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US. DEPARTMENTOF H W ANI) H C I W SERVICES

The NIkI Guidv a i i n o m x s scientitic initiatives and provides polic) m d administrativy ink)rrnation t o indivi du;ib and organizations \Tho need to h r kepr informed ofopponunitirs. requiremene. :md changes in extra mwi l programs administered by the National Insritutes of1 lealth.

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NIH Guide Distribution Center National Institutes of Health Room B4B-N-08, Building 31 Bethesda, Maryland 20892

First-class Mail Postage & Fees Paid

PHSlNI HlOD Permit No. G-291

Vol. 17, No. 17 l4ay 6, 1988

Vol. 17, No. 17, May 6, 1988

NOTICES

4 FEDERAL HUMAN NUTRITION RESEARCH AND INFORMATION MANAGEMENT ( H N R I M ) SYSTEM DATA BASE NOW AVAILABLE TO THE PUBLIC ........................ 1 National I n s t i t u t e s of Health Index: NATIONAL INSTITUTES OF HEALTH

GUIDELINES FOR LABORATORY PERSONNEL WORKING WITH HUMAN IMMUNODEFICIENCY VIRUS ..................................................... 1 National I n s t i t u t e s of Health Index: NATIONAL INSTITUTES OF HEALTH

SCIENCE SCHOLARS PROGRAM .................................................... 2 Divis ion of Research Grants Index: RESEARCH GRANTS

DATED ANNOUNCEMENTS (RFPs AND RFAs)

BIOMEDICAL WORKSHOP ON SUPERCOMPUTING TECHNIQUES............................ 2 Divis ion of Research Resources Index: RESEARCH RESOURCES

INHALATION REPRODUCTIVE T O X I C I T Y TESTING ( R F P ) . . ............................ 3 Nat iona l I n s t i t u t e of Environmental Health Sc iences Index: ENVIRONMENTAL HEALTH SCIENCES

PROGRAM PROJECTS ON THE BIOLOGY OF THE IMMUNE SYSTEM ( R F A ) . . . . . . . . . . . . . . . . . . 3 Nat iona l I n s t i t u t e of Al le rgy and I n f e c t i o u s Diseases Index: ALLERGY AND INFECTIOUS DISEASES J

DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES ( R F A ) . . . . . . . . . . . .... 5 Divis ion of Research Resources Index: RESEARCH RESOURCES

MYCOLOGY RESEARCH UNITS (RFA) ............................................... 6 National I n s t i t u t e of Allergy and I n f e c t i o u s Diseases Index: ALLERGY AND INFECTIOUS DISEASES

ASTHMA AND ALLERGIC DISEASE. CENTERS (RFA) ................................... 7 National I n s t i t u t e o f Al le rgy and I n f e c t i o u s Diseases Index: ALLERGY AND INFECTIOUS DISEASES

DIABETES CENTERS ( R F A ) . ..................................................... 9 Nat iona l I n s t i t u t e o f Diabetes and Diges t ive and Kidney Diseases Index: DIABETES AND DIGESTIVE AND KIDNEY DISEASES

IO N G O I N G PROGRAM ANNOUNCEMENTS

FACTORS CONTRIBUTING TO THE SEQUENCING OF ALCOHOL AND OTHER DRUG USE (PA) ......................................................... 10 National I n s t i t u t e on Alcohol Abuse and Alcoholism Nat iona l I n s t i t u t e on Drug Abuse Index: ALCOHOL ABUSE ANJI ALCOHOLISM; DRUG ABUSE

NOTICES

- -muf

Vd

"-d'

FEDERAL HUMAN NUTRITION RESEARCH AND INFORMATION MANAGEMENT ( H N R I M ) SYSTEM DATA BASE NOW AVAILABLE TO THE PUBLIC

P.T. 16; K.W. 0710095, 1004008

Nat ional I n s t i t u t e s o f Heal th

The Human N u t r i t i o n Research and Information Management (HNRIM) system d a t a base provides information on human n u t r i t i o n r e sea rch and r e sea rch t r a i n i n ga c t i v i t i e s supported i n whole o r i n p a r t by t h e Federal Government. The d a t a base con ta ins approximately 4,000 p r o j e c t s f o r each o f f i sca l years 1982-86,and inc ludes t h e fo l lowing types of information about each p r o j e c t :

sponsoring o rgan iza t ionp r o j e c t i d e n t i f i e r numbers p r o j e c t t i t l e p r i n c i p a l i n v e s t i g a t o ro rgan iza t ion name, address n u t r i t i o n c l a s s i f i c a t i o n c a t e g o r i e sp r o j e c t a b s t r a c t (does NOT inc lude r e sea rch r e s u l t s ) percent r e l a t e d t o n u t r i t i o n f i s c a l year and start d a t e

The d a t a base may be purchased through t h e Nat ional Technical Information Serv ice (NTIS), U.S. Department of Commerce ( D O C ) , 5285 Por t Royal Rd.,Spr ing f i e ld , VA 22161, (703) 487-4807. Data are suppl ied on computer t ape , s u i t a b l e f o r use on an IBM-compatible mainframe o r minicomputer, and t h e purchaser w i l l need t o c r e a t e customized sof tware i n o rde r t o access t h e d a t a . Those wishing t o purchase t h e d a t a base should con tac t NTIS d i r e c t l y , and should r e fe rence NTIS access ion number PB88-161690IAS.

The HNRIM d a t a base w a s developed i n accordance with t h e Nat ional A g r i c u l t u r a l . Research, Extension, and Teaching Pol icy A c t of 1977 ( 7 USC 3177). P a r t i c i p a t i n g agencies inc lude t h e Department of Heal th and Human Se rv ices , t h e U.S. Department o f Agr icu l ture , t h e Veterans Adminis t ra t ion, t h e Agencyf o r I n t e r n a t i o n a l Development, t h e Department of Defense, and D O C - N O M . The d a t a base is maintained a t t h e o f f i c e o f t h e N u t r i t i o n Coordinat ing Committee,National I n s t i t u t e s of Health, under t h e auspices o f t h e Interagency Committee on Human N u t r i t i o n Research.

For f u r t h e r information con tac t NTIS, o r :

HNRIM System Coordinator c/o N u t r i t i o n Coordinat ing Committee Building 31, Rm. 4B63 National I n s t i t u t e s o f Heal th 9000 Rockvi l le Pike Bethesda, Maryland 20892 Telephone: (301) 496-9035

GUIDELINES FOR LABORATORY PERSONNEL WORKING WITH HUMAN IMMUNODEFICIENCY VIRUS

P.T. 16; K.W. 1002045, 0715175

National I n s t i t u t e s o f Heal th

The Divis ion o f Sa fe ty , Nat ional I n s t i t u t e s o f Heal th announces t h e a v a i l a b i l i t y o f t h e Agent Summary Statement f o r Human Imrnunodeficienc Virus ( H I V ) and g u i d e l i n e s f o r l abora to ry personnel working with H I V . Included i n t h i s annota ted ve r s ion of "Biosafety i n Microbiological and Biomedical Labora tor ies" are t h e recommended f a c i l i t i e s , and p r a c t i c e s and procedures for l abo ra to ry personnel working a t Biosafe ty Level 2/3 and Biosafe ty Level 3. Biosafe ty Level 213 inc ludes a c t i v i t i e s involv ing c l i n i c a l specimens, bodyf l u i d s and t i s s u e s from humans o r inocula ted animals . Guidel ines f o r work conducted a t Biosafe ty Level 3 involv ing i n d u s t r i a l - s c a l e , large-volumeproduct ion o r h igh concen t r a t ions and manipulat ion of concent ra ted H I V are a l s o desc r ibed .

