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NIH CTSA Awards: NIH CTSA Awards: A Home for Clinical & Translational A Home for Clinical & Translational
ScienceScience
Trial Trial DesignDesign
Advanced Advanced Degree-Granting Degree-Granting
ProgramsPrograms
Participant Participant & Community & Community InvolvementInvolvement
Regulatory Regulatory SupportSupport
BiostatisticsBiostatistics
Clinical Clinical ResourcesResources
Biomedical Biomedical InformaticsInformatics
Clinical Research Clinical Research EthicsEthics
CTSACTSAHOMEHOME
Industry
Industry
OtherOther
Institutio
ns
Community
Community
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NIH CTSA Awards: NIH CTSA Awards: A Home for Clinical & Translational A Home for Clinical & Translational
ScienceScience
Background leading to CTSABackground leading to CTSA
CTSA OrganizationCTSA Organization
CTSA CoresCTSA Cores
CTSA ImplementationCTSA Implementation
Centers and Cores: UTMBCenters and Cores: UTMB
1990 1992 1994 1996 1998 2000 2002
CentersCenters
Cores/ProgramsCores/Programs
Protein Chemistry
Molecular Biology
Membrane Protein Lab
Bioinformatics Genomics CoreProteomics/Mass SpectrometryDrug Design Optical Imaging
Analytical Ultracentrifugation
Cell BiologyHistopathology
Animal Knockout
ComputationalBiology
Protein Purification
Organic SynthesisSignal Transduction
NMR
X-Ray
Biophysics
Macromolecular Assembly
Animal MRI
BSL4 Facility
Planning Molecular SciencesTropical Diseases
Sealy Center for Molecular Sciences
Planning Bioinformatics/Proteomics/Genomics
Planning Membrane Protein Program
(HHMI)
Center for Biodefense and Emerging Infectious Diseases
Sealy Center for Aging
Planning Structural Biology
Sealy Center for Structural Biology
DARPA Program
WHO Center for Tropical DiseasesSealy Center for CancerNIEHS Center GRIP
Sealy Center for Vaccine Development
Welch Center in ChemicalBiology
Proteomics Center
2004
WRCEand NBL
Designation
IHII
CTSA
CTD/CLO
Future -BSL3/4: cryoEM NanotechMetabonomicsSystems BiologyVirtual Patients
Planning Translational Sciences
2006
Drug Design
Protein Chemistry
Molecular Biology
Membrane Protein Lab
Bioinformatics Genomics CoreProteomics/Mass Spectrometry
Optical ImagingMetabonomicsSystems Biology
Analytical Ultracentrifugation
Histopathology
Nanotechnology
Animal Knockout ComputationalBiology Protein Purification
Organic Synthesis
Signal Transduction
NMR
X-Ray
Animal MRI
BSL4 Facility
Sealy Center Molecular Medicine
HHMI Membrane Protein Program
Inst. Human Immunity & Infections
Sealy Center Aging
Sealy Center Structural BiologySealy Center Vaccine
Development
Welch Center ChemicalBiology
Proteomics Center
BSL3 cryoEM
Assess Team Translational/ClinicalSeekResearch Development Products
TI-3D
Sealy Center CancerCenter BiomedicalEngineering
(UTMB and UTA)
Center for Nanotechnology
3T HumanMRI
Inst. ComputationalEngineering Sciences
Texas AdvancedComputer Center
Inst. Clinical & Translational Research
Dell PediatricResearch Inst.
