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Frontiers in Neuroscience & Neuroengineering Series ............................................3

Clinical Neuroscience................................................16

Neuroscience ............................................................23

Lab Animal Science ..................................................27

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New!

Alzheimer'sDiseaseTargets for NewClinical Diagnosticand TherapeuticStrategies Edited by

Renee D. WegrzynPhD, Adlyfe, Inc., Rockville, Maryland, USA

Alan S. RudolphPhD, MBA, Center for Neuroengineering, Duke University,Durham, North Carolina, USA

In recent years, a tremendous amount of effort hasbeen focused on better understanding the fundamen-tals of Alzheimer’s disease (AD) to facilitate early andaccurate diagnosis and appropriately targeted thera-peutic treatments. Alzheimer’s Disease: Targets forNew Clinical Diagnostic and Therapeutic Strategiesprovides a detailed synopsis of the current state of theart of diagnostics and therapeutics and identifiesemerging technologies and molecules that show prom-ise in the management and treatment of AD.

With contributions from experts drawn from acade-mia, clinical practice, and the biotechnology andpharmaceutical industries, the book explores:• The basis of AD and the role of Aβ oligomers indevelopment of disease

• Existing and emerging in vitro biomarker-basedmethodologies for the diagnosis of AD, focusingon genetic, biochemical, and conformationalstrategies

• In vivo imaging diagnostic approaches• Evolving diagnostic criteria, health regulatoryguidelines, biomarkers in clinical trials, and available and emerging therapies

• Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emergingneuroprotective/neurorepair approaches

• How a case study of AD raises issues regardingclinical and pathologic criteria, risk factors, andthe amyloid hypothesis

• The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could representnew targets for disease-modifying therapies

• The latest epidemiological, pathological, bio-chemical, and behavioral studies that may shedsome light on the risk of developing AD andsimilar dementias after traumatic brain injury

Examining current hypotheses and suggesting possi-ble new approaches to therapeutic clinical applica-tions, this volume paves the way for a robust pipelineof therapeutics to combat not only AD, but a wholehost of other neurodegenerative diseases.

Catalog no. K11334, April 2012, 298 pp.ISBN: 978-1-4398-2708-6, $149.95 / £95.00Also available as an eBook

New!

TheNeurobiologicalBasis of SuicideEdited by

Yogesh DwivediUniversity of Illinois at Chicago,USA

With recent studies using genetic, epigenetic, andother molecular and neurochemical approaches, anew era has begun in understanding the pathophysi-ology of suicide. Emerging evidence suggests thatneurobiological factors are not only critical in provid-ing potential risk factors but also present a promisingapproach to developing more effective treatment andprevention strategies. The Neurobiological Basis ofSuicide discusses the most recent findings in suicideneurobiology.

Psychological, psychosocial, and cultural factors areimportant in determining the risk factors for suicide;however, they are often weak predictors and can beof less clinical use. Interestingly, cognitive characteris-tics are different among depressed suicidal anddepressed nonsuicidal subjects, and could be involvedin the development of suicidal behavior.

The characterization of the neurobiological basis ofsuicide is in delineating the risk factors associated withsuicide. This volume focuses on how and why theseneurobiological factors are crucial in the pathogenicmechanisms of suicidal behavior and how these find-ings can be transformed into potential therapeuticapplications.

Features:

• Presents cutting-edge research on the neurobiology of suicide

• Covers the rapidly growing field of suicideresearch, including gene expression, microRNA,genetics, epigenetics, and the molecular basis of suicide

• Discusses how recent neurobiological approach-es may transform suicide treatment modalities

• Addresses neurochemical/neuroanatomical/neuropathological approaches, geneticapproaches, intermediate endophenotypes, and epigenetic approaches

Catalog no. K11764, June 2012, 482 pp.ISBN: 978-1-4398-3881-5, $149.95 / £95.00Also available as an eBook



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Forthcoming!

TranscranialBrainStimulationEdited by

Carlo MiniussiUniversity of Brescia-IRCCS FBF,Italy

Walter PaulusGeorg-August University of Gottingen, Germany

Paolo M. RossiniUniversity Campus Bio Medico, Roma, Italy

Recent years have seen the introduction and rapiddevelopment of non-invasive brain stimulation tech-niques, such as transcranial magnetic stimulation(TMS) and transcranial electrical stimulation.Transcranial Brain Stimulation reviews these recentadvances made in the understanding of brain stimu-lation techniques. The text presents the wide range ofpossible brain stimulation applications in combinationwith neuroimaging and discusses what new informa-tion can be gained from using this technique on thedynamics of brain functions, hierarchical organization,and effective connectivity. With this timely resource,the authors aim to make a substantial impact onmany areas of clinical and basic neuroscience.

Contents:

Basic Aspects. Methodological Aspects of TMS(Including Coils Design). Physiological Basis of TMS(Including Waveform and Current Direction InducedEffects etc.). Effects of Electric and Magnetic Fields:Study in Animal Models and In Slice. MethodologicalAspects and Physiological Basis and of tES (i.e., tDCS;tRNS; tACS). Biophysical Foundations: FromNeuronal to Current Distribution Model of TMS andtES. Patterned Protocols of TMS. Motor Cortical andCorticospinal Measures in Health and Disease. BrainStimulation, Functional Neuroanatomy of CorticoConnectivity and Mechanisms of Neuroplasticity.Understanding Homeostatic Plasticity. Safety ofTMSand tES. Biology. Brain Stimulation and MolecularMarkers. Imaging-Brain Mapping. Non Invasive BrainStimulation and Neuroimaging (Including NavigatedBrain Stimulation). Perception and Cognition. TMS -tES in Perception and Cognitive Functions.Therapeutic Applications. TMS - tES TherapeuticApplications in Psychiatry. TMS - tES TherapeuticApplication in Neurology.

Catalog no. K13512, December 2012, c. 464 pp.ISBN: 978-1-4398-7570-4, $159.95 / £99.00Also available as an eBook

Dopamine –GlutamateInteractions inthe BasalGangliaEdited by

Susan JonesUniversity of Cambridge, UK

The basal ganglia are involved in complex brain func-tions and are implicated in numerous neurologicaland psychiatric disorders. At the heart of both func-tion and dysfunction of basal ganglia circuits is theinteraction of dopamine and glutamate. Improvedlabeling, imaging, recording, and genetic manipula-tion approaches have yielded new information onhow dopamine and glutamate interact to generatethe circuit activity underpinning basal ganglia func-tion. This volume presents current insights on individ-ual neurons and synapses, detailed circuit analysis,and learning and action functions of the basal ganglia.It also discusses compromised dopamine–glutamateinteraction in various disorders of basal ganglia func-tion.