To rece ive a copy, send your r eques t t o :

NIHIDS H I V Laboratory P r a c t i c e s Building 31, Room 1C05 Bethesda, Maryland 20892

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SCIENCE SCHOLARS PROGRAM

P.T. 34; K.W. 1014002, 0901026

Divis ion o f Research Grants

The Divis ion o f Research Grants ( D R G ) i s p leased t o announce i t s Science wScholars Program. A small number of s e n i o r s c i e n t i s t s from o u t s i d e t h e Federa l Government w i l l have t h e oppor tuni ty t o p a r t i c i p a t e i n ana lyses o f extramural s c i e n t i f i c merit review, i n p o l i c y eva lua t ion , and i n t h e formulat ion of recommendations for DRG. Science s c h o l a r s w i l l work i n DRG on short- term assignments, from 3 t o 6 months.

ELIGIBILITY: Appl icants f o r t h e Science Scholars Program may be b a s i c or app l i ed s c i e n t i s t s or c l i n i c i a n s . They must, however, have had ex tens ive biomedical or behaviora l r e sea rch experience and must have served on a DRG Study Sec t ion o r equiva len t N I H i n i t i a l review group.

CONTENT OF PROGRAM: Science s c h o l a r s w i l l be involved i n eva lua t ions and ana lyses o f peer review practices and t r e n d s us ing a v a r i e t y o f s t a t i s t i c a l da tabases and r e sources . It is expected t h a t t h e Scholars w i l l a l s o confer widely with N I H s t a f f and c o n s u l t a n t s . I n a d d i t i o n t o such reviews and ana lyses? t h e Scho la r s may formulate and p resen t conclus ions and recommendations on a broad range o f i s s u e s a f f e c t i n g peer review. S t u d i e s mayinvolve p a r t i c u l a r f i e l d s or d i s c i p l i n e s or may be broad-based. Science Scholars w i l l be encouraged t o a t t e n d and p a r t i c i p a t e i n seminars r e l a t e d t o peer review, sc i ence admin i s t r a t ion , and p o l i c y .

INVITATIONAL PROCESS: Developing a proposal f o r t h e Science Scholars Programi s a j o i n t e f f o r t involv ing prospec t ive a p p l i c a n t s and s e n i o r DRG s t a f f . I n d i v i d u a l s i n t e r e s t e d i n t h i s program should con tac t t h e Di rec to r or DeputyDi rec to r . A prospec t ive app l i can t may have a s p e c i f i c p r o j e c t or s tudy i n mind or seek advice from DRG s t a f f Fibout p o s s i b l e p r o j e c t s . Before submi t t ing a formal l e t t e r of a p p l i c a t i o n , a p p l i c a n t s should have developed a specif icp lan or pro toco l .

REVIEW PROCESS: I n accord with p e r t i n e n t Federa l personnel p o l i c i e s and r egu la t ions , t h e Di rec to r , DRG, w i l l make recommendations or s e l e c t i o n s based on q u a l i f i c a t i o n s o f t h e ind iv idua l , t h e proposed s tudy p ro toco l , and t h e Div is ion ' s p r i o r i t i e s and. r e sources .

APPOINTMENTS1 P o s i t i o n s i n t h e DRG Science Scholars Program may be f i l l e d by a v a r i e t y o f s p e c i a l temporary appointments. For example, t h e Intergovernmental Personnel A c t ( I P A I mechanism permi ts c o s t sha r ing arrangements t o be nego t i a t ed between t h e p a r t i c i p a t i n g p a r t i e s and may be used f o r i n d i v i d u a l s seeking a s a b b a t i c a l assignment.

Announcements of appointment w i l l be pub l i c i zed i n r e l e v a n t p r o f e s s i o n a l and s c i e n t i f i c j o u r n a l s and, a s appropr i a t e , o t h e r media.

DRG CONTACTS:

Jerome G . Green, M . D . Direc to r Divis ion o f Research Grants Room 450, Westwood Bldg. National I n s t i t u t e s of Heal th Bethesda, Maryland 20892 Telephone: (301) 496-7211

Donald H . Luecke, M . D . Deputy Di rec to r Divis ion of Research Grants Room 448, Westwood Bldg. National I n s t i t u t e s o f Health Bethesda, Maryland 20892 Tel.ephone: (301 1 496-7461

DATED ANNOUNCEMENTS (RFPs AND RFAs 1

BIOMEDICAL WORKSHOP ON SUPERCOMPUTING TECHNIQUES

P.T. 42; K.W. 1004000

Divis ion o f Research Resources

Appl ica t ion Receipt Date: June 15, 1988

The P i t t sbu rgh Supercomputing Center (PSC) is conducting a 4 and 112 dayworkshop on supercomputing techniques f o r biomedical r e s e a r c h e r s August 8-12, 1988. It is funded by a Nat ional I n s t i t u t e s of Health ( N I H ) g r an t from t h e Divis ion o f Research Resources' Biomedical Research Technology (BRT) Program.

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The workshop is aimed a t experienced FORTRAN programmers, bu t p r i o rsupercomputing exper ience is no t necessary . The t o p i c s inc lude an i n t r o d u c t i o n t o VMS (half-day, o p t i o n a l ) , t h e Cray-VAX i n t e r f a c e , Cray jobc o n t r o l , op t imiza t ion techniques , an overview of a v a i l a b l e biomedical sof tware , and a d e s c r i p t i o n o f access pa ths t o t h e PSC.

Trave l , meals, and h o t e l accommodations are covered f o r academic p a r t i c i p a n t s 3 rd under t h e g r a n t . A l i m i t e d number of openings f o r i ndus t r i a l ly -based

biomedical r e s e a r c h e r s may be a v a i l a b l e f o r a fee o f $1,000. THE DEADLINE FOR THE SUBMISSION OF APPLICATIONS I S J U N E 15, 1988. Enrollment is l i m i t e d t o twenty p a r t i c i p a n t s .

