Nuk Leo Tida

33
NUKLEOTIDA Dr. I Dewa Ayu Susilawati, drg. M. Kes

description

cvfb ffbbvb

Transcript of Nuk Leo Tida

Page 1: Nuk Leo Tida

NUKLEOTIDA

Dr. I Dewa Ayu Susilawati, drg. M. Kes

Page 2: Nuk Leo Tida

A nucleotide is composed of a nucleobase (nitrogenous base), a five-carbon sugar, and one to three phosphate groups

Page 3: Nuk Leo Tida

NUCLEOTIDE * make up the structural units of RNA and DNA* play central roles in metabolism, they serve as

sources of chemical energy: adenosine triphosphate (ATP) and guanosine triphosphate (GTP),

* participate in cellular signaling: cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP), cofactors of enzymatic reactions: coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), and nicotinamide adenine dinucleotide phosphate (NADP)

Page 4: Nuk Leo Tida

• MononucletideATP, GTP, ADP, AMP, dll

• DinucleotideFAD, NAD

• PolynucleotideDNA, RNA

Page 5: Nuk Leo Tida

nucleobase = nitrogenous base= basa nitrogen* adenin* guanin* timin

* cytosin* uracil

* nicotinamide* flavin

Page 6: Nuk Leo Tida

BASA NITROGEN: PURIN & PIRIMIDIN

A purine is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring

Page 7: Nuk Leo Tida

BASA NITROGEN: NICOTINAMIDE

• Nicotinamide = niacinamide =nicotinic acid amide, is the amide of nicotinic acid (vitamin B3 / niacin). Nicotinamide is a water-soluble vitamin and is part of the vitamin B group. Nicotinic acid, also known as niacin

Page 8: Nuk Leo Tida

FLAVIN: A ketone, C10H6N4O2, act as coenzymes of flavoprotein.

BASA NITROGEN: FLAVIN

Page 9: Nuk Leo Tida

five-carbon sugar (ribosa)

• Ribose and its related compound, deoxyribose, are the building blocks of the backbone chains in nucleic acids.

• Ribose and deoxyribose are classified as monosaccharides, aldoses, pentoses, and are reducing sugars

Ribose Deoxyribose

Page 10: Nuk Leo Tida
Page 11: Nuk Leo Tida
Page 12: Nuk Leo Tida

cAMP & cGMP

Page 13: Nuk Leo Tida
Page 14: Nuk Leo Tida
Page 15: Nuk Leo Tida
Page 16: Nuk Leo Tida
Page 17: Nuk Leo Tida
Page 18: Nuk Leo Tida

Polinukleotid

Page 19: Nuk Leo Tida
Page 20: Nuk Leo Tida
Page 21: Nuk Leo Tida
Page 22: Nuk Leo Tida
Page 23: Nuk Leo Tida
Page 24: Nuk Leo Tida
Page 25: Nuk Leo Tida
Page 26: Nuk Leo Tida
Page 27: Nuk Leo Tida
Page 28: Nuk Leo Tida

Sintesis Purin

Page 29: Nuk Leo Tida

Sintesis Pirimidin

Page 30: Nuk Leo Tida

Degradasi nukleosid asam urat(katabolisme purin)

Page 31: Nuk Leo Tida

Katabolisme Pirimidin

Page 32: Nuk Leo Tida

Schematic overview of pyrimidine de novo synthesis, salvage and degradation. Nucleotides synthesized de novo enter the nucleotide pool and become further converted to nucleic acids and other metabolic intermediates. Breakdown of nucleotides to uridine and uracil may lead to complete degradation or the resynthesis of UMP in the salvage pathway. Increased activity of URH in overexpressor mutants leads to marked stimulation of pyrimidine degradation but not of salvage pathway activity or de novo synthesis.

Page 33: Nuk Leo Tida

PR: ASAM URAT

• Uric Aciduric acid is a normal constituent of the human body. Ordinarily about one-third of the uric acid in our system comes from food, especially foods like those noted earlier that are rich in purines. The rest we produce ourselves through ordinary metabolism.

• These classical signs of inflammation, together with sudden and extreme pain, strongly suggest an acute attack of gout. The diagnosis is confirmed by laboratory finding of uric acid crystals in fluid taken from the affected joint.