Western Regional Center of
Excellence Biodefense
National BiocontainmentLab
Microelectronics Center
IC2
Imaging ResearchCenter
Centers/Institutes
Cores
Resource LeveragingResource Leveraging
UTMBUTMB• Medical SchoolMedical School• WRCEWRCE• Biodefense & EID CenterBiodefense & EID Center• Sealy Centers Vaccine Sealy Centers Vaccine
Dev. & Structural BiologyDev. & Structural Biology• Galveston National LabGalveston National Lab• World Leader in World Leader in
Biodefense & EIDBiodefense & EID• Biomedical EngineeringBiomedical Engineering• UTMB Austin ProgramUTMB Austin Program
UT AUSTINUT AUSTIN• TI-3DTI-3D• Natural Sciences Natural Sciences • Pharmacy & ToxicologyPharmacy & Toxicology• National Center Bioterror National Center Bioterror
CountermeasuresCountermeasures• Medicinal ChemistryMedicinal Chemistry• School of EngineeringSchool of Engineering• Business SchoolBusiness School• Established Incubator, Established Incubator,
Business AcceleratorBusiness Accelerator• TACCTACC
Major ParticipantsMajor Participants
School of MedicineSchool of Medicine
School of NursingSchool of Nursing
School of Allied HealthSchool of Allied Health
Graduate School of Biomedical Graduate School of Biomedical SciencesSciences
UTMB Hospitals & ClinicsUTMB Hospitals & Clinics
UTMB Austin Regional CampusUTMB Austin Regional Campus
School of Natural School of Natural SciencesSciences
College of PharmacyCollege of Pharmacy
School of Social WorkSchool of Social Work
College of EngineeringCollege of Engineering
LBJ School of Public LBJ School of Public PolicyPolicy
School of LawSchool of Law
College of EducationCollege of Education
College of Liberal Arts College of Liberal Arts (Psychology)(Psychology)
UT-Houston CTSAUT-Houston CTSA
Seton Health NetworkSeton Health Network
Brackenridge Hospital (Austin)Brackenridge Hospital (Austin)
Dell Children’s Hospital (Austin)Dell Children’s Hospital (Austin)
Principles Principles guidingguiding our approach our approach
• Focus on teams Focus on teams • Integrating training Integrating training • Encouraging mentoringEncouraging mentoring• Engaging underserved populationsEngaging underserved populations• Establishing proactive processesEstablishing proactive processes• Enhancing partnershipsEnhancing partnerships• Continuing evaluation Continuing evaluation • Integrating ethics Integrating ethics
CTSA AIMSCTSA AIMS
1. To transform the research environment at the University of Texas Medical Branch (UTMB) & the University of Texas at Austin (UT Austin) to maximally facilitate clinical and translational research
2. To transform the training environment at UTMB & UT Austin to produce the next generation of leaders in clinical & translational science
3. To partner with other CTSAs, in particular the recently funded UT-Houston and MD Anderson CTSA in collaborative networks to support and conduct clinical and translational research
4. To design administrative processes to support research and education to achieve Aims 1 and 2; and to implement, evaluate and revise them and ultimately to disseminate successful processes to other academic institutions.
OrganizationOrganization
PresidentPresident
UTMBUTMB
ProvostProvost
UT AustinUT Austin
CTSA DirectorCTSA Director
(Goodwin)(Goodwin)
Core LeadersCore Leaders
Deputy DirectorDeputy Director
UT AustinUT Austin
(Sage)(Sage)
Deputy DirectorDeputy Director
UTMB GalvestonUTMB Galveston
(Goodwin)(Goodwin)
Deputy DirectorDeputy Director
UTMB AustinUTMB Austin
(Shomaker)(Shomaker)
CTSA OrganizationCTSA OrganizationAdministration (J. Goodwin, W. Sage & S. Shomaker)
Tracking and Evaluation (K. Ottenbacher & K. Wooten)
Research Education, Training and Career Development (K. Anderson & L. Abraham)
Biomedical Informatics (B. Luxon & E. Marcotte)
Design Biostatistics and Database Management (D. Freeman & L. Meyers)
Community Engagement and Research (S. Shelton & M. Velasquez)
Coordinating (W. Calhoun & B. Iverson)
Pilot Projects (E. Volpi & K. Diller)
Novel Methodologies (D. Gorenstein & S. Stavchansky)
Multidisciplinary Team Support (C. Soto & R. Helmrich)
Translational Technologies (A. Brasier & J. McDevitt)
Drug Discovery (B. Iverson & S. Gilbertson)
Participant and Clinical Interaction Resources (D. Powell & T. Erlinger)
Research Ethics (H. Brody & J. Robertson)
Regulatory Knowledge & Support (L. Stanberry & W. Sage)
CTSA-wide Committees & Meetings Organized by Administrative Core
Meetings Attendees Frequency Length Purpose
Steering Comm. See Table 5 Weekly 60 min. See Section 5.b.3.
External Advisory Comm.
Ext. Ad. Comm. plus CTSA members as needed
Twice yearly One day in fall; 4 hours in spring
Review of all activities
Internal Advisory Comm.
See Table 6 Monthly 60 min See Section 5.b.5
Investigators governance meetings
All CTSA investigators, trainees, & staff
Monthly 60 min. Information on activities, input on directions.
