NSF 2011 NSEC Grantees Conference...Nanoscale Science & Engineering Center for Integrated...

International Institute for NanotechnologyNanoscale Science & Engineering Center for Integrated Nanopatterning and Detection TechnologiesNorthwestern University

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NSF 2011 NSEC Grantees ConferenceNanoscale Science & Engineering Center for Integrated

Nanopatterning and Detection Technologies

Chad A. Mirkin, Director

Milan Mrksich, Associate Director

Northwestern University


Center Vision

NSEC for Integrated

Nanopatterning and

Detection Technologies

New Educational Paradigms

Integrated Research

Nanostructure

Characterization

Knowledge Creation

Design & Fabrication of

Soft NanostructuresNanoscale Experiments,

Theory and Engineering

New Detection Technologies

Unique Sub-100 nm Surface

Patterning Capabilities


Synergistic Team 10 mi

UIUC

80 mi

NU

UCANL


Mission

To advance discovery and knowledge within the field of

nanotechnology through focused and collaborative research leading

to the development of powerful new biological and chemical

detection systems that have the potential to revolutionize many

diverse fields.

This research forms the foundation for, and is effectively integrated

with, innovative and diverse educational outreach programs that seek

to inform, engage, and inspire people of all ages and broaden the

participation of underrepresented minorities.


Participating PIs by Department

ChemistryFranz Geiger

Mark Hersam, JABrian Hoffman, JA

Joseph HuppMercouri Kanatzidis

Thomas MeadeChad Mirkin

Milan Mrksich, UCSonBinh Nguyen

Teri OdomMonica Olvera de la Cruz, JA

George SchatzTamar Seideman

Stephen Sligar, UIUC, JAJ. Fraser StoddartSamuel Stupp, JA

Richard Van Duyne

Materials Science and EngineeringMichael BedzykVinayak DravidMark HersamJiaxing HuangLincoln LauhonChad Mirkin, JATeri Odom, JA

Monica Olvera de la CruzDavid SeidmanSamuel Stupp

MedicineThomas Meade, JA

Chad Mirkin, JAStephen Sligar, UIUC-JA

Samuel Stupp, JA

Electrical Engineering and Computer Science

Matthew GraysonChang Liu, JA

Mechanical EngineeringCate Brinson

Horacio EspinosaChang Liu, JAWing Kam Liu

Jane Wang

Neurobiology and PhysiologyWilliam Klein

Thomas Meade, JA

Kellogg School of MgmtBarry Merkin

Physics and AstronomyMichael Bedzyk, JA

Donald EllisJohn Ketterson

Weinberg College Writing ProgramJohn Anderson

BiochemistryStephen Sligar, UIUC-JA

Thomas Meade, JA

Biomedical EngineeringChad Mirkin, JA

Chemical and Biological Engineering

Chad A. Mirkin, JAJustin Notestein

Monica Olvera de la Cruz, JA

Civil and Environmental EngineeringKimberly Gray

Physical ScienceMichael Davis, HWC

Medical Humanities and EthicsLaurie Zoloth

Medicine – Infectious Diseases

Steven Wolinsky

Medicine - Urology

C. Shad Thaxton

181 FTE graduate students

53 graduate student fellowships

114 FTE postdocs


Research Objectives

Develop a suite of high throughput, parallel

nanolithography tools with soft matter compatibility for

patterning materials on surfaces with sub-100 nm

spatial resolution and evaluate their potential for building

the targeted devices.

Develop detection systems with novel receptors and

signal transduction methods made possible through the

development of these novel lithographic tools and

related nanostructures.