For a p p l i c a t i o n forms and a d d i t i o n a l information, c a l l o r wri te :

Cherolyn Brooks User Se rv ices P i t t s b u r g h Supercomputing Center 4400 F i f t h Avenue P i t t sbu rgh , Pennsylvania 15213 Telephone: (412) 268-5206

(800) 222-9310 - i n s i d e Pennsylvania( 8 0 0 ) 221-1641 - o u t s i d e Pennsylvania

JNHALATION REPRODUCTIVE TOXICITY TESTING

RFP AVAILABLE8 NIH-ES-88-16

P.T. 34; K.W. 1007009, 1007002, 1007003, 0775030

Nat iona l I n s t i t u t e o f Environmental Heal th Sc iences

The purpose o f t h i s p r o j e c t is t o provide t e s t i n g o f inha led chemical agen t s .Th i s p r o j e c t c o n s i s t s o f two phases . Phase I involves t h e t e s t i n g o f chemical agen t s f o r t h e i r p o t e n t i a l t o cause t e r a t o g e n i c i t y and developmental t o x i c i t y .Phase I1 involves t h e t e s t i n g o f chemical agen t s f o r t h e i r p o t e n t i a l t o cause reproduct ive t o x i c i t y . I n o rde r t o be considered, an o f f e r o r must be capableo f performing both phases . The t y p e s o f chemicals t o be t e s t e d may inc lude ,bu t no t be l i m i t e d t o : i n d u s t r i a l s o l v e n t s , p l a s t i c i z e r s , food p r e s e r v a t i v e sand c o l o r a n t s , drugs, p e s t i c i d e s , and heavy metals. This p r o j e c t w i l l cover a f ive-year performance pe r iod . The Government estimates t h a t approximately 3.5

" *Id s ta f f y e a r s o f p r o f e s s i o n a l e f f o r t , 3 .0 s t a f f yea r s o f t e c h n i c a l e f f o r t and 0 .5 s t a f f y e a r s o f c l e r i ca l e f f o r t w i l l be r equ i r ed each c o n t r a c t y e a r . One award w i l l be made.

Th i s is an announcement o f an a n t i c i p a t e d r eques t f o r proposa ls .

RFP NIH-ES-88-16 w i l l be i s sued on o r about May 15, 1988 wi th a c l o s i n g d a t e f o r r e c e i p t o f p roposa l s o f J u l y 15, 1988.

Requests should r e f e r e n c e RFP NIH-ES-88-16 and should be forwarded t o :

Nat iona l I n s t i t u t e o f Environmental Heal th Sc iences ATTN: E l i zabe th B. Ford Cont rac t s Management Office, OAM 79 T.W. Alexander Drive, 4401 Research Commons Bui ld ing P.O. Box 12874 Research T r i a n g l e Park, North Caro l ina 27709 Telephone: (919) 541-7893

PROGRAM PROJECTS ON THE BIOLOGY OF THE IMMUNE SYSTEV

RFA AVAILABLE: 88-AI-10

P.T. 34; K.W. 0705040, 1002000, 1002004, 1002008, 0710065

Nat iona l I n s t i t u t e o f Al le rgy and I n f e c t i o u s Diseases

Let ter o f I n t e n t Receipt Date: May 27, 1988

Application Receipt Datez July 15, 1988

BACKGROUND INFORMATION

L/ The Immunobiology and Immunochemistry Branch o f t h e Immunology, A l l e r g i c and Immunologic Diseases Program o f t h e Nat iona l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases ( N I A I D ) , suppor t s fundamental s t u d i e s on t h e s t r u c t u r e and

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func t ion o f t h e immune system t o ga in an understanding of immune responsemechanisms a t t h e i r b a s i c c e l l u l a r and molecular l e v e l s as they func t ion i n h e a l t h and d i s e a s e . Program P r o j e c t s on t h e Biology o f t h e Immune System rep resen t an award mechanism which t h e Branch has employed t o meet t h i s o b j e c t i v e . They are intended t o support i n t e g r a t e d , m u l t i d i s c i p l i n a r y , b a s i c s t u d i e s of immunologically-functional lymphocyte and o t h e r r e l e v a n t ce l l popula t ions . Th i r t een such program p r o j e c t s a r e c u r r e n t l y funded al though support f o r two is scheduled t o conclude i n 1988. This r eques t f o r a p p l i c a t i o n s i s intended t o encourage t h e development of proposa ls from c o l l a b o r a t i n g i n v e s t i g a t o r s and t o coord ina te t h e submission and review of new and renewal program p r o j e c t a p p l i c a t i o n s .

RESEARCH GOALS AND SCOPE

The goa l of t h e s e Program P r o j e c t s is t h e a t ta inment of a completeunderstanding of t h e s t r u c t u r e and func t ion o f t h e immune system and i ts products , i t s i n t e r a c t i o n with o t h e r body systems, and f u l l knowledge o f t h e g e n e t i c and o t h e r f a c t o r s which r e g u l a t e i ts development and func t ion . An u l t i m a t e p r a c t i c a l a p p l i c a t i o n o f t h i s information is t h e use of s e l e c t e d cloned ce l l s o f t h e system, o r t h e i r products , f o r t h e c l i n i c a l c a r e o f r e c o n s t i t u t i o n o f immunodeficient i nd iv idua l s , t o a l l e v i a t e a l l e r g i c s ta tes , t o provide r e s i s t a n c e t o l i f e - t h r e a t e n i n g i n f e c t i o n s and t o c o r r e c t abe r ran t o r d e f e c t i v e immunoregulatory mechanisms.

The scope o f t h e s e program p r o j e c t s i nc ludes s t u d i e s of every facet o f t h e immune response, ranging from t h e i n i t i a l s t e p o f an t igen r ecogn i t ion t o t h e f i n a l e l a b o r a t i o n o f immunologically d i s t i n c t i v e products o f s p e c i f i cimmunocytes. Research c u r r e n t l y supported by t h i s mechanism was designed t o expand knowledge o f t h e morphologic and f u n c t i o n a l he te rogenei ty o f lymphocytepopula t ions and develop t h e c a p a b i l i t y f o r i d e n t i f i c a t i o n and s e l e c t i o n of lymphocyte subpopulat ions, with s p e c i f i c immune r e a c t i v i t y o r molecular composition, f o r use i n somatic h y b r i d i z a t i o n o f such popula t ions and s e l e c t i v e product ion o f s p e c i f i c , b i o l o g i c a l l y a c t i v e , lymphocyte products .S imi l a r s t u d i e s of macrophages, o t h e r accessory and e f f e c t o r c e l l s , and networks o f ce l l s and molecules t h a t a f f e c t t h e a c t i v a t i o n , d i f f e r e n t i a t i o n and r e g u l a t i o n of c e l l s o f t h e immune system are appropr i a t e . P r o j e c t s t h a t involve improving t h e e f f i c i e n c y o r s c a l e o f prepar ing and s e l e c t i n ghybridomas and o t h e r r e l e v a n t c e l l l i n e s f o r def ined purposes, and p r o j e c t sdesigned t o modify genes encoding immunologically r e l evan t macromolecules t o improve t h e i r b i o l o g i c a l e f f i c i e n c y , o r d i a g n o s t i c and t h e r a p e u t i c u t i l i t y , are encouraged.

MECHANISM OF SUPPORT

Program p r o j e c t g r a n t s a r e awarded t o an i n s t i t u t i o n on behal f o f a programd i r e c t o r f o r t h e support o f a broadly based, m u l t i d i s c i p l i n a r y , long-termresea rch program which has a s p e c i f i c major o b j e c t i v e o r b a s i c theme. A program p r o j e c t g e n e r a l l y involves t h e organized e f f o r t s of groups o f i n v e s t i g a t o r s who conduct r e sea rch p r o j e c t s r e l a t e d t o t h e o v e r a l l programo b j e c t i v e . The g r a n t can provide support f o r t h e p r o j e c t s and f o r c e r t a i n c o r e r e sources shared by ind iv idua l s where t h e sha r ing f a c i l i t a t e s t h e t o t a l r e sea rch e f f o r t . Each component p r o j e c t , supported under a program p r o j e c t g r a n t , is expected t o c o n t r i b u t e and be d i r e c t l y r e l a t e d t o a common theme. The p r o j e c t s should demonstrate an e s s e n t i a l element of u n i t y and interdependence. A t least two awards are planned f o r 1988.

