OCT guidance for distal LM lesions - Bifurc.net · - OCT is able to provide nice characterization...
Transcript of OCT guidance for distal LM lesions - Bifurc.net · - OCT is able to provide nice characterization...
OCT guidance for distal LM lesions
FRANCESCO BURZOTTA INSTITUTE OF CARDIOLOGY
CATHOLIC UNIVERSITY OF THE SACRED HEART ROME, ITALY
LM suitability for OCT
Parodi G et al. Eurointervention 2010
At FU in stented LM
KEY TECHNICAL POINTS: - 6 F or 6.5 F sheathless GC - automatic contrast medium injection (dose adjusted to LM size: 4ml/s or
6ml/s in case of large LM >6mm) - C7 System; C7 Dragonfly; LightLab Imaging Inc/ St Jude Medical
In de novo, non-ostial LM lesions
LM suitability for OCT
Eurointervention 2015
In de novo, non-ostial LM lesions
LM suitability for OCT
Eurointervention 2015
STUDY END-POINT: Nr of artifacted frames (failure of MLA automatic calculation)
In de novo, non-ostial LM lesions
LM suitability for OCT
Eurointervention 2015
STUDY END-POINT: Nr of artifacted frames (failure of MLA automatic calculation)
% artifacted frames
In de novo, non-ostial LM lesions
LM suitability for OCT
Eurointervention 2015
STUDY END-POINT: Nr of artifacted frames (failure of MLA automatic calculation)
% artifacted frames If your doubts are lumen size and morphology
in these areas, OCT is very good option !!!
What can we see with OCT in distal LM?
5 mm
LAD ostium
5 mm
Distal LM POC
Fibrotic plaque Fibrocalcific plaque
Fibroateroma TCFA
Burzotta, Dato et al. Submitted
What can we see with OCT in distal LM?
5 mm
LAD ostium
5 mm
Distal LM POC
Burzotta, Dato et al. Submitted
Mean cap thickness (µm)
LAD ostium Distal LM POC
111 85
109
What can we see with OCT in distal LM?
Burzotta, Dato et al. Submitted
OCT to guide LM management: limits
WHICH PARAMETER ?
<5mm2
<6mm2
WHICH CUT-OFFS?
OCT to guide LM management: limits
WHAT ABOUT MORPHOLOGY?
OCT to guide LM management: limits
Fujino Y et al. Cath Cardiovasc Int 2010
In LM, OCT estimation of MLA is 15% lower compared with IVUS
Looking for cut-offs in intermediate LM disease
Looking for cut-offs in intermediate LM disease
Park et al. JACC-Intv 2014
At IVUS study, MLA value of 4.5 mm2 predicts FFR +
Signficant disease of very large LMs can be undestimated by conservative MLA cut-offs
and recognized by % Area Stenosis
Looking for cut-offs in intermediate LM disease
FFR 0.79
First experience with OCT guidance in angiographically-intermediate LM disease
Angiographically Intermediate LM bifurcation disease (n=84)
OCT assessment
- AS >75% any MLA ?
REVASCULARIZATION (n= 49) (38 PCI, 11 CABG)
DEFER TREATMENT (n=31)
- AS >50%<75% and MLA<4 mm2 ?
- AS >50%<75% and LM ulceration ?
Clinical follow-up (mean: 2 years)
- incomplete imaging of the LM bifurcation (n=2) - poor image quality preventing reliable analyses (n=2)
OCT-guided management (n=80)
LM UCSC criteria:
First experience with OCT guidance in angiographically-intermediate LM disease
CRITERIA PROMPTING FOR REVASCULARIZATION
Revascularized group (n=49)
LM AS >75% any MLA 8 (16%) LM AS >50%<75% and MLA<4 mm2 9 (18%) LM AS >50%<75% and LM ulceration 12 (24%)
LAD or LCX ostium critical stenosis 28 (57%)
First experience with OCT guidance in angiographically-intermediate LM disease
Characteristics Revascularized group (n=49)
Deferred group (n=31)
P
Age 67±10 69±11 0.3 Female sex 10 (20%) 9 (29%) 0.4 Hypertension 37 (76%) 24 (77%) 0.8 Hyperlipidemia 31 (63%) 22 (71%) 0.5 Diabetes 15 (31%) 11 (35%) 0.7 Family history 8 (16%) 7 (23%) 0.5 Current smoking 6 (12%) 3 (10%) 0.7 Chronic renal failure 13 (27%) 8 (26%) 0.9 Clinical presentation Stable CAD NSTE-ACS or recent STEMI
33 (67%) 16 (33%)
19 (61%) 12 (39%)
0.6
Ejection fraction (%) 57 ± 9 56 ± 9 0.8 EuroSCORE (Additive) 5 ± 4 5 ± 4 0.9 Coronary disease beyond LM: 1-vessel disease 2-vessel disease 3-vessel disease
20 (41%) 18 (37%) 11 (22%)
13 (42%) 13 (42%) 5 (16%)
0.8
First experience with OCT guidance in angiographically-intermediate LM disease
TVF
0 6 12 18 24
100
80
60
40
20
0
Time
Sur
viva
l pr
obab
ility
(%)
Event Revascularized group (n=49)
Deferred group (n=31)
Death 1 (2%) 0 MI 1 (2%) 0 TVR 2 (4%) 1 (3%)
Primary endpoint TVF (death-MI-TVR)
REVASCULARIZATION
DEFER TREATMENT
P=0.35
Conclusions
- OCT is able to provide nice characterization of bifurcation disease
- OCT cut-offs to guide decisions on LM are lacking but probably the combination of %AS stenosis, plaque morphology and MLA values (lower than IVUS !!!) should be taken into account
- Preliminary observations suggest the possible safety of OCT-based revascularization deferral when %AS is <75%, MLA is >4 mm2 and LM ulceration is absent
In patients with angiographycally-intermediate distal LM disease:
THANK YOU FOR KIND ATTENTION