NSF-NIEHS Centers for Oceans and Human Health
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Transcript of NSF-NIEHS Centers for Oceans and Human Health
NSF-NIEHS Centers for
Oceans and Human Health
- Novel integration of NIH and NSF.
- Stimulated by scientific community,
and by CORE, an NRC report, and
the Directors of NSF and NIEHS.
- Focus on HAB, pathogens, pharmaceuticals,
- Integrate biological / oceanographic approaches.
NSF-NIEHS Centers for
Oceans and Human Health- Joint Request for Applications (RFA)
- Competitive review of Center grant applications.
- 20 plus applications
- Four Centers funded: -Washington
-Hawaii
-Woods Hole
-Miami
Woods Hole Centerfor
Oceans and Human Health
Integrated effort by three Institutions:
Woods Hole Oceanographic Inst.
Marine Biological Laboratory
Massachusetts Inst. of Technology
Woods Hole Center for Oceans and Human Health
Internal AdvisoryCommittee
External AdvisoryCommittee
Administrator WHOI Administration
D. AndersonD. Erdner
D. Mcgillicuddy
R. GastL. Amaral-Zettler
M.PolzJ. Lerczak
RESEARCHPROJECTS
M. SoginH. Morrison
GENOMICSFACILITY CORE
S. HajdukM. Hahn
PILOTPROJECTS
COHH DirectorJ. Stegeman
Deputy DirectorD. Mcgillicuddy
Research Focus
Harmful algal blooms (2 projects)
Infectious agents (2 projects)
Temperate Coastal Waters
New England waters as a model system.
AdvancedGenomics
Population Biology
CoastalHydrodynamics
Woods Hole Center for Oceans and Human Health
Administrative CoreStegeman McGillicuddy
Core Facility Sogin Morrison
1. Anderson: HABs 2. McGillicuddy: HABs3. Gast and Amaral-Zettler: Infectious Diseases
4. Polz and Lerczak: Infectious Diseases
Pilot Projects Director: Hajduk co-Director: Hahn
Woods Hole Center for
Oceans and Human Health
Other COHH
EHS Centers
Other Institutes& Centers
MBL MIT
WHOI
Human Pathogens in the Environment
understanding ecology = understanding risk--> prediction and prevention
-reservoirs-favorable growth-Gene transfer
environmentalamplification
?
transportShellfish poisoning,
toxicosis….
Mt. Hope Bay
Heavily impacted by humans
– Sewage outfalls, industrial waste, thermal discharge
Mt. Hope Bay Natural Laboratory
– Centralized data bases
– Predictive current models under development
– No microbial or pathogen sampling program
Proxy for other New England bays
Vibrio infections - a worldwide problem
V. vulnificusV. parahaemolyticus
Wound, eye and ear infection:- rising worldwide- numbers not well known
Seafood consumption:- up to 10,000 infections/yr in US and reports of infection rising (CDC);- 95% of all seafood related deaths
- Environmental prevalence and growth factors- Gene transfer and evolution- Risk assessment
Environmental reservoirs,routes of transmission and infection
• Understand• Predict• Protect
WH-COHH Vibrio project
Human Pathogens: Presence & Persistence
in the Coastal Marine Environment
Studies of traditionally non-marine human pathogens in coastal marine waters:
Essential to determine their potential to impact human health
Evidence and vectors Sea otters, whales, and shellfish can
harbor protistan pathogens such as Giardia and Cryptosporidium
– Shellfish and protists (such as Acanthamoeba) can harbor bacterial pathogens such as Legionella and Vibrio, and enhance pathogenicity.
(Giardia)
(Legionella in amoeba)
HAB threats to human health in temperate waters of the northeastern U.S.
Woods Hole COHH HAB projects• Overall objective: to link dinoflagellate population structure, physiology, and toxicity in order to
improve prediction and prevention of HABs.
• Rationale: cellular toxicity varies with environmental and genetic factors; cell number is not always a good proxy for toxicity
Genotype
Physiology
Physical-biological coupled model
Toxicity
Paralytic shellfish poisoning (PSP)
• causes paralysis and death; • causative organism Alexandrium fundyense (dinoflagellate);• widespread and recurrent annual problem; • ongoing shellfish monitoring programs in ME, NH, MA, CT
GerminationGermination Only Only
Germination, GrowthGermination, Growth &Mortality&Mortality
Germination, Growth, Germination, Growth, Mortality & Nutrient lim.Mortality & Nutrient lim.
May
Jun
Jul
Aug
Woods Hole Center for Oceans and Human Health
Pilot Project Program
Steve Hajduk (MBL), DirectorMark Hahn (WHOI), Deputy Director
2004 Call for Proposals
Objectives
Pilot Project Program
• Support short-term projects to assess feasibility of new research topics
• Generate preliminary data
• Expand scope of Center research
• Expand participation in Center
Areas of emphasis
Pilot Project Program
• Harmful algal blooms (HABs)
• Water- and vector-borne diseases
• Marine-derived pharmaceuticals and probes
RFP: http://grants1.nih.gov/grants/guide/rfa-files/RFA-ES-03-003.html
NRC/NAS (1999) From Monsoons to Microbes: Understanding the Ocean’s role in Human Health
NSF/NIEHS Oceans and Human Health roundtable report, December 2001
Eligibility
Pilot Project Program
• MBL, MIT, WHOI Scientific and Sr. Technical Staff
Budgets
Pilot Project Program
• up to $50K direct costs• 1 year + no-cost extension if needed• Earliest start date: October 1, 2004
• Salaries• Supplies• Student stipend and tuition
• Equipment - not usually• Travel - meetings: No• Travel - sample collection: If strongly justified• Ship time - if strongly justified
Pre-proposal(required)
Pilot Project Program
• Due July 15, 2004• 1 page summary of project• Direct and indirect costs• 2p CV/Biosketch for PI and other key personnel (NSF or NIH format)• Submit electronically:
Steve Hajduk, MBL ([email protected]) orMark Hahn, WHOI ([email protected])
Full proposals
Pilot Project Program
• Due August 15, 2004 at 5 PM EDT.• Title page• Research Plan (5 pp.)
a) Objectivesb) Background & Rationalec) Experimental design and methodsd) Facilities available and/or use of genomics coree) Relevance to COHH programf) Broader impacts (see NSF guidelines)g) References (not included in 5p limit)
• Budget (Direct and indirect costs)• Budget justification (1 p)• 2p CV/Biosketch for PI and other key personnel(NSF/NIH format)• Other support (Key personnel; NIH or NSF format)• Human subject / Vertebrate animal approvals• Submit hard copy (1) and electronically
Review
Pilot Project Program
• Phase I- Woods Hole COHH Internal Advisory Committee (IAC)- outside reviewers (EAC) as needed- Written critiques
• Phase II- presentations (10 min) to IAC
Review criteria
Pilot Project Program
• Scientific merit
• Relevance and potential impact
• Innovation
• Investigators
• Facilities
• Broader impacts
Questions?
Pilot Project Program
Model run: cyst germination plus growth and mortality
Present model assumes that all Alexandrium fundyense cells are the the same (i.e., same growth rate, nutrient responses, toxicity, motility, etc.)
Will address different strains known to exist.
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Woods Hole COHH
• Addressing public health issues.
• Incorporating advanced genomic studies and oceanography.