New Approaches to Vaccines for Human and Veterinary ...

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New Approaches to Vaccines for Human and Veterinary Tropical Diseases May 22–26, 2016 Southern Sun Cape Sun | Cape Town | South AfricaScientific Organizers: Vish Nene, Vishva M. Dixit, Rafi Ahmed and Yasmine Belkaid

Part of the Keystone Symposia Global Health SeriesHuman and livestock vaccines can contribute to improved human welfare and income generation by maintaining human health and meeting the demand for meat, milk and fish in developing countries. All of these factors contribute to the growing importance of improving food safety, availability and nutritional security. An important component of this Keystone Symposia meeting will be to stimulate crosstalk between the human and veterinary vaccine communities by highlighting cross-cutting technical advances and new science and knowledge from laboratory and field research. The meeting will also provide a rare opportunity for scientists from the Northern and Southern hemispheres to interact and pool resources and knowledge in the common fight against tropical diseases.

Session Topics: • The Challenge of Helminth Vaccines• Human and Bovine Tuberculosis• Vaccination Strategies for Malaria• Vaccination Strategies for East Coast Fever in Cattle• New Approaches to Viral Vaccines

Submitting an abstract is a great way of participating in the conference through poster presentation and possible selection for a short talk.Global Health Travel Award Deadline: Dec 22, 2015 Scholarship & Discounted Abstract Deadline: Jan 21, 2016Abstract Deadline: Feb 23, 2016Discounted Registration Deadline: Mar 22, 2016For additional details, visit www.keystonesymposia.org/16M1.

www.keystonesymposia.org/meetings | 1.800.253.0685 | 1.970.262.1230a 501(c)(3) nonprofit educational organization

• Understanding Immune Responses to Inform Vaccine Design• Profiling Immune Responses to Infection and Vaccines• Synthetic Genomics-Based Vaccinesplus four workshops

SUNDAY, MAY 22Arrival and Registration

MONDAY, MAY 23Welcome and Keynote Address *Vish Nene, International Livestock Research Institute, KenyaGuy Palmer, Washington State University, USAVaccination as a Driver to Achieve the Sustainability DevelopmentGoals

The Challenge of Helminth Vaccines *Vish Nene, International Livestock Research Institute, KenyaBen Makepeace, University of Liverpool, UKThe Onchocerciasis Vaccine for Africa Initiative: A Critical Role forCattleDonald A. Harn, University of Georgia College of VeterinaryMedicine, USADeveloping Schistosome Vaccines for People and LivestockMarshall Lightowlers, University of Melbourne, AustraliaEffective Recombinant Vaccines against Cysticercosis and CysticEchinococcosisRebecca Katie Shears, University of Manchester, UKShort Talk: Vaccine Design for Whipworm: Type 2 Cytokine InducingAntigens from Trichuris

Workshop 1 *Thomas J. Scriba, University of Cape Town, South AfricaMpala Mwanza, Tropgan University Teaching Hospital, ZambiaRetinoic Acid Elicits a Coordinated Expression of Gut Homing Markerson T Lymphocytes with Oral Typhoid, But Not Viral, Vaccines inZambian MenEren Zink, Uppsala University, SwedenAfrican Experiences of International Collaboration in Research onTropical Diseases: A Qualitative Study of Scientists in Uganda,Ghana and ZimbabweDawit Gebreegziabiher Hagos, Mekelle University, EthiopiaThe Effect of Maternal Helminth Infection on Maternal and NeonatalImmune Function and Immunity to TuberculosisKatja Becker, University of Zurich, SwitzerlandMolecular Characterization of Posttranslational Modifications inMycobacterial LipoproteinsMurad R. Mamedov, University of California, San Francisco, USAHighly Focused Post-Acute gammadelta T Cell Response to Mouseand Human Malaria

Human and Bovine Tuberculosis *Yasmine Belkaid, NIAID, National Institutes of Health, USAHelen McShane, Jenner Institute, UKClinical Trials with New TB VaccinesCarlos Martin, University of Zaragoza, SpainMTBVAC: An Attenuated Vaccine based on the Human PathogenMycobacterium tuberculosis in Clinical Trials