METHOD OF APPLYING

Before prepar ing an a p p l i c a t i o n , t h e p rospec t ive app l i can t should r eques t a copy of t h e Information Brochure: Program P r o j e c t s and Center Grants, N I A I D , from:

D r . N i r m a l Das Executive Sec re t a ry Allergy, Immunology and Transplan ta t ion

Research Committee Nat ional I n s t i t u t e o f Al le rgy

and I n f e c t i o u s Diseases Nat ional I n s t i t u t e s of Heal th Westwood Building, Room 706 Bethesda, Maryland 20892 Telephone: (301) 497-7966

STAFF CONTACT

sw.

For f u r t h e r programmatic information and a copy of t h e d e t a i l e d RFA, con tac t :

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Joseph F . Albr ight , Ph.D. Chief , Immunobiology and Immunochemistry Branch, IAIDP National I n s t i t u t e o f Al le rgy and I n f e c t i o u s Diseases Westwood Building, Room 757 National I n s t i t u t e s o f Health Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-7551

Prospec t ive a p p l i c a n t s a r e encouraged t o submit a one-page l e t t e r of i n t e n t t h a t inc ludes a d e s c r i p t i v e t i t l e of t h e proposed r e sea rch and i d e n t i f i c a t i o n of any o t h e r p a r t i c i p a t i n g i n s t i t u t i o n s . The I n s t i t u t e r eques t s such l e t t e r s by May 27 , 1988, f o r t h e purpose o f providing an i n d i c a t i o n o f t h e number and scope o f a p p l i c a t i o n s t o be rece ived . A l e t t e r o f i n t e n t is no t b inding . It w i l l no t e n t e r i n t o t h e review of any a p p l i c a t i o n subsequent ly submit ted and is no t a necessary requirement f o r a p p l i c a t i o n .

Letters o f i n t e n t should be d i r e c t e d t o D r . Albr ight a t t h e address shown.

DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES

RFA AVAILABLE: 88-RR-03

P.T. 34; K.W. 1002002

Div is ion o f Research Resources

Appl ica t ion Receipt Dates: August 8 , 1988 and December 1 , 1988

BACKGROUND

A s p a r t o f i ts mission t o create, develop, and maintain animal resources needed by NIH-supported biomedical i n v e s t i g a t o r s throughout t h e Nation, t h e Div is ion of Research Resources (DRR) is cont inuing i ts competi t ive g ran t program t o he lp i n s t i t u t i o n s upgrade and develop t h e i r animal f a c i l i t i e s . DRR a n t i c i p a t e s t h a t $11.958 mil l ion may be a v a i l a b l e t o support such improvement g r a n t s i n F i s c a l Year 1989.

RESEARCH GOALS AND SCOPE

I n s t i t u t i o n a l animal resource improvement p r o j e c t s are awarded t o assist '1-d biomedical r e sea rch and educa t iona l i n s t i t u t i o n s i n t h e upgrading of t h e i r

animal f a c i l i t i e s and i n t h e development of c e n t r a l i z e d animal c a r e programs.A major o b j e c t i v e is t o enable i n s t i t u t i o n s t o comply with t h e USDA Animal Welfare A c t and DHHS p o l i c i e s on t h e care and t rea tment of animals . These awards are l i m i t e d t o a l t e r a t i o n s and renovat ions (A&R) t o improve l a b o r a t o r yanimal f a c i l i t i e s and r e l a t e d major resource equipment such as animal cagesand cage washers. It is not t h e purpose o f t h e improvement g ran t t o providegene ra l ope ra t ing c o s t s f o r t h e resource; e . g . , funding f o r personnel ,consumable s u p p l i e s for r o u t i n e animal care, e t c . The p r o j e c t s are supportedf o r one year , a f te r which t h e app l i can t i n s t i t u t i o n is expected t o assume complete f i n a n c i a l r e s p o n s i b i l i t y f o r i t s b a s i c animal resource .

To ga in approval and suppor t , both t h e need f o r resource improvement and a sound p lan t o m e e t t h e requirements of t h e Publ ic Heal th Serv ice Po l i cy on Humane Care and U s e o f Laboratory Animals must be presented and descr ibed i n t h e contex t o f t h e biomedical r e sea rch and r e sea rch t r a i n i n g program o f t h e i n s t i t u t i o n .

ELIGIBILITY AND REVIEW

Any domestic pub l i c , o r p r i v a t e i n s t i t u t i o n , o rgan iza t ion o r a s s o c i a t i o n with one o r more r e sea rch p r o j e c t s supported by t h e Publ ic Heal th Se rv ice and involv ing t h e use o f animals is e l i g i b l e t o apply. Appl icants are expected t o develop a s i n g l e proposal f o r campus-wide s e r v i c e .

Appl ica t ions w i l l be rece ived by t h e Div is ion of Research Grants . Applicants must use PHS Form 398 (Rev. 9 / 8 6 ) , "Applicat ion f o r Publ ic Heal th Se rv ice Grant." The fol lowing r e c e i p t d a t e s have been e s t a b l i s h e d : August 8 , 1988 and December 1 , 1988. Appl ica t ions rece ived a f te r t h e s e d a t e s w i l l be r e tu rned without f u r t h e r process ing . The RFA l a b e l a v a i l a b l e i n t h e PHS Appl ica t ion Form 398 ( r ev i sed 9 / 8 6 ) must be a f f i x e d t o t h e bottom o f t h e face page. F a i l u r e t o use t h i s l a b e l could r e s u l t i n delayed process ing of t h e a p p l i c a t i o n such t h a t it may not reach t h e review committee i n t i m e f o r review. A l l a p p l i c a t i o n s submitted i n response t o t h i s RFA w i l l be reviewed

\/ by t h e DRR Animal Resources Review Committee (ARRC) f o r s c i e n t i f i c merit and t h e Nat ional Advisory Research Resources Council (NARRC) f o r programcons ide ra t ions . Appl ica t ions meeting t h e August 8 , 1988, deadl ine w i l l

5

r ece ive i n i t i a l review by t h e ARRC i n November 1988, and f i n a l review by t h e NARRC i n February 1989. Appl ica t ions meeting t h e December 1 dead l ine w i l l r ece ive i n i t i a l review by t h e ARRC i n March 1989, and f i n a l review by t h e NARRC i n June 1989. A l l a p p l i c a t i o n s w i l l be i n cons ide ra t ion through t h e June 1989 Council .

MECHANISM OF SUPPORT

Awards w i l l be made as compet i t ive resource g r a n t s f o r a p r o j e c t per iod o f one yea r . It is expected t h a t from 30 t o 40 awards w i l l be made i n F i s c a l Year 1989. The number o f g r a n t s and t h e s p e c i f i c amount of awards w i l l depend on t h e m e r i t and scope o f t h e a p p l i c a t i o n s rece ived as wel l as t h e a v a i l a b i l i t y of funds. A l l p o l i c i e s and requirements which govern t h e g ran t programs o f t h e PHS apply .

