Nutraceutical Adjunts To Bhrt
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Transcript of Nutraceutical Adjunts To Bhrt
NUTRACEUTICAL ADJUNTS TO BHRT
It’s never just about the hormones: Vitamins, Supplements, Herbs used in support of hormone
healthBy
Mark Burger, Pharm.D., RPhHealth First! Pharmacy &
Compounding Center
Introduction
… Compounding Pharmacists
Objectives Give compounding pharmacists some
Evidence Based logic supporting the use of vitamins, nutraceuticals and herbs in augmenting BHRT;
Discuss the hormone mimicry, homonogenics and general phytocrinology of plant substances;
Discuss and demonstrate the physiology of PCOS, endometriosis, breast and (?) other cancers as related to estrogen metabolism;
Discuss the individual nutraceuticals, their clinically effective dose ranges and commercial products that contain them
Discuss the support of the thyroid gland with nutraceuticals and phytotherapy.
Consults and Testing
BHRT Supplement Reviews Medication Therapy Management Symptom Driven Saliva Testing for Hormones Nutrient Testing (Serum) Neurotransmitter (AM Urine) NeuroEndocrine (AM Urine/Saliva)
Genomics and Epigenomics
TIME Magazine, January 6, 2010: Why Your DNA ISN’T Your Destiny (cover story)
WHAT WE DO TODAY AFFECTS THE NEXT GENERATION (Darwin was wrong, Lamarck was right)
Lamarck, Darwin, Mendel
(which one DON’T you know?)
Homunculi in sperm as drawn by N. Hartsoecker
in 1695
What Grandpa ate, affects
how long the Grandkid lives
[by as much as 32 years!]
Nutritional & Functional Medicine Approaches to Hormone Balance
Obesity = ↑ Estrogen ↑ Insulin ↓ Leptin High-Protein = ↓ insulin +↑ glucagon
(especially important in the AM when cortisol is naturally elevated)
Upper GI Support: ↑ Acid = ↑ protein +↑methyl donors (Vitamin B’s & FA)+ ↑Fe/Mg/Zn absorp.
Liver Support: ↑ Phase I & II metabolism → effective elimination of estrogen metabolites
Lower GI Support: Pre- & Probiotics, N-3 Fish Oils, Fiber (lignans)
Genomic & Epigenomic Infuences(remember: you CAN change this!)
Low or Slow METHYLATORS (exacerbated by ↓ gastric acidity)
High AROMATIZERS (driven by ↑ insulin) Nrf2 (NF-E2-Related Factor 2: transcription
factor) ↑ production of SOD and glutathione ↓ production of NF-kappa B & other pro-
inflammatory factors In Norrbotten, if you were born during the
abundant years, your kids might live 32 fewer years!
How Do Nutraceuticals Compare?
Drugs
Celec
oxib
Nutraceuticals
“For a long time, doctors thought that testosterone, the male sex
hormone, fueled the growth of some prostate tumors, he says. Prostate cancer treatment, therefore, has
focused on blocking testosterone.
But more recently, "we began to realize that
estrogen is involved as well.””
“But by a year later, 25% of men taking Acapodene had developed
prostate cancer compared with 31% of those on a placebo.
"For every 100 men with PIN treated with the drug for a year, [nearly
seven cancers] are prevented," Price says.”
By Charlene Laino WebMD Feature Reviewed Below
“Conclusions: In men undergoing RP
BMI was associated with adverse pathological
features
and a greater risk of biochemical
progression.”FREEDLAND, STEPHEN J. Et al. OBESITY
AND RISK OF BIOCHEMICAL PROGRESSION FOLLOWING RADICAL
PROSTATECTOMY AT A TERTIARY CARE REFERRAL CENTER.
Journal of Urology. 174(3):919-922, September 2005. BELOW
http://www.wmfurology.com/pca.htm
Conclusion: The percentage of obese men
undergoing RP in our data set doubled in the last 10 years. Obesity was associated with
higher-grade tumors, a trend toward increased
risk of positive surgical margins, and higher
biochemical failure rates among men treated with RP. A BMI 35 kg/m2 was associated with a higher risk of failure than a BMI
between 30 and 35 kg/m2.
Journal of Clinical Oncology, 10.1200/JCO.2004.04.181Received April 28, 2003
Accepted November 10, 2003
“First my nads shrink, then my willy won’t work, now my
prostate is whacked. I have got to lose some weight!”
“The diet known as calorie restriction (CR) is the most reproducible way to extend the lifespan of mammals.