Translational Research meetings
All CTSA investigators, trainees, & staff
Monthly 60 min. Presentations of research in progress
Seminar Series in Translational Research
All CTSA investigators, trainees, & staff, and academic communities
Monthly 60 min. Topics in translational research from basic and clinical perspective
Scientific Review Committee
Members listed in Pilot Projects Core
Six times yearly at CTSA retreat
Variable Evaluate and rank proposals to PPC, NMC, PCIR, and Education Core
Catalysts for Innovation Leadership Contract
Members listed in Novel Methodologies Core
Six times yearly at CTSA retreat
120 min. Brainstorm/develop ideas for applications of novel technologies
Tracking and Evaluation (K. Ottenbacher & K. Wooten)
Aim 1.Aim 1. Provide standardized training in program evaluation Provide standardized training in program evaluation and assessment to all core leaders, faculty, trainees, and and assessment to all core leaders, faculty, trainees, and staff;staff;
Aim 2.Aim 2. Based on the training provided in Aim 1, implement a Based on the training provided in Aim 1, implement a consistent protocol for data collection, tracking and consistent protocol for data collection, tracking and assessment of outcomes across all cores and CTSA assessment of outcomes across all cores and CTSA components; andcomponents; and
Aim 3.Aim 3. Conduct a team evaluation of the UTMB and UT Conduct a team evaluation of the UTMB and UT Austin research infrastructure to identify fundamental Austin research infrastructure to identify fundamental processes that require modification or change in order to processes that require modification or change in order to create an environment and culture supportive of create an environment and culture supportive of translational research teams.translational research teams.
Relationship of components of formative & summative evaluation
Influences
Resources Activities Outputs
Short-termOutcomes
Mid-TermOutcomes
Long-termOutcomes
Formative Evaluation
Summative Evaluation
What aspects or situations shape the ability to do the proposed work
What was the program intended to accomplish in what environment
What is the assessment of what resulted from the proposed activities
What was learned about the outcomes and the scope of project impact
Logic Model
Context
Relationships
& Capacity
Implementation
Quality
& Quantity
Outcomes
Effectiveness, Magnitude & Satisfaction
Research Education, Training and Career Development
Aim 1.Aim 1. Employ a nationally acclaimed framework for Employ a nationally acclaimed framework for constructive learning constructive learning
Aim 2.Aim 2. Reorganize current training programs so that all trainees Reorganize current training programs so that all trainees are placed in active multidisciplinary collaborative translational are placed in active multidisciplinary collaborative translational research clusters.research clusters.
Aim 3.Aim 3. Ensure all trainees are provided mentoring teams Ensure all trainees are provided mentoring teams
Aim 4.Aim 4. Provide a novel educational pipeline mechanism by Provide a novel educational pipeline mechanism by establishing the Texas Academy of Healthcare Leadership for establishing the Texas Academy of Healthcare Leadership for select undergraduate students, expanding undergraduate select undergraduate students, expanding undergraduate research opportunities, and expanding existing programs for research opportunities, and expanding existing programs for talented high school and minority studentstalented high school and minority students
Aim 5.Aim 5. Revise existing predoctoral, postdoctoral and faculty Revise existing predoctoral, postdoctoral and faculty development programs to increase the number of successful development programs to increase the number of successful clinical and translational investigatorsclinical and translational investigators
Potentially Relevant Doctoral Programs at UT AustinPotentially Relevant Doctoral Programs at UT Austin
Aerospace EngineeringAnthropologyBiochemistryBiological SciencesBiomedical EngineeringCell & Molecular BiologyChemical EngineeringChemistryCivil EngineeringCommunication Sciences & DisordersComputational & Applied MathematicsComputer SciencesCurriculum & InstructionEcology, Evolution, & BehaviorEducational PsychologyElectrical & Computer EngineeringElectrical EngineeringEngineering MechanicsHealth Education
Human Development & Family SciencesJurisprudenceLinguisticsMarine ScienceMaterials Science & EngineeringMechanical EngineeringMicrobiologyMolecular BiologyNeuroscienceNutritional SciencesNursing SciencePharmacyPhysical EducationPlant BiologyPsychologyPublic PolicyScienceScience EducationSocial WorkSpecial Education
Biomedical InformaticsBiomedical Informatics
Create a highly interconnected, Create a highly interconnected, web-based data management web-based data management and analysis infrastructureand analysis infrastructure that facilitates interoperability in that facilitates interoperability in a multidisciplinary, multi-team a multidisciplinary, multi-team clinical & translational clinical & translational environment, regardless of environment, regardless of where members may be where members may be physically locatedphysically located
