doors That Open Toward

New Beginnings



Macrocycles in Medicine• All Cancer

Bladder Cancer Brain Tumors Breast Cancer Cervical Cancer Colorectal Cancer Esophageal Cancer Lymphoid Cancer Leukemia

Liver Cancer Lung Cancer Ovarian Cancer Pancreatic Cancer Prostate Cancer

Skin Cancer Thyroid Cancer

• Alzheimer’s• Antibiotics• Antifungals

•Antivirals (Hepatitis & HIV)

• Coronary Artery Disease• Dementia• Diabetes• Epilepsy• Fragile X Syndrome

• Lou Gehrig’s Disease-ALS• Macular Degeneration• Mad Cow Disease-TSE• Obesity• Parkinson’s Disease

• Rheumatoid Arthritis• Stroke

THOUSANDS of Undervalued Drug Leads!



Water Purification$22 billion globally

• PPM-PPT metal sequestration

– monitoring, concentrating, removing, recovery– reversible

– non-reversible

• Disinfection/Photodynamic effect

– microbes

• Bleaching

• Destruction of organics

• Oil spill bio-remediation



Healthcare

• Antimicrobials

– for textiles

• bedding

• bandages etc.

– for hard surfaces

• Antibacterials for hard surfaces

• Biomaterials

• Biosensors

– Medical

– Agricultural

– Environmental

– Industrial

• Medical Devices



Transportation

• Corrosion Protection

– High Ox/Red

– Non-Toxic

– Primer & Pigment coats

• Fuel Cells

• Batteries

• Synthetic Rubber

• Lubricants

• Anti-icing

• Self-Cleaning Glass

• Advanced materials

• Recyclable materials



Macrocycle-Based Plastics50 billion pounds plus annually

• Low Viscosity

– Fewer imperfections– Lower processing temperatures

• No Out-Gassing

– Fewer imperfections

– Less toxic Consumer Products

– Greener

• More Advanced Products (Hyper Car Project)

– Lighter than steel

– More Impact Resistant than Steel

• Recyclable



Soaps, Detergents, Surfactants

• Non-peroxide bleaching catalysts

– textiles (better bleaching, less dye damage)

– wood pulp

• Detergents with antiviral, hemolytic, and antibacterial activities

• Anti-static agents



Food & Beverages

• Flavors & Fragrances

• Food preservatives

• Packaging

• Sensing for contamination

• Tasting



Macrocycle-Based Solar Cells

UV Vis

IR



Fueling the Futurewith fuel cells and batteries



Fuel Cells & Batteries

Without massive investments into the electrical grid, agreen economy will only succeed with the development

of ways to store energy. Fuel cells are not only attractive

power sources for running our green devices: everything

from cell phones to automobiles, and computers to

commercial generators, they are necessary for storing

both wind and solar energy in a distributive power grid at

times when the wind is not blowing and the sun is not

shining.



These drugs are used to treat MRSA, C. difficile, and otherhigh profile superbugs. However, they are very difficult to

make, and it is virtually impossible to make analogs

(relatives of the original drug), which are important once

bacteria become resistant to the original drug. It is for this

reason that it has been more than twenty years since the lastnew antibiotic was introduced, and the reason that most

major pharmaceutical companies have abandoned the

antibiotic business.

Peptide Antibiotics



New Light on MedicinePhotodynamic Therapy (PDT)

Laser Light

Macrocycle

Tumor cell death

Killer Oxygen

Super-Charged Macrocycle-Oxygen complex



Photodynamic therapy (PDT) is a bimodal treatment for cancer (and otherdiseases), which has few side effects. Unfortunately, the clinical

performance of this treatment has not lived up to expectations. This is due

to the fact that the macrocyclic drugs used in PDT are isolated from nature

as impure substances, and can not be optimized for efficacy. Second and

third generation synthetic macrocycles perform much better than theirnatural counterparts, but they are too expensive to use. Unfortunately,

companies that have pioneered this area are now going out of business and

there is a risk that this technology will be abandoned.

Macrocyclic PDT Drugs



In yet another emerging crisis, the world-widedemand for natural rubber will outpace the supply

in less than 5 years, so research on synthetic

rubbers is at a frantic pace. Some synthetic rubbers

are currently being used on high-end performanceand race cars, but the cost is still too high for mass

development and commercialization.

Synthetic Rubber from Macrocycles



Supply is a serious obstacle to the development of many

promising marine-based therapies. The concentrations of

many highly active compounds in marine invertebrates areoften minute, sometimes accounting for less than 0.1 % of

the wet weight. If one of these compounds were to make it

to the market the annual need for a single compound is

estimated to be roughly 3,000–16,000 metric tons of

biomass per year. It is obvious that such a large amount of

biomass, consisting of either sponges, tunicates or other

pharmacologically promising marine invertebrates, can

never be harvested without risking extinction. Synthetic

strategies for environmentally sound and economicallyfeasible supplies of marine natural products are therefore

needed.

Drugs from the Sea



ODIN’s technology makes cutting-edge science and

technology commercially viable now, and accelerates research

in emerging industries that would not otherwise be viable for

many years into the future.

The Bottom Line



An Ordinary DayAn Ordinary Day’’s Works Work……

1000 assembled Model T chassis1000 assembled Model T chassis



Now imagine if this process did not just apply to one product,

but thousands of new and innovative high-tech products!



ODIN’s Experimental Use Privilege…speeding research on emerging technologies for those who need it most

ODIN will also be offering an “experimental use privilege” to the

academic community and other non-profit organizations because we

believe that we can help speed many important new diagnostics,

therapeutics, and other cyclic compound-based technologies to thepeople who need them most.



ODIN’S INTELLECTUAL PROPERTY POSITION

ODIN controls proprietary technology relating to the synthesis of macrocyclic compounds and

compounds (“ODIN Technology") that is the subject of U.S. Patent Application No. 11/059,796

and many other international applications filed February 17, 2005 in the names of ThomasJohnson and Billy Fowler for “Methods, Compositions, and Apparatuses for Forming Macrocyclic

Compounds”. Based on a review of the technology incident to patent filing by Intellectual

Property Technology Law (IPTL), Research Triangle Park, NC, AND by the United States Patent

& Trade Office ODIN’s intellectual property is a novel and fundamental enabling technology for

the manufacture of macrocyclic compounds. The technology resolves a number of basic problems

that have limited the prior commercial synthesis of macrocyclic compounds to small yield andsmall-volume production involving costly and complex purification procedures. By enabling high

yields of macrocyclic compounds to be economically achieved at high volume, the technology

makes these compounds widely available at low costs.

UPDATE 05/04/2010: The first of ODIN’s patents have issued in theUnited States, Singapore, and Mexico. Many other applications are

patent pending and are expected to issue over the next few years.



ODIN Corporate Development

ODIN Industries

ODIN

Proprietary Holdings

ODIN

Applied ResearchLaboratories

ODIN EnvironmentalODIN Power

Phase 1

Phase 2

Phase 3

Phase 4ODIN Therapeutics ODIN Plastics

Non-ODIN

Companies

Non-ODINCompanies Non-ODINCompanies



ODIN

Pharmaceuticals

BiotechnologySpecialtyChemicals

IndustrialChemicals

AdvancedMaterials

LifeSciences

RenewableEnergy

Nanotechnology

Technology, Vision & Timing

Odin Tech Summary_ksa v07

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