Many of the early hypotheses to explain this effect were based on it being a passive
alteration in metabolism. Yet, recent data from yeast,
worms, flies, and mammals support the idea that CR is not simply a passive effect but an active, highly conserved stress response that evolved early in
life's history to increase an organism's chance of surviving
adversity.” Sinclair DA. Toward a unified
theory of caloric restriction and longevity regulation. Mech Ageing
Dev. 2005 May 10; PMID: 15893363 PubMed Below
http://images.art.com/images/PRODUCTS/large/10087000/10087743.jpg
“The wooly mammoths are getting harder and hard to find.”
Liver Support
Diet,
Exercise,
Stress Mgmt.
Product Information Below
2 with meals 2 scoops 1 – 4+ / day1 TID 3 with UC
Lipotropic Factors Detox Medical FoodLiver Tonic Detox Buffer
Milk Thistle Extract 70 mg [standardized to 80%
silymarin (56 mg)]to supports healthy liver
function and helps protect liver tissue
Nutrients involved in fat metabolism,
including inositol, choline, and taurine, methyl donors, folic acid, vitamins B6 &
B12, and select herbs that are traditionally used to support bile flow & healthy liver
fxn.
15 Gm N2, 160 Kcal, 19 Gm CHO, 3 Gm Fat + catechins + B vites + A, D, E, C, Biotin + AAs
for liver detox
Vitamins A, C, D, E, Thiamin, B6, B2,
Niacin, L-5-methyltetrahydrofolate, B12 to support Phase
I and Phase II liver detoxification
“DALLAS - March 3, 2005 - Cholesterol, often stigmatized for its role in heart disease, has long been known to be essential for the health
of the fat-laden membranes that surround individual cells.”
“Through an interaction with a protein called the oxysterol binding protein (OSBP), cholesterol holds together a group of enzymes that deactivates extracellular signal-related kinase (ERK). Overactive ERK is associated with multiple
cancers.”Researchers discover a good side to cholesterol in controlling cell signals http://www.utsouthwestern.edu/utsw/cda/dept37389/files/210108.html
Media Contact: Megha Satyanarayana 214-648-3404
e-mail: [email protected]
ARTICLE BELOW
"Cell signals have to be tightly controlled," said Dr.
Richard G.W. Anderson, chairman of cell biology and senior author of the study.
"If the signaling machines do not work,
which can happen when the cell doesn't have
enough cholesterol, the cell gets the wrong
information, and disease results."
Statin Sales
Cholesterol prevents cancer.
FIGURE 2. Hypothetical scheme showing potential mechanisms whereby
n–6 (promote) polyunsaturated fatty acids (PUFAs) and n–3 (suppress) PUFAs
may promote and suppress carcinogenesis, respectively.
Am
J Clin
Nu
tr. 2004 Jun
;79(6):935-45. P
MID
: 15159222
Therefore, our results raise the possibility that GLA-induced
transcriptional repression of the Her-2/neu oncogene may
represent a molecular approach
to treat Her-2/neu–overexpressing carcinomas, i.e.,
in combination with trastuzumab. Although extensive
preclinical and clinical studies are necessary before GLA can
enter clinical trials, our findings suggest that future studies
assessing the clinical relevance of GLA-regulated Her-2/neu
promoter activity are warranted.
J Natl Cancer Inst. 2005 Nov 2;97(21):1611-5. PMID:
16264182 Below
“GLA exerts selective toxic effects on cancer cells without
affecting normal cells.”http://www.northwestern.edu/newscenter/stories/2005/11/gammalinolenic.html
Below
Picture:http://www.esew.org/warning_lists/plants/plants5.htm
Omega 3 Oils & Cancer Prevention1. Reduce inflammation2. Reduce angiogenesis3. Decrease Oncogenes4. Induce differentiation5. Suppress NFKB6. Suppress bcl-2 (apoptosis blocker)7. Reduce cachexia
NFKBCOX-2
CancerSupply
Line
EPA/DHAVirus / Inflammation
1,5
2
3
4
6 7
Anti -Cancer
Pro -CancerArticle
Below
The Ultimate DetoxComplete Protein
- Methionine - Cysteine
MCT’s (energy)Fiber (transit time)Energy Nutrients - B1, B2, B3, B5, Mg
Phase II conjugates - NAC, (GSH synthesis)
- Sodium Sulfate, - Amino Acids
Methylation Support - 5MTHF, B12, B6
- Methionine, CholineBi-functional modulators - Ellagic Acid, (pomegranate)
- Catechins, (green tea) - Watercress (PEITC)
Additional Support - Silymarin (SOD)
- Artichoke (anti oxidant) - Vitamins, minerals,
- additional anti oxidants
Big 8
GeneticNutritioneering
Pleo + PolyMorphic
Functional Medicine
Plant Nutrients1 Scoop QD
Pancreatic Enzymes5 TID away from food
Multi No Iron2 BID
Immune Support15 drops QID
Product info Below
Omega 3’s 4 to 10 + / day
Activated Omega 62 BID
