NioSkinTM

Innovative Solution for Dermal Delivery

Nioskin niosomes are a new and effective delivery system designed to improve skin penetration of natural ingredients.

NIOSKIN ULTRA-FLEXIBLE NIOSOME

The latest generation of skin delivery system.

• easy to formulate • total natural compound • preservative free

Nioskin™ Active Ingredients are patented.

NIOSKINTM TECHNOLOGYBiologically active molecules of natural origin are included in special natural vesicles to pursue an optimal bioavailability, enhancing skin penetration through the stratum corneum.

The clinically tested positive effects of NioSkin™ are related to the high rate of absorption through the skin.

HIGH ELASTICITY AND DEFORMABILITYNioskin vesicles are elastic and can squeeze through the pores in the stratum corneum performing penetration along intercellular routes.

Nioskin niosomes are highly hydrophilic and when applied on the skin help to secure an additional hydration, migrating into the water-rich deeper stratum of the skin.

NIOSKINTM ARE NIOSOMES SPECIFICALLY DESIGNED TO ENCAPSULATE PHYTOACTIVES

• lipophilic active compounds

can be associated with the

bilayer

• hydrophilic active compunds

can be entrapped in the

acqueous cavity

The bilayer of the ULTRA-FLEXIBLE NIOSOME is made by polyglycerols single-chain surfactant being elastic to maximized the penetration throught the skin.

2015

Conventional NiosomeLiposomes Ethosomes Ultra-flexible Niosomes

NIOSKINTM

A vesicle of O 100-200 nm,

composed of amphiphilic

molecules + an aqueous

cavity suitable to

incorporate large molecules

as natural active compunds

The vesicle shape to size the pore and then return to the

original shape in the deeper epidermis stratum.

Small size < 200 nm and maximum flexibility enhance skin

and mucosal absorption

The active compound is directly driven into the epidermis cells

= maximum efficacy.

Epidermis

CorneocyteStratum Corneum (15 µm)

Lipid regions (20-40 nm)

Flexible Niosome (100-200 nm)

NIOSKINTM ULTRA-FLEXIBLE NIOSOMEThe latest generation of skin delivery system

NIOSKINTM

ADVANTAGES FOR COSMETIC FORMULATION

• Easy to formulate by • Self-preservative

introduction in the water • Soluble in water and dispersible in lipid

or lipid phase of emulsion • Stable at a wide range of pH

• Direct use in cold phase • Solvent free

ApplicationNioSkin is suitable to formulate a wide range of dermocosmetics for face and body care.

• Emulsion W/O • BB creams

• Emulsion O/W • Serum and day base creams

• Balm and Lipstick • Eye care serum

• Lotion • Facial mask

TECHNICAL SUPPORTDocumentation• Total natural components • Preservative free

• Allergen free • GMO free

• Gluten free • Dermatologically tested (Patch Test and Repeated Patch Test)

• Paraben free

Clinical tests• Skin barrier and hydration • Skin aging (Ultrasound Skin-Imaging)

• Trans Epidermal Water Loss (TEWL) • Skin inflammation

• Skin pigmentation • Skin elasticity

Recommended usage dosage: 2% w/w

NIOSKINTM ACTIVE INGREDIENTSPLATFORM

NioSkin™ RCL40 Red Clover Isoflavone Aglycones Extract

AQUA, OLIVE OIL POLYGLYCERYL-6 ESTERS, POLYGLYCERYL-6 LAURATE, GLYCERIN, TRIFOLIUM PRATENSE LEAF EXTRACT, MAGNOLOL, HONOKIOL

