· PDF fileNorbert Goebels and Reinhard Hohlfeld ... viii Contents. 25 Osteoarthritis ......
Transcript of · PDF fileNorbert Goebels and Reinhard Hohlfeld ... viii Contents. 25 Osteoarthritis ......
vii
Contents
Preface ............................................................................................................................ v
Contributors .................................................................................................................. .xi
PART I. MOLECULAR MECHANISMS IN RHEUMATIC DISEASES
1 GeneticsPeter K. Gregersen ............................................................................................... 3
2 VirusesAndras Perl ......................................................................................................... 15
3 ApoptosisJohn D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, and Tong Zhou .......... 35
4 Humoral ResponseGary S. Gilkeson ................................................................................................ 59
5 T-Cell SignalingGary A. Koretzky and Erik J. Peterson ............................................................. 75
6 Adhesion and Costimulatory MoleculesVassiliki A. Boussiotis, Gordon J. Freeman, and Lee M. Nadler .................. 87
7 Transcription FactorsHenry K. Wong ................................................................................................. 109
8 Immune ComplexesMark H. Wener ................................................................................................. 127
9 ComplementV. Michael Holers ............................................................................................. 145
10 Eicosanoids and Other Bioactive LipidsLeslie J. Crofford .............................................................................................. 161
11 CollagensSergio A. Jiménez ............................................................................................. 175
PART II. CELLULAR MECHANISMS IN RHEUMATIC DISEASES
12 T-LymphocytesNilamadhab Mishra and Gary M. Kammer ................................................... 199
13 B-LymphocytesRobert F. Ashman ............................................................................................ 213
14 Monocytes and MacrophagesJames M. K. Chan and Sharon M. Wahl ........................................................ 225
15 Polymorphonuclear CellsMichael H. Pillinger, Pamela B. Rosenthal, and Bruce N. Cronstein ......... 243
16 SynoviocytesDavid E. Yocum ................................................................................................ 259
17 ChondrocytesTariq M. Haqqi, Donald D. Anthony, and Charles J. Malemud .................. 267
18 Osteoblasts and OsteoclastsStavros C. Manolagas ..................................................................................... 279
19 Animal ModelsThomas J. Lang and Charles S. Via ............................................................... 293
PART III. PATHOGENESIS OF RHEUMATIC DISEASES
20 Systemic Lupus ErythematosusStamatis-Nick C. Liossis and George C. Tsokos ............................................ 311
21 Rheumatoid ArthritisRichard M. Pope and Harris Perlman ............................................................ 325
22 Inflammatory MyopathiesNorbert Goebels and Reinhard Hohlfeld ........................................................ 363
23 Systemic SclerosisTimothy M. Wright ........................................................................................... 375
24 VasculitisJörg J. Goronzy and Cornelia M. Weyand ..................................................... 385
viii Contents
25 OsteoarthritisA. Robin Poole and Ginette Webb ................................................................... 401
26 OsteoporosisStavros C. Manolagas ...................................................................................... 413
27 Heritable Disorders of Connective TissuePetros Tsipouras ............................................................................................... 423
PART IV. MOLECULAR ASPECTS OF TREATMENT OF RHEUMATIC DISEASES
28 CorticosteroidsHenry K. Wong and George C. Tsokos ........................................................... 439
29 Cytotoxic DrugsDavid A. Fox and W. Joseph McCune ............................................................ 451
30 Complement InhibitorsSavvas C. Makrides .......................................................................................... 465
31 Cytokine Response ModifiersRichard E. Jones and Larry W. Moreland ..................................................... 477
32 Restoration of Immune ToleranceWoodruff Emlen ............................................................................................... 487
33 Metalloproteases and Their Modulation as Treatment in OsteoarthritisJohanne Martel-Pelletier, Ginette Tardif, Julio Fernandes,and Jean-Pierre Pelletier ................................................................................. 499
34 Gene TherapyRobert P. Kimberly ........................................................................................... 515
Index ........................................................................................................................... 525
ix Contents