Technology Base

Technology Integration

Lithography software development

Year 6 Year 7 Year 8 Year 9 Year 10

Knowledge Base

Development of routine chemistry and

methods for fabricating combinatorial

nanostructure libraries

Development of methods for structural and spectroscopic characterization

of lithographically generated nanostructures

Development of inks, low wear tip coatings,

and alignment strategies in the context of

multiple tip arrays

DPN probes with integrated Inking channels;

Integrated ink wells and stamp pads;

Multimode lithography

Nanolithography integration with

complementary fabrication techniques

1 million pen

passive writing

with multiplexed

Inking

Fabrication of

combinatorial

Polyvalent recog-

nition nanopatterns

Multi-valency site

recognition and assembly

1-dimensional passive and active probes

2-dimensional passive and active probes

Alignment sensors

On-chip DNA and

peptide synthesis

Versatile chemistry

& materials research

tool system

Coupled nanotechnology

research/manufacturing systems

Optimized active

probe actuation:

Pneumatics and

piezoelectrics

Integration of

nanolithography tool with

larger scale fabrication

techniques

1 million pen

active writing

with multiplexed

inking

Strategic Framework I – Versatile Parallel Nanolithography Tool

Multiplexed ink

deposition for DNA

and protein arrays


Technology Base

Technology Integration

Year 6 Year 7 Year 8 Year 9 Year 10

Knowledge Base

• Dye-enhanced LSPR

• Plasmon-enhanced

diffraction


MALDI-TOF

• Multiplexing BCA

• Plasmon wire sensing

• Polymer-electro-

chemical probes

• Nanoporous materials

for small-molecule

sensing


SHG probes

• Detection of 10 different

targets with BCA

• Photonic arrays for

SERS

• Integrated photonic/

plasmonic sensors

• Single particle Raman

sensing

• Intracellular Raman

sensing

• Detection of 20+ different

targets with BCA sensor

• Semiconductor light

sources integrated with

metal plasmonics

Bio-barcode detection uses nanoparticle

enhanced equilibrium to beat conventional

sensing limits

Electrochemical detection uses polymer

amplification

Nanodisc receptors provide new

functionality to membrane bound proteins

Enhanced Raman sensing and allosteric

amplification enables molecule-specific

detection of small molecule targets

Quantification of photonic

sensors and barcode assays

Nanopatterning for electrical detection

Universal probe design

Single particle plasmonic sensors

Nanomaterials for amplificationIntegrated microfluidics and electrophoresis

“The breadboard”

Multiplexed HIV detection

using bio-barcodes in patient

samples

AD detection panel

assay based upon

LSPR and barcodes

Sepsis detection using bio-barcodes, with

onboard electrophoretic capabilities

Multiplexed protein,

DNA, and RNA detectionSmall molecule/Raman integrated detection

with onboard sample processing

Strategic Framework II – Integrated Point-of-Care Device


Synergistic Research Groups

Nanopatterning SRG

Leader: Mark Hersam

Co-Leader: Teri Odom

Signal Transduction & Receptor Design SRG

Leader: Milan Mrksich

Co-Leader: George Schatz

Integrated Biodetection Chip SRG

Leader: Vinayak Dravid

Co-Leader: Chang Liu


Notable Research AccomplishmentsFundamentals of Patterning in 2001

State-of-the-art available in 2001

Dip-pen Nanolithography (DPN)

Microcontact Printing (μCP)

Nanoimprint Lithography

Nanosphere Lithography (NSL)

Feedback Controlled Lithography (FCL)

Conventional (Photolithography, EBL)

Parallel DPN using two-pen

cantilever and single feedback

Nanosphere Lithography (NSL)

93 nm


Multi-Step FCL


Dip-pen Nanolithography

Microcontact Printing

Nanoimprint Lithography

Nanosphere Lithography

Feedback Controlled Lithography

Photolithography

Polymer Pen Lithography

Electrochemical DPN

Liquid Phase Nanolithography

Field Induced Oxidation

Soft Interference Lithography

Cathodic Electrografting

Laser-assisted Embossing

Soft E-Beam Lithography

PEEL (Phase-shifting photolithography, Etching,

Electron-beam deposition, Lift-off)