NioSkin™ HMRLignan Picea Abies Purified Lignan 7-Hydroxymataresinol Extract

AQUA, OLIVE OIL POLYGLYCERYL-6 ESTERS, POLYGLYCERYL-6 LAURATE, GLYCERIN, PICEA ABIES WOOD EXTRACT, MAGNOLOL, HONOKIOL

NioSkin™ Ginkgo Ginkgo Biloba 24/6 Extract

AQUA, OLIVE OIL POLYGLYCERYL-6 ESTERS, POLYGLYCERYL-6 LAURATE, GLYCERIN, GINKGO BILOBA LEAF EXTRACT, MAGNOLOL, HONOKIOL

NioSkin™ Bilberry European Bilberry Anthocianins Extract

AQUA, OLIVE OIL POLYGLYCERYL-6 ESTERS, POLYGLYCERYL-6 LAURATE, GLYCERIN, VACCINIUM MYRTILLUS FRUIT EXTRACT, MAGNOLOL, HONOKIOL

NioSkin™ MedCan Cannabis sativa CBD Extract (THC free)

AQUA, OLIVE OIL POLYGLYCERYL-6 ESTERS, POLYGLYCERYL-6 LAURATE, GLYCERIN, CANNABIS SATIVA EXTRACT, MAGNOLOL, HONOKIOL

Produced with GMP certified active ingredients and in compliance with the highest quality standards.

NioSkin™ Active Ingredients fulfil the requirements of the European Cosmetic Regulation 1223/2009 and its amendments and the Guidelines for Safety Evaluation of Cosmetic Ingredients.

COSMETIC APPLICATION

RCL40

HMRLIGNAN

GINKGO

BILBERRY

MEDCAN

• Anti-aging in mature skin (+40)

• Hyperpigmentation in aging

• Dryness of skin and mucosae

• Anti-wrinkle at any age

• Anti-aging in young skin (+30)

• High hydration and eye-lines recover

• Skin irritation and sensitive skin

• Anti-aging sunscreen formula

• Anti-aging, moisturizing

• High hydration and fine lines recover

• Local tissue microcirculation

• Body care

• Antioxidant & antiaging

• Capillary protection & couperose

• Dark eye circle serum

• Anti-inflammatory

• Dermatosis

• Contact dermatitis

• Immunological related skin disorders

NIOSKINTM RCL40A UNIQUE CONCENTRATED NATURAL PHYTOACTIVE FROM RED CLOVER

NioSkin RCL40 demonstrates a superior improvement of skin elasticity providing a younger appearance and a firming tone

INDICATION

ANTI-AGINGFirming action on mature skin (+40)

• Skin elasticity

• Increases dermal density

• Increases skin thickness

• Moisturizes aged skin

• Repairs the skin barrier

CLINICAL TESTSOverall antiaging effects have been proven through clinical trials with significance evidence in skin elasticity, hydration and derma re-modelling for long term repairing effect.

Significant reduction of the elastic Young’s modulus E -17.14 %**

Significant reduction of the skin Time Retraction (R) -19.02 %**

Significant reduction of VE Viscoelasticity -16.28 %**

Significant increase of Dermal Density +24.40 %**

Red clover is the preferred natural source of isoflavones as free aglycones.

Nioskin RCL40 has been formulated with the superior concentrated and standardized Red Clover Extract 40% isoflavones in their ready-active form.

SKIN ELASTICITYA study on skin elasticity was carried out on 12 subjects by evaluating the reduction

of the Young’s elastic modulus (E), Time Retention (R) and VE Viscoelasticity.

The volunteers were required to apply a 2% O/W cream twice a day for a period of 4

consecutive weeks, on the forearm inner side and on the face. A formulation without NioSkin was used

as control.

Results show that topical application of 2% NioSkin RCL40 produces a significant increase in skin elasticity after 2 weeks, reaching the maximum value after 28 days.

DERMASCANA study on skin thickness and dermal density was carried out on 18 subjects by Dermascan Ultra-sound High Resolution Image Analysis, a new non-invasive methodology for the in-vivo study of the skin aging process.

The volunteers were required to apply a 2% O/W emulsion twice a day for a period of 8 consecutive weeks, on the forearm inner side. A formulation without NioSkin was used as control.