Glyn Hewinson, Animal & Plant Health Agency, UKA One Health Approach to Developing Vaccines against BovineTuberculosisThomas J. Scriba, University of Cape Town, South AfricaT Cell Differentiation: Implications for Tuberculosis VaccineDevelopmentVirginie Rozot, University of Cape Town, South AfricaShort Talk: Deep Immuno-Phenotyping and Functional Assessment ofLeukocyte Responses to M. Tuberculosis using Cytometry byTime-of-Flight

Poster Session 1

TUESDAY, MAY 24Vaccination Strategies for Malaria *Helen McShane, Jenner Institute, UKWilliam Ballou, GlaxoSmithKline, USARTS/S - Current StatusThomas L. Richie, Sanaria Inc., USAThe March toward Licensure and Deployment of a Highly ProtectivePfSPZ Malaria Vaccine Shahid Khan, Leiden University Medical Center, NetherlandsDevelopment of Genetically Attenuated Parasite (GAP) Vaccineagainst MalariaAdrian V. S. Hill, Jenner Institute, University of Oxford, UKImproving Pre-Erythrocytic Malaria Subunit VaccinesJulius C. R. Hafalla, London School of Hygiene and TropicalMedicine, UKShort Talk: Broad Repertoire of the CD8+ T Cell Response to MalariaPre-Erythrocytic Stage Infection

Poster Session 2 Workshop 2 *George Warimwe, University of Oxford, UK*Søren Buus, University of Copenhagen, DenmarkSara Suliman, University of California, San Francisco, USABCG Revaccination of Latently Mycobacterium tuberculosis (M.tb)Infected Adults Induces Durable Unconventional Immune ResponsesBrandon Sack, Center for Infectious Disease Research, USAA Phase 1 Trial to Assess the Safety, Attenuation andImmunogenicity of Genetically-attenuated p52-/ p36-/sap1- GeneKnockout Plasmodium falciparum Parasites Anne Rechtien, University Medical Center Hamburg-Eppendorf,GermanyA Signature of Early Innate Immune Markers Predicts GP-SpecificAntibody Responses following Vaccination with the Ebola VaccinerVSV-ZEBOV Ismaila Shittu, National Veterinary Research Institute, NigeriaHighly Pathogenic Avian Influenza (H5N1) Diagnosis in Nigeria, 2015:Widespread Involvement of Co-Infection with Infectious Bronchitis andNewcastle Disease VirusesClement Adebajo Meseko, National Veterinary Resesrch Institute,Vom, NigeriaIsolation and Molecular Characterization of P4b Core Protein ofRecent Field Cases of Fowl Poxvirus in Nigeria Compared to VaccineStrain

* Session Chair † Invited but not yet accepted Program current as of January 6, 2022. Meal formats are based on meeting venue. For the most up-to-date details, visit https://www.keystonesymposia.org.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

New Approaches to Vaccines for Human and Veterinary Tropical Diseases (M1)May 22-26, 2016 • Southern Sun Cape Sun • Cape Town, Western Cape, South Africa

Scientific Organizers: Vish Nene, Vishva M. Dixit, Rafi Ahmed and Yasmine BelkaidPart of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation. Supported by: Robert Bosch Stiftung

GmbHGlobal Health Travel Award Deadline: December 22, 2015 / Discounted Abstract & Scholarship Deadline: January 21, 2016 / Abstract Deadline: February 23, 2016 / Discounted

Registration Deadline: March 22, 2016

Karl Dietrich Brune, University of Oxford, UKPlug-and-Display: Genetically Encoded Superglue for Decoration ofVirus-Like and Nano-Particles