Partnership with UT HSC Houston Partnership with UT HSC Houston and MD Anderson CC CTSAand MD Anderson CC CTSA
Link EMRs with rEMRsLink EMRs with rEMRs
Design Biostatistics and Database Management
1. Provide investigators & 1. Provide investigators & trainees with trainees with biostatisticians and biostatisticians and epidemiologists to epidemiologists to implement optimal implement optimal study designs based on study designs based on state-of-the-art state-of-the-art statistical methodsstatistical methods
2. Develop and implement 2. Develop and implement new statistical and new statistical and mathematical modeling mathematical modeling techniques for clinical & techniques for clinical & translational research translational research
3. Provide web-based data 3. Provide web-based data collection and study collection and study tracking systems for tracking systems for clinical studiesclinical studies
Initial meeting with Coordinating Center
Assignment of Biostatistician & DB Programmer Grant AwardedGrant Writing
1 Biostatistician: assist study design, testable hypotheses
7 Assist in revising grant
3 Power analysis and Sample Size Determination
4 Write Statistical Analysis section of grant
5 Submit Grant
6 Review Study Section critique with investigator
11 Biostatistician: statistical analysis and MS preparation
13 Begin writing next grant
12 Publish Results
8 Biostatistician: assist with obtaining sample, data forms
(EMR)
10 Biostatistician: assist in database development
2 Database programmer: dev plan for data collection (with BIC/BIC
work groups)
9 Database programmer: start making database (BIC)
Community Engagement & ResearchCommunity Engagement & Research
Aim 1:Aim 1: Establish Community Research Establish Community Research Coordinating Center (CRCC) as a Coordinating Center (CRCC) as a mechanism to represent community mechanism to represent community interests, provide support to interests, provide support to researchers, and coordinate the use of researchers, and coordinate the use of relevant community assets. relevant community assets.
Aim 2:Aim 2: Develop, maintain, and coordinate Develop, maintain, and coordinate Practice-Based Research Network Practice-Based Research Network (PBRN) of community health care (PBRN) of community health care providers providers Aim 3:Aim 3: Provide education Provide education and development in community-based and development in community-based participatory research participatory research
Aim 4:Aim 4: Coordinate the community Coordinate the community advisement and communications advisement and communications function for the CTSAfunction for the CTSA
Aim 5:Aim 5: Engage voluntary health Engage voluntary health organizations (VHO) in the CTSAorganizations (VHO) in the CTSA
Aim 6Aim 6: Develop and disseminate information : Develop and disseminate information to public audiences, policy makers, to public audiences, policy makers, and community cliniciansand community clinicians
Texas Clinical Networks
Coordinating CoreCoordinating Core
Aim 1. To provide ‘one-stop shopping’ for investigators desiring to participate in CTSA-related research
Aim 2. To coordinate multidisciplinary Translational Teams and Research clusters
Aim 3. To facilitate clinical and translational research, by identifying project needs, allocating resources, and monitoring progress
Aim 4. To increase throughput and efficiency of translational research, by identifying and overcoming rate-limiting resource barriers for CTSA core activities, eliminating possible duplication of effort
Core InteractionsCore Interactions
Reso
urce C
ore
Reso
urce C
ore
Reso
urce C
ore
Reso
urce C
ore
Reso
urce C
ore
Coordinating Core CoordinatorsCoordinating Core Coordinators
Tracking & EvaluationTracking & Evaluation
Research Education & TrainingResearch Education & Training
Multidisciplinary Team Support
Aim 1.Aim 1. Provide administrative and mentoring support to Provide administrative and mentoring support to form new research clusters and help existing clusters form new research clusters and help existing clusters achieve stable external funding achieve stable external funding
Aim 2.Aim 2. Assist in creation, implementation, maintenance and Assist in creation, implementation, maintenance and termination of Translational Teamstermination of Translational Teams
Aim 3.Aim 3. Conduct ongoing evaluation of the processes and Conduct ongoing evaluation of the processes and outcomes of Translational Teams outcomes of Translational Teams
Aim 4.Aim 4. Conduct education and training in team processes Conduct education and training in team processes
Multidisciplinary Team SupportAim 4. Conduct education and training in team processesAim 4. Conduct education and training in team processes
Module Topic Module Content
Effective Team Processes Types of teams, Models of Team effectiveness, Team assessment procedures, Team followership versus leadership, Stages of development/evolution, Development of team culture and norms, Use of Creativity
Meeting Facilitation/Management
Developing agendas, Contextual and constituent planning, Stakeholder analysis, Facilitation skills and techniques, Identifying roles and tasks, Dealing with disruptive behavior, Time management, Meeting techniques and procedures, Feedback and documentation.