2 scoops BID to TID 3 BID to TID
Detox + Buffer
Any Green Food
300 mg EPA + 200 mg DHA per Softgel
Protease 104,000 USP, Amylase 104,000 USPLipase 16,640 USP
Per 1 tablet
Any borage seed oil, an essential fatty acid that is converted in the body
to DGLA (dihomo-gamma-linolenic acid), the direct precursor of beneficial series 1 prostaglandins
15 Gm N2, 160 Kcal, 19 Gm CHO, 3 Gm Fat + catechins + B vites + A, D, E, C, Biotin + AAs
for liver detox (conjugation)
Vitamins A, C, D, E, Thiamin, B6, B2,
Niacin, L-5-methyltetrahydrofola
te, B12 to support Phase I and Phase II liver detoxification
Extracts from live mycelial and fruiting stages of specially
cultivated mushroom strains
Any good, absorbable, professional-line
multivitamin
Estrogen Metabolism
1.Diet, Exercise, Stress Management
– FLT2. Increase
Brassica Family (2-OH)
3. Support for Liver
(glucoronidation, sulfation,
methylation)4. Support for
Bowel Clearance4. Antioxidant
Support
© Rakowski, 2006
Life Pyramid
Think, Drink, Sleep, Eat, Poop, Move, Talk
Vegetables, Fruits (9 + Colorful Servings)
Lean, CLEAN (organic if possible) Protein (Maintain BCM - BIA)
Unprocessed Grains (mostly Gluten Free)
Pure Fats / Oils 1:1 Omega 3 to 6
P
L - Love; discipLine
Supplments: EFA’s, Multi (92% sub RDA), Plant Nutrients
7
The M agnificent Seven
Eat right
Drink rightThink right Poop rightM ove right
Talk rightSleep rightEat right
Drink rightThink right Poop rightM ove right
Talk rightSleep right
Estrogens, whether you make them, whether you
take them . . . whether you have been unknowingly,
intoxicated by them . . .
Whether you are a man or a woman . . .
You need to get rid
of them every day . . .
IN A HEALTHY WAY!!!!
© Robert Rakowski, DC, PA 2003
(Cytochrome P450)
PHASE 1- oxidation- reduction- hydrolysis- hydration
- dehalogenation
ROS
(Conjugation)
PHASE II- SULFATION
GLUCORONIDATION- glutathione conjugation
- acetylation-METHYLATI ON
- amino acid conjugation- glycine- taurine
- glutamine- ornithine- arginine
HO
CH3
CH3
HESTRIOL
OH
HOH
CONCLUSIONS: This study supports the
hypothesis that
breast cancer can be initiated by
estrogen exposure
and that
estrogen metabolizing
genes are involved in
this mechanism.
Chin Med J (Engl). 2005 Sep 20;118(18):1507-16. PMID:
16232327 Below
HO
CH3
CH3
HOH
12
4
16
17Estrogen Metabolism
A B
C D
4 -0H = “dangerous” estrogen
2 -0H = “good” estrogen
DANGER
16 -0H = “caution” estrogen
© Rakowski, 2006
The Fate of Estrogen
1B1(4-OH)
Glucoronidation, Sulfation, Methylation, Anti-Oxidants
1E1 (16-OH)1A2 (2-OH)
Estrogen Metabolism is
important.
“We believe it would represent a serious error in judgment with regard to public health to ignore the clear message from these combined studies
published in the Journal of the National Cancer
Institute and the Journal of the American Medical
Association that estrogen/progestin
therapy increases the risk to breast cancer.”
Kuller LH. Effect. Effect of hormone replacement
therapy on breast cancer risk: estrogen versus
estrogen plus progestin. J Natl Cancer Inst. 92(4):328-332.
Hey, why do you cells
continue to proliferate?
I’m just following orders. Estrogen says
divide, I divide.
CONCLUSIONSAdipocytokines were shown
to participate to some extent in the process of
carcinogenesis, …”
“It is well documented that obesity increases the risk of some types of cancer such
as that ofcolon, breast and prostate.”
Leptin, the most widely studied member of a family,
stimulatesgrowth, migration and
invasion of cancer cells in vitro and also potentiates
angiogenesis, thushaving the capacity of promoting malignant
biological behavior of cancer in vitro.
Physiol Res. 2005 Oct 17; PMID: 16238454 Below +
article below
obesity has been linked to leptin resistance”
Nat Clin Pract Gastroenterol Hepatol. 2005 Jun;2(6):273-80. PMID: 16265231
http://www.svimr.unimelb.edu.au/price1.htm
“Leptin, the most widely studied member of a family, stimulates
growth, migration and invasion of cancer cells” “also potentiates angiogenesis”
Physiol Res. 2005 Oct 17; PMID: 16238454 Below + article belowLeptin (from
fat)
is aPro-carcinogen
The increasing risk of breast cancer and other
cancers has paralleled the proliferation of
synthetic chemicals
since World War II. An estimated 85,000
synthetic chemicals are registered in the United
States, yet
toxicological screening data are available for
only 7 percent of these chemicals.
http://tuftsjournal.tufts.edu/archive/2003/february/oped/in
dex.shtml Below
Ana M. Soto, M.D.
