New Insight Into the Human Genome Through the Lens of

Evolution and decode Mystery Sequences Involved

in Gene Regulation.  

Christian Sánchez Valencia Medicine Student III Semester Molecular BiologyUPB 

 

Abstract Thanks to advancing technological age in which we

live today, it is possible that the field of research has taken such force, such as molecular biology

and his constant study of the sequences involved in gene regulation to give as result the main carrier of

such information: DNA.

DNA is the starting point for the perfect compression of human functioning, demonstrated

by comparison of genetic information between men of the past and those of us in the present. finding

vital changes that help the study of various pathologies.

This important molecule has been used for the diagnosis and treatment of many diseases, so it is

vital to speak and learn about structure and interaction with other components of the human body, hoping each time finding new alternatives

that benefit humans.

New Insight Into the Human Genome Through

the Lens of Evolution. July 11, 2013. 

A new study shows that possibly up to 30% of DNA , is also conserved at the level of RNA structure, through a process known as 'transcription‘.

New Insight Into the Human Genome Through the Lens of Evolution. July 11, 2013. 

DNA is a biological blueprint that must be copied into another form before it can be actualized. Through a process known as 'transcription', DNA is copied into RNA, some of which 'encodes' the proteins that carry out the biological tasks within our cells. Most RNA molecules do not code for protein, but instead perform regulatory functions, such as determining the ways in which genes are expressed.

New Insight Into the Human Genome Through the Lens of

Evolution. July 11, 2013. 

Dr Martin Smith and Professor John Mattick, from Sydney's Garvan Institute of Medical Research, devised a method for predicting these complex RNA structures, At the same time, they matched mutations found in the genomes with consistent RNA structures. 

New Insight Into the Human Genome Through the Lens of Evolution. July 11, 2013. 

Many RNA transcripts are associated with diseases and developmental conditions, this is the first step. The next is describe the relate to our normal development and to disease. 

New Insight Into the Human Genome Through the Lens of

Evolution. July 11, 2013. 

Personal comment 

It's really amazing how DNA and RNA are the basis of many human

body pathological explanations given by the evolution of their

studies. Is important stand out as will be possible in the future diagnosis and treatment of

diseases from the same DNA line before transcrip into RNA,

becoming a therapeutic method with benefits for humans.

Scientists Decode Mystery Sequences Involved in

Gene Regulation. July 10, 2013 

  Scientists know that much of

what a gene does and produces is regulated after it is turned on. A gene first produces a molecule

called RNA, to which tiny proteins called RNA binding proteins

(RBPs) bind and control its fate. For instance, some of these

proteins cut out parts of the RNA molecule so that it makes a

particular protein, while other RBPs help destroy the RNA before

it even produces a protein.

Scientists Decode Mystery Sequences Involved in Gene

Regulation. July 10, 2013    The mechanisms that may benefit or affect RNA

chain are not well known, have been difficult to decipher. To understand this regulation is necesary advanced laboratory techniques to identify patterns of RNA sequences

This motivate Tim Hughes (University of Toronto and the Canadian Institute for Advanced Research) to produce the first compendium of RNA-binding sequences with a modern advanced laboratory techniques. 

Scientists Decode Mystery Sequences Involved in Gene Regulation. July 10, 2013   

Scientists Decode Mystery Sequences Involved in Gene

Regulation. July 10, 2013   

Was a long study that needed many years finding complexes that bind specifically to the RNA at the end of its transcription and cause dysregulation in gene expression, generating many diseases such as autism. Therefore its study is useful. 

Scientists Decode Mystery Sequences Involved in Gene Regulation. July 10, 2013   

Personal comment 

Its very interesting to see how since the search of complexes that bind to RNA different diseases can be diagnosed as autism example of this investigation, but it is still more interesting because knowing these sequences are targeted to produce medicines and treatments to help to the correction of these genes prevents pathologies own treating them from the genetic line. 

Medical Utility Its very important for

medicine because open a big therapeutic field, treating of diseases in

the DNA own chain. 

Medical Utility Its very interesting for

medicine, with the study of the genome can be discovered genetic disorders that result in changes in behavior or physical appearance in humans before born. 

Medical Utility For medicine is very useful

to know which specific complex is causing damage,

so that it acts directly on the fault, preventing accidental cause any

damage to the patient but with a benefit the cure of

the disease. 

Medical Utility

Be able to identify specific abnormalities in a DNA laboratory exam and warn of the possible consequences that the patient can have for this damage. 

References MARTINEZ SANCHEZ, Lina María. Biología Molecular. 7 ed. Medellín: UPB. Facultad de Medicina. 2013.

New Insight Into the Human Genome Through the Lens of Evolution. [on line] Science daily. July 11, 2013.

.Scientists Decode Mystery Sequences Involved in Gene Regulation. [on line] Science daily. July 10, 2013

Thanks !!!