NON-LINEAR ANALYSIS OF SURFACE ELECTROMYOGRAPHY IN PARKINSON’S DISEASE Matthew Flood 1,2* 1 School...
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NON-LINEAR ANALYSIS OF SURFACE
ELECTROMYOGRAPHY IN PARKINSON’S DISEASE
Matthew Flood1,2*
1School of Electrical & Electronic Engineering,University College Dublin,Belfield,Dublin 4.
Prof. Madeleine Lowery1,2
2Insight Centre for Data Analytics,
O'Brien Centre for Science,Belfield,Dublin 4.
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Parkinson’s Disease
Bradykinetic gait
Muscle tremorMuscle rigidity
Akinesia
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Parkinson’s Disease
No biomarkerNeed to quantify disease severity
Levodopa medication & deep brain stimulation
Limited research on nonlinear analysis of EMG
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Aim
To distinguish Parkinsonian EMG from healthy controls using advanced signal analysis,
enabling early diagnosis and biomarkers to assess therapeutic
interventions.
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Experimental Methods
Time (s)
EMG of Rectus Femoris (PD)
-0.3
-0.2
-0.1
0
0.1
0.2
0.3
8.8 8.9 9 9.1 9.2
EM
G
Time (s)
EM
G
EMG of Rectus Femoris (Control)
-0.3
-0.2
-0.1
0
0.1
0.2
10.65 10.75 10.85 10.95
B. Upper leg muscles
A. Experimental
setup
C. Surface EMG
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Recurrence Quantification Analysis
Embedding Dimension * Time Delay *
Trajectory Radius * Line length
0.20.1
0-0.1
-0.2-0.2
-0.1
0
0.1
-0.05
0
0.05
0.1
0.15
-0.15
-0.1
0.2
PD
Controlshttps://code.google.com/p/girs/downloads/list
Rössler System
EMG
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Recurrence
Plot
EMGEM
G
(mV
)Tim
e
(sec)
PD Patient
Time - (seconds)
Tim
e - (
seco
nds)
Recurrence Plot of Right Rectus Femoris of PD Patient (Subject 2 - Trial 1)
0.5 1
0.5
1
0 0.5 1-1
0
1
Time- (Seconds)
Ampl
itude
(mV)
Plot of Right Rectus Femoris sEMG of Parkinson's Patient
%DET = 38.76%
Time - (Seconds)
Tim
e - (
Sec
onds
)
Recurrence Plot of Purely Stochastic Signal
0.5 1
0.5
1
0 0.5 1-1
0
1
Time - (Seconds)
Ampl
itude
(mV)
Plot of Purely Stochastic Signal
%DET = 0%Noise
Time (seconds)
Tim
e (s
econ
ds)
Recurrence Plot of Right Rectus Femoris of Healthy Control (Subject 3- Trial 6)
0.5 1
0.5
1
0 0.5 1-1
0
1
Time - (Seconds)
Ampl
itude
(mV)
Plot of Right Rectus Femoris EMG of Healthy Control
%DET = 3.545%
Healthy Control
Time (sec)
Time (sec)
Time (sec)
Recurrence Quantification Analysis
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Agonist-antagonist EMG Coherence
Intermuscular Coherence
Frequency (Hz)
Intermuscular Coherence of PD and Control SubjectsControls
PD
Inte
rmus
cular C
oher
ence
0
0.1
0.2
0.3
0.4
0.5
0 10 20 30 40 50 60
Significance Threshold
θδ α β γ
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EMG Kurtosis and skew Kurto
sis
Skewness
Negative Skew
Positive & Negative Kurtosis
Positive Skew
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Results: Recurrence Quantification Analysis
Controls Parkinson's05
10152025303540
Left LeftRight Right
Determinism of EMG Signal%
DE
T
*
* p = 0.0475
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δ (0-4 Hz) θ (4-8 Hz) α (8-15 Hz) β (15-30 Hz) γ (30-60 Hz)0
0.5
1
1.5
2
2.5
3
EMG Coherence Between Agonist & Antagonist
Muscles
Frequency Bands
Inte
rmusc
ula
r C
ohere
nce
Results: Agonist-antagonist EMG coherence
* * *
**Parkinson 's Disease Controls
* p < 0.001** p = 0.014
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Results: EMG Kurtosis and Skew
Series10
0.05
0.1
0.15
0.2
0.25
SkewnessControls
Abso
lute
Skew
Series10
0.51
1.52
2.53
3.54
4.5
KurtosisControls Parkinson's Disease
Kurt
osi
s
*
* p = 0.0457
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Conclusions
Determinism of EMG signal increases in Parkinson’s Disease, greater motor unit synchrony.
Coherence higher in patients in θ, α, β, & γ frequency bands, greater shared common input across muscles.
Kurtosis higher in Parkinson’s disease, greater signal structure.
Pathological synchrony of motoneuron firing patterns in isometric muscle contractions in Parkinson’s disease.
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Future Work
Sensitivity analysis of recurrence quantification parameters to optimize for parkinsonian EMG.
Identify relationship between coherence and other nonlinear measures (e.g. Sample Entropy, LZ Complexity).
Use simulation modelling to identify mechanisms underlying difference in parkinsonian EMG.
Apply analysis methods to quantify the efficacy of exercise intervention in PD patients.
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The researchers would like to thank Prof. Bente Jensen and colleagues at the Dept. of Exercise and Sports Sciences at the
University of Copenhagen, Denmark, for contributing their data.
This project was funded under the SFI Insight Centre for Data Analytics.
Acknowledgements