“85,000 synthetic chemicals
are registered”
7% are screenable.
7% is approximately 1 in 14200 chemicals found in newborns
Theoretically could be 2800.
"One of the first duties of the
physician (pharmacist?) is to educate the masses not to
take medicine."
William OslerThe Principles and
Practice of Medicine (1892)
http://goanimal.com/newsletters/2005/big_pharma/big_pharma.html
http://www.health.library.mcgill.ca/osler/archives/index.htm
William Osler
http
://m
cgo
vern
.libra
ry.tmc
.edu
/O
slersW
eb/O
P1
/F
P00
00
aB.h
tm
Can We Eat to Starve Cancer?: William Li, MD
Turmeric Soy Vitamin E Artichoke Selenium Vitamin D3 Tea Green Tea Lavender Brassica Grapes Garlic
http://www.ted.com/talks/william_li.html
Ferlitsch K, et al. Body mass index, follicle-stimulating hormone and their predictive value in in vitro fertilization. J Assist Reprod
Genet. 2004 Dec;21(12):431-6. PMID: 15704518 BELOW
“16% decrease in fertility for each unit increase of BMI”
Not Enough Too Much
“Cortisol is regenerated from cortisone by 11ß-
hydroxysteroid
dehydrogenase type 1 (11HSD1),
amplifying glucocorticoid action in adipose tissue and liver. (11)HSD1 inhibitors are
being developed for type 2 diabetes and
may be most effective inobesity, where adipose 11HSD1 is increased.”
Diabetes. 2005 May;54(5):1364-70. PMID: 15855321 Below with
article
FIG. 1. Metabolism of d4-cortisol to form d3-cortisone and d3-cortisol. D, deuterium = 2H.
“Life was not as
stressful when I was
thin.”
Adipose magnifies cortisol
Progesterone to Estrogen
Ratio“Before menopause,
progesterone-to-estrogen ratios vary from about 20:1 to about 170:1, at different phases of the menstrual cycle. For a pregnancy to occur, an ideal ratio of 30:1 or possibly 60:1 may be
needed. . . A low progesterone-to estrogen
ratio, such as 10:1, can result in infertility in pre-menopausal women and
abnormal uterine bleeding in women of
menopausal age.”
HO
CH3
CH3
OH
CHC
1000 X
Ethinyl Estradiol(birth control pill)
“These birth control pills
work great. I have not had a cycle in 6
years.”
Bland, New Approaches to Anti-Aging: 2001, page 71
“Insulin resistance, per se, seems to be necessary for the
components of Syndrome X to develop, but it is not sufficient. In
order to understand the pathophysiology of Syndrome X, it
must be realized that not all tissues respond similarly to insulin
within the same individual. For example, although the ability of
insulin to stimulate glucose uptake by muscle and inhibit adipose
tissue lipolysis is highly correlated within an individual, insulin resistance at the level of the
muscle and adipocyte does not mean that insulin action on the
kidney is impaired.”Reaven, Gerald M. SYNDROME X
INSULIN RESISTANCE, HYPERINSULINEMIA, AND
CORONARY HEART DISEASEChapter 28 - April 1, 2002,
http://www.endotext.org/diabetes/diabetes9/diabetes9.htm
ARTICLE BELOW
How will dysglycemia affect your body?
- Fatty Liver- Heart Attack
- Stroke- Neuropathy
- Hypertension- Dementia- Depression- Retinopathy
- Obesity- inflammation
- Infertility- Gout
- Sexual Dysfunction
“In a 1981 landmark report, Doll and Peto, 1
estimated that
35% of US cancer deaths were
attributable to dietary factors.”
“Although recent findings on fruit and vegetable
consumption and cancer may be disappointing, reductions
in blood pressure and epidemiological evidence for lower risks of cardiovascular
disease provide sufficient reason to consume these
foods in abundance.” Willett, W. Diet and Cancer An
Evolving Picture JAMA. 2005;293:233-234.
ARTICLE BELOW
2004 Estimated US Cancer Deaths*
ONS=Other nervous system.Source: American Cancer Society, 2004.
