NiMOC: Nature-inspired Modeling, Optimization and ControlR. Guthke European Co-ordination Action...

NiMOC: Nature-inspired Modeling, Optimization and Control R. Guthke

European Co-ordination Action ‘Nature-inspired Smart Information Systems’

Focus Group NiMOC

Nature-inspired Modeling, Optimization and Control

Chairman: Reinhard Guthke, HKI Jena, Germany

Vice Chairman: Ronald Westra, Univ. Maastricht, The Netherlands

NiSIS - NiMOC


NiMOC: 29 Members

K. Bayer, J. Borges, S. Burgess, G. Coghill, R. Dudda, J. Garibaldi, R. Guthke, M. Hecker, C. Hummert, C. Igel, S. Jovanovic, K. Leiviskä, J. Lemos, E. Lenart, K. Lieven, D. Linkens, T. Mendonca, D. Naso, A. Nowe, A. Offenhaeusser, S. Pizzuti, E. Plahte, M. Pfaff, M. Poel, P. Rocha, J. Sobecki, K. Tuyls, R. Westra, S. Zellmer

From 10 countries:

AT, BE, DE, FI, IT, NO, NL, PL, PT, UK


• NiMOC’s Contribution to the Roadmap

• NiMOC’s further Activities

NiMOC: Activities


Contribution of NiMOC to the NiSIS Roadmapwww.nisis.risk-technologies.com/tte/Roadmap.aspx

1. Introduction2. State-of-the-Art…2.3. Modeling and Systems…

3. Applications and Existing Challenges…3.3. Modeling, Optimization and Control

4. Grand Challenges…4.3. NiMOC Grand Challenges

5. Impacts

Annex...

Aachen 2007


NiSIS Meetingon “Grand Challenges and

Impact”Aachen, Sept 6-7, 2007


Accomplisehed Activities 2007

• Special Issue: Lecture Notes in Bioinformatics 4366 (2007), Eds. K. Tuyls, R. Westra, Y. Saeys, A. Nowé

• Teresa Mendonca, Jose Lemos: Case Study “Case Study: Contributions to Modeling and Identification of Biomedical Systems”

• Teresa Mendonca, Jose Lemos: NI Modelling and Control of Anaesthesia Including a Summer School on Modelling and Control of Physiological Variables: Nature Inspired Approaches, Portugal, on May 2-3, 2007

• Michael Pfaff, Reinhard Guthke: NiSIS School and Workshop, March 15-16, 2007, Jena, Germany, School: “Integrated Analysis of Transcriptome and Proteome Data”,Workshop on “Data and Knowledge Based Biomolecular Network Reconstruction”

• George Coghill: Visit at BCJ and HKI Jena for participation in the NiMOC Workshop

• NiMOC committee Meeting, Malta, November 26, 2007


• Teresa Mendonca, Jose Lemos: Case Study “Case Study: Contributions to Modeling and Identification of Biomedical Systems”



• Teresa Mendonca, Jose Lemos: NI Modelling and Control of Anaesthesia Including a Summer School on Modelling and Control of Physiological Variables: Nature Inspired Approaches, Portugal, on May 2-3, 2007



NiSIS / JCB / DFG International Spring School and Workshop

Data Mining and Modelling in Systems BiologyData Mining and Modelling in Systems Biology

International Spring School

Integrative Analysis of Transcriptome and Proteome DataIntegrative Analysis of Transcriptome and Proteome Data

15th March 2007, Jena/Germany

International Workshop

Data and Knowledge Based Biomolecular Network ReconstructionData and Knowledge Based Biomolecular Network Reconstruction

16th March 2007, Jena/Germany



Michael Pfaff, Reinhard Guthke: NiSIS School, March 15, 2007, Jena, Germany



Michael Pfaff, Reinhard Guthke: NiSIS Workshop, March 16, 2007, Jena, Germany


• NiSIS Spring School on “Integrated Analysis of Transcriptome and Proteome Data”, Jena, March 15, 2007

• NiSIS Workshop on “Data and Knowledge Based Biomolecular Network Reconstruction”, Jena, March 16, 2007

70 participants from 6 countries (Austria, U.K., The Netherlands, Sweden, Swizerland, Germany)

NiMOC Activities 2007


Nature-inspired Modelling, Optimization and Control are dedicated to the investigation of intelligent paradigms existing in Nature and studied by systems approaches, such as Systems Biology, in order to learn from them how to better design smart, i.e. intelligent, adaptive and advanced information systems.

Nature-inspired Algorithms are most appropriate for problems of optimization, scheduling, chemometrics, routing, and assignment, management, organization, and logistics.

NiMOC Conclusions (1/3)


Regulatory gene expression and cellular signal transduction may be considered as some kind of data processing or information processing. Together with motif recognition on promoters and enhancers they seem to have the potential for the design of new Nature-inspired algorithms of data and information processing.

Within NiSIS, Reverse Engineering in Systems Biology may also be considered an essential first step to elucidate/reconstruct some of Nature’s information processing principles in order to proceed towards design of more advanced artificial information systems.



Approaches to Nature-inspired Modeling, Optimization and Control represented by NiMOC members are:•Reverse Engineering

•Fuzzy rule-based modeling

•Linguistic reasoning and fuzzy modeling and inference

•Fuzzification as coarse graining in multiscale modeling and simulation

•Cellular automata, Turing models

•Neuro-fuzzy hybrid models

•Coupling intragranular dynamics with extragranular dynamics

•Modeling from sparse data

•Hierarchical decomposition of decision-making and control

•Modelling self-organizing adaptive behaviour

•Multi-objective optimisation/goal seeking using Particle Swarm Intelligence

•Modelling Coupled moduls

•Artificial Immune System

•Piecewise Linear Dynamic Modeling

•Network Modelling and Simulation from sparse, incomplete and uncertain data


NiMOC: Nature-inspired Modeling, Optimization and ControlR. Guthke European Co-ordination Action...

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