News and view
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ELSEVIER Drug and Alcohol Dependence 39 (1995) 73-74 College on Problems of Drug Dependence, Inc. a World Health Organization Collaborating Center News and Views Executive Officer: Martin W. Adler, Ph.D. Temple University, Department of Pharmacology, 3420 North &pad Street, Philadelphia, PA 19140. Tel. 12151 707-3242; Fax (215) 707- 1904. Board of Directors Robert L. Balatar, PhD, President Medical College of Virginia Stephen G. Hoitzman, PhD, President-Elect Emory University Edward M. Sellers, MD, PhD., Past President Addiction Resaarch Foundation George E. Bigelow, PhD, Treasurer Johns Hopkins University Edgar H. Brenner, Esq. Behavioral Law Canter Leonard Cook, PhD, Consultant Linda B. Cottlar, PhD, MPH Washington University School of Medicine Linda A. Dykstra. PhD University of North Carolina Avram Goldstein, MD Stanford Univaraity (emeritus) John R. Hughes, MD University of Venom M. Ross Johnson, PhD Pamassus Pharmaceuticals, Inc. Thomss R. Kostan, MD Yale University Michael J. Kuhar, PhD NIDA Addiction Research Center Scott E. Lukas, PhD Harvard Medical School Billy R. Martin, PhD Medical Collage of Virginia A. Thomas McLallan, PhD University of Pennsylvania Roy W. Pickans, PhD NIDA Addiction Research Canter Berry J. Primm, MD Addiction Research Treatment Corporation Peter Reuter, PhD University of Maryland Sidney H. Schnoll, MD, PhD Medical Collage of Virginia Charles R. Schuster, PhD Wayne State University James E. Smith, PhD Bowman Gray School of Medicine Maxine L. Stitxer, PhD Johns Hopkins University EULOGY Julian E. Villarreal, MD, PhD Dr. Julian E. Villarreal died of liver cancer on January 17, 1995. Julian, as he was known to many of his many friends and colleagues, was born in Mexico City on April 10, 1937.Upon receiving the MD degreefrom the Univer- sity of Mexico in 1960,he traveled north to Ann Arbor to enter the graduate program of the Department of Pharmacology of The University of Michigan. Julian completeda doctoral researchproject under the supervi- sion of Dr. Edward Domino. Before Julian had a chance to write and defend his doctoral dissertation, Dr. Maurice Seevers, Chairman of the Department, tapped him to take over the “monkey laboratory” that Seevers had established years earlier to study the phenomenon of physical dependenceto opiate analgesics.As an In- structor, Assistant Professor,and Associate Professorof Pharmacology, Julian directed the research activities of the laboratory, studying opiate tolerance and physical dependence in rhesus monkeys and other laboratory animals. Under the auspices of the Committee (now College) on Problems of Drug Dependence,he screened hundreds of coded compounds for their capacity to pro- duce morphine-like physical dependencein the rhesus monkey. Julian eventually received the Ph.D. degree from The University of Michigan, after writing and defending a doctoral dissertation on the original opiate researchthat he performed while he was director of the laboratory. Julian returned to Mexico city with his growing fami- ly in the early 1970s. Over a IO-year period he was af- filiated with the Miles Institute of Experimental Therapeutics, first as Director of Behavioral Pharmacol- ogy, then as Director of the Institute. Subsequently, he returned to the National University of Mexico as Pro- fessor of Pharmacology, finishing his career as Chair- man of the Department. He took a two-year leave from the University to servethe people of Mexico as Director General of the Drug Regulation Office, Mexican Health Secretariat,an office analogous to the Commissioner of the Food and Drug Administration in the United States. Julian will be remembered for his innovative research and his enviable ability to theorize. He introduced pupilography and measurementof core body tempera- ture as meansof quantifying the acute effects of opiate drugs and the intensity of opiate withdrawal in mon- keys. He developed a paradigm of aversive social inter- 0376-8716/95/$09.50 0 1995 Elsevier Science Ireland Ltd. All rights reserved SSDI 0376-8716(95)01149-?
Transcript of News and view
ELSEVIER Drug and Alcohol Dependence 39 (1995) 73-74
College on Problems of Drug Dependence, Inc. a World Health Organization Collaborating Center
News and Views
Executive Officer: Martin W. Adler, Ph.D. Temple University, Department of Pharmacology, 3420 North &pad Street, Philadelphia, PA 19140. Tel. 12151 707-3242; Fax (215) 707- 1904.
Board of Directors Robert L. Balatar, PhD, President
Medical College of Virginia Stephen G. Hoitzman, PhD, President-Elect
Emory University Edward M. Sellers, MD, PhD., Past President
Addiction Resaarch Foundation George E. Bigelow, PhD, Treasurer
Johns Hopkins University Edgar H. Brenner, Esq.