Men290,890
Women272,810
•25% Lung & bronchus
•15% Breast
•10% Colon & rectum
• 6% Ovary
• 6% Pancreas
• 4% Leukemia
• 3% Non-Hodgkinlymphoma
• 3% Uterine corpus
• 2% Multiple myeloma
• 2% Brain/ONS
•24% All other sites
Lung & bronchus 32%
Prostate 10%
Colon & rectum 10%
Pancreas 5%
Leukemia 5%
Non-Hodgkin 4%lymphoma
Esophagus 4%
Liver & intrahepatic 3%bile duct
Urinary bladder 3%
Kidney 3%
All other sites 21%
Lung 13%, 12%
Prostate 33%
Breast 32%
CancerCases
Tobacco Use in the U S, 1900 -2000
0
500
1000
1500
2000
2500
3000
3500
4000
4500
5000
1900
1905
1910
1915
1920
1925
1930
1935
1940
1945
1950
1955
1960
1965
1970
1975
1980
1985
1990
1995
2000
Year
Per
Cap
ita C
igar
ette
Con
sum
ptio
n
0
10
20
30
40
50
60
70
80
90
100
Age
-Adj
uste
d Lu
ng C
ance
r D
eath
R
ates
*
*Ag e-adjusted to 2000 US standard population. Source: D eath rates: U S M ortality Public U se T apes, 1960-2000, US M ortality Volum es, 1930-1959, National Center for Health Statistics, Centers for D isease Control and Prevention, 2002. C igarette consum ption: US Departm ent of Agriculture, 1900-2000.
P er capita c iga rette consum ption
M a le lung cancer death rate
Fem ale lung cance r death rate
1/3 + of cancers are
related to poor diet.
February 23, 2004
Talk
Stress Adipose Toxins Insomnia
Poor DietImpaired Cellular Communication
Lack of Anabolic Hormones
The Oxidative Seven
“ . . .oxidation of the carcinogenic 4-hydroxy
catechol estrogens (CE) of estrone (E1) and estradiol (E2) to catechol estrogen-3,4-quinones (CE-3, 4-Q) results in electrophilic
intermediates that covalently bind to DNA to
form depurinating adducts. The resultant apurinic sites
in critical genes can generate mutations that
may initiate various human cancers.”
Cavalieri,E.L. et al.; Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators Proc. Natl. Acad. Sci.
USA Vol. 94, pp. 10937-10942, September 1997
4-OH estrogens increase
cancer risk.
Nutritional Influences on Estrogen Metabolism
http://www.cabecahealth.com/media/sites/36/files/NutrInfluencesEstrogen.pdf
{ The Good
{ The Bad
{ The Ugly
Table 1. Sources of Estrogens
Environmental
Estrogens 31Dietary Estrogens 32-35
(“Phytoestrogens”)
Endogenous Estrogens
• Organochlorine chemicals such as vinyl chlorides, dioxins, PCBs, and perchloro-ethylene (~1/2 of “endocrine disrupters” are in this class)• Non-organochlorine chemicals such as phthalates and phenols (plasticizers),aromatic hydrocarbons, & some surfactants• Medications such as hormone replacement, oral contraceptives, tamoxifen, & cimetidine• Agricultural hormones in animalproducts consumed by humans
• Isoflavones (e.g., genistein, daidzein, equol, puerarin, coumestrol, glycitein, biochanins) (from soy, beans, peas,clover, alfalfa, & kudzu)• Lignans (e.g., matairesinol, pinoresinol, secoisolariciresinol) (especially from flaxseed, rye, wheat, & sea vegetables esp. Sea Buckthorn Oil)• Certain flavonoids (e.g., rutin, naringenin, luteolin, resveratrol, quercetin) (especially from citrus fruits and grapes)
• Estradiol (E2)• Estrone (E1)• Estriol (E3)• Hydroxylated (2-OH, 16-OH, 4-OH) estrogen metabolites• Methoxylated (2MeO, 4-MeO, estrogen metabolites• Other estrogen metabolites (3,4-quinones !!!!)