Vaccination Strategies for East Coast Fever in Cattle *Shahid Khan, Leiden University Medical Center, NetherlandsVish Nene, International Livestock Research Institute, KenyaB-Cell Vaccines against East Coast FeverIvan Morrison, University of Edinburgh, UKVaccination against Theileria Parasites by Induction of T CellResponsesJoana Carneiro da Silva, University of Maryland School of Medicine,USAGenomics of Vaccine Efficacy: Lessons from the Buffalo WildlifeReservoir of East Coast FeverJerome Nyhalah Dinga, University of Buea, CameroonShort Talk: Immune Responses to TpUB05: A Homologue ofPlasmodium falciparum UB05 Antigen, is Indicative of ProtectiveImmunity against East Coast Fever

WEDNESDAY, MAY 25New Approaches to Viral Vaccines *William T. Golde, Moredun Research Institute, UKLouis F. Fries III, Novavax, Inc., USARecombinant Nanoparticle Vaccines: Respiratory and EmergingVirusesRafi Ahmed, Emory University School of Medicine, USASustained Immune Activation in Ebola Virus Infected PatientsGeorge Warimwe, University of Oxford, UKOne Health Vaccinology for Emerging Infectious DiseasesBryan Charleston, Pirbright Institute, UKStructural Enhancements to Foot-and-Mouth Disease VaccinesAshley St. John, Duke-NUS Medical School, SingaporeShort Talk: Serocomplex Cross-Reactive Immunity Primes forProtection during Flavivirus Infections

Understanding Immune Responses to Inform Vaccine Design *Rafi Ahmed, Emory University School of Medicine, USABali Pulendran, Stanford University School of Medicine, USASystems VaccinologyYasmine Belkaid, NIAID, National Institutes of Health, USAVaccine Responses and Commensal Control of Tissue ImmunityWilliam T. Golde, Moredun Research Institute, UKAnalysis of T and B Lymphocyte Responses to RecombinantVaccines for Foot-and-Mouth Disease (FMD)Denise L. Doolan, James Cook University, AustraliaShort Talk: Systems-Based Characterization of Immunity toPlasmodium Infection in Humans

Poster Session 3

THURSDAY, MAY 26Profiling Immune Responses to Infection and Vaccines

*Vishva M. Dixit, Genentech, Inc., USASøren Buus, University of Copenhagen, DenmarkLarge-Scale Mapping of T Cell EpitopesWilliam H. Robinson, Stanford University School of Medicine, USAAntibody Discovery via Single B Cell AnalysesSachdev S. Sidhu, University of Toronto, CanadaSynthetic Proteins as Therapeutics for Infectious DiseaseChristine Dahlke, University Medical Center Hamburg-Eppendorf,GermanyShort Talk: Safety and Reactogenicity of rVSV-ZEBOV: Phase I Trialin Germany

MConf Demonstration: Virtual Tour Kasandra Pillay, Meraka Institute, South AfricaMConf is a web conferencing and collaboration tool for Research andEducation

Workshop 3: Bioinformatics in Vaccine Design *Joana Carneiro da Silva, University of Maryland School of Medicine,USAPenny L. Moore, University of the Witwatersrand and NationalInstitute for Communicable Diseases, South AfricaHIV and Antibody Dynamics: Implications for Vaccine DesignEdward P. Rybicki, University of Cape Town, South AfricaDesigning Vaccines to be Made in PlantsDean Everett, Malawi-Liverpool-Wellcome Trust Clinical ResearchProgramme, MalawiDeveloping Appropriate Vaccines through Bioinformatics in AfricaW. Florian Fricke, University of Hohenheim, GermanyAutomated and Interactive Comparative Genomics Tools for theIdentification of Vaccine Candidates

Synthetic Genomics-Based Vaccines *Vish Nene, International Livestock Research Institute, KenyaRino Rappuoli, GlaxoSmithKline Vaccines, ItalyOpportunities and Challenges for VaccinesSanjay Vashee, J. Craig Venter Institute, USASynthetic Bacterial and Viral Backbones as Antigen Delivery Vehicles

Closing Keynote Address *Vishva M. Dixit, Genentech, Inc., USAChris Wilson, Bill & Melinda Gates Foundation, USACross-Disciplinary Science to Accelerate the Discovery of Vaccines forGlobal, Zoonotic and Emerging Infectious Diseases

FRIDAY, MAY 27Departure







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