Behavioral Law Canter Leonard Cook, PhD,
Consultant Linda B. Cottlar, PhD, MPH
Washington University School of Medicine
Linda A. Dykstra. PhD University of North Carolina
Avram Goldstein, MD Stanford Univaraity (emeritus)
John R. Hughes, MD University of Venom
M. Ross Johnson, PhD Pamassus Pharmaceuticals, Inc.
Thomss R. Kostan, MD Yale University
Michael J. Kuhar, PhD NIDA Addiction Research Center
Scott E. Lukas, PhD Harvard Medical School
Billy R. Martin, PhD Medical Collage of Virginia
A. Thomas McLallan, PhD University of Pennsylvania
Roy W. Pickans, PhD NIDA Addiction Research Canter
Berry J. Primm, MD Addiction Research Treatment Corporation
Peter Reuter, PhD University of Maryland
Sidney H. Schnoll, MD, PhD Medical Collage of Virginia
Charles R. Schuster, PhD Wayne State University
James E. Smith, PhD Bowman Gray School of Medicine
Maxine L. Stitxer, PhD Johns Hopkins University
EULOGY
Julian E. Villarreal, MD, PhD
Dr. Julian E. Villarreal died of liver cancer on January 17, 1995.
Julian, as he was known to many of his many friends and colleagues, was born in Mexico City on April 10, 1937. Upon receiving the MD degree from the Univer- sity of Mexico in 1960, he traveled north to Ann Arbor to enter the graduate program of the Department of Pharmacology of The University of Michigan. Julian completed a doctoral research project under the supervi- sion of Dr. Edward Domino. Before Julian had a chance to write and defend his doctoral dissertation, Dr. Maurice Seevers, Chairman of the Department, tapped him to take over the “monkey laboratory” that Seevers had established years earlier to study the phenomenon of physical dependence to opiate analgesics. As an In- structor, Assistant Professor, and Associate Professor of Pharmacology, Julian directed the research activities of the laboratory, studying opiate tolerance and physical dependence in rhesus monkeys and other laboratory animals. Under the auspices of the Committee (now College) on Problems of Drug Dependence, he screened
hundreds of coded compounds for their capacity to pro- duce morphine-like physical dependence in the rhesus monkey. Julian eventually received the Ph.D. degree from The University of Michigan, after writing and defending a doctoral dissertation on the original opiate research that he performed while he was director of the laboratory.
Julian returned to Mexico city with his growing fami- ly in the early 1970s. Over a IO-year period he was af- filiated with the Miles Institute of Experimental Therapeutics, first as Director of Behavioral Pharmacol- ogy, then as Director of the Institute. Subsequently, he returned to the National University of Mexico as Pro- fessor of Pharmacology, finishing his career as Chair- man of the Department. He took a two-year leave from the University to serve the people of Mexico as Director General of the Drug Regulation Office, Mexican Health Secretariat, an office analogous to the Commissioner of the Food and Drug Administration in the United States.
Julian will be remembered for his innovative research and his enviable ability to theorize. He introduced pupilography and measurement of core body tempera- ture as means of quantifying the acute effects of opiate drugs and the intensity of opiate withdrawal in mon- keys. He developed a paradigm of aversive social inter-
0376-8716/95/$09.50 0 1995 Elsevier Science Ireland Ltd. All rights reserved SSDI 0376-8716(95)01149-?
74 News /Drug and Alcohol Dependence 39 (1995) 73-74
action between monkeys in order to study the effects of drugs on punished behavior in a manner that closely paralleled situations likely to occur with a human sub- ject population. As the new class of mixed-action opioids - drugs with both agonist and antagonist pro- perties - began to gain prominence, Julian played a leading role in characterizing in the monkey the then- unique pharmacology of these compounds. He publish- ed some of the earliest review articles describing the reduced physical dependence potential of mixed-action opioids relative to morphine, and helped organize inter- national scientific meetings to promote exchange of in- formation and ideas about these drugs. In his more recent publications, Julian focused on developing theo-
retical constructs for the states of opioid dependence and withdrawal.
Julian Villarreal was a true scholar who could address with equal cogency and aplomb the major social issues of the time and how seasonal variations in the makeup of alfalfa might affect responses of the isolated guinea- pig ileum to opiate drugs. He was a delightful and sup- portive mentor and colleague. We will miss his in- sightfulness, his self-deprecating manner, his unflaggin- gly cheerful demeanor, and his friendship. We extend our sincerest condolences to Julian’s lovely and loving family.
Prepared by: Stephen G. Holmnan, PhD, and James H. Wo&, PhD