“Bisphenol A (BPA), a chemical that mimics
the action of the human hormone estrogen, can
leach from polycarbonate plastic.3 Human exposure to BPA
is widespread. A Centers for Disease
Control study detected BPA in the urine of 95
percent of adults sampled.4 Scientists
have measured BPA in the blood of pregnant women, in umbilical
cord blood and in the placenta, all at
levels demonstrated in animals to alter
development.5,6”
SOURCE BELOW: http://www.environmentalobser
vatory.org/library.cfm?refid=77083
© Rakowski, 2004
Women with extra Testosterone,Men with Extra
Estrogen
HO
CH3
CH3
H OH
12
4
16
17
A B
C D
Xenoestrogens
BPA95%
penetrance
Table 2. Mechanisms through which dietary and nutritional factors may influence estrogen
metabolismMechanism of Action Nutrient
↑ C-2 hydroxylation over C-4 and/or C-16α hydroxylation of estrogens
Cruciferous vegetables, indole-3-carbinol, isoflavones (soy, kudzu, flax)
↓ the oxidation of catechol estrogens (2-OH and 4-OH)
A, E, & C, N-acetylcysteine, turmeric, green tea, lycopene, ALA, flavonoids (resveratrol)
↑ the methylation of catechol estrogens(2-OH and 4-OH)
Folate (5-FormylTHF), vitamins B2, B6, & (metyl- & hydroxy-)B12 , tri- and di-imethylglycine, Mg
↑ circulating concentrations of sex
hormone binding globulin (SHBG), thus ↓ levels of unbound, active estrogens
Fiber, lignans (flaxseed), isoflavones (soy, kudzu) NOTE: ‘flavus = yellow’
↓ the activity of aromatase, which
converts T & androstenedione → E2 & E1 respectively
Lignans (flaxseed), flavonoids [flavones, flavonol, flavanone, flavanonol, isoflavones, proanthocyanidins]
↑ the detoxification of estrogens by ↑-regulating Phase I (MAO, Flavin-containing, Cytochrome P450, Esterases, etc.) & Phase II Enzymes
Turmeric (curcumin), D-limonene, magnesium, vitamins B2, B6, & B12, flavonoids
↓ the activity of β-glucuronidase, which decon-jugates estrogens in the large intestine, allowing them to be reabsorbed & re-metabolized
Fiber, probiotics (acidophilus, bifidobacteria), calcium D-glucarate
Modify estrogen receptor activity Isoflavones (soy, kudzu), lignans (flaxseed), I3C
“The effects of 2-Methoxyestradiol (2ME)-induced apoptosis was
examined in human leukemia cells (U937 and Jurkat) in relation to mitochondrial
injury, oxidative damage, and perturbations in signaling pathways. 2ME induced
apoptosis in these cells in a dose-dependent manner”
Gao N. et al. 2-Methoxyestradiol-induced
apoptosis in human leukemia cells proceeds through a
reactive oxygen species and Akt-dependent process Oncogene
(2005) 24, 3797−3809.
ABSTRACT BELOW
Nutrients to Promote 2-methoxy estrogensFlax Lignans, Kudzu, Soy, I3C (also Aromatase Inhibitors)Folic Acid, 5-Formyl THF, TMG/DMG, Choline, Betaine HCl, B6, B12 (methyl donors)Magnesium (co-factor for COMT)
This peripheral blood smear shows several very immature myeloid precursors. These cells are leukemic cells circulating in large numbers in the peripheral
blood. Wright-Giemsa stain.http://edcenter.med.cornell.edu/CUMC_PathNotes/Neoplasia/Neoplasia.html
Notes + Picture links below2-Methoxyestrogens kill Leukemia cells.
“Among 2266 women with breast cancer, as compared
with 7953 controls, the use of antibiotics was more
common; the risk of breast cancer was greater with
longer duration of antibiotic use and was consistent across
antibiotic classes. This observation is potentially
worrisome in that antibiotic exposure is common and sometimes nonessential.”Roberta B. Ness, MD, MPH;
Jane A. Cauley, DrPH ,Antibiotics and Breast Cancer—What's the Meaning of This? JAMA Vol. 291 No. 7,
February 18, 2004ARTICLE BELOW
Prescriptions FilledZITHROMAX 39,535,047AMOXICILLIN 35,768,145 75,303,192
2004 Estimated US Cancer Deaths*
ONS=Other nervous system.Source: American Cancer Society, 2004.
Women272,810
•25% Lung & bronchus
•15% Breast•10% Colon & rectum• 6% Ovary• 6% Pancreas• 4% Leukemia• 3% Non-Hodgkin
lymphoma• 3% Uterine corpus• 2% Multiple myeloma• 2% Brain/ONS•24% All other sites
Antibiotics are associated
with increased breast cancer.
Breast CancerConditions causally related to obesity.
1. arthritis, 2. breast cancer, 3. heart disease, 4. colorectal cancer, 5. type 2 diabetes, 6. endometrial cancer, 7. end-stage renal disease, 8. gallbladder disease, 9. hypertension, 10. liver disease, 11. low back pain, 12. renal cell cancer, 13. obstructive sleep apnea, 14. stroke and 15. urinary incontinence.16. Sexual Dysfunction *17. Infertility *18. Fatigue *19. Depression
http://www.obesity.org/treatment/cost.shtml Below
http://www.kbsplit.hr/rakdojke/breastcancer.htm Below
ETIOLOGY
genetic, endocrine and exogenous factors (28).
The Ugly: 3,4-quinones of E2 and E1
Use of CEE (Premarin or PremPro) promotes
Presence of BENZENE RING (critical to effect on DNA) [NOTE: also dopamine!]