Results show that topical application of 2% NioSkin RCL40 produces a significant increase in skin thickness and dermal density.

OTHER ANTI-AGING TESTSNIOSKIN RCL40 has been tested on TEWL and Corneometric Skin Hydration showing significant improvement.

5.00

-2.50

-10.00

-17.50

-25.00

0.00

-7.50

-15.00

-22.50

-30.00

0.00

-5.00

-10.00

-15.00

-20.00

80.00

67.50

55.00

42.50

30.00

Day 7 Day 14 Day 28

Day 7 Day 14 Day 28

Day 7 Day 14 Day 28

**

**

**

**

Day 0 Day 28 Day 56

Nioskin RCL40

**

***

**

*

Placebo

NIOSKINTM HMRLIGNANA ULTIMATE NATURAL AND PURIFIED LIGNAN FOR COSMETIC USE

NioSkin HMRlignan demonstrates a rapid improvement of skin wrinkle lines, showing a superior hydration and protecting effects on sensitive skin

INDICATION

ANTI-AGING• Anti-wrinkle

• Repairs the skin barrier

• Long term Moisturizing

• Prevents skin aging by increasing dermal density

& skin thickness

• Ideal for sensitive skin

CLINICAL TESTSAntiaging effects have been proven through clinical trials with significance evidence in restoring the skin barrier and hydration, being the first answer to wrinkles and lines at any age, with an overall evidence of derma re-modelling for long term repairing effect. Effective on sensitive skin.

HMRlignan is a unique patented extract from Picea Abies knots, rich in a particular type of lignans.

7-hydroxymatairesinol is the purified lignan with superior antioxidant and anti- inflammatory properties in NioSKin HMRlignan

SKIN BARRIER AND FAST HYDRATION

A study on skin barrier and restoring hydration was carried out on 12 subjects by

evaluating the Trans Epidermal Water Loss (TEWL).

The volunteers were required to apply a 2% O/W cream twice a day for a period of 4 consecutive

weeks, on the forearm inner side and on the face. A formulation without NioSkin was used as control.

Results show that topical application of 2% NioSkin HMRlignan produces a significant increase in skin barrier and hydration after 2 weeks, reaching the maximum value after 28 days.

DERMASCANA study on skin thickness and dermal density was carried out on 18 subjects by Dermascan Ultra-sound High Resolution Image Analysis, a new non-invasive methodology for the in-vivo study of the skin aging process.

The volunteers were required to apply a 2% O/W emulsion twice a day for a period of 8 consecutive weeks, on the forearm inner side. A formulation without NioSkin was used as control.

Results show that topical application of 2% HMRLignan produces a significant increase in skin thickness and dermal density.

OTHER ANTI-AGING TESTSNIOSKIN HMRlignan has been tested on Skin Elasticity and Corneometric Hydration showing significant improvement. NIOSKIN HMRlignan has been specifically tested on sensitive skin, showing significant rapid improvement of skin conditions.

Significant reduction of TEWL - 18.50 %**

Significant variation of Short-Term Skin Moisturizing Index

Significant increase of Dermal Density + 32.90 %**

10.00

0.00

-10.00

-20.00

-30.00

24

18

12

6

0

80.00

67.50

55.00

42.50

30.00

Day 7 Day 14 Day 28

0 5 minutes 15 minutes 30 minutes 60 minutes

Day 0 Day 28 Day 56

Significant increase of Skin Thickness + 8.40%*** 1.600

1.500

1.400

1.300

1.200 Day 0 Day 28 Day 56

Nioskin HMRLignan Placebo

**

***

**

**

**

***

***

***

*

14.5316.48

9.969.39

NIOSKINTM BILBERRYA CONCENTRATE BLUE PHYTOACTIVES FROM BILBERRY FRUITS FOR COSMETIC USE

NioSkin Bilberry demonstrates an improvement of skin elasticity, showing antiaging and protecting effects

INDICATION

ANTI-AGING• Skin moisturizing

• Repairs Skin Barrier

• Increases Skin Elasticity

• Antiaging & Antioxidant

CLINICAL TESTSOverall antiaging effects have been proven through clinical trials with significance evidence on skin elasticity and hydration for an antioxidant repairing effect.