TERMS OF AWARD

A l t e r a t i o n s and renovat ions (Am) are l i m i t e d t o a maximum award of $500,000from t h i s g r a n t program. Equal matching funds from non-Federal sources are r equ i r ed f o r a l l A&R. I n a d d i t i o n t o t h e A&R r eques t of up t o $500,000,i n s t i t u t i o n s may r eques t major equipment i tems for t h e i r animal resource on a nonmatching b a s i s . Support f o r new cons t ruc t ion is not au thor ized . Funds awarded f o r A&R may not be ob l iga t ed u n t i l f i n a l a r c h i t e c t u r a l drawings, s p e c i f i c a t i o n s , and updated c o s t estimates are rece ived and approved by t h e Divis ion o f Research Resources.

INQUIRIES

A copy of t h e complete RFA, which d e s c r i b e s t h e r e sea rch goa l s and scope, terms and cond i t ions , review procedures and c r i t e r i a , and method o f applying, may be obtained by con tac t ing t h e Animal Resources Program, DRR:

Leo A . Whitehair , D .V.M. , Ph.D. Direc to r Labora tory Animal Sc iences ProgramAnimal Resources Program Branch Divis ion o f Research Resources National I n s t i t u t e s of Heal th Building 31, Room 5B59 Bethesda, Maryland 20892 Teleghonei (301) 496-5175

This program i s descr ibed i n t h e Catalog o f Federal Domestic Ass is tance No. 13.306, Laboratory Animal (Sciences P r i m a t e Research. Awards w i l l be made under t h e a u t h o r i t y o f t h e Publ ic Heal th Se rv ice A c t , T i t l e 111, Sec t ion 301 (Pub l i c Law 78-410, as amended; 42 USC 241) and adminis tered under PHS g ran t p o l i c i e s and Federa l Regulat ions 42 CFR P a r t and 45 CFR P a r t 74. This programi s not sub jec t t o t h e intergovernmental review requirements o f Executive Order 12372 or Health Systems Agency review.

WCOLOGY RESEARCH UNITS

RFA AVAILABLE: 88-AI-11

P . T . 34; K.W. 1002029, 07115125, 0710030 National I n s t i t u t e o f Al le rgy and I n f e c t i o u s Diseases

Letter of I n t e n t Receipt Date: August 15, 1988 Appl ica t ion Receipt Date : October 14, 7 988

BACKGROUND INFORMATION

The Nat ional I n s t i t u t e o f Al le rgy and I n f e c t i o u s Diseases ( N I A I D ) i n v i t e s a p p l i c a t i o n s f o r program p r o j e c t g r a n t s t o be i n i t i a t e d during N 1989 f o r p a r t i c i p a t i o n i n an ongoing program of r e sea rch i n Mycology. The f u n g i of medical importance inc lude , but are not l i m i t e d t o , Coccidioides i m m i t i s ,Histoplasma capsulatum, Blastomyces de rma t i t i des , Cryptococcus neoformans,Candida a lb i cans , and Aspeirgil lus fumigatus. An a c t i v e r e sea rch program i n mycology and r e l a t e d a r e a s is of c r u c i a l importance t o he lp r e so lve t h e s e r i o u s p u b l i c h e a l t h problem of fungal d i s e a s e .

RESEARCH GOALS AND SCOPE

A. The N I A I D proposes t o maintain i t s program i n i t i a t i v e i n mycologyand fungal d i s e a s e r e sea rch . The goa l o f t h i s program is t o inc rease t h e knowledge o f t h e biology o f t h e causa l microorganisms

6

caw

-a

and o f hos t -pa ras i t e i n t e r a c t i o n s . This fundamental knowledge w i l l t hen be app l i ed t o development and improvement o f means o f d iagnos is , p revent ion , and therapy of t h e s e i n f e c t i o n s .

B. The N I A I D wishes t o develop m u l t i d i s c i p l i n a r y mycology r e sea rch u n i t s t o s e rve as f o c i f o r r e sea rch i n fungal d i s e a s e s . These u n i t s w i l l be funded as program p r o j e c t g r a n t s . S t u d i e s o f i n t e r e s t inc lude , but are not l i m i t e d t o t h e fol lowing areas of mycology r e sea rch : v i ru l ence , epidemiology, immunology,pathogenesis , d iagnos is , and chemotherapy. It is d e s i r a b l e t h a t a s t rong c l i n i c a l component be made a p a r t of any program p r o j e c ta p p l i c a t i o n .

MECHANISM OF SUPPORT

Appl ica t ions considered appropr i a t e responses t o t h i s announcement are those f o r r e sea rch program p r o j e c t s (Pol). The N I A I D p l ans t o support a t least two awards cont ingent on t h e o v e r a l l merit o f t h e proposed r e sea rch and t h e a v a i l a b i l i t y o f funds. N I A I D is p r e s e n t l y funding two Mycology Research Units , whose support t e rmina te s on August 31, 1989. Support o f new MycologyResearch Uni t s o r con t inua t ion o f e x i s t i n g u n i t s w i l l be on a compet i t iveb a s i s . It i s es t imated t h a t t h e d i r e c t c o s t s f o r each o f t h e r e sea rch u n i t s w i l l be approximately $450,000 per yea r . Up t o f i v e yea r s o f support is a n t i c i p a t e d .

The i n i t i a l review f o r s c i e n t i f i c and t e c h n i c a l merit w i l l be made by a review group t o be convened by t h e Program Pro jec t Review Branch, N I A I D ; secondaryreview w i l l be made by t h e Nat ional Advisory Allergy and I n f e c t i o u s Diseases Council . Funding d e c i s i o n s w i l l be based upon r e l a t i v e s c i e n t i f i c merit, program re levance , and a v a i l a b i l i t y o f appropr ia ted funds. The r e c e i p t d a t e f o r a p p l i c a t i o n s w i l l be October 14, 1988. Formal a p p l i c a t i o n s t h a t a r e not rece ived by October 14, 1988 or are considered t o be non-responsive t o t h e RFA w i l l be r e tu rned t o t h e i n v e s t i g a t o r . The ear l ies t p o s s i b l e s t a r t d a t e w i l l be J u l y 1, 1989.

STAFF CONTACT

For f u r t h e r information and f o r a d e t a i l e d copy of t h i s RFA, i n v e s t i g a t o r s are encouraged t o c o n t a c t :

Darrel D . Gwinn, Ph.D. 9b. l Mycology Program Officer

Bacter iology and Virology Branch Nat ional I n s t i t u t e s o f Heal th Westwood Building, Room 738 Bethesda, Maryland 20892 Telephone: (301) 496-7728

ASTHMA AND ALLERGIC DISEASE CENTERS

RFA AVAILABLE% 88-AI-09

P.T. 0 4 ; K.W. 0715110, 0705040, 0710030 National I n s t i t u t e o f Al le rgy and I n f e c t i o u s Diseases

Appl ica t ion Receipt Dater October 14, 1988

BACKGROUND INFORMATION

The Asthma and Al le rgy Branch of t h e Immunology, A l l e r g i c and ImmunologicDiseases Program o f t h e Nat iona l I n s t i t u t e of Allergy and I n f e c t i o u s Diseases ( N I A I D ) sponsors fundamental and c l i n i c a l r e sea rch concerned with asthma,a l l e r g i c and immunologic d i s e a s e s and with r e l evan t mechanisms o f h y p e r s e n s i t i v i t y and inflammation. For t h i s purpose, twelve Asthma and A l l e r g i c Disease Centers (AADC) a r e c u r r e n t l y funded; support f o r one i s scheduled t o conclude i n 1989. This reques t f o r a p p l i c a t i o n s (RFA) is intended t o encourage submissions from c l i n i c a l i n v e s t i g a t i v e groups meetingt h e c r i t e r i a and requirements f o r an AADC and t o coord ina te review o f new and renewal a p p l i c a t i o n s t h u s provid ing e q u i t a b l e oppor tuni ty f o r both t o competef o r funds c u r r e n t l y available f o r t h i s programmatic a c t i v i t y . RESEARCH GOALS AND SCOPE

' IrJ The fundamental o b j e c t i v e of t h e N I A I D ' s AADC program is t o f o s t e r a c c e l e r a t i o n o f t h e a p p l i c a t i o n of knowledge on t h e immune system emergingfrom r e l e v a n t biomedical s c i ences t o c l i n i c a l h y p e r s e n s i t i v i t y d i s o r d e r s .