2-double bonded OXYGENS at the 3 & 4 positions
Formation of DNA Adducts (Adenine & Guanine)
Leaves a –OH (hydroxyl) “stub” on DNA May be responsible for MANY cancers See work of Ercole Cavalieri, et al Univ
Neb.
Anti-Oxidant Influences
Vitamins A, E, C, D3, Selenium Curcumin (turmeric) Grean Tea (polyphenols like EGCG) Flavonoids
Flavonols: myricetin & quercetin Flavones: apigenin & luteolin Flavanones: herperidin & naringenin Flavan-3-ols: catechin, epicatechin,
epicatechin gallate, epigallocatechin, & EGCG Anthocyanidins: cyanidin, pelargonidin
(Umcka)
Anti-Oxidant Influences (cont.)
Scutellaria barbata extract Astragalus root extract N-acetylcysteine (→ glutathione-S-
transferase →GSH mercapturates) Resveratrol Iodine Methyl-donors (B6, B12, 5-MTF, Di- & Tri-
methyl glycine aka betaine HCl (Phase II) Calcium D-glucarate (Phase II)
Anti-Oxidant Influences (cont.)
Mushrooms (esp. Coriolus & Reishi) Lycopene 5 mg PO QD Vitamin D3 (at levels 50-80 ng/mL) Alpha Lipoic Acid (ALA) [↓ insulin’s ↑
effect on aromatase] Magnesium [necessary co-factor for
COMT]
Phytocrine Infuences
Four types of HormonesI. Endo-crine (from some other place in body)II. Auto-crine (from the same place/cell)III. Para-crine (from an adjacent cell)IV. Phyto-crine (from a plant outside the body)
3 main mechanisms of action (for AGONISTIC action)i. Functional Mimetic (doesn’t sit on hormone receptor)ii. Improved hormone production (phytohormonogenic)iii. Direct binding to HR (phytohormone)
a. Phyto-estrogen (flax, soy, hops, sesame oil, tofu, etc.)b. Phyto-progestins (diosgenin)c. Phyto-androgens (pine pollen extract)
Phytocrine Infuences (cont.)
Phyto-Anti-Hormones (antagonists) Saw Palmetto (serenoa repens) 320 mg QD Holy Basil (ocimum sanctum) aka Tulsi 2 caps
QD Nettle root (urtica dioca) 300 mg/day Fenugreek (trigonella foenum-graecum) Sweet fennel (foeniculum vulgare) [beta-
sitosterol] Pygeum (africanum) [beta-sitosterol] 100
mg/day Sea buckthorn oil [highest beta-sitosterol
content at 1650 mg/100mL]
Phytocrine Infuences on Thyroid
Sea Kelp (iodine source) Bladderwrack (iodine source+anti-estrogen) Hops (enhances uptake of iodine &
suppresses NF-Kappa B →↓TNFa & ↓IL-6 Coleus forskolii (mimics TSH ↑Na-I-symporter
or NIS, promotes secretion of T3 & T4) L-Tyrosine (source of thryoxine backbone) Ashwaganda (↑ production of thryoid horm.) Bacopa moniera (↑ T4 with →T3)
Phytocrine Infuences on Thyroid(continued)
Anything that reduces inflammation (↓NF-kappa B) will improve 5’-deiodinase and therefore ↓ rT3 formation!
Guggul, Rosemary oil, Sage, Hops, Coleus and Asragalus all do this to some extent
They also increase the expression of the RXR receptors (retinoid-X-receptors) where thyroid receptors (TR) couple with RXR to form a heterodimer that is thought to be the principle mediator of target gene regulation on target cells by the T3 hormone! (↓BPA)
Dosing of Nutraceutical and Products
Betaine HCL (BPP by Thorne) 2-6 w/meal Detox Factors (ITI) or LiverMax (Adv Naturals) Ultra-Clear (MG); Medi-Clear (Thorne) or Clear
DeTox (PE) [medical foods] BID meal R-Plus NAC (Geronova Research) [R-LA + NAC] Meta Lipoate 300 (Metagenics) 1 cap PO BID Resvoxitrol (OrthoMolec) 1 cap PO BID w/food Resveratrol Plus (PE) 1 cap BID w/food Nrf2 Activator (Xymogen) [brocc, turm, green
tea, bioperine, pterostilbenes] 1 cap QD to BID w/f
Dosing of Nutraceutical and Products (cont.)
Breast Defend (ecoNugenics): DIM, coriolus, reishi, turmeric, scutellaria, quercetin, astragalus 1-4 caps PO BID w/food
Cell Guardian (Natura): NAC, DIM, CDG, B6, B12, FA, Se, broccoli, cabbage, wasabi & pomegranate 3 caps QD to BID
CDG EstroDIM (OrthoMolecular): DIM + Calcium d-glucarate + I3C 2 caps QD w/food
DIMension 3 (Xymogen): Turmeric + DIM + Bioperine 2 caps QD to BID w/food
Dosing of Nutraceutical and Products (cont.)