Interpersonal Communication Models of interpersonal communication, Models of effective interpersonal communication, Non verbal communication, Styles of communication, Influencing individuals, Influencing teams, Listening skills, Communicating across genders, ethnic orientations, and generational lines
Conflict Resolution/Negotiation
Types of conflict, Origins and diagnosis of conflict cycles, Steps and skills to reduce conflict, Negotiation planning, Negotiation strategies, Managing strategic relationships
Project Management Supervision, Legal and institutional considerations, Team membership, setting goals, identifying resources
Funds to be awarded by Pilot Projects Core# /yr Amt Term $$ /yr Deadline
Pilots awarded with CTSA and institutional funds
Research Grants 2-4 50-100 K 1-2 yr 200 K August
Novel Technologies Awards 4-6 25-125 K 1-2 yr 400 K December
Seed Money 10-15 5-30 K 2-12 mo
150 K April, August, December
Trainee Awards 8-15 5-30 K 1 yr 125 K April, August, December
Support for symposia 1-2 5-10 K < 1 yr 15 K April
Other support awarded with CTSA funds
Grantsmanship support 10 0.5 K 1 mo 5 K April, August, December
Other support awarded with institutional funds only
Translational research faculty leave 4 50 K 6 mo 200 K April
Bridging Grants 2-4 50-100 K 1 yr 400 K August
Support for CTSA resource utilization with CTSA and institutional funds
Analytical support 15-50 < 30 K 1 yr 200 K April, August, December
Novel MethodologiesNovel Methodologies
Aim 1.Aim 1. To create a “Catalysts for Innovation Leadership To create a “Catalysts for Innovation Leadership Council”(CILC) to seek out promising early-stage Council”(CILC) to seek out promising early-stage technologiestechnologies
Aim 2.Aim 2. To sponsor new methodologies that accelerate To sponsor new methodologies that accelerate translational research and product development for translational research and product development for Pilot Project Core Funding.Pilot Project Core Funding.
– New Core grantsNew Core grants to develop novel cores or centers to develop novel cores or centers
• 1-3 yrs @ $50-125,000/yr1-3 yrs @ $50-125,000/yr
– Enabling Technologies planning grantsEnabling Technologies planning grants to lay the to lay the foundation for Pilot Core grant or extramural grant foundation for Pilot Core grant or extramural grant applications applications
• 1-2 yrs @ $25-50,000/yr1-2 yrs @ $25-50,000/yr
Aim 3. To build on UTMB and UT Austin's success in developing academic-industry partnerships to improve the product development pipeline for translational research
Novel Methodologies: Enhanced Novel Methodologies: Enhanced therapeutics pipelinetherapeutics pipeline
Yellow boxes = Yellow boxes = possible new possible new NMC cores NMC cores
Green = BIC, TTCGreen = BIC, TTC
Gray = DDC & Gray = DDC & other CTSA other CTSA corescores
Translational TechnologiesTranslational TechnologiesAim 1.Aim 1. Adopt uniform processes in Adopt uniform processes in
study design, sample handling study design, sample handling and data processing.and data processing.
Aim 2.Aim 2. Support high-throughput Support high-throughput
genomics to identify disease genomics to identify disease susceptibility and treatment susceptibility and treatment response.response.
Aim 3.Aim 3. Enable biomarker discovery in Enable biomarker discovery in
proximal fluids of diseased proximal fluids of diseased tissues. tissues.
Aim 4.Aim 4. Serve as a focal point for Serve as a focal point for training in the use of high-training in the use of high-throughput post-genomic tools in throughput post-genomic tools in patient-oriented research.patient-oriented research.