Bilberry is the most famous fruit and concentrated source of antioxidant poliphenol pigments, the blue anthocyanins.

Nioskin Bilberry contains the superior concentrated and standardized extract from Bilberry fruits 36% anthocyanins, totally stabilized.

SKIN ELASTICITYA study on skin elasticity was carried out on 12 subjects by evaluating the reduction

of the Young’s elastic modulus (E), Time Retention (R) and VE Viscoelasticity.

The volunteers were required to apply a 2% O/W cream twice a day for a period of 4

consecutive weeks, on the forearm inner side and on the face. A formulation without NioSkin was used

as control.

Results show that topical application of 2% NioSkin Bilberry produces a significant increase in skin elasticity after 2 weeks, reaching the maximum value after 28 days.

CORNEOMETRIC SKIN HYDRATIONA study on skin hydration was carried out on 12 subjects by evaluating the Corneometric Hydration Index at Short-Term and Long-Term.

The volunteers were required to apply a 2% O/W cream on the face, for the 24 hours test and twice a day for a period of 4 consecutive weeks. A formulation without NioSkin was used as control.

Results show that topical application of 2% NioSkin Bilberry produces an extremely significant rapid increase in skin hydration after 15 minutes, with evidence of high significant efficacy on long term treatment.

OTHER ANTI-AGING TESTSNIOSKIN Bilberry has been tested on Dermascan and Corneometric Hydration showing positive improvement.

Significant reduction of the elastic Young’s modulus E -17.28 %**

Significant reduction of VE Viscoelasticity -15.24 %**

Significant reduction of the Skin Time Retraction (R) -18.22 %**

Significant increase of Long Term Skin Moisturizing Index

5.00

-2.50

-10.00

-17.50

-25.00

0.00

-5.00

-10.00

-15.00

-20.00

0.00

-5.00

-10.00

-15.00

-20.00

30.00

22.50

15.00

7.50

0.00

Day 7 Day 14 Day 28

Day 7 Day 14 Day 28

Day 7 Day 14 Day 28

**

**

***

**

Day 0 Day 7 Day 14 Day 28

Nioskin Bilberry

****

***

***

*

*

Placebo

NIOSKINTM GINKGO A CONCENTRATED PHYTOACTIVES FROM THE ANCIENT GINKGO TREE FOR COSMETIC USE

NioSkin Ginkgo demonstrates an improvement of skin moisturizing and skin firmness showing a superior protecting effects from oxidative stress

INDICATION

ANTI-AGING• Skin moisturizing

• Anti-wrinkle

• Protecting the skin from oxidative stress and inflammation

CLINICAL TESTSOverall antiaging effects have been proven through clinical trials with significance evidence on skin hydration and skin barrier, improving skin firmness, contrasting fine lines and wrinkles, and offering a superior antioxidant protecting effect.

Ginkgo biloba is the oldest tree. The leaves of Ginkgo contain unique flavonoids and terpenes not found in any other plants, being an elective source of antioxidant compounds. Nioskin™ Ginkgo has been formulated with the standardized Ginkgo Biloba extract 24-6% flavonoids & terpenes recognized for their radical scavenging properties that protect tissue against oxidative stress which leads to aging and inflammation. Ginkgo helps to eliminate toxins, strengthen the skin’s defenses, improving the dermal microcirculation and lymphatic drainage and stimulate fibroblast for an overall antiaging effect.