LifeShield Immunity (New Chapter): 18 mushrooms 1 cap BID anytime
Reishi (New Chapter) 2 caps QD anytime Coriolus-MRL (Mycology Research Labs) 2 to
6 tablets PO QD Alapars (niacin + NAC) 1 tablet PO TID Clinical Nutrients for Diabetics (ITI) 2 tabs
PO w/each meal Methyl-SP (Apex) [B6, B12, FA, Mg, choline,
TMG, MSM, beet root, betaine HCl] 2 caps TID
Dosing of Nutraceutical and Products (cont.)
Prostate Optimizer (Jarrow) [D3, SP, Lyco, N3, Milk thistle, Nettle, Lignans, Grean tea, Broccoli]
1 sofgel PO TID w/food Testo-Gain (Douglas Labs) [2.25 grams of an
herbal blend of ashwag, damiana, mucuna, etc.] 3 caps PO QD w/food
ITI Man (ITI) [maca, yohimbine, rhodiola, horny goat weed, ginseng, tongat ali] 1 cap BID
Maca-3 (PE) [macamides, macaenes, tuber]1 cap BID anytime (AM & mid-afternoon)
“Another effective strategy for prolonging the lifespan
is caloric restriction: in data presented here, the persistence of estrogen-
sensitive cells in the hypothalamus of caloric restricted 22-month-old
female mice, may explain the persistence of
reproductive function at an age, when reproductive
function has long ceased in ad libitum fed controls.”
Timiras PS et al. The ageing phenome: caloric restriction and hormones promote neural cell
survival, growth, and de-differentiation Mechanisms of Ageing and Development
Volume 126, Issue 1 , January 2005, Pages 3-9 ABSTRACT BELOW
“Obese men are 30% more likely to experience
erectile problems than those of normal weight.”
Lewis RW. Can weight loss improve the erectile function of
obese men? Nature Clinical Practice Urology (2004) 1, 68-69
ARTICLE BELOW
Dysglycemia Support
1 or 2 BID PC
2 scoops 1 to 5x / day
Diet,
Exercise,
Stress Mgmt
Exercise & Diabetes
are virtually
incompatible
600 mg / day
2 BID
1 or 2 TID 1 or 2 TID
Neuropathysupport
Islet Cell Support PPAR supportHerbal Glucose Support
Dysglycemia Medical
Food
Dysglycemia Support
tabs
Containing: 15 Gm N2, 175 kcal, chromium,
biotin, cinnamon, etc.
Alpha Lipoic Acid, Cinnamon,
L-carnosine, Taurine, B-vites, Chromium, Zinc,
Biotin, Selenium, EGCG, Vanadium, Etc.
Fenugreek Seed 6.5:1 Extract 1,000 mg; Bitter Gourd 10:1 Ext. 152 mg; Gymnema Leaf 10:1 Ext.
100 mg
Niacinamide 500 mg,
N-acetylcysteine 200 mg. to inhibit PARS, free radical
generation, cytokines, and collagenase.
Conjugated Linoleic Acid 1 Gm. + Rosemary Leaf
40 mg. to support healthy glucose and insulin
metabolism through its activation of PPAR alpha
and PPAR gamma—potent insulin sensitizers.
Alpha Lipoid Acid 200 mg/2 tabs to support
the health and function of
neurological tissue, especially peripheral nerves. Crosses the blood-brain barrier.
“OBJECTIVE: Physicians’ suicide rates have repeatedly been reported to be higher than those of the general population or
other academics,” “RESULTS: The aggregate suicide rate ratio for male physicians,
compared to the general population, was 1.41, with a 95% confidence interval (CI) of 1.21–1.65. For female physicians the
ratio was 2.27” Schernhammer, ES et al. Suicide Rates Among Physicians: A
Quantitative and Gender Assessment (Meta-Analysis), Am J Psychiatry 161:2295-2302, December 2004 PMID: 15569903 Below
Maybe I should
consider natural
medicine!
Be a Badger
Aggressiveness, Reliance, Self-ExpressionThe power of the Badger totem is its aggressiveness
and the willingness to fight for what it wants.This aggression can also be turned to healing – for Badger is the keeper of Earth's healing herbs.
Badger people are quick to express their feelings with concern for the consequences. They are often healers who have the courage to use unconventional methods.Badger has the ability to persist to find a cure.
Badger people are often leaders and bosses, the one who will get the job done.
If you have a Badger as a totem, you will likely be solitarybut comfortable being alone.You are comfortable within yourself and very self-reliant.
Badger anger can get you out of apathy,but be careful not to cut yourself (or others) to ribbons using.Badger is a powerful totem when used properly.
Thank you!