Drug DiscoveryDrug Discovery
Aim 1.Aim 1. Establish a coordinating infrastructure between Establish a coordinating infrastructure between UTMB & UT Austin in synchrony with a newly UTMB & UT Austin in synchrony with a newly established administrative structure for the Texas established administrative structure for the Texas Institute for Drug and Diagnostics Development (TI-Institute for Drug and Diagnostics Development (TI-3D) 3D)
Aim 2.Aim 2. Establish ‘cradle-to-clinic’ Drug Discovery Establish ‘cradle-to-clinic’ Drug Discovery Research Teams (DDRTs) to move drugs from the Research Teams (DDRTs) to move drugs from the lab into the clinic & marketplace lab into the clinic & marketplace
Aim 3.Aim 3. Establish a High Throughput Screening Facility Establish a High Throughput Screening Facility (HTSF) to vastly increase investigators’ ability to (HTSF) to vastly increase investigators’ ability to identify efficacious compounds for a given disease identify efficacious compounds for a given disease state or modelstate or model
Pathway of drug Pathway of drug discovery discovery processesprocesses
Figure 1
Participant & Clinical Interactions ResourcesParticipant & Clinical Interactions Resources
Aim 1. To transform clinical research at UTMB and UT Austin by creating:
a. Central, high intensity clinical research sites in Galveston and Austin, including development of a CRC in Austin
b. A network of flexible collaborative disease-associated clinical research sites in the AHCs
c. Low intensity research sites for community-based investigations both in Galveston and Austin
Aim 2. To establish a participant recruitment resource to provide subjects of all ages, genders and ethnicities for clinical research
Aim 3. To develop and implement a sample preparation and repository laboratory
Aim 4. To serve as a training facility for clinical research education, and as a “home” for multidisciplinary research support personnel
Research EthicsAim 1.Aim 1. Create a continuum of ethical best Create a continuum of ethical best
practices across the life cycle of practices across the life cycle of translational research translational research
Aim 2. Generate new knowledge by Aim 2. Generate new knowledge by conducting hypothesis-driven conducting hypothesis-driven research into emerging Clinical and research into emerging Clinical and Translational Research Ethics Translational Research Ethics issuesissues
Aim 3. Proactively engage the diverse Aim 3. Proactively engage the diverse CTSA constituencies in a Bioethics CTSA constituencies in a Bioethics Community Dialogue InitiativeCommunity Dialogue Initiative
Regulatory Training & SupportRegulatory Training & Support
Aim 1. To provide comprehensive, “user-friendly” regulatory support services, including Intellectual Property, to CTSA investigators and research subjects
Aim 2. To provide both compliance training and continuing education for investigators and the research community about the relationship between the regulatory environment & public policy
Aim 3. To promote research and development of better systems for regulatory management, compliance, and education, including barriers to local and national collaboration among translational researchers
Next StepsNext Steps
Implementation Phase: Pre-FundingImplementation Phase: Pre-Funding
Institutional Leadership. Detailed and specific letters of participation from the chief academic officers of UTMB and UT-Austin, relevant Deans, Center Directors, and Department/Unit Chairs commit recourses, space, and personnel
Institute for Clinical and Translational Science Mission: to promote and conduct innovative, interdisciplinary, translational
research including basic and clinical scientists as co-investigatorsDirector: James S. Goodwin M.D. – created 9/1/06– increased visibility & prestige– ability to make faculty appointments~ 3,600 sq. ft. of contiguous office, conference room, classroom and research
space has been designated in the 5th floor of the John Sealy Hospital next to existing General Clinical Research Center (GCRC)
UTMB Austin Programs DeanSam Shomaker, MD, JD (appointed Fall 2006)
UT Austin Vice Provost for Health AffairsWilliam Sage, MD, JD (appointed Fall 2006)
NIH CTSA Awards: NIH CTSA Awards: A Home for Clinical & Translational A Home for Clinical & Translational
ScienceScience
Trial Trial DesignDesign
Advanced Advanced Degree-Granting Degree-Granting
ProgramsPrograms
Participant Participant & Community & Community InvolvementInvolvement
Regulatory Regulatory SupportSupport
BiostatisticsBiostatistics
Clinical Clinical ResourcesResources
Biomedical Biomedical InformaticsInformatics
Clinical Research Clinical Research EthicsEthics
CTSACTSAHOMEHOME
Industry
Industry
OtherOther
Institutio
ns
Community
Community
Partners