7

Espec ia l ly sought as t h e r e q u i s i t e f a c t o r s wi th in a p a r t i c i p a t i n g i n s t i t u t i o n are q u a l i t y r e sea rch i n : ( a ) b a s i c s c i ence ( s1 , ( b ) c l i n i c a l i n v e s t i g a t i o nsupported by adequate c l i n i c a l f a c i l i t i e s and s t a f f e x p e r t i s e i n d i agnos i s and management o f as thmat ic and a l l e r g i c p a t i e n t s , and ( c ) access t o (an)appropr i a t e p a t i e n t popula t ion(s1 wi th in a s u i t a b l e academic / inves t iga t iveenvironment designed t o favor m u l t i d i s c i p l i n a r y i n t e r a c t i o n .

The scope of t h e AADC program r e p r e s e n t s an e f f o r t t o f o s t e r c o l l a b o r a t i v e approaches t h a t w i l l i n t e g r a t e b a s i c concepts i n a l l e r g y , immunology,pathophysiology, gene t i c s , microbiology, biochemistry, b i o s t a t i s t i c s ,b io ins t rumenta t ion , computer science and pharmacology i n t o c l i n i c a l i n v e s t i g a t i o n s , which, i n a d d i t i o n t o t h e f i e l d s of a l l e r g y and c l i n i c a l immunology, may inc lude such areas as dermatology, rheumatology, i n f e c t i o u s d i seases , pulmonary medicine, hematology, and otorhinolaryngology, when a highdegree of re levance t o immunology e x i s t s . Because t h e r o l e o f h y p e r s e n s i t i v i t y and immune-related inflammatory mechanisms has become inc reas ing ly ev iden t i n d i s o r d e r s of t h e sk in , immunodermatologic s t u d i e s are e s p e c i a l l y encouraged wi th in an AADC. Because o f t h e alarming inc rease i n asthma m o r t a l i t y s i n c e 1979, s t u d i e s are a l s o sought t o examine t h i s t r e n d .

Program o b j e c t i v e s are: t o encourage c o l l a b o r a t i o n between b a s i c and c l i n i c a l s c i e n t i s t s ; t o provide a r e sea rch environment favorable f o r such i n t e r a c t i o n ;and t o implement c l i n i c a l a p p l i c a t i o n of adequately t e s t e d r e sea rch f i n d i n g sand prorcedures.

I n a d d i t i o n , a f e a t u r e o f t h e AADC program is t h e oppor tuni ty f o r d i r e c t o r s t o implement educa t iona l o r community a c t i v i t i e s . Within t h e r e sea rch framework of t h e cen te r , a v a r i e t y of out reach and demonstrat ion p r o j e c t s may be supported.

MECHANISMS OF SUPPORT

AADC g r a n t s are awarded t o an i n s t i t u t i o n on behal f o f a program d i r e c t o r f o r t h e suppor t o f a broadly based, m u l t i d i s c i p l i n a r y , long-term re sea rch programwhich may have a s p e c i f i c o b j e c t i v e or basic theme, o r may involve t h e i n t e g r a t i o n of s e v e r a l themes. An AADC gene ra l ly involves t h e e f f o r t s of groups o f i n v e s t i g a t o r s who conduct r e sea rch r e l a t e d t o t h e o v e r a l l programo b j e c t i v e . The g ran t can provide support f o r t h e p r o j e c t s and f o r c e r t a i n co re r e sources shared by i n d i v i d u a l s where t h e sha r ing f a c i l i t a t e s t h e t o t a l r e sea rch e f f o r t . Each component p r o j e c t supported under an AADC g ran t is expected t o c o n t r i b u t e t o , and be d i r e c t l y r e l a t e d t o , a common theme; t h e component p r o j e c t s should demonstrate an e s s e n t i a l element of u n i t y and interdependence. I n fiscal. year 1989, t h e N I A I D p l a n s t o fund a t l eas t one new or competing renewal Asthma and A l l e r g i c Disease Center a p p l i c a t i o n ,depending on t h e a v a i l a b i l i t y of funds.

METHOD OF APPLYING

Before prepar ing an a p p l i c a t i o n , t h e p rospec t ive a p p l i c a n t should r eques t a copy o f t h e N I A I D Information Brochure on Program P r o j e c t s from:

D r . N i r m a l Das Executive Sec re t a ry Allergy , Immunology and Transp lan ta t ion

R e search Committee Nat iona l I n s t i t u t e of Allergy and

I n f e c t i o u s Diseases Nat ional I n s t i t u t e s o f Heal th Westwood Building, Room 707 Bethesda, Maryland 20892 Telephone: (301) 496-7966

STAFF CONTACT

A more d e t a i l e d RFA may be obta ined from:

Dorothy D . Sogn, M.D. Chief , Asthma and Al le rgy Branch Immunology, A l l e r g i c and Immunologic

Diseases ProgramNational I n s t i t u t e of Al le rgy

and I n f e c t i o u s Diseases Westwood Building, Room 752 Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-8973

Prospec t ive a p p l i c a n t s are encouraged t o submit a one-page l e t t e r o f i n t e n t t h a t inc ludes a d e s c r i p t i v e t i t l e o f t h e proposed r e sea rch and i d e n t i f i c a t i o n

8

*cJ

of any o t h e r p a r t i c i p a t i n g i n s t i t u t i o n s . The N I A I D r e q u e s t s such l e t t e r s byJune 15, 1988, f o r t h e purpose of providing an i n d i c a t i o n o f t h e number and scope of a p p l i c a t i o n s t o be rece ived . A l e t t e r of i n t e n t is n o t b inding . It w i l l no t e n t e r i n t o t h e review of any a p p l i c a t i o n subsequent ly submitted and is not a necessary requirement f o r a p p l i c a t i o n . Letters o f i n t e n t and i n q u i r i e s should be d i r e c t e d t o D r . Sogn a t t h e above address .

THE RFA LABEL AVAILABLE I N THE 9/86 REVISION OF APPLICATION FORM 398 MUST BE AFFIXED TO THE BOTTOM OF THE FACE PAGE. FAILURE TO USE THIS LABEL COULD RESULT I N DELAYED PROCESSING OF YOUR APPLICATION SUCH THAT IT MAY NOT REACH THE REVIEW COMMITTEE I N TIME FOR REVIEW.