Catalog no. 88793, December 2011, 284 pp.ISBN: 978-1-4200-8879-3, $149.95 / £95.00Also available as an eBook

AstrocytesWiring the BrainEdited by

Eliana Scemes andDavid C. SprayAlbert Einstein College ofMedicine, Bronx, New York, USA

Astrocytes play diverse roles in central nervous system(CNS) function and dysfunction, and the connectionsthat the astrocyte makes with other cells of the brainare essential for a variety of important neural tasks.This volume emphasizes cellular connections and sur-veys the most current findings on astrocyte activity.The book identifies major astrocyte biomarkers anddescribes how they define the different connectivitydomains. It examines the role of these connectionsand explains how their function can be manipulatedand how dysfunction of the connectivity leads toaberrant brain performance. The final section exploresthe alterations of glia that have been observed in spe-cific diseases of the brain.

Catalog no. K11240, November 2011, 440 pp.ISBN: 978-1-4398-2584-6, $149.95 / £95.00Also available as an eBook




5



Neurobiology of DepressionEdited by

Francisco López-MuñozUniversity of Alcalá, Madrid,Spain and Camilo José CelaUniversity, Madrid, Spain

Cecilio ÁlamoUniversity of Alcalá, Madrid,Spain

Major depressive disorders have recently been associ-ated with impairments in signaling pathways that reg-ulate neuroplasticity and cell survival. Agentsdesigned to directly target molecules in these path-ways hold promise as new therapeutics for depres-sion. With the collaboration of the most prestigiousinternational specialists in biochemistry, molecularbiology, genomics, psychiatry, psychology, and phar-macology, Neurobiology of Depression discussesthe nature of the central nervous system circuitsresponsible for the modifications of neuronal func-tioning that lead to depression.

The book begins by discussing animal, neurophysio-logical, and neuropsychological models of depressionas well as neural foundations. It explores genetic fac-tors that contribute to depression and describes theeffect of monoaminergic systems in the central nervous system. Next, the book profiles the rise ofpsychopharmacology in the treatment of depressionand the research into serotonin and monoaminereuptake inhibitors. It examines the role of the gluta-matergic, endocannabinoid, and opioid systems inthe pathophysiology of mood disorders, as well as theeffect of biological rhythms on the human body.

Later chapters review the role of CRF-related ligands,CRF receptors, HPA axis activity, and glucocorticoidreceptors in the regulation of the stress response anddepression. They also describe cytokine modulation ofmolecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, andphosphodiesterases, and discuss the use of tachykininantagonists in treatment. Finally, they analyze theneurobiological basis for the development of newantidepressant agents.

Exploring myriad aspects of a disease that plagues alarge percentage of the population worldwide, thisvolume captures the state of the science of this debil-itating disorder, facilitating further research and discovery.

Catalog no. K11746, September 2011, 522 pp.ISBN: 978-1-4398-3849-5, $149.95 / £95.00Also available as an eBook

The NeuralBases ofMultisensoryProcessesEdited by

Micah M. MurrayCIBM, Lausanne, Switzerland

Mark T. WallaceVanderbilt Brain Institute,Nashville, Tennessee, USA

It has become accepted in the neuroscience commu-nity that perception and performance are quintessen-tially multisensory by nature. Using the full palette ofmodern brain imaging and neuroscience methods,this volume details current understanding in the neu-ral bases for these phenomena as studied acrossspecies, stages of development, and clinical statuses.The book examines anatomy and neurophysiologicalbases and how multisensory stimuli can dramaticallychange the encoding processes for sensory informa-tion. It also discusses combinatorial principles andmodeling, development and plasticity, clinical mani-festations, how perception and action are affected byaltered sensory experience, and attention and spatialrepresentations.

Catalog no. K10614, August 2011, 809 pp.ISBN: 978-1-4398-1217-4, $149.95 / £95.00Also available as an eBook

Neurobiology ofSensation andRewardEdited by

Jay A. GottfriedNorthwestern University,Chicago, Illinois, USA

A comprehensive systems overview of sensory andreward processing in the brain, this book exploreswhat reward processing can teach us about the sens-es and what sensory processing can teach us aboutreward. In examining this neurobiological interface,the book reveals how the instrinsic properties of sensory systems effectively define and constrain theambitions of reward-related processing in human andnon-human brains. With contributions from leadinginvestigators in the fields of sensation and reward, thetext injects the “sensory” back into the study ofreward processing, and the "rewarding" back into thestudy of sensory processing.

Catalog no. 67265, March 2011, 466 pp.ISBN: 978-1-4200-6726-2, $149.95 / £95.00Also available as an eBook






Neurobiology of Huntington’sDiseaseApplications to Drug DiscoveryEdited by

Donald C. LoDuke University Medical Center,Durham, North Carolina, USA

Robert E. HughesBuck Institute for Age Research, Novato, California, USA

Highlighting advances in the discovery and develop-ment of new drug therapies for neurodegenerativedisorders, this volume focuses on the many aspects ofthe research on drugs to treat Huntington's disease. Itdiscusses genetics, genomics, and proteomics, andthe latest in high-throughput and high-contentscreening. The authors provide introductory back-ground as well as highly sophisticated information oncurrent and future directions of research. Exploringthe interplay between academic and industrialresearch, the investment community, and non-profitcontributors, the book also examines the practicalrealities of preclinical testing, clinical testing strategies,and, ultimately, clinical usage.

Catalog no. 9000, July 2010, 338 pp.ISBN: 978-0-8493-9000-5, $159.95 / £99.00Also available as an eBook

TheSomatosensorySystemDeciphering theBrain's Own BodyImageEdited by

Randall J. NelsonUniversity of Tennessee,Memphis, USA

Exploring new and past research in the understandingof how the brain deals with its own body image, TheSomatosensory System: Deciphering the Brain'sOwn Body Image provides a review of pertinent lit-erature and offers comprehensive descriptions oftechnical approaches. The material includes newframeworks for the conceptualization of the system'srepresentations, scientific and clinical applications thatstem from these approaches based on the new con-cepts, and a discussion of tools used to study theinterface of the brain and the body.

