NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic...
Transcript of NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic...
![Page 1: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/1.jpg)
NIH and Birth Defects Research:
Current Funding and Future Opportunities
Lorette Javois, Ph.D.Program Director
Eunice Kennedy ShriverNational Institute of Child Health & Human
Development
![Page 2: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/2.jpg)
NIH has no “home” for birth defects research
• There is the Office of the Director (OD) along with 27 Institutes and Centers
• Of these, 11 Institutes and 2 OD Offices have an interest in birth defects research
NHLBINIAMSNINDSNIDCDNIDCRNIDDKNEI
NICHDNIEHS
Office of Rare Disease ResearchOffice of Dietary Supplements
NHGRINCI
![Page 3: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/3.jpg)
Women suffer no harmful effects from reproduction
Every baby is born healthy and achieves their full potential
People lead healthy, productive, independent lives through rehabilitation
![Page 4: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/4.jpg)
• Child Development and Behavior• Contraception and Reproductive Health• Demographic and Behavioral Sciences• Developmental Biology, Genetics, and Teratology• Endocrinology, Nutrition, and Growth• Intellectual and Developmental Disabilities• Obstetrics and Pediatric Pharmacology• Pediatric, Adolescent, and Maternal AIDS• Pregnancy and Perinatology• Reproductive Sciences
![Page 5: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/5.jpg)
Developmental Biology, Genetics & Teratology Branch
Supports basic and clinical research on normal and abnormal development that relates to the causes and prevention of
congenital structural birth defects
![Page 6: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/6.jpg)
Intellectual & Developmental Disabilities Branch
Supports biomedical, biobehavioral, behavioral, and translational research in
etiology, pathophysiology, screening, prevention, treatment, and epidemiology of
intellectual and related developmental disabilities.
![Page 7: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/7.jpg)
Pregnancy and Perinatology Branch
Supports research on maternal health, pregnancy, fetal well being, labor and
delivery, and the developing child
![Page 8: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/8.jpg)
NHLBI’s Bench to Bassinet ProgramPediatric Cardiac Genomic ConsortiumCardioVascular Development ConsortiumPediatric Heart Network
NICHD’s Structural Birth Defects Working Group
NIDCR’s FaceBase Consortium
Samples of Funded Efforts Across NIH
![Page 9: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/9.jpg)
Brief Overview: NIH Granting Process
Types of Research Grant MechanismsFunding Opportunity Announcements Solicited versus Investigator-InitiatedSubmission ProcessAssignment of ApplicationsReview Funding
![Page 10: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/10.jpg)
Types of Research Grants Mechanisms
Small grants for 2 yearsR03 small projects $100K/2yrsR21 high risk/high impact $275K/2yrs
Basic R01 up to 5 years Modular $25K up to $250K Direct CostNon-Modular <$500K Direct CostsLarge >$500K Direct Costs
Program Project Grant (P01)
![Page 11: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/11.jpg)
Funding Opportunity Announcement
NIH GuideElectronic Submission“Parent” Announcements
Investigator-InitiatedTargeted Solicitations
RFA: Request for ApplicationsPA: Program AnnouncementPAR: Program Announcement with
Special Review
![Page 12: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/12.jpg)
Submission ProcessGrants.gov ↔ NIH eRA Commons
Register early!
Carefully follow the requirements in the FOA
Check your application for common errors
Correct any errors before the submission deadline
![Page 13: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/13.jpg)
Verify that your application is viewable in the NIH eRA Commons!
Submit early to reduce stress and ensure a successful submission
Complete the Submission Process!
![Page 14: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/14.jpg)
Assignment of Applications
Study Section for reviewCenter for Scientific Reviewor Institute Review
Scientific Review Officer (SRO)
Institute for funding purposesProgram Officer (PO)
![Page 15: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/15.jpg)
Review Center for Scientific ReviewIndividual Institute
Standing Study SectionsSpecial Emphasis Panels
Methods of reviewin personon phoneby videoconferencevia internet
PO listens
SRO Convenes
![Page 16: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/16.jpg)
Review
Summary Statement
Institute Funding Decision
IMPACT
![Page 17: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/17.jpg)
Funding
Institutes and CentersPrimary Assignment Secondary Assignment(what does this really mean?)
Co-funding from Offices
![Page 18: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/18.jpg)
How do you get started?Think of ideas
Talk to colleagues
Register (Grants.gov and NIH Commons) both you and your institution
Look at NIH Institute web sites – where’s the best fit for your research?
Talk to the relevant Program Officer – are there targeted FOAs?
![Page 19: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/19.jpg)
Learn how reviews are conducted - watch the CSR video
Write the application and get feedback (mentoring) well before the submission deadline
Rewrite the application because it’s well before the submission deadline
Or, consider the “feed-forward” approach
Talk to a Scientific Review Officer – which study section is best?
![Page 20: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/20.jpg)
R03 grant mechanism supports ($50K/year for 2 yrs nonrenewable)
Pilot and feasibility studies
Secondary analysis of existing data
Small, self-contained research projects
Development of research methodology
Development of new research technology
![Page 21: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/21.jpg)
NHGRI, NIA, NIAAA, NIAID, NIBIB, NICHD, NIDA, NIEHS, NIMH, NINDS, NINR
![Page 22: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/22.jpg)
Developmental Biology, Genetics & Teratology FOAs
Birth Defects Initiative: foster synergy between basic scientists and clinicians
PAR-12-034 Developmental Mechanisms ofHuman Structural Birth Defects (P01)
PA-11-085 Genetic Susceptibility & Variabilityof Human Structural Birth Defects (R01)
![Page 23: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/23.jpg)
Systems Biology: regulatory logic andcausal relationships driving development
PAR-11-257 Systems Developmental Biologyfor Understanding Embryonic Development & the Ontogeny of Structural Birth Defects
![Page 24: NIH and Birth Defects Research€¦ · Birth Defects Initiative: foster synergy between basic scientists and clinicians PAR-12-034 Developmental Mechanisms of Human Structural Birth](https://reader033.fdocuments.net/reader033/viewer/2022052002/6014d14968935b1b1d799185/html5/thumbnails/24.jpg)
Biophysical & Biomechanical Aspects: the role of physical forces during development
PAR-10-221 Biophysical and BiomechanicalAspects of Embryonic Development (R01)
Studies aimed at understanding how disruptionsin biophysical and biomechanical processesmight lead to known developmental disorders