New Techniques and Advanced Fabrication Methods

Liquid Phase

Nanolithography

1.3 Million Probe 2-D Passive Array



Conducting Polymers

290 nm

55 nm

65 nm

Silicon Nanostructures

Sol Gel Templates290 nm

New Substrates, Surface Chemistries, and Materials

100 nm

4mm

DNA and Protein Nanoarrays

1 mm

Single Nanoparticles

PZT

500 nm

Multifunctional Oxides

Polymer Brushes

500 nm

40nm

Complex ShapesssDNA-CNT on Si(111):H

Cylindrical Nanostructures


1 nm

Feedback Controlled Lithography(10,000,000,000 Dots/200 × 200 µm2)

Notable Research AccomplishmentsFundamentals of Patterning in 2010Higher Density, Higher Throughput, & Improved Spatial Resolution

single atom precision

Polymer Pen Array3-inch wafer

with 11 million pens


Notable Research AccomplishmentsSignal Transduction and Receptors in 2010

Mechanisms of selective target detection

– Polyvalent molecular recognition

– Biomimetic molecules for protein recognition

– Small molecule recognition with genetically engineered proteins

– Non biological receptors via supramolecular chemistry capable allosteric amplification

Nanostructure assembly to transduce target recognition into signals

– Surface-directed assembly

– Receptor-functionalized polymeric linkers

– Film formation and nanostructure assembly


Notable Research AccomplishmentsSignal Transduction and Receptors

Microfluidic bio-barcode assays

Novel Receptors and High-throughput Methods

Multiplexed detection

PSA

mAb

HCG

mAb

100 aM sensitivity,

a standing record

Supramolecular structuresNanodics Nanoflares


Notable Research AccomplishmentsAdvanced Sensing Capabilities

Detection of:

Alzheimer’s

HIV

Cancer markers

Influenza

PSA

Sepsis

Cholera

Biowarfare agents

Carbohydrates

Calmodulin

Human Cyt P450

Outlet

Chip

Inlet


Notable Research AccomplishmentsOther Advanced Capabilities

Targeted injection for therapeutics at the single cell level

Multiplexed gas sensing at ppm sensitivity

Room temperature

multiplexed gas sensor


Major NU-NSEC Outputs

Over 700 total publications

– Highly cited, 59 with >100 citations, 26 with >200,

18 with >300

1177 citations – Mirkin, et al. “Photoinduced conversion of

silver nanospheres to nanoprisms,” Science, 2001, 294, 1901.

936 citations – Mirkin, et al. “Nanoparticles with Raman

spectroscopic fingerprints for DNA and RNA detection,”

Science, 2003, 297, 1536.

613 citations – Van Duyne, et al. “A nanoscale optical

biosensor: Sensitivity and selectivity of an approach based on

the LSPR spectroscopy of triangular silver nanoparticles ,”

JACS, 2002, 124, 10596.

473 citations – Schatz, et al. “Controlling anisotropic

nanoparticle growth through plasmon excitation,” Nature, 2003,

425, 487.

11 publications

13 publications

15 publications

37 publications

22 publications

Fundamental insight into design, fabrication, and engineering of

nanomaterials


Major NU-NSEC Outputs

Nanosphere Verigene

Nanostructures that optimize and amplify detection events in

the context of many important chemical, biological, and

medical analytes

Flexible, massively parallel nanofabrication system now used

in 23 countries

First nanotechnology based point-of-care medical diagnostic

system, now with 5 FDA-approved assays

NanoInk NscriptorNanointegris SWCNT


Domestic Collaborations

Academic

Industrial

36 Academic Institutions 6 National Labs 70 Industrial Partners


International Collaborations

Collaborations in 19 Countries

Active exchange programs with Tel-Aviv University and NTU in Singapore


Research & Knowledge Transfer

Metrics To Date

702 publications

65 patents

144 inventions disclosures

Findings presented at seminars

& colloquia

– 1,419 domestic

– 71 international

163 workshops and short

courses given by NSEC

researchers to industry/others

16 spin-off companies launched– >$500M venture investment realized

Nanotechnology Corporate Partners– $620K in unrestricted funds to date

The journal Small launched in 2005– Partnership with Wiley Publishing


Electron ProbeInstrumentationCenter (EPIC)