DIABETES CENTERS

RFA AVAILABLE: 88-DK-13

P.T. 0 4 ; K.W. 0715075, 0785035, 0785055, 0403004, 0404000

Nat ional I n s t i t u t e o f Diabetes and Diges t ive and Kidney Diseases

Appl ica t ion Receipt Date: November 16, 1988

The Nat ional I n s t i t u t e o f Diabetes and Diges t ive and Kidney Diseases ( N I D D K )i n v i t e s a p p l i c a t i o n s f o r a Center g ran t t o be awarded i n F i s c a l Year 1989. N I D D K a n t i c i p a t e s t h e compet i t ive award o f one Diabetes Research and Tra in ingCenter (DRTC) i n F i s c a l Year 1990.

BACKGROUND

A t t h e p re sen t t i m e , t h e N I D D K suppor ts s i x DRTCs. These c e n t e r s are p a r t o f an i n t e g r a t e d program o f d i abe te s - r e l a t ed r e sea rch support wi th in t h e N I D D K . Centers have provided a focus f o r i nc reas ing t h e e f f i c i e n c y and c o l l a b o r a t i v e e f f o r t among groups of success fu l i n v e s t i g a t o r s a t i n s t i t u t i o n s wi th e s t a b l i s h e d comprehensive d i a b e t e s r e sea rch bases .

OBJECTIVES AND SCOPE

The o b j e c t i v e o f t h e DRTCs is t o b r ing toge the r i n v e s t i g a t o r s from re l evan t d i s c i p l i n e s i n a manner which w i l l enhance and extend t h e e f f e c t i v e n e s s o f r e sea rch and t r a i n i n g being conducted i n t h e f i e l d of d i a b e t e s and its complicat ions. A Diabetes Center must be an i d e n t i f i a b l e u n i t wi th in a s i n g l eu n i v e r s i t y medical c e n t e r or a consortium o f cooperat ing i n s t i t u t i o n s ,inc luding an a f f i l i a t e d u n i v e r s i t y . The o v e r a l l goal o f t h e DRTC is t o b r ingt o g e t h e r on a coopera t ive b a s i s , c l i n i c a l and b a s i c s c i ence i n v e s t i g a t o r s and t h o s e involved i n d i a b e t e s t r a i n i n g and information t r a n s f e r i n a manner which w i l l en r i ch t h e e f f e c t i v e n e s s of d i a b e t e s research , t r a i n i n g , and information t r a n s f e r . When f u l l y developed, t h e DRTCs are expected t o encompass t h e fol lowing: 1 ) f a c i l i t a t i n g and s t rengthening b a s i c and c l i n i c a l r e sea rch r e l a t e d t o d i a b e t e s and i t s complicat ions; 2 ) t r a i n i n g pos tdoc to ra l f e l lows t o conduct d i a b e t e s - r e l a t e d research; 3) t r a i n i n g h e a l t h p r o f e s s i o n a l s about d iabe tes and i ts management; 4) developing a model demonstration f a c i l i t y t o c o n t r i b u t e t o t h e above endeavors; and, 5 ) t r a n s f e r r i n g advances i n t h e f i e l d o f d i a b e t e s i n t o improved care f o r people with d i a b e t e s . A l l o f t h e s e areas need not be developed t o t h e same degree. However, a s t r o n g base o f biomedical r e sea rch is t h e most important func t ion of a c e n t e r . Accordingly, a program of exce l l ence i n biomedical r e sea rch i n t h e area o f d i a b e t e s and r e l a t e d metabol ic and endocrine d i s o r d e r s i n t h e form o f NIH-funded r e sea rch p r o j e c t s , program p r o j e c t s , or o t h e r peer-reviewed r e sea rch must be i n ex i s t ence a t t h e t i m e of submission of a Center a p p l i c a t i o n . Close cooperat ion, communication, and c o l l a b o r a t i o n among a l l involved personnel o f a l l p r o f e s s i o n a l d i s c i p l i n e s are u l t i m a t e o b j e c t i v e s . Appl icants should r eques t a copy o f t h e DRTC gu ide l ines and consu l t wi th N I D D K s t a f f concerningp lans f o r t h e development o f t h e Center .

The DRTCs a r e based on t h e core concept . Cores are def ined as shared resources t h a t enhance p r o d u c t i v i t y or i n o t h e r ways b e n e f i t a group of i n v e s t i g a t o r s working i n d i a b e t e s or d iabe te s - r e l a t ed areas t o accomplish t h e s t a t e d goa l s of t h e Center . Two o t h e r t ypes o f a c t i v i t i e s may a l s o be supported with c e n t e r funding - a p i l o t and f e a s i b i l i t y program and an enrichment program. The p i l o t and f e a s i b i l i t y program provides modest supportfor new i n i t i a t i v e s or f e a s i b i l i t y r e sea rch s t u d i e s for new i n v e s t i g a t o r s or f o r e s t a b l i s h e d i n v e s t i g a t o r s i n o the r r e sea rch d i s c i p l i n e s where t h e i r e x p e r t i s e may be app l i ed t o d i a b e t e s r e sea rch . These inc lude biomedical,epidemiologic, behaviora l , and h e a l t h care r e sea rch as it p e r t a i n s t o t h e Center ' s mandate f o r t h e t r a i n i n g o f p r imar i ly h e a l t h care p r o f e s s i o n a l s . The Center g ran t may a l s o inc lude l i m i t e d funds f o r program enrichment such as seminars, v i s i t i n g s c i e n t i s t s , consu l t an t s , workshops, e tc .

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MECHANISM OF SUPPORT

N I D D K expec t s t o award one DRTC Grant i n F i s c a l Year 1990 on a compet i t ive b a s i s . The r e c e i p t o f one compet i t ive con t inua t ion a p p l i c a t i o n is a n t i c i p a t e d , and it w i l l be i n competi t ion f o r t h e award t o g e t h e r wi th o t h e r a p p l i c a t i o n s rece ived i n response t o t h i s announcement. Foreign i n s t i t u t i o n s are no t e l i g i b l e t o apply . The a n t i c i p a t e d award w i l l be f o r f i v e yea r s and is cont ingent upon t h e a v a i l a b i l i t y of appropr ia ted funds. The Guidel ines f o r t h e DRTC and c o n s u l t a t i o n may be obtained from:

D r . Sanford Gar f i e ld Diabetes Centers Program Di rec to r Diabetes , Endocrinology, and Metabolic

Diseases Div is ion Nat iona l I n s t i t u t e o f Diabe tes and

Diges t ive and Kidney Diseases Westwood Building, Room 626 Bethesda, Maryland 20892 Telephone: (301) 496-7418

REVIEW PROCEDURES

Appl ica t ions f o r a DRTC g ran t w i l l be eva lua ted i n n a t i o n a l compet i t ion by t h e N I H g ran t peer review process . Appl ica t ions w i l l be reviewed i n i t i a l l y by a s p e c i a l review committee convened by t h e N I D D K and subsequent ly by t h e Nat ional Diabetes and Diges t ive and Kidney Diseases Advisory Counci l .

