New Targets in Osteoporosis Therapy - eft-aktuell.ch · 2013-09-11 · Neue Targets in der...
Transcript of New Targets in Osteoporosis Therapy - eft-aktuell.ch · 2013-09-11 · Neue Targets in der...
Neue Targets in der Osteoporosetherapie 12 New Targets in Osteoporosis Therapy F. Jakob, L. Seefried, P. M. Jehle
„Solche Daten zeigen, dassdie Interfaces, die der Knochenzu anderen Organsystemenaufweist, sei es dasImmunsystem, die Muskulaturoder der Stoffwechsel,bislang erheblich unterschätztwurden und dass hierhochinteressante Entwicklungenmöglich sind, die über denKnochen alleine hinausgehen.“
Science 3 June 2005 Vol. 308. no. 5727, pp. 1456 - 1460
Science 3 June 2005 Vol. 308. no. 5727, pp. 1456 - 1460
Science 3 June 2005 Vol. 308. no. 5727, pp. 1456 - 1460
Ca
mammopoesis
RANK Ligand
menstruation menstruationovulation
E2 P
IL6 IL6 IL6 IL1
resorption of bone synthesis of bone
osteoclast osteoblaststeadystate
IL6IL6
determination proliferation differentation polarisation resorption
PV1 M-CSF
ranklc-fosNFB
V2TRAF6CSr6
cathepsin kcarbone
anhydrase IIH+-ATPase
The breast and the skeleton communicate during lactation to provide a steady supply of calcium for milk production.
Wysolmerski J J JCEM 2012;97:2947-2956
©2012 by Endocrine Society
PTHrPIL6
Osteoklasten GM-CSF
Ca
NFkB
Wachstumsfaktoren
FornarinaLancet, 360, 2061 Fornarina
Bone and the epidermo-pilosebaceous unit of the skin share alifelong renewal activity where similar molecular players operate,and because mammary glands and hair follicles are both skin
appendages
Das Progesteron bereitet den weiblichen Körper auf die
Fortpflanzung vor
Antirheumatika
unter 30 J.12%
30-39 J.14%
40-54 J.24%
55-64 J.21%
65+ J.29%
Alterstruktur Männer (22 Mio. Verordnungen)
Alterstruktur Frauen(32 Mio. Verordnungen)
unter 30 J.9%
30-39 J.9%
40-54 J.19%
55-64 J.18%
65+ J.45%
Quelle: IMS Health, VIP
50%50%63%
37%bis 54 ab 54 bis 54
ab 54
Factors mediating luteal ce ll apoptosis in humans. The Fas and Fas-ligand and Bcl-2 and Bax systems are involved in the intracellu lar signaling pathway for apoptosis, and apoptosis is induced by caspase-3 activation. Cytokines may also be involved inapoptosis. HCG works as a survival factor by regulating apoptosis-related factors, such as Fas, the Bcl-2 and Bax syst em and survivin
9 MAY 2 0 1 3 | VO L 4 9 7 | N AT U R E | 2 1 1
Adiponectin
Cell 130, 456
Osteoblast
Osteocalcin
Leptin
Adipozyt
Osteocalcin-ZellenInsulin
Adiponectin
Pankreas
Osteocalcin, a bone-derived multifunctional hormone. Undercarboxylated osteocalcin stimulates insulin secretion and β-cell proliferation in the pancreas, energy expenditure by muscle, and insulin sensitivity in adipose tissue, muscle and liver. In addition, it promotes male fertility by stimulating testosterone synthesis in Leydig cells of the testis through the activation of its receptor, GPRC6A, in these cells.
Der zum Diabetes neigende Stoffwechsel und die Überproduktion an Androgenen verringern die Energieverluste durch Wärme und sorgen für den Aufbau von Fettdepots. Insulin trägt zusammen mit dem Hormon Leptin, das Appetit und Fettmasse reguliert, zum Erhalt von Energiebalance und der Funktion der Eierstöcke be
Leider wendet sich dieser evolutionsbiologisch angelegte Vorteil in Zeiten hochkalorischer Nahrungszufuhr ins Gegenteil
Our results show for the first time that female O/PCOS-prone rats gain a survival advantage over their lean-prone congenics when confronted with a challenge of time-limited feeding and an opportunity for food-related activity
The longer survival of female O/PCOS-prone rats compared with their lean-prone congenics relates to higher baseline energy reserves, greater
When leptin signaling is defective, as in the O/PCOS-prone rats, the energy homeostasis pathway involving feeding-related peptides, such as neuropeptide Y, is impaired. This impairment results in increased appetite, decreased energy expenditure, and greater fat accumulation—effects that are advantageous for survival in the AAC
Leider wendet sich dieser evolutionsbiologisch angelegte Vorteil in Zeiten hochkalorischer Nahrungszufuhr ins Gegenteil
MESENCHYMAL STEM CELLS
MYOBLAST CHONDROCYT OSTEOBLAST ADIPOCYTE
24 OCTOBER 2008 VOL 322 SCIENCE