Obesity - the challenge; the potential for cross-disciplinary studies in Food Science and Medicine
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Transcript of Obesity - the challenge; the potential for cross-disciplinary studies in Food Science and Medicine
Obesity - the challenge;Obesity - the challenge;the potential for cross-disciplinary the potential for cross-disciplinary
studies in Food Science and Medicinestudies in Food Science and Medicine
Anthony R LeedsAnthony R LeedsFaculty of Life Sciences, University of Copenhagen,Faculty of Life Sciences, University of Copenhagen,
Diabetes Centre, Central Middlesex Hospital, London;Diabetes Centre, Central Middlesex Hospital, London;Medical Director,Medical Director,
Cambridge Weight PlanCambridge Weight PlanFood for thoughtWorkshop IUniversity of Copenhagen29th August 2011 [email protected]
http://www.cambridgeweightplan.com/healthcare-professionals.asp
BBC Website BBC Website
Global governments must get tough on Global governments must get tough on ObesityObesity
At: At: http://www.bbc.co.uk/news/health-14669203
On 26On 26thth August 2011 August 2011
Obesity – a global and national Obesity – a global and national crisiscrisis
We know some of the causesWe know some of the causesWe know how to influence some of themWe know how to influence some of themBut we don’t have proven long term But we don’t have proven long term
methods for treatment (except perhaps methods for treatment (except perhaps surgery)surgery)
Drug and Surgical treatments are/will be Drug and Surgical treatments are/will be costlycostly
Do we have any food-based solutions?Do we have any food-based solutions?
Is there a food-based solution?Is there a food-based solution?
Qualitative and Quantitative aspectsQualitative and Quantitative aspects– Food properties and diet composition can be Food properties and diet composition can be
manipulatedmanipulatede.g proportion of energy from protein, glycaemic e.g proportion of energy from protein, glycaemic indexindex
– Pay attention to the quantitative aspectsPay attention to the quantitative aspects– Weight loss is related to the energy deficitWeight loss is related to the energy deficit– Current medical research shows that amounts Current medical research shows that amounts
of weight loss needed are more than can be of weight loss needed are more than can be achieved by usual diets (500 to 600kcal/d achieved by usual diets (500 to 600kcal/d deficits)deficits)
Food development through Food development through interdisciplinary studiesinterdisciplinary studies
A solution for the need for greater energy A solution for the need for greater energy deficitsdeficitsTake the dietary intake down to a lower level Take the dietary intake down to a lower level
– either a VLCD (very low-calorie diet – either a VLCD (very low-calorie diet <800kcal/d) or a LCD (low-calorie diet 800-<800kcal/d) or a LCD (low-calorie diet 800-1000kcal/d)1000kcal/d)
To supply all needed micronutrients and To supply all needed micronutrients and sufficient protein - led over 26 years ago to sufficient protein - led over 26 years ago to the development of formula dietsthe development of formula diets
In the last few years there has been a In the last few years there has been a renewed interest in this old idearenewed interest in this old idea
To demonstrate efficacyTo demonstrate efficacy ‘‘how do I know that the Cambridge Diet does what how do I know that the Cambridge Diet does what
you say it does’you say it does’ To measure the amount of effectTo measure the amount of effect
‘‘how much weight will I lose and will it be safe?’how much weight will I lose and will it be safe?’ To measure health benefitsTo measure health benefits
‘‘how does losing weight benefit me?’how does losing weight benefit me?’ To determine frequency of adverse or side-To determine frequency of adverse or side-
effects [and take action to reduce these]effects [and take action to reduce these] ‘‘will I lose my hair?, get constipated? feel cold?’will I lose my hair?, get constipated? feel cold?’
To demonstrate weight maintenanceTo demonstrate weight maintenance ‘‘how will I avoid re-gaining weight afterwards’how will I avoid re-gaining weight afterwards’
Medical Research ProgrammeMedical Research Programme Objectives Objectives and questionsand questions
Our requirementsOur requirements
The programme must be evidence basedThe programme must be evidence basedThere must be research evidence for There must be research evidence for
translation into primary care or other translation into primary care or other contextscontexts
Fully defined adverse events profiles must Fully defined adverse events profiles must be publishedbe published
Independent analyses of health economics Independent analyses of health economics implications of the treatment must be implications of the treatment must be publishedpublished
Food development through Food development through interdisciplinary studiesinterdisciplinary studies
Industrial partner
Adverse eventsprofiles
Evidence ofeffect
Parker Institute, andLIFE, Copenhagen
UniversityEffect of weight loss in
Obese people with kneeosteoarthritis
Reformulationto reduce
adverse events
Food development through Food development through interdisciplinary studiesinterdisciplinary studies
Industrial partner
Skin flakiness –? Modify dietary
fat profile
Gentofte Hospital, and
LIFE, KUEffect of weight loss in
Obese people with psoriasis
Development and Reformulation
to modify responses
Food development through Food development through interdisciplinary studiesinterdisciplinary studies
Industrial partner Gentofte Hospital, and
LIFE, KUEffect of weight loss in
Obese people with psoriasis
Development and Reformulation
to modify responses
Bispebjerg Hospital, and
LIFE, KUEffect of weight loss in
Obese people after heart attack
Food development through Food development through interdisciplinary studiesinterdisciplinary studies
Industrial partner Gentofte Hospital, and
LIFE, KUEffect of weight loss in
Obese people with psoriasis
Development and Reformulation
to modify responses
Bispebjerg Hospital, and
LIFE, KUEffect of weight loss in
Obese people after heart attack
Sønderborg Hospital, and
Parker InstituteEffect of weight loss in
Obese people before knee replacement
Problems inProblems inPrivate-Public partnershipsPrivate-Public partnerships
Vested interestsof all team members
Who owns the data?
Transparencywith respect to roles
Academic,Healthcare provider
partner
Industrial partner
Problems and Solutions inProblems and Solutions inPrivate-Public partnershipsPrivate-Public partnerships
Vested interestsof all team members
Full declarations
Who owns the data?
The research teamAnd there must be
full publicationof data
Transparencywith respect to roles
Full public description
Incl travel grants
Academic,Healthcare provider
partner
Industrial partner
Obesity - the challenge;Obesity - the challenge;the potential for cross-disciplinary the potential for cross-disciplinary
studies in Food Science and Medicinestudies in Food Science and Medicine
Food is produced by private companiesFood is produced by private companiesPrivate-public partnerships in research Private-public partnerships in research
mustmustDefine the relationship clearly at outsetDefine the relationship clearly at outsetState data ownership at the startState data ownership at the startFullly publish the data (compare the record of Fullly publish the data (compare the record of
the pharmaceutical industry) including the pharmaceutical industry) including adverse eventsadverse events
Be fully transparent – declaration of interestsBe fully transparent – declaration of interests