Neuroscience Cellular and molecular neuroscience Neuroanatomy Systems neuroscience.
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Transcript of Neuroscience Cellular and molecular neuroscience Neuroanatomy Systems neuroscience.
Neuroscience
• Cellular and molecular neuroscience
• Neuroanatomy
• Systems neuroscience
The astonishing hypothesis
• Perception
• Thought
• Emotion
• Memory
• Consciousness
• Material processes in vast networks of neurons
• “You’re nothing but a pack of neurons.”
Perception
• Where physics meets psychology
• Vision
• Hearing
• Touch
• Etc.
Light
• Photon energy = Planck’s constant x
frequency
• Wavelength x frequency = speed of light
Wavelength
Amplitude
Figure by MIT OCW.
Electromagnetic spectrum
• White = superposition of all frequencies.
Gam
ma
rays
X-r
ays
Ultr
a-vi
olet
rays
Infr
ared
rays
Rad
ar
Bro
adca
stba
nds
AC
circ
uits
Visiblelight
Violet Red
Higherenergy
LowerenergyWavelength (nm)
Figure by MIT OCW.
Why is “visible” where it is?
• Notch in water absorption spectrum
• “Visible” light is what is available in the ocean.
• Evolution has exploited this fact.
Image removed due to copyright reasons. Please see figure on page 291 in: Jackson, John David.Classical Electrodynamics. 3rd ed. New York: Wiley, 1999. ISBN: 047130932X.
Reflection and absorption
• Lightness - Dark objects absorb more than light ones
• Color - Frequency-dependent absorption
Reflection Absorption
Figure by MIT OCW.
Refraction
Figure by MIT OCW.
Functions of the eye
• Forming a stable image on the retina
• Emphasizing spatial and temporal differences in images
Gross anatomy of the eye
Figure by MIT OCW. After figure 9.4 in:Bear, Mark F., Barry W. Connors, and MichaelA. Paradiso. Neuroscience: Exploring the Brain.2nd ed. Baltimore, Md.: Lippincott Williams &Wilkins, 2001. ISBN: 0683305964.
Opthalmoscopic view
Image removed due to copyright reasons. Please see figure 9.5 in: Bear, Mark F., Barry W.Connors, and Michael A. Paradiso. Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.:Lippincott Williams & Wilkins, 2001. ISBN: 0683305964.
Blind spot demo
Figure by MIT OCW. After Box 9.1 in: Bear, Mark F., Barry W. Connors, and Michael A. Paradiso.Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins, 2001.ISBN: 0683305964.
Further reading:V.S. Ramachandran and S. Blakeslee, Phantoms in the Brain
Filling in
Figure by MIT OCW. After Box 9.1 in: Bear, Mark F., Barry W. Connors, and Michael A. Paradiso.Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins, 2001.ISBN: 0683305964.
Moral: perception is an active process.“Seeing is believing.”“Believing is seeing.”
Cross-sectional anatomy
Figure by MIT OCW. After: Bear, Mark F., Barry W. Connors, and Michael A. Paradiso.Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins,2001. ISBN: 0683305964.
Refraction by the cornea
Figure by MIT OCW. After figure 9.7 in: Bear, Mark F., Barry W. Connors, and Michael A. Paradiso.Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins, 2001.ISBN: 0683305964.
Focal Distance
Refractive Power (Dlopters)
Focal Distance (m)
Accommodation
Figure by MIT OCW. After figure 9.8 in: Bear, Mark F., Barry W. Connors, and Michael A. Paradiso.Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins, 2001.ISBN: 0683305964.
Visual field
Figure by MIT OCW. After figure 9.9 in: Bear, Mark F., Barry W. Connors, and Michael A. Paradiso.Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins, 2001.ISBN: 0683305964.
Retinal images are inverted.
