Novel Drug Delivery in Pediatric Medulloblastoma
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Transcript of Novel Drug Delivery in Pediatric Medulloblastoma
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Novel Drug Delivery in Pediatric Medulloblastoma
Group 37 – Arvin Soepriatna (Presenter), Chris Peng, Blessan Sebastian
Client: Mr. Mike Sabo, Pulse Therapeutics, Inc.BME 401, Prof. Anastasio
10/28/2013
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NeedMore efficient treatment process regarding
drug delivery with chemotherapeutic agentsCurrently no method to exclusively target
tumorsChemotherapy side effects are serious
Increased drug dosage without side-effectsShorter and more effective treatment time
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Specific Design RequirementsParameters Specifications
Imaging Phantom Size < 3x3 ft
Imaging Phantom Weight ≤ 30 lbs
Magnet Device Controller < 3x3 ft
Magnetic Field Strength < 1 T
Localization Duration < 5 min
Imaging Depth < 10 cm
Standard Operation Time < 4 hrs
System Power Inlet Standard 110V
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Phantom Designs• Box Obstacle
Course• 3D Styrofoam
Brain Phantom• Blood Vessel
Phantom
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Magnetic Control DeviceCartesia
n
Conical Spherical
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Advantages and Disadvantages
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Imaging Technology AlternativesPositron Emission Tomography (PET)
Measures γ-rays emission from radioactive tracer[1]
Half-life of tracers[2]
13N ~ 20 min. 18F ~ 110 min.
Recent discoveries 64Cu ~ 12.7 hours [3]
Nanoparticle conjugation[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.[2] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.[3] Anderson, Carolyn J., Farrokh Dehdashti, P. Cutler, Sally Schwarz, Richard Laforest. "64Cu-TETA-Octreotide as a Pet Imaging Agent for Patients with Neuroendocrine Tumors." The Journal of Nuclear Medicine 42.2 (2001): 213-21. Print.
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Imaging Technology AlternativesSingle Photon Emission Computed
Tomography (SPECT)Similar to PET
γ-rays emission Radioactive tracer
Average half-lives ~6 hours[1]
Difference from PET[2]
Lower resolution High Noise
[1] Jadvar H., and Parker J. A. "Pet Radiotracers." Clinical PET and PET/CT 10.279 (2005): 45-67. Springer. Web. 25 Oct. 2013.[2] Rahmim, Arman, and Habib Zaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.
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Imaging Technology AlternativesDoppler Ultrasound
Measures the time it takes for pulse signals to be returned to the receiver from its generation.[1]
High resolution imagesProblem:
Distortion through thick bones[2]
High signal to noise ratioTranscranial Ultrasound
Suboccipital Window [3][1] Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.[2] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.[3] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.
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Imaging Technology AlternativesSpectral Computed Tomography (CT)
Measures X-ray attenuation coefficient Utilizes photon counting detectors [1]
Broad spectrum info from X-ray Lower dosage of X-ray
High Resolution
[1] Persson, Mats. "Reconstruction of Spectral CT Images." Thesis. Royal Institute of Technology, 2011. Reconstruction of Spectral CT Images. 2011. Web. 26 Oct. 2013.
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Advantages and Disadvantages
[1] Asbury, Carolyn, John A. Detre, Ulrich Andrian, and Michael L. Dustin. "Brain Imaging Technologies and Their Applications in Neuroscience." The Dana Foundation Journal (2006): 1-45. Print.[2] Rahmim, Arman, and Habib Zaidi. "PET versus SPECT: Strengths, Limitations, and Challenges." Nuclear Medicine Communications 29.3 (2008): 193-207. Johns Hopkins University. Lippincott Williams & Wilkins. Web. 23 Oct. 2013.
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Chosen DesignMagnetic Control Device: Conical Movement
Imaging Technology: Transcranial Doppler Ultrasound
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PhantomStyrofoam thickness: 3cm
Model skull + brain IV tubing Diameter: 0.5 cm
CSF = 0.7 – 1.0 mPa*s @37o C[1]
Saline = 0.72 mPa*s[2]
Pathway fixturesPlastic hooksThin plastic cable wires
[1] Roselli, Robert J., and Kenneth R. Diller . Biotransport: Principles and Applications. 1st ed. New York: Springer Science Business Media, 2011. p. 139. eBook. [2] Kestin, Joseph, H. Ezzat Khalifa, et al, et al. "Tables of the Dynamic and Kinematic Viscosity of NaCl Solutions." J. Phys. Chem. Ref. Data. 10.1 (1981): 71-89. Web. 27 Oct. 2013.
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Conical Magnetic Control DeviceJoint modification of the machine made by
Pulse TherapeuticsMotor specs for joints
300 WattsMotor specs for rotating magnet
Up to 300 RPM
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Peak Voltage Output of MagnetVoltage measured using 3D magnetic
transducer probe
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Doppler UltrasoundLocation of transducer
Angle of incidenceProperties of transducer
For adults[1]
3-MHz transducersFor pediatric
5-MHz transducers
[1] Coley, Brian D., Lynn A. Fordham, and Harris L. Cohen. "Transcranial Doppler Ultrasound Examination for Adults and Children." Medical Ultrasound (2012): 1-12. American Institute of Ultrasound in Medicine. Aium. Web. 25 Oct. 2013.Image source: Deane, Colin. "Doppler Ultrasound: Principles and Practice." Doppler in Obstetrics (2002). Print.
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Project Timeline
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Team OrganizationTeam Member Responsibilities
Chris Peng Webpage, CAD Specialist, MATLAB specialist
Arvin Soepriatna Progress PresentationImaging Research, Experimental
Analysis
Blessan Sebastian Final PresentationDesign Parameters and Safety,
Phantom Development
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Thank you for listening!