METHOD OF APPLYING

P o t e n t i a l a p p l i c a n t s are urged t o submit a l e t t e r o f i n t e n t regard ing t h e i r a p p l i c a t i o n . The l e t t e r of i n t e n t i s nonbinding and is not a precondi t ion f o r an award. The l e t t e r o f i n t e n t should inc lude t h e name(s1 o f t h e p r i n c i p a l i n v e s t i g a t o r and p r i n c i p a l c o l l a b o r a t o r s , d e s c r i p t i v e t i t l e s o f t h e co re f a c i l i t i e s and p i l o t / f e a s i b i l i t y p r o j e c t s , and t h e o r g a n i z a t i o n ( s ) involved.

The dead l ine f o r r e c e i p t of a p p l i c a t i o n by t h e N I H , Div is ion o f Research Grants ( D R G ) , is November 16, 1988. Send t h e o r i g i n a l and fou r cop ie s to:

Appl ica t ion Receipt Office Divis ion o f Research Grants Nat iona l I n s t i t u t e s of Heal th Westwood Building, Room 240 Bethesda, Maryland , 20892M

Two a d d i t i o n a l cop ie s of t h e a p p l i c a t i o n are t o be s e n t t o :

D r . Anthonv Demsev Review Brahch National I n s t i t u t e o f Diabe tes and Diges t ive and Kidney Diseases, N I H Westwood Building, Room 406 Bethesda, Maryland 20892

Appl ica t ions must be submit ted us ing Form 398 (Rev. 9/86). The RFA l a b e l contained i n t h e a p p l i c a t i o n k i t must be a f f i x e d t o t h e bottom of t h e face page o f t h e o r i g i n a l copy of t h e a p p l i c a t i o n . F a i l u r e t o use t h i s l a b e l could r e s u l t i n delayed process ing and review o f your a p p l i c a t i o n .

The s p e c i a l s i n g l e r e c e i p t d a t e f o r submissions i n response t o t h i s announcement is November 16, 1988. Any a p p l i c a t i o n s no t rece ived by t h i s d a t e w i l l be cons idered i n e l i g i b l e .

-O N G O I N G PROGRAM ANNOUNCEMENTS

F H UE GFOF ALCOHOL AND 0THER DRUG USE;

P.T. 34; K.W. 0404003, 0404009

Nat iona l I n s t i t u t e on Alcohol Abuse and Alcoholism National I n s t i t u t e on Drug Abuse

Appl ica t ion Receipt Date: February 1, June 1, October 1

SUMMARY AND PURPOSE

The Nat iona l I n s t i t u t e on AJcohol Abuse and Alcoholism ( N I A A A ) and t h e Nat ional I n s t i t u t e on Drug Abuse ( N I D A I make g ran t awards f o r b a s i c and

10

1.

“11

app l i ed r e sea rch p r o j e c t s . This announcement s p e c i f i c a l l y seeks g ran ta p p l i c a t i o n s suppor t ing r e sea rch aimed a t understanding t h e f a c t o r s t h a t c o n t r i b u t e t o t h e progress ion from i n i t i a l drug and a lcohol use t o drug and a lcohol dependence. This announcement is intended t o encourage r e sea rch proposa ls which w i l l i d e n t i f y drug sequencing p a t t e r n s among d i f f e r i n gsubpopulat ions o f adolescents and t o i d e n t i f y t h e b i o l o g i c a l , psychological ,and s o c i a l markers of t h e t iming of progress ion from one c lass of subs tances t o another . B io log ica l f a c t o r s which adverse ly a f f e c t endocrine func t ion maya l t e r adolescent phys ica l and psychosexual development and may p lay a r o l e i n sequencing. Endogenous neu ro t r ansmi t t e r and neuropept ide systems are known t o affect mood, motivat ion and a p p e t i t e . These f a c t o r s may profoundly inf luence drug involvement and t h e s tudy of t h e i r impact is encouraged. Other a r e a s of r e sea rch i n t e r e s t inc lude v a r i a t i o n s by gender, economic and s o c i a l class,geographic reg ion , u rban iza t ion , e t h n i c groups and b i r t h cohor t s . N I A A A and N I D A urge g ran t a p p l i c a t i o n s t o g ive added a t t e n t i o n t o t h e inc lus ion o f women and m i n o r i t i e s i n s tudy popula t ions . If m i n o r i t i e s and women are not included i n a given s tudy , a clear r a t i o n a l e f o r t h e i r exc lus ion should be provided.

ELIGIBILITY

Research g ran t a p p l i c a t i o n s may be submit ted by p u b l i c o r p r i v a t e nonpro f i t o r f o r p r o f i t o rgan iza t ions such as u n i v e r s i t i e s , c o l l e g e s , h o s p i t a l s ,l a b o r a t o r i e s , r e sea rch i n s t i t u t e s and o rgan iza t ions , u n i t s o f S t a t e o r l o c a l governments and e l i g i b l e agencies o f t h e Federal Government. Women and minori ty i n v e s t i g a t o r s are encouraged t o apply.

HOW TO APPLY

. o The d a t e o f r e c e i p t o f a l l a p p l i c a t i o n s w i l l be February 1 , June 1 ,and October 1 of each yea r . They w i l l be reviewed i n accordance wi th t h e r e g u l a r PHS re sea rch g ran t a p p l i c a t i o n review schedule .

o Appl ica t ion f o r t h i s award should be made on Form PHS 398 ( r e v i s e d9 /86 ) . When applying, type t h e name o f t h i s announcement 'Sequencing o f Alcohol and Other Drug Use' on page 1 Item 2 of PHS 398. S t a t e and Local Agencies should use Form PHS 5161-1. Appl ica t ion k i t s conta in ing t h e necessary forms and i n s t r u c t i o n s (PHS 398) may be obta ined from i n s t i t u t i o n a l bus iness o f f i c e s o r o f f i c e s of sponsored r e sea rch a t most u n i v e r s i t i e s , c o l l e g e s ,medical schools , and o t h e r major r e sea rch f a c i l i t i e s . Appl ica t ionforms may a l s o be obta ined from t h e Nat ional Clearinghouse f o r Alcohol and Drug Information, Reference Department, P.O. Box 2345,Rockvil le , Maryland 20852, ( te lephone: (301) 468-2600). The s igned o r i g i n a l and s i x permanent l e g i b l e copies ( o r i g i n a l and two copies i f us ing Form PHS 5161-1) of t h e completed a p p l i c a t i o n and any appendices should be submit ted t o :

Div is ion of Research Grants, N I H Westwood Bldg. , Room 240 Bethesda, Maryland 20892XX

INQUIRIES

P o t e n t i a l a p p l i c a n t s are encouraged t o seek p r e a p p l i c a t i o n c o n s u l t a t i o n . Please con tac t e i t h e r o f t h e two i n d i v i d u a l s l i s t e d below:

Thomas C . Harford, Ph.D. Direc to r , Div is ion of Biometry and EpidemiologyNational I n s t i t u t e on Alcohol Abuse and Alcoholism 5600 Fishe r s Lane, Room 14C-26,Rockvil le , Maryland 20857 Telephone: (301) 443-3306

Roy W . Pickens, Ph.D. Direc to r , Div is ion of C l i n i c a l Research National I n s t i t u t e on Drug Abuse 5600 Fishe r s Lane, Room 10A-38,Rockvil le , Maryland 20857 Telephone: (301) 443-6697

11 u. s. COUERN~KNT P R I N T I N G OFFICE: 1988-201-770 : 5 9 3 4 0