NR33 ANTIHYPERTENSIVE MEDICATIONS
Transcript of NR33 ANTIHYPERTENSIVE MEDICATIONS
Antihypertensive Pharmacologic Agents
NR33
K Burger, MSEd, MSN, RN, CNEReferenced from:
Lilley et al (2005)
Pharmacology and the nursing process (4th ed). Elsevier
Categories
Adrenergic agents-Alpha blockers-Beta blockers-Alpha/Beta blockers
Angiotensin-converting enzyme inhibitorsAngiotensin II receptor blockersCalcium channel blockersVasodilatorsDiuretics
Components of Blood Pressure
Blood pressure = CO X SVRCO = cardiac outputSVR = systemic vascular resistance
Adrenergic Agents
Alpha Blockers(peripherally acting)
Prazosin (Minipress) Blocks norepinephrine
at receptor sites Sympathetic Nervous
System not stimulated Blood vessel dilation
results in decreased BP
Alpha Blockers
(centrally acting)
Clonidine (Catapres) Reduces norepinephrine
production Sympathetic Nervous
System not stimulated Blood vessel dilation
results in decreased BP
Adrenergic Agents
Beta Blockers
atenolol (Tenormin) metoprolol (Lopressor) propranolol (Inderal) Block SNS stimulation of heart; reduces SA node activity Reduces ventricular contraction rate Reduction in cardiac output results in lower BP Also used as: Antidysrhythmic, Antianginal
Adrenergic Agents
Alpha / Beta Blocker Combination
Carvedilol ( Coreg )
Dual antihypertensive effect on both CO and SVR Alpha blocker promotes vasodilation; decreased SVR Beta blocker reduces heart rate; decreased CO Overall effect = decreased BP
Adrenergic AgentsNursing Implications
Orthostatic hypotension common;take alphas @ bedtime Other side effects:
fatigue, dizziness, sedation, constipation Potentiates CNS depressants (Alcohol/Opiods) Abrupt withdrawal of central alpha blocker causes
rebound hypertension Less side effects with peripheral acting and/or
combination adrenergics Monitor HR =>60 for beta blockers
Angiotensin-Converting Enzyme InhibitorsACE Inhibitors
Inhibit the conversion of Angiotensin I to Angiotensin II resulting in:Vasodilation,decreased SVR, decreased BP Decreased aldosterone,diuresis,decreased SVR&BP
May be combined with a thiazide diuretic or calcium channel blocker
Safe and effective; often used as first line Rx Used also for: CHF, post MI to stop LVH progress Renal protective effects in patients with diabetes
ACE Inhibitors
captopril (Capoten)Short half-life, must be dosed more frequently than others
enalapril (Vasotec)The only ACE inhibitor available in oral and parenteral forms
Newer agents, long half-lives, once-a-day dosing
ACE InhibitorsNursing Implications
Dry, nonproductive cough common
Other side effects: fatigue,dizziness,headache, mood changes,taste alterations, angioedema
First-dose hypotensive effect may occur
Additive effects when given with diuretics or other antihypertensives
Antagonistic effects when given with NSAIDs
If given with K supplement may cause hyperK
Angiotensin II Receptor BlockersARBs
Losartan ( Cozaar ) Valsartan ( Diovan ) Block the binding of Angiotensin II to AT1
receptors on vessels & adrenal gland thereby:- promoting vasodilation / lower aldosterone- decreased SVR and decreased BP
Newer class and well-tolerated
ARBNursing Implications
Possible side effects:Upper respiratory infectionAngioedema & Headache
Less likely to cause hyperkalemia (unlike ACE) Can be used in pts who cannot tolerate ACE Rx Do not cause coughing Used cautiously in geriatric pts and impaired
renal function
Calcium Channel BlockersCCBs
Diltiazem (Cardizem) Verapamil ( Calan ) Nifedipine ( Procardia ) Cause smooth muscle relaxation by blocking the
binding of calcium to its receptors, preventing muscle contraction
This causes decreased peripheral smooth muscle tone, decreased SVR and BP
Slows cardiac conduction; decreases HR&CO&BP Also used as : antidysrythmic, antianginal
Calcium Channel BlockersNursing Implications
Considered safe with limited side-effects
First line drug choice
More effective in geriatric and African-American patients
Possible side effects:hypotension, dysrythmias, constipation, nausea,rash,peripheral edema, dermatitis
Vasodilators
hydralazine HCl (Apresoline) sodium nitroprusside (Nipride, Nitropress)
Directly relaxes arteriolar smooth muscle
vasodilation; decreased SVR; decreased BP May be used in combination with other agents Sodium nitroprusside is reserved for the
management of hypertensive emergencies
VasodilatorsNursing Implications
Hydralazine Side Effects: dizziness, headache, anxiety, tachycardia
Sodium Nitroprusside Side Effects: bradycardia, hypotensionControlled administration/IV infusion pump
CHECKPOINT
The physician has ordered prazosin (Minipress) for Mrs. McAdams. What patient teaching should she receive?