Features:

• Presents the neurophysiological basis of touchand tactile discrimination deficit

• Describes methods to quantify large-scale brainactivity in behaving animals

• Discusses the neurophysiological basis of plasticneuronal reorganization in adult animals

• Provides computational strategies for sensorimo-tor integration of the mammalian brain

• Includes algorithms for the design and imple-mentation of haptic interfaces and tactile dis-placement

Contents:

Central Organization of the Body Image

The Periphery and its Contribution to the BodyImage

Orientation and the Body Image

Learning and Attention

Applications for Deciphering the Code

Models of the Body Image

Changing the Body Image

Catalog no. 2336, November 2001, 424 pp.ISBN: 978-0-8493-2336-2, $169.95 / £108.00Also available as an eBook

Advances in theNeuroscience ofAddictionEdited by

Cynthia M. KuhnDuke University Medical Center,Durham, North Carolina, USA

George F. KoobThe Scripps Research Institute,La Jolla, California, USA

Featuring contributions from leading experts, thisbook presents an excellent overview of the availableand emerging approaches used to investigate theneurobiological mechanisms of drug addiction.Discussion includes the behavioral strategies and char-acteristics of addiction as well as mechanisticapproaches to understanding the underlying neurobi-ology. The authors provide information from mathe-matical models, model organisms, animal models,and experiments conducted in humans. They delivera comprehensive introduction to the methodologiesof the field for students and beginning researchersand an essential reference source for established inves-tigators.

Catalog no. 7391, April 2010, 238 pp.ISBN: 978-0-8493-7391-6, $145.95 / £93.00Also available as an eBook




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Brain AgingModels, Methods,and MechanismsEdited by

David R. RiddleWake Forest University, Winston-Salem, North Carolina, USA

Bringing together critical studies of brain aging in ani-mal models and insights from human brain imaging,this text focuses on fundamental age-related changesin the brain. Offering significant depth and breadth ofcoverage, it provides an overview of structural andfunctional changes at the molecular, systems, andcognitive levels. Written by pioneering researchers, itreviews unbiased methods for quantifying changesand stereological methods for clarifying the extentand nature of age-related neurological changes. It alsoexplores the distinct methodological challenges inher-ent in investigating the aging nervous system.


SerotoninReceptors inNeurobiologyEdited by

AmitabhaChattopadhyayCenter for Cellular & MolecularBiology, Hyderabad, India

Modulating mood, appetite, sexual activity, bodytemperature, and sleep, serotonin has implications innumerous disease states, including depression, anxi-ety, social phobia, schizophrenia, obsessive-compul-sive disorder, and panic disorder. A comprehensivebook on the subject from a multidisciplinary perspec-tive, Serotonin Receptors in Neurobiology is amongthe first books to be published after serotonin recep-tor knock-out studies. With contributions from leadingexperts in their fields, this book covers a range of topics from contemporary techniques in receptorresearch to fundamental interactions of the 5-HTreceptors with the lipid bilayer to behavioral studies.

Features:

• Assesses the current understanding of physiologically important 5-HT1AR-mediated signaling cascades

• Unravels poorly understood processes that have yet to be delineated through further experiments

• Describes a technique to directly image vesicularsetotonin in live neurons

• Explores methods for the quantitative measure-ment of the intracellular cAMP concentration inliving cells with good spatial and temporal resolution

• Elucidates the emerging roles for calmodulin asa regulator of 5-HT receptor function

• Describes recent work suggesting that calmod-ulin may be a so-called RIP (receptor-interactingprotein) that binds to and modifies the functionsof G protein-coupled 5-HT receptors

Catalog no. 3977, May 2007, 224 pp.ISBN: 978-0-8493-3977-6, $165.95 / £105.00Also available as an eBook

TRP Ion ChannelFunction inSensoryTransductionand CellularSignalingCascadesEdited by

Wolfgang B. LiedtkeDuke University Medical Center, Durham, North Carolina, USA

“ … the most advanced compilation of work in thisarea to date.”

— Anticancer Research

TRP channels have been shown to respond to a widerange of stimuli from both within and outside the cell.This volume highlights progress in the elucidation ofthe in vivo function of the various members of the TRPion channel family. It covers the role of TRP channelsin sensory transduction and signaling cascades anddiscusses the development of novel pharmaceuticalsfor the treatment of cancer, heart disease, andimmune system dysfunctions.

Catalog no. 4048, September 2006, 467 pp.ISBN: 978-0-8493-4048-2, $179.95 / £115.00Also available as an eBook






NeuralPlasticity andMemoryFrom Genes to BrainImagingEdited by

Federico Bermúdez-RattoniNational University of Mexico,Mexico City, Distrito Federal

This volume provides a multidisciplinary review ofresearch being conducted on the neurobiology ofmemory. It examines the synaptic communicationelements identified as being susceptible to modifica-tion through the accumulation of experience. It alsoexplains how cell circuitry is modulated and ultimate-ly modified by neurotransmitters and hormones during the process of acquiring, consolidating, andretrieving information. In each chapter, researcherspresent findings and explain their innovative method-ologies. The text also addresses current memory studies involving human brain imaging.


NeuralProstheses forRestoration ofSensory andMotor FunctionEdited by

John K. ChapinState University of New YorkHealth Science Center, Brooklyn,USA

Karen A. MoxonDrexel University, Philadelphia, Pennsylvania, USA

While the creation of a bionic man may still be far intothe future, neural prostheses are rapidly becomingviable for patients with injury or disease of the nervoussystem. This book explores the recent advances inneural prosthetic techniques and applications. Itdetails some of the most successful sensory and motorprosthetic devices available and then examines thegrowing field of brain-implantable devices for thecontrol of artificial prosthetic devices or neural pros-thetics.


Methods forNeuralEnsembleRecordingsSecond EditionEdited by

Miguel A. L. NicolelisDuke University Medical Center,Durham, North Carolina, USA

This second edition of a bestseller distills the currentstate of the science and provides the nuts and boltsfoundation of the methods involved in this rapidlygrowing science. With contributions from pioneeringresearchers, it discusses microwire array design forchronic neural recordings, new surgical techniques forchronic implantation, microelectrode microstimula-tion of brain tissue, multielectrode recordings in thesomatosensory system, and recordings from the cen-tral gustatory-reward pathways. It also explores theuse of Brain-Machine Interface to restore neurologicalfunction and proposes conceptual and technicalapproaches to human neural ensemble recordings inthe future.


In Vivo OpticalImaging ofBrain FunctionSecond EditionEdited by

Ron D. FrostigUniversity of California, Irvine,California, USA

Reflecting continual development in this emergingarea, this volume reaches across disciplines to reviewa variety of noninvasive optical techniques used tostudy activity in the living brain. Leading authoritiesfrom such diverse areas as optical hardware, cognitivebehavior, and neuroscience present a host of perspec-tives that range from a single neuron to large assem-blies of neurons several million strong, captured atvarious temporal and spatial resolutions. Introducingtechniques that were unavailable just a few years ago,the book describes their theory, setup, and analyticalmethods and provides examples that highlight theadvantages of each particular method.