SKIN MOISTURIZING AND BARRIER

A study on skin barrier and moisturizing was carried out on 12 subjects by evaluating

the trans Epidermal Water Loss (TEWL). The volunteers were required to apply a

2% O/W cream twice a day for a period of 4 consecutive weeks, on the forearm inner side and

on the face. A formulation without NioSkin was used as control. Results show that topical application of 2%

NioSkin Ginkgo produces a significant increase in skin barrier and hydration after 2 weeks, reaching the maximum value after 28 days.

Aging and related changes of epidermal structure can affect skin capacity to maintain water inside the stratum corneum. Measurements of skin hydration are of great importance in evaluating skin barrier and anti-aging protecting effects.

SKIN HYDRATATIONA study on skin hydration was carried out on 12 subjects by evaluating the Corneometric Hydration Index at Short-Term and Long-Term. The volunteers were required to apply a 2% O/W cream on the face, for the 24 hours test and twice a day for a period of 4 consecutive weeks. A formulation without NioSkin was used as control. Results show that topical application of 2% NioSkin Ginkgo produces an extremely significant rapid increase in skin hydration after 15 minutes, with evidence of high significant efficacy on long term treatment.

OTHER ANTI-AGING TESTSNIOSKIN Ginkgo has been tested on Dermascan and Skin Elasticity showing positive improvement.

Significant reduction of TEWL -17.28 %**

Significant increase of Long-Term Skin Moisturizing Index

Significant increase of Short-Term Skin Moisturizing Index

% Significant variation of Short-Term Skin Moisturizing Index

0.00

-4.50

-9.00

-13.50

-18.00

230

185

140

95

50

24

18

12

6

0

18.00

13.50

9.00

4.50

0.00

Day 7 Day 14 Day 28

**

***

**

*

Day 0 Day 7 Day 14 Day 28

Nioskin Ginkgo

0 5 minutes 15 minutes 30 minutes 60 minutes

**

**

**

**

0 5 minutes 15 minutes 30 minutes 60 minutes

Placebo

7.92

21.66

14.46

1.56

NioSkin™ The result of a balanced combination

of Nature and Science

NIOSKINTM MEDCAN AN INNOVATIVE CONCENTRATE PHYTOACTIVES FROM CANNABIS FOR TOPICAL USE

Linnea Nioskin™ Cannabis contains a concentrated total cannabis extract standardized in cannabidiols (CBD)

INDICATION

Skin• Anti-inflammatory

• Dermatosis

• Contact dermatitis

• Immunological related skin disorders

Cannabis phytocomplex and its phytocannabinoids may have a relevant medicinal value for certain diseases.

Cannabis phytocomplex has a role in the control of epidermal physiology and skin differentiation genes, anti-inflammatory and immunological related skin disorders, neurodermitis, contact eczema, hitching dermatosis, rosacea.

About Linnea Located in the Swiss canton of Ticino, Linnea is a high-quality manufacturer of Botanical Extracts

and Active Pharmaceutical Ingredients of Natural Origin in Bulk form.

Linnea Ingredients are suitable for the use in the Pharmaceutical, Health-Food and Cosmetic Industries.

The company employs a team of experienced professionals specialized in the extraction

and purification of plant materials and in the synthesis of fine chemicals.

Best solutions, everywhereLinnea’s service is tailored to the needs of its customers.

With our extensive knowledge of international requirements and dispatch procedures, prompt efficient

delivery is guaranteed just about anywhere in the world.

Thanks to the company’s competence and reliability, Linnea exports its products to more than 60

countries across 5 continents and supplies more than 200 clients per year.

Headquarters Linnea SA Via Cantonale CH-6595 Riazzino (TI) Switzerland Tel: +41 (0)91 850 5050Fax: +41 (0)91 850 5070 info@linnea.ch www.linnea.ch

US office Linnea Inc. 435 McCartney Street Easton, PA 18042USATel: 888-253-0044 (US) or +1 610-253-7950Fax: +1 610-253-7970dstanek@linnea.chwww.linnea-us.com