Keck Interdisciplinary Surface Science Center

Nanoscale Imaging, Fabrication, Testing & Instrumentation(NIFTI)

Advanced Photon Source (ANL)

Integrated Molecular Structure Eduand Research Center

(IMSERC)

J.B. Cohen X-Ray Diffraction Facility

NSEC Secured $7M in State Funding to Provide

Instrumentation for Centralized Facilities

Biological ImagingFacility

NSEC


Special Events Organized/Sponsored

104 Frontiers in Nanotechnology Seminars held (~10,000 total attendees)

8 IIN Symposiums (>4760 total attendees)

5 Summer Institutes on Nano Mechanics & Materials

Swiss Nanotechnology Road Show

Singapore Econ Dev Workshop on Nanotechnology

2 ASME Nano Training Boot Camps

International Symposium on the Relations between Homogeneous and Heterogeneous Catalysis

Gateway to the Future of Nanotechnology

Symposium on Electronic Processes and Molecular Properties at the Nanoscale

SERS-Ablation Conference

Pan-American Advanced Studies Institute

Program (PASI) on Nano and Biotechnology,

Argentina

Workshop on New Advances in AFM and Optical

MEMS Measurement

Nanotechnology Frontiers Workshop I, DC

Productive Nanosystems: Launching the

Technology Roadmap

NSF-MEXT Young Scientists Exchange Program

& Symposium, US/Japan

Nanotechnology Frontiers Workshop II, DC

Illinois Biotechnology Index Event

Summer Institute on Energy Challenges &

Nanotechnology

US-India-Israel Workshop on Nanoscale

Phenomena in Soft & Hybrid Materials


Educational Program Achievements

Nanotechnology Museum Exhibit

– Partnership with the Museum of Science & Industry, Chicago

– Set to open in 2013

– 2,000,000 potential visitors per year

All Scout Nano Day

– Annually since 2003

– 715 pre-college children to date

– One of first participants is now an engineering graduate student at Northwestern

Research Experience for Teachers

– 88 teachers supported and 88 curriculum projects developed

– ~11,000 students impacted @ 125 students per teacher

Research Experience for Undergraduates

– 255 undergraduates supported

– 94% of recent participants indicated that the

program had positively influenced their decision to

go to graduate school

Nanoscape Undergrad Journal

– 8 issues published, on-line & print

– Mailed to >1,000 academic libraries

Nanoscience Module

– Developed for pre-college classrooms

– Being disseminated nationwide by the Materials

World Modules (MWM) program

DiscoverNANO

– Educational website

– ~1,000,000 visitors a year


NU-NSEC Diversity Program Achievements

Source: NSF Division of Science Resource Statistics, 2006

0%

5%

10%

15%

20%

25%

Year 10 Ctr Faculty National Averages

Women Minorities

0%

5%

10%

15%

20%

25%

30%

35%

Year 10 Ctr Graduate Students National Averages

Women Minorities

0%

5%

10%

15%

20%

25%

30%

35%

40%

45%

Year 10 Ctr Undergrads National Averages

Women Minorities


$95M Leveraged by NU-NSEC

Some Samples of NU-NSEC leveraged grants:

Center of Cancer Nanotechnology Excellence$ 31,817,440

REU Site $ 697,994

Programs organized by request of the National Nanotechnology Initiative

(US-MEXT Young Researchers Exchange, Frontier Nano 1.0 and 2.0)$ 151,100

NCP Program $ 688,750

State of Illinois $ 12,000,000

Specific Detection of HIV Targets by Gold Nanoparticle Probes $ 376,659

AFOSR Bio-Mechanical Interfaces for Cell-Based Microsystems $ 659,387

HSARPA-Bioinformatics and Assays Development Program $ 1,461,025


Cd-SnO2

Zn-SnO2

5 µm

A

+

+

Cd-SnO2

Zn-SnO2

5 µm

A

Cd-SnO2

Zn-SnO2

5 µm

A

+

+

End

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