Visual angle
Figure by MIT OCW. After figure 9.10 in: Bear, Mark F., Barry W. Connors,and Michael A. Paradiso. Neuroscience: Exploring the Brain. 2nd ed.Baltimore, Md.: Lippincott Williams & Wilkins, 2001. ISBN: 0683305964.
• Distance on the retina corresponds to visual angle.
• 20/20 vision= resolution of 1/12 degree
Retinal circuitryOutput
Ganglion cell axonsProjecting to forebrain
Amacrinecell
Bipolarcell
Horizontalcell
Direct pathway
Ganglion cells
Photoreceptors
Input
Figure by MIT OCW. After figure 9.11 in: Bear, Mark F., Barry W. Connors, andMichael A. Paradiso. Neuroscience: Exploring the Brain. 2nd ed.Baltimore,Md.: Lippincott Williams & Wilkins, 2001. ISBN: 0683305964.
Laminar organization
Figure by MIT OCW. After figure 9.12 in: Bear, Mark F., Barry W. Connors, and Michael A. Paradiso.Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins,2001. ISBN: 0683305964.
Ganglion Cell Layer
Inner Plexiform Layer
Inner Nuclear Layer
Outer Plexiform Layer
Outer Nuclear Layer
Layer of Photoreceptor Outer Segments
Pigmented Epithelium
Rods and cones
Figure by MIT OCW. After figure 9.13 in: Bear, Mark F., Barry W. Connors, and Michael A.Paradiso. Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins,2001. ISBN: 0683305964.
Cell bodies
Scotopic/nightVision 1000 x moreLight sensitive
photoreceptor
Synapticterminals
Inner segments
Photopic/day visionColor vision
Outer segments
ConePhoto-recepto
Spatial organization
• Photoreceptors less dense in periphery
• Ratio of photoreceptors to ganglion cells higher in the periphery
• Acuity is lower, sensitivity higher in the periphery
Images removed due to copyright reasons. Please see figures 9.14 a and b in: Bear, Mark F., BarryW. Connors, and Michael A. Paradiso. Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.:Lippincott Williams & Wilkins, 2001. ISBN:0683305964.
Fovea in cross section
Figure by MIT OCW. After figure 9.15 in: Bear, Mark F., Barry W. Connors, and Michael A. Paradiso.Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins, 2001.ISBN: 0683305964.
Lateral displacement of ganglion cells at fovea improves acuity
Neurotransmission and phototransduction
Figure by MIT OCW. After figures 9.16 a and b in: Bear, Mark F., Barry W. Connors, and Michael A.Paradiso. Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins,2001. ISBN: 0683305964.
Response to light
• Dark current due to open sodium channels
• Light depletes cGMP, closing sodium channels
Figure by MIT OCW. After figures 9.17 a and b: Bear, Mark F., Barry W. Connors, and Michael A.Paradiso. Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins,2001. ISBN: 0683305964.
Rhodopsin photoactivation
Figure by MIT OCW. After figure 9.18 in: Bear, Mark F., Barry W. Connors, and Michael A. Paradiso.Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.: Lippincott Williams & Wilkins, 2001.ISBN: 0683305964.
Opsin has seven transmembrane alpha helices, like other GPCRs
Signaling cascade
Images removed due to copyright reasons. Please see figures 9.19 a and b in: Mark F. Bear, BarryW. Connors, Michael A. Paradiso. Neuroscience: Exploring the Brain. 2nd ed. Baltimore, Md.:Lippincott Williams & Wilkins, 2001. ISBN: 0683305964.
Chemical amplification
• Each rhodopsin activates many G-proteins
• Each PDE converts many cGMPs
• Detection of a single photon is possible!
Further reading:B. Sakitt, Counting every quantum, J. Physiol. (London) 223:131-150, 1972.P.B Detwiler et al., Engineering aspects of enzymatic signal transduction: photoreceptors in the retina, Biophys. J. 79:2801-17 (2000).R.W. Rodieck, The first steps in seeing, Sinauer (1998).