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Fat DetectionTaste, Texture, andPost Ingestive EffectsJean-PierreMontmayeurCentre des Sciences du Hout,Dijon, France

Johannes le CoutreNestlé Research Center,Lausanne, Switzerland

Taking a multidisciplinary approach, this volumesheds new light on critical concerns regarding dietaryfat and its relation to obesity. Going far beyond thewell-known concerns, it offers new scientific data onthe many aspects of fat, including psychological,behavioral, genetic, and physiological factors thatcontribute to its desirability, perception, intake, andimpact on human health. Bringing together cross-dis-ciplinary research, it includes information on geneticpredisposition, neural imaging, and endocrineimpacts on metabolism. It also provides a progressiveintegrated view on fat taste, fat preference, and nutri-tion at the molecular level.


DNA ArraysTechnologies andExperimentalStrategiesEdited by

Elena V. GrigorenkoMillennium Pharmaceuticals,Inc., Cambridge, Massachusetts,

A quantum leap in technology took place a few yearsago with the introduction of cDNA arrays that havebeen developed in response to the need for simulta-neous analysis of the patterns of expression of thou-sands of genes. DNA Arrays: Technologies andExperimental Strategies offers a broad view of dif-ferent aspects of this rapidly developing technology,including oligonucleotide and electrochemical arrays.Distinguished investigators from academia and industry provide up-to-date insights into method-ological fundamentals of construction of DNA arrays,optimization of hybridization conditions, the use ofexpression data in bioinformatics, software tools, andthe application of microarray technology for drug discovery.

Contents:

Technology Development for DNA Chips

A System Approach to Manufacturing and AnalyzingDNA Arrays

Nylon Platform: Pros and Cons

Electrochemical Detection of Biomolecules

Oligonucleotide Array Technologies for GeneExpression Profiling

DNA Microarrays in Neurobiology

Data Management in Microarray Fabrication, ImageProcessing, and Data Mining

Zeroing In on Essential Gene Expression Data

Application of High-Density Nylon Arrays for Analysisof Gene Expression in Different Experimental Models

Supplier List

List of Web Sites Related to DNA Arrays


The Role of theNucleus of theSolitary Tract inGustatoryProcessingEdited by

Robert M. BradleyUniversity of Michigan, School ofDentistry, Ann Arbor, USA

The nucleus of the solitary tract (NST) provides anessential brainstem relay for three cranial nerves, coor-dinating highly complex sensory information. Whileother functions of the NST have received attention, itsrole in gustatory processing has received little. Thiswork is the first reference on the NST devoted exclu-sively to gustatory processing. Compiling past andcurrent research into a single volume, it documentsthe anatomy of the NST, explores the properties ofsynaptic transmitters and neurons in the NST, com-pares the gustatory NST with the caudal NST, andconsiders the challenges involved in identifying NSTneural circuits.

Catalog no. 4200, October 2006, 158 pp.ISBN: 978-0-8493-4200-4, $179.95 / £115.00Also available as an eBook






TranslationalPain ResearchFrom Mouse to ManEdited by

Lawrence KrugerUniversity of California, LosAngeles, USA

Alan R. LightUniversity of Utah, Salt LakeCity, USA

Advances in molecular biology and the new toolsderived from molecular genetics have revolutionizedpain research and its therapeutic applications. Thisbook brings together recent advances in modern neu-roscience, genetic studies in mice and humans, andthe results of clinical trials. It examines rodent modelsfor pain associated with bone cancer, osteoarthritis,and cardiac episodes. It covers the cloning of highlyspecific receptors and the analysis of modular molec-ular mechanisms relevant to painful neuropathies. Thebook also considers the trend toward translationalresearch in the commercial pharmaceutical industry.

Catalog no. K10609, November 2009, 432 pp.ISBN: 978-1-4398-1209-9, $174.95 / £112.00Also available as an eBook

The PrimateVisual SystemEdited by

Jon H. Kaas andChristine E. CollinsVanderbilt University, Nashville,Tennessee, USA

"Chapters are well written and offer clear examplesof complicated system interconnectivity."—Contemporary Topics in Laboratory Animal Science

Exploring the neural behavior of visuomotor process-ing in the primate brain, this book discusses theanatomical and functional organization of the primatevisual system and proposes new directions forresearch. It describes state-of-the-art methods forinvestigating the visual system and examines how it isformed during development. It considers a range oftopics concerning various primates and covers pro-cessing from the eye to neural codes for action, andfrom basic perception to memory.


Methods ofBehaviorAnalysis inNeuroscienceSecond EditionEdited by

Jerry J. BuccafuscoMedical College of Georgia,Augusta, USA

A comprehensive reference for the most well-studiedbehavioral approaches in animal subjects, this bookexamines disease effects and therapeutic treatments.The second edition features material on the relevanceof transgenic mouse models for Alzheimer’s disease,behavioral methods for assessing the cognitive impair-ment associated with major psychotic disorders, therevival of the scopolamine reversal model for assessingthe clinical relevance of new AD drugs, and newapproaches for assessing cognitive impairment inaged mice. Each chapter presents theoretical back-ground, methodology, and data interpretation.


TheNeurobiology of OlfactionEdited by

Anna MeniniS.I.S.S.A, Trieste, Italy

A comprehensive overview of the current status ofknowledge and research on olfaction, this volumetakes an interdisciplinary approach to include contentfrom genetics to behavior and from nematodes tohumans. It offers chapters on discoveries in odor cod-ing from the olfactory epithelium to the cortical cen-ters, and in neurogenesis in the olfactory epitheliumand the olfactory bulb. Written by a top researcher inthe field, each subject-specific chapter provides anextensive list of reviews and original articles for students and scientists interested in further reading.






11



NeuroproteomicsEdited by

Oscar AlzateUniversity of North Carolina,Chapel Hill, USA

With an extensive background in mathematics andphysics, editor Dr. Oscar Alzate exemplifies the newestgeneration of biological systems researchers. In thisvolume, he organizes an overview of neuropro-teomics that is practical and progressive. Approachesdiscussed include mass spectrometry, electrophoresis,chromatography, surface plasmon resonance, proteinarrays, immunoblotting, computational proteomics,and molecular imaging. Leading researchers detail theprinciples, approaches, and difficulties of the tech-niques, showcasing the questions that neuropro-teomics can answer as well as those it raises. The bookIncludes research that is redefining our understandingof Parkinson’s, Alzheimer’s and other neurological andmental diseases.


NeuralPlasticity inAdult SomaticSensory-MotorSystemsEdited by

Ford F. EbnerVanderbilt University, Nashville,Tennessee, USA

Synthesizing current information about sensory-motor plasticity, this book describes the dynamicprocesses that occur in somatic sensory-motor corticalcircuits or somatic sensory pathways to the cortex dueto experience, learning, or damage to the nervoussystem. It emphasizes changes in the cortex that arelinked to changes in movement or behavior, anddemonstrates the potential for direct brain-basedinterventions to improve the quality of life for peoplewith sensory-motor disabilities. The book includesstudies that document the dynamic changes in sys-tem properties that occur with normal experience orin recovery from brain damage.


New Conceptsin CerebralIschemiaEdited by

Rick C. S. LinUniversity of Mississippi MedicalCenter, Jackson, USA

Providing a detailed description of the techniques andtheories employed in both basic and clinical research,this volume delineates the mechanisms underlyingneuronal damage induced by ischemia. It coversmethods to elucidate the pathogenesis of ischemia,technologies used in the design of specific strategiesto protect neurons from further injury, and newapproaches to treating patients with acute ischemicepisodes. It includes methods and therapeuticapproaches for neuronal protection against acute andchronic ischemic episodes and describes new animalmodels for ischemia research including the applica-tion of transgenic animals.


Methods inInsect SensoryNeuroscienceEdited by

Thomas A. ChristensenUniversity of Arizona, Tucson,USA

Written by recognized experts in sensory biology, thisvolume synthesizes the latest information and reviewsthe most current methods for studying the specializedsensory systems of insects. Bridging the gap betweenexperimentalists and theorists, the book exploresanatomical pathway tracing, electrophysiologicalrecording, genetic and pharmacological manipula-tions, computational modeling, and behavioral obser-vations. Each chapter discusses the most challengingquestions facing sensory neuroscience today and pro-vides a unique synopsis of the developments that aredriving the field forward.








Functional andNeuralMechanisms ofInterval TimingEdited by

Warren H. MeckDuke University, Durham, NorthCarolina, USA

"[A] thorough and richly informative book."—Journal of Clinical Psychiatry

This critically praised work synthesizes the currentknowledge of animal behavior and human cognitionas related to both technical and theoretical approach-es in the study of duration discrimination. Chapterswritten by the foremost experts in the field integratethe fields of time quantum and psychophysics, rhyth-mic performance and synchronization, as well asattentional effort and cognitive strategies through thelinkage of time as information in brain and behavior.

Catalog no. 1109, March 2003, 600 pp.ISBN: 978-0-8493-1109-3, $179.95 / £115.00Also available as an eBook

Methods inAlcohol-RelatedNeuroscienceResearchEdited by

Yuan LiuNational Institute ofNeurological Disorders & Stroke,Bethesda, Maryland, USA

David M. LovingerLaboratory of Integrative Neuroscience, NIAAA, Nashville,Tennessee, USA

Written by a panel of experts, this volume provides anoverview of the effects of alcohol on the brain, offer-ing technical guidance for investigators doingresearch at the molecular, cellular, systems, andbehavioral levels. These techniques include a widevariety of approaches, ranging from gene mappingand examination of molecular interactions of alcoholat the sub-cellular level, to recording of neural activi-ties in freely-behaving animals, and imaging alcoholeffects on the living human brain.

Catalog no. 0347, February 2002, 416 pp.ISBN: 978-0-8493-0203-9, $169.95 / £108.00Also available as an eBook

PrimateAuditionEthology andNeurobiologyEdited by

Asif A. GhazanfarPrinceton University, New Jersey,USA

Bridging the epistemological gap between primateethologists and auditory neurobiologists, this bookbrings together leading scientists who apply theirmethods to a variety of issues related to primate vocalbehavior and the neurobiology of the primate audito-ry system. The synthesis of ethological and neurobio-logical approaches to primate vocal behavior will yielda rich understanding of the acoustic and neural basesof primate audition and shed light on the evolution-ary precursors to speech.

Catalog no. 0956, August 2002, 336 pp.ISBN: 978-0-8493-0956-4, $179.95 / £115.00Also available as an eBook

Methods inChemosensoryResearchEdited by

Sidney A. Simon andMiguel A. L. NicolelisDuke University Medical Center,Durham, North Carolina, USA

Exploring the field of neuronal chemoreception, thistext describes new molecular, electrophysiological,engineering, genetic, behavioral, psychophysical, andimaging techniques that have recently been adaptedto investigate the basic neuronal mechanisms under-lying chemoreception. The contributors specialize inolfaction, gustation, baroreception, and chemical irri-tation caused by environmental pollutants. They pro-vide novel methods to investigate all aspects of tasteand olfaction, ranging from the molecular level to theinvestigation of individual cell taste and olfactoryepithelia.






13



Methods inPain ResearchEdited by

Lawrence KrugerUniversity of California, LosAngeles, USA

" … an important book for neuroscience librariesand laboratories involved in the study of pain. 4Stars!”

—Doody's Notes

Addressing a rapidly growing area of neuroscience,this volume surveys the methods used to study a reac-tion or "sensory report" in humans that can only beinferred by indirect means in animal or tissues studies.The book examines techniques used in studying pain,including gene linkage, brain imaging methods, theuse of transgenic rodent models, painful sensory neu-ropathy models, and more. It also covers convention-al methods of pain study, including anatomical andelectophysiological techniques.

Catalog no. 0035, June 2001, 336 pp.ISBN: 978-0-8493-0035-6, $179.95 / £115.00Also available as an eBook

Animal Modelsof CognitiveImpairmentEdited by

Edward D. LevinDuke University Medical Center,Durham, North Carolina, USA

Jerry J. BuccafuscoMedical College of Georgia,Augusta, USA

Animal models of cognitive function—including learn-ing, memory, and attention—are critical for determin-ing the neurobehavioral basis for cognition and forthe development of new therapeutic treatments forcognitive impairment. This volume integrates molec-ular and neurochemical approaches in translationalmodels with behavioral and clinical applications. Thetext also discusses current research on genetic, lesion,pharmacological toxicant, and aging models. Itexplores the significance of this research to the treat-ment of various addictions and disorders such asstroke, autism, Alzheimer’s, schizophrenia, andADHD.


Biology of theNMDA ReceptorEdited by

Antonius M. VanDongenDuke University Medical Center,Durham, North Carolina, USA

The NMDA receptor, a subclass of the ionotropic glutamate receptor family, plays a critical role in thedevelopment of the central nervous system and inadult neuroplasticity, learning, and memory.Describing important aspects of NMDA receptor biol-ogy, this text highlights discoveries that have beenmade over the past decade. It reviews various molec-ular genetics studies that illustrate the importance ofthis class of receptors. It also presents a discussion ofrecent crystallographic X-ray structures of its ligandbinding domains.


NeurosteroidEffects in theCentral NervousSystemThe Role of theGABA-A ReceptorEdited by

Sheryl S. SmithSUNY Health Sciences Center,Brooklyn, New York, USA

A complete overview of the effects of steroid hor-mones in the brain and new methods for investigat-ing these effects, this book discusses theories onsteroid action in the central nervous system and thetechniques for receptor localization, quantification,and enzyme regulation. The author explores the useof transgenic/antisense strategies to determine sitesand the cellular effects of steroid action in the brain.He examines steroid action on mood, cognition, sen-sorimotor action, neuroprotection, and plasticity, anddescribes methods using molecular, electrophysical,and behavioral techniques to link cellular mechanismsof steroid action with behavioral effects.








Methods inDrug AbuseResearchCellular and CircuitLevel AnalysesEdited by

Barry D. WaterhouseMCP-Hahnemann School ofMedicine, Philadelphia,Pennsylvania

Assembling information from a wide variety ofresources, this book bridges the gap between cellularand molecular studies of drug actions and behavioralapproaches to questions in drug abuse research. Thebook covers procedures, methods, and equipmentused in experiments combining multiple technicalapproaches. It presents critical reviews of the experi-mental strategies used to dissect the problem of com-pulsive drug use and addiction at the systems orwhole brain level.


IndwellingNeural ImplantsStrategies forContending with theIn Vivo EnvironmentEdited by

William M. ReichertDuke University, Durham, NorthCarolina, USA

This compendium of contributions from notedexperts in neuroprosthetics and tissue repair address-es the impact, characterization, and mitigation of thehealing of tissues that surround an implant. It exam-ines performance issues of implanted neuroprosthet-ics, presents both in vitro and in vivo approaches toassessing wound healing response to materials, anddescribes molecular and materials strategies for intervening in CNS wound repair and enhancing theelectrical communication between electrode and surrounding tissue.


NicotinicReceptors inthe NervousSystemEdited by

Edward D. LevinDuke University Medical Center,Durham, North Carolina, USA

This volume provides integrated coverage of researchon neuronal nicotinic systems relevant to smokingaddiction and cognitive dysfunction. Bringing togeth-er molecular and neurochemical applications, it pro-vides the key to understanding function and dysfunc-tion of nicotinic systems and their significance for disease, addiction, and the development of noveldrug treatments. The book presents readers with thebasic mechanistic background for these treatments aswell as the functional assessment necessary to deter-mine therapeutic effects.

Catalog no. 2386, August 2001, 312 pp.ISBN: 978-0-8493-2386-7, $169.95 / £108.00Also available as an eBook

ElectrochemicalMethods forNeuroscienceEdited by

Adrian C. MichaelUniversity of Pittsburgh,Pennsylvania, USA

Laura M. BorlandBooz Allen Hamilton, Inc., Joppa,Maryland, USA

Providing an updated summary of the current state ofthe field, this volume lays the scientific foundation forincorporating electrochemical techniques into emerg-ing research. The text outlines the applications andbenefits of a wide range of electrochemical tech-niques. It explores the methodology and protocolsbehind the acquisition of neurochemical and neurobi-ological data through continuous amperometry, fastscan cyclic voltammetry, high-speed chronoamper-ometry, ion-selective microelectrodes, enzyme-basedmicroelectrodes, and in vivo voltammetry withtelemetry.






15



Motor Cortex inVoluntaryMovementsA Distributed Systemfor DistributedFunctionsEdited by

Alexa RiehleINCM - CNRS, Marseille, France

Eilon VaadiaThe Hebrew University, Jerusalem, Israel

This book presents developments in motor cortexresearch that make it possible to read and interpretneural activity and use the data to reconstruct move-ments. It focuses on how neuronal activity changesduring learning, the neuronal representations of voluntary movements, and the mechanism of theirgeneration during learning. Along with detailed cov-erage of advanced approaches to motor cortexresearch, the book also includes classical studies ofneuronal activity in frontal sensorimotor fields.


ModernNeurosurgeryClinical Translationof NeuroscienceAdvancesEdited by

Dennis A. TurnerDuke University Medical Center,Durham, North Carolina, USA

Focusing on how increased understanding of brainfunction affects clinical neuroscience, this volumeexplores the interface between non-clinical and clini-cal neuroscience advances by examining the hypothe-ses that drive this evolution. It reviews the relevantunderpinnings of neurosurgical techniques, treat-ments, and conceptual approaches that are likely tocontinue to shape clinical neuroscience over the nextfew years and underscores targeted areas in each field,including high grade gliomas, spinal dysraphism, andendovascular treatment advances.


Advances inVagal AfferentNeurobiologyEdited by

Bradley J. UndemJohns Hopkins Asthma Center,Baltimore, Maryland, USA

Daniel WeinreichUniversity of Maryland,Baltimore, USA

Taking a comprehensive approach in which all aspectsof the vagal afferent system are considered, this exten-sive text reviews the development, neurochemistry,anatomy, biophysics, pharmacology, and physiologyof the vagal afferent nerves. The authors presentexperimental techniques used to investigate thedevelopment, morphology, electrophysiology andreflex function of the vagal afferent nerves, andinclude state-of-the-art reviews of vagal afferent neu-robiology by some of the world's leading experts inthese fields.


The ThirdHistamineReceptorSelective Ligands asPotentialTherapeutic Agentsin CNS DisordersEdited by

Divya VohoraHamdard University, New Delhi, India

Since their discovery, the potential of histamine H3receptor ligands in various CNS disorders has receivedmuch attention. This resource presents recentadvances with an emphasis on pharmacology. It cov-ers identification and localization of receptors and thedevelopment of novel ligands incorporating pre-clinical and clinical studies indicating earliest possiblestages of development. The book provides anoverview of histamine as a neurotransmitter and dis-cusses receptor pharmacology, signal transduction,selective ligands, and therapeutic potential.







Clinical Neuroscience

Bestseller!

Atlas ofFunctionalNeuroanatomySecond EditionWalter Hendelman, M.D.University of Ottawa, Ontario,Canada

“… an excellent tool for introducing the basic concepts of neuroanatomy …”—Estrada J. Bernard Jr., M.D., Journal of Neurosurgery

A visual and textual guide, the Atlas of FunctionalNeuroanatomy, Second Edition clearly presents thehuman central nervous system. Completely revisedand now containing color illustrations, the atlasimparts information in a format that fosters a thor-ough understanding of complex neuroanatomy. Theillustrations and text accompanying each illustrationsupply the appropriate neuroanatomical informationto gain a full understanding of the human CNS froma functional perspective. Clinical aspects add to thevalue of the atlas.

Features:

• An organized orientation to the CNS with newand revised material, and the lucid presentationof sensory and motor functional systems

• A systematic description of the cerebral bloodsupply and a detailed histological study of brainstem and spinal cord neuroanatomy

• A fresh approach to the limbic system that provides a clearer understanding of its structuresand functions

• Color illustrations throughout the text, an annotated bibliography, and a glossary of terms

• An interactive CD-ROM with text, color illustrations, 3D visualization, and animation

The illustrations, text, selection of the content, andthe accompanying CD-ROM are unique features thatdifferentiate this atlas from others and will make it oneof the most used references for scientists and studentsin a diverse array of fields.

Catalog no. 3084, October 2005, 296 pp.Soft CoverISBN: 978-0-8493-3084-1, $67.95 / £43.99Also available as an eBook

New!

Chemotherapy-InducedNeuropathicPainEdited by

Robert B. Raffa, Richard Langford,Joseph V. Pergolizzi, Jr.,Frank Porreca, and Ronald J. TallaridaThere have been tremendous recent advances in thepharmacotherapy, dose regimens, and combinationsused to treat cancer and for the treatment or preven-tion of the spread of disease. As a direct result of theseadvances, there are an increasing number of cancersurvivors, although research dealing with chemother-apy-induced pain is still in its early years.

Written for pain management specialists, oncologists,pharmacologists, students, and primary care practi-tioners, Chemotherapy-Induced Neuropathic Painprovides insight into the critical area of pain manage-ment among cancer patients. It reviews the basic andclinical research into the normal physiology of paintransmission pathways, neuropathic pain pathology,the chemotherapeutic drug mechanisms of actionand adverse effects, chemotherapy-induced neuropa-thy, and drug discovery efforts for treatment.

The contributors comprise an impressive list of clinicaland basic science experts in the fields of pain mecha-nisms and pain management. Included are clinical direc-tors of pain clinics and clinical research facilities, directorsof large academic pain research laboratories, analgesicdrug developers, and presidents of the InternationalAssociation for the Study of Pain (IASP), Association ofChronic Pain Patients (ACPP), and the British Pain Society(BPS). The book provides readers with an exceptionalopportunity to acquire a fundamental understanding ofthe basic concepts related to this topic.

Contents:

Chemotherapy-Induced Neuropathic Pain: ClinicalFeatures. Assessment and Grading of CancerChemotherapy-Induced Neuropathic Pain.Chemotherapy-Induced Peripheral Neuropathy:Review of Clinical Studies. Orofacial Neuropathy andPain in Cancer Patients. Cancer Chemotherapy-Induced Neuropathic Pain: The UnderlyingPeripheral Neuropathy. Bedside to Bench: Researchon Chemotherapy-Induced Neuropathic Pain. In VivoModels and Assessment of Pharmacotherapeutics forChemotherapy-Induced Neuropathic Pain. DrugTreatment for Chemotherapy-Induced NeuropathicPain: Amitriptyline as an Example. ExperimentalDesign and Analysis of Drug CombinationsApplicable to Chemotherapy-Induced NeuropathicPain. Central Neuromodulation for Chemotherapy-Induced Neuropathic Pain. Nerve Decompression forChemotherapy-Induced Neuropathic Pain.

Catalog no. K12881, July 2012, 233 pp.ISBN: 978-1-4398-6218-6, $149.95 / £95.00Also available as an eBook



17



EpilepsyThe Intersection ofNeurosciences,Biology,Mathematics,Engineering, andPhysicsEdited by

Ivan Osorio, Hitten P. Zaveri, Mark G. Frei, and Susan ArthursOne of the most prevalent neurological disorders,epilepsy affects approximately one percent of theworld's population. Epilepsy: The Intersection ofNeurosciences, Biology, Mathematics, Engineering,and Physics seamlessly brings together these fieldsalong with the computational sciences and clinicalepileptology to present to readers a practically usefulknowledge base.

Laying out the foundations of signal analysis, dataconditioning, linear and non-linear analysis, introduc-tion to dynamical systems and fundamental anatomi-cal and neurophysiological concepts, this book:• Introduces non-physicians to language and concepts necessary to establish a meaningfuldialog with epileptologists

• Introduces physicians to dynamical theory andsignal processing

• Combines knowledge from fields devoted to theinvestigation of aperiodic paroxysmal relaxationphenomena to lay the proper scientific founda-tions for epileptology and foster much neededtherapeutic advances efficiently

• Reviews spatiotemporal behavior of seizures,mechanisms of epileptogenesis and ictogenesis,and seizure control and ancillary technology

• Highlights nocturnal frontal lobe epilepsy as apotentially fruitful paradigm for advancingseizure prediction.

Of all neurological disorders, epilepsy demands ofinvestigators the broadest and deepest knowledge ofdynamical, control, and system theories, knowledgethat cannot be amassed without possessing a certainlevel of sophistication in relevant areas of neuro-sciences, physics, mathematics, and engineering.Narrowing the inescapable cultural chasm that com-monly fragments multidisciplinary efforts, this bookcaptures and enriches the burgeoning interdiscipli-nary synergism in the nascent field of dynamicalepileptology.

Catalog no. K11766, May 2011, 546 pp.ISBN: 978-1-4398-3885-3, $189.95 / £121.00Also available as an eBook

PediatricEpilepsy CaseStudiesFrom Infancy andChildhood throughAdolescenceEdited by

Kevin Chapman andJong M. RhoBarrow Neurological Institute, Phoenix, Arizona, USA

The amount of information currently available onpediatric epilepsy, as with all burgeoning fields, canseem overwhelming. Pediatric Epilepsy CaseStudies: From Infancy and Childhood throughAdolescence reviews the recent flood of new infor-mation on the pathophysiology, genetics, and treat-ment of the various pediatric epilepsy syndromes anddistills it into an easy-to-use guide. Edited by respect-ed and well-known leaders in the field, the book pro-vides brief but thorough descriptions of the differentsyndromes commonly encountered in clinical practiceacross the pediatric age range.

Grasping the complexity and nuances associated withvarious epileptic syndromes can be daunting, so thebook begins with an introduction to the fundamentalsof epilepsy. Subsequent sections include succinct casepresentations and clinically relevant discussions of themore common epilepsy syndromes affecting each agegroup. The resource section provides an authoritativeguide to relevant findings scattered in the literature.

Research in the field of epilepsy will continue at arapid pace, with the ultimate hope of curing manyintractable epilepsy syndromes. Organized chrono-logically, from neonate through adolescence, thisbook is the culmination of a group effort involvingleading physicians and researchers whose contribu-tions constitute a concise and practical reference forhealth professionals in training.

Selected Contents (Abridged)

The Basics. A Pediatric Epilepsy Primer.Developmental Pharmacokinetics: Principles andPractice. Dietary Therapies for Epilepsy... TheNeonate Benign Familial Neonatal Seizures.Hypoxic-Ischemic Encephalopathy (NeonatalSeizures)... The Infant Febrile Seizures. GeneralizedEpilepsy with Febrile Seizures Plus (GEFS+). BenignMyoclonic Epilepsy of Infancy. Severe MyoclonicEpilepsy in Infancy. Infantile Spasms. GelasticSeizures. Tuberous Sclerosis Complex... The Child.Benign Epilepsy of Childhood with Central-TemporalSpikes. Childhood Absence Epilepsy... TheAdolescent. Juvenile Myoclonic Epilepsy. Epilepsy inAdolescent Females. Unverricht–Lundborg Disease.Post-Traumatic Seizures and Epilepsy... Index.

Catalog no. 83422, September 2008, 296 pp.ISBN: 978-1-4200-8342-2, $89.95 / £57.99





New!

MultipleSclerosisRehabilitationFrom Impairment toParticipationEdited by

Marcia FinlaysonUniversity of Illinois at Chicago,USA

This comprehensive resource guides health and reha-bilitation practitioners as they engage in the rehabili-tation process with people with multiple sclerosis(MS). The text provides a broad-based perspective onthe disease and examines how it influences everydaylife. It also examines the strategies that can beemployed by rehabilitation practitioners to enablepeople with MS to fully engage in life. The first sectionoffers an overview of MS basics, and the next twodescribe MS rehabilitation to manage impairmentsand enhance activity and participation. The final sec-tion discusses contextual factors that may influenceMS rehabilitation efforts.

Catalog no. K11417, August 2012, 603 pp.ISBN: 978-1-4398-2884-7, $149.95 / £95.00Also available as an eBook

Bestseller!

Traumatic BrainInjuryRehabilitation,Treatment, and Case Management, Third EditionEdited by

Mark J. AshleyCentre for Neuro Skills of California, Bakersfield, USA

" ...will provide a valuable resource to non-specialists. … excellent material."

—Journal of the Royal Society of Medicine

Since the bestselling second edition was publishedalmost a decade ago, the field of brain injury treat-ment has undergone tremendous change, largelyimpacting access to treatment.

With updated and expanded clinical coverage,Traumatic Brain Injury: Rehabilitation, Treatment,and Case Management, Third Edition delineates abroad spectrum of advanced theoretical clinical con-structs and detailed diagnostic and treatment inter-ventions for traumatic brain injury.

This text is a clinical guide to rehabilitative treatmentof persons with traumatic brain injury following theacute phase of treatment. It provides a concise sourceof information about the scientific and therapeuticrealms involved in the rehabilitation of a person withtraumatic brain injury, specifically as they relate to per-sistent deficits. The book also details long-term conse-quences of brain injury and effective approaches tovocational rehabilitation and case management.

Topics discussed include:• Metabolic and bioenergetic factors in brain injury• Neuroendocrine dysfunction following braininjury

• Blast injury• Ethical issues in treatment of brain injury• Neuropharmacological and neuropsychologicalinterventions following brain injury

• Interventions for the minimally conscious patient• Dietary and exercise considerations after braininjury

This volume is a complete source of pharmacological,anatomical, and physiological information for basictherapeutic rationales.


The Neuroscienceof HandwritingApplications forForensic DocumentExaminationMichael P. CaligiuriUniversity of California, San Diego, La Jolla, USA

Linton A. MohammedRile, Hicks, & Mohammed, SanBruno, California, USA

Bridging the gap between theory and practice, thisvolume examines the essential neuroscientific princi-ples underlying normal and pathological hand motorcontrol and handwriting. The book discusses funda-mental principles in the neuroanatomy and neuro-chemistry of hand motor control and their applicationto research in handwriting. It examines the epidemiol-ogy, pathophysiology, and motor characteristics ofneurogenerative diseases and their effects on hand-writing and describes the impact of psychotropic med-ications, substance abuse, and aging. The authorspresent new findings on the kinematic analyses of gen-uine, disguised, and forged signatures and include lab-oratory research on authentic and forged signatures.

Catalog no. K13270, February 2012, 267 pp.ISBN: 978-1-4398-7140-9, $139.95 / £89.00Also available as an eBook




19



PocketHandbook ofNonhumanPrimate ClinicalMedicineEdited by

Dr. Angela CourtneyUniversity of California, Davis,USA

An easy-to-understand pocket manual, this indispen-sible reference compiles key and important clinicalmedical information unique to the rhesus macaqueand the cynomolgus macaque. The chapter authorsdenote specific treatments for other nonhuman pri-mate species where applicable. Practical and user-friendly, this book mirrors the knowledge gained bycompleting a residency in clinical primate medicine. Itprovides formulary and drug dosages, special precau-tions, and important notations; discusses diseases andclinical problems; outlines treatment based on currentmedicine; and explains common procedures withcolor illustrations.

Catalog no. K13021, October 2012, 232 pp.Soft CoverISBN: 978-1-4398-6728-0, $99.95 / £63.99Also available as an eBook

The IntegratedNervous SystemA SystematicDiagnostic ApproachWalter J. HendelmanUniversity of Ottawa, Ontario,Canada

Peter HumphreysChildren's Hospital of EasternOntario, Canada

Christopher SkinnerOttawa Hospital, Ontario, Canada

“ … an appropriate supplementary text for anyclinically-based neuroscience course or an excellentreference book. The DVD contains all the illustra-tions in the text, animations of reflexes and neuronal pathways, additional case studies, work-sheets for the clinical cases, and information onneural imaging. Suggested readings are in theform of journal articles listed at the end of eachchapter. Also, an annotated bibliography, organ-ized by topic and with a synopsis of each entry, isfound at the back of the book. A helpful glossary isalso included.”

—The Internet Journal of Allied Health Science and Practice

To demonstrate the connection between academicneuroanatomy and the practice of clinical neurology,The Integrated Nervous System: A SystematicDiagnostic Approach presents carefully chosen clini-cal cases that illustrate how the nervous system is con-structed and how it functions under normal circum-stances. It contains a fail-safe localization/etiologychecklist and details autoimmune, neoplastic, degen-erative, and genetic disorders. The book instructs onhow to differentiate between various causes ofseizures, stroke, and Parkinsonism, and provides com-plete case summaries, treatment, management, andoutcomes to clarify the material.

Offering the foundation needed to encounter neuro-logical diseases, this reference teaches students andresidents how to integrate a patient’s clinical historyand examination with neuroanatomy. In addition tocolor illustrations throughout, the book is supple-mented by an invaluable DVD and access to a state-of-the-art website with additional materials that areupdated periodically. User-friendly worksