NF-149 A New Fungicide for Control of Powdery Mildew IR-4 Food Use Workshop Tampa - 2007.
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Transcript of NF-149 A New Fungicide for Control of Powdery Mildew IR-4 Food Use Workshop Tampa - 2007.
NF-149
A New Fungicide for Control of Powdery Mildew
IR-4 Food Use Workshop
Tampa - 2007
NF-149
• NF-149 is a new fungicide for control of a wide range of powdery mildews on various crops
• New chemical discovered by Nippon Soda Co. Ltd.
• No cross resistance to existing powdery mildew products– Biochemical MOA not yet defined
• Common name: cyflufenamid
CF3
HN
OO
NF
F
NF-149
• Powdery Mildew on Grapes
NF-149
• Powdery Mildew on Apples
NF-149
• Powdery Mildew on Cucurbits
NF-149
Fig. 3 Inhibition sites of cyflufenamid on life cycle of Erysiphe graminisFig. 3 Inhibition sites of cyflufenamid on life cycle of Erysiphe graminis
conidiospore
primarygermtube
Secondarygermtube
appressorium
haustoriumformation
growth ofsecondary hypha
conidiosporeformation
haustoria development
papilla
NF-149Effect of Cyflufenamid Against Powdery Mildews on Various Crops
(greenhouse screening, minimum inhibitory concentration)
NF-149Effect of Cyflufenamid Against a Powdery Mildew Strain Resistant to
other Commercial Fungicides (greenhouse screening, minimum inhibitory concentration)
PathogenCommercial--------fungicides
SensitivityCommercial
fungicideMIC(ppm)
cyflufenamidMIC(ppm)
S < 0.1 < 0.8
R > 100 < 0.8
triflumizole S < 0.1 < 0.8
R 5 < 0.8
S 1 < 0.8
R > 100 < 0.8
thiophanate-----------methyl
Sphaerotheca ---------- cucubitae
kresoxim----------------methyl
NF-149
• Currently registered in Japan, Korea, and the several EU countries– Cereals, fruiting vegetables, pome fruit, stone fruit– Favorable toxicological, e-fate, and eco-tox profile
• Data Submission to US EPA Planned for 2008
• Initial US formulation: 10% SC
• Low Use Rate: 12.5 to 25 grams a.i./hectare(0.011 to 0.022 lb a.i./A or 1.7 to 3.4 oz form./A)
• Planned crops for the US: grapes; 3 day PHIpome fruit; 14 day PHIcucurbits; 0 day PHIstrawberries; 0 day PHI
NF-149
• Other potential US uses include: stone fruitfruiting
vegetablesleafy vegetablescole cropshopscane berriesgrainsornamentals