NIDA's AIDS Research Program
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Transcript of NIDA's AIDS Research Program
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Jacques Normand, Ph.D.
Director, AIDS Research ProgramNIDA
The Johns Hopkins UniversityBaltimore, MarylandNovember 5, 2014
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Objectives
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NIDA HIV/AIDS FY13 Program Profile
17%
16%
1%
55%
3% 4% 2%
Behavioral and Social Science
Natural History & Epidemiology
Etiology & Pathogenesis
Vaccines
Therapeutics
Training Other
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NIDA HIV/AIDS Budget by Research Area
Natural History and Epidemiology-------------- $44M
Etiology and Pathogenesis----------------------- $41M
Microbicides----------------------------------------- $0
Vaccines---------------------------------------------- $4M
Behavioral and Social Science----------------- $188M
Therapeutics----------------------------------------- $8M
Training, Infrastructure, and
Capacity Building------------------------------ $13M
Information Dissemination----------------------- $2M
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On Nov. 2013, Dr. Collins charge to OAR’s Advisory Council “Produce a report that outlines the highest
priority AIDS research in 3 areas”
• Prevention - including vaccines, microbicides, ARV-based prevention, behavioral research focused on risk reduction, stigma, and adherence
• Treatment - including advances in therapeutic interventions and research toward a cure
• Co-morbidities - neurologic, cardiovascular, oncologic, and accelerated aging
The document should also identify priorities that cut across the above mentioned areas with regard to basic science, training, and information dissemination.
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OAR Priority Report (June, 2014)
• PreventionVaccines, microbicides, PrEP,
Integrated Strategies (combination)
• Treatment: Anti-retroviral Therapy
More efficient Tx
• The Prevention and Care Continua
STTR
• Cure Animal models, latency, reservoirs
• Co-infection, Co-morbidities, &complications TB, HCV, cardio, kidney,
neuro, & aging (in presence of HIV)
• Basic ScienceSystem Bio, Animal models
• Behavioral & Social Sciences Innovative methods, comparative
effectiveness
• Implementation ScienceAccess, uptake, retention, scale-up,
Sustainability
• Training, infrastructure, and Capacity-building
• Information Dissemination
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Managing NIH HIV/AIDS ProgramProactively
• OAR approval of all FOAs
• Review of HIV/AIDS relatedness of Applications (CSR)
• Develop Trans-NIH definition of what is HIV/AIDS research
• Develop trans-NIH policy for proportional funding (Prorate)
Next step: Portfolio review to identify low priority grants
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FY15 & FY16 Priorities
Promoting Retention in HIV Care
HIV Prevention in Vulnerable Populations in the U.S.—Emphasis on youth, the Homeless and Black/African American Women and Young Black/African American Men
Developing Comprehensive Interventions for Substance Using MSM
Implementation Science Research
Transformative Research
Prevention and Treatment of HCV in those with and at Risk for HIV
Enhancing Treatment as Prevention through Use of Incentives and Technology
Training, Infrastructure, and Capacity Building
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FY15 Initiatives
Avant-Garde RFA (DP1)
A-START PAR (R03/$100K)
NIDA/ANRS Fellowship ($75K)
Advancing exceptional HIV/AIDS Research RFA (R01)
Extracellular Vesicles in HIV/AIDS and Substance Abuse RFA (R21, R01)
NIDA Drug Abuse and HIV Cohorts PAR (U01)
Technology-Based Interventions to Promote Engagement in Care & TxAdherence & For Substance Abusing Populations with HIV PA (R01,R34)
HIV, Drugs, & Vulnerable Pop PA (R21, R01)
AVENIR (AIDS) RFA (DP2)
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FY15 Initiatives (Cont.)
Substance Use & Abuse, Risky Decision Making & HIV/AIDS PA (R03, R21, R01)
Centers for AIDS Research & Developmental Centers for AIDS Research PA (P30)
Drug Abuse Aspects of HIV/AIDS PA (R03, R21, R01)
Prevention & Tx of HCV in Those with and at Risk for HIV PAR (R21, R01, R34)
Long-Term Retention in Care for US Substance Using Pops PA (R01, R21, R34)
International Research Collaboration on Drug Abuse & Addiction Research (R21, R01)
Development and Testing of Novel Interventions to Improve HIV Prevention, Care, and Program Implementation PA (R34)
Note: NIDA has also joined many other ICS’ FOAs
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FY16 Initiatives
Avant-Garde RFA (DP1)
A-START PAR (R03/$100K)
NIDA/ANRS Fellowship ($75K)
Advancing exceptional HIV/AIDS Research RFA (R01)
AVENIR (AIDS) RFA (DP2)
Substance Use & Abuse, Risky Decision Making & HIV/AIDS PA (R03, R21, R01)
Centers for AIDS Research & Developmental Centers for AIDS Research PA (P30)
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FY16 Initiatives (Cont.)
Drug Abuse Aspects of HIV/AIDS PA (R03, R21, R01)
Prevention & Tx of HCV in Those with and at Risk for HIV PAR (R21, R01, R34)
Long-Term Retention in Care for US Substance Using Pops PA (R01, R21, R34)
International Research Collaboration on Drug Abuse & Addiction Research (R21, R01)
Development and Testing of Novel Interventions to Improve HIV Prevention, Care, and Program Implementation PA (R34)
Note: NIDA has also joined many other ICS’ FOAs
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New FY16 Initiatives
Role of Polysubstance use in HIV Cure/Remission Research: Novel Approaches RFA (R03, R21, R01)
Integration of Infectious Diseases and Substance Abuse Treatment for HIV Positive Patients RFA (R01 & R34)
Enhancing Seek, Test, Treat, & Retain Strategies for Substance Using Adolescents and Young Adults RFA (R01)
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Role of Polysubstance use in HIV
Cure/Remission Research: Novel Approaches
• Goals: Provide basic/clinical research
evidence on specific role of polySU that
may be most critical in HIV pathophysiology
• NIH Towards the cure—emphasis on virus
in primary peripheral sites (CD4+ and other
immune cells)
• This RFA will emphasize two critical areas:
– 1) Towards a cure in brain (in vivo
emphasis with in vitro components)
– 2) Towards a cure in substance using
populations (periphery)
• Critical research on reservoirs within
macrophage, microglia, and astrocytes
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Integration of Infectious Diseases and
Substance Abuse Treatment for HIV Positive
Patients
Goals To develop and evaluate comprehensive integrated treatment
services for HIV and co-infections among substance abusers
Support implementation research to determine how to best provide comprehensive, integrated effective preventive and treatment interventions that are scalable, sustainable, and cost-effective in diverse populations
Note: This initiative can provide data on the beneficial health effects of drug treatment on other than HIV outcomes
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• Target US youth age 14-25
• Prioritize intervention studies that recruit highest risk youth & address developmental, legal and service delivery issues
– Lead to improvements in serostatus knowledge, linkage to care/retention, & achievement of undetectable viral loads.
Enhancing Seek, Test, Treat, & Retain Strategies for Substance Using Adolescents and Young Adults
Estimated Cascade of Care among HIV+ Youth in the US (age 13-29)
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Topics Under Consideration
Cascade of Care Retention Gap
Combination HIV Prevention Strategy
Alcohol, drug abuse, and HIV Functional collaboration with NIAAA
STTR/TasP
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WWW.DRUGABUSE.GOV/AIDS