A. She should weigh herself daily, and report any weight loss to the physician.
B. She must increase her potassium intake by eating more bananas and apricots.
C. The impaired taste associated with the medication usually goes away in 2 to 3 weeks.
D. She should take her first dose while lying down, because there is a first-dose effect with the prazosin.
Antihypertensive Agents General Nursing Implications
Educate patients about the importance of not missing a dose, taking the medications exactly as prescribed, never doubling up on doses, and not stopping abruptly
Patients should not take any OTC drugs without first checking with MD
PO meds should be taken with meals
Educate patient on concurrent lifestyle modifications:Diet, Exercise, Stress Reduction
Instruct patients on how to monitor their own BP
Antihypertensive AgentsNursing Implications
Instruct patients that these drugs should not be stopped abruptly, as this may cause a rebound hypertensive crisis, and perhaps lead to CVA.
Oral forms should be given with meals so that absorption is more gradual and effective.
Administer IV forms with extreme caution and use an IV pump.
Antihypertensive Agents General Nursing Implications
Instruct patients to change positions slowly
Hot showers, tubs, weather, exercise, alcohol, prolonged sitting/standing may cause hypotension, dizziness, fainting
Patients should report: SOB, dyspnea, peripheral and/or angioedema, excessive weight gain, chest pain, palpitations
Men may experience impotence as expected SE
Diuretics
Main classifications:Thiazide and thiazide-likeLoopPotassium-sparing
Others: Osmotic Carbonic Anhydrase Inhibitors
Thiazide Diuretics
Hydrochlorothiazide ( HydroDIURIL )Inhibits Na reabsorption at distal tubule
resulting in diuresis; decreased SVR & BPAlso acts to relax arterioles;decrease SVRFirst line medication regimen for HTNSafe for most patients; inexpensiveOften used in combination w/ other drugs
Loop Diuretics
Furosemide (Lasix)Blocks Cl and Na reabsorption at Loop of
Henle resulting in diuresis; decreased SVR and decreased BP
Stimulate prostaglandins; vasodilation ofrenal, lung, system vessels
Rapid onset and most potent diureticCan be given once dailyEffective even in renal impaired patients
Thiazide and Loop DiureticsNursing Implications
Monitor K levels closely for hypokalemia Teach patient to eat high K foods Cross allergies may exist to sulfonamides Concurrent digoxin Rx may lead to digoxin
toxicity NSAIDS may decrease diuretic effect Concurrent antiglycemic Rx may lead to
hyperglycemia Monitor for I & O.
NCLEX QUESTION
A 66 y.o. client who is taking several medications including Digoxin and Diuril comes to the clinic complaining of not feeling well. Which of the following assessment data would indicate a potential diagnosis of digoxin toxicity?
A. chest pain, hypotension, and paresthesia
B. constipation, dry mouth, and sleep disorder
C. double vision, loss of appetite, and nausea
D. dyspnea, edema, and palpitations
Potassium-sparing Diuretics
Spironlactone ( Aldactone )Works in the collecting ductBinds and blocks aldosterone receptors
resulting in blocked Na water reabsorption;decreased SVR and BP
Considered a weak diureticOften used in conjunction with more potent
K depleting diuretics
Potassium-sparing DiureticNursing Implications
Monitor K levels closely for hyperkalemiaEspecially with renal impairment, use of potassium supplements, or ACE drugs
May cause gynecomastia, impotence in men; amenorrhea, and post-menopausal bleeding in women.
Other side effects: dizziness, ha, cramps, nausea,diarrhea.
DiureticsGeneral Nursing Implications
Instruct patient to take early in the day to avoid sleep disturbances
Geriatric patients more sensitive to fluid balance changes; caution for postural hypotension
Monitor weights, potassium levels as well as Na and Cl
Instruct patients to notify MD if ill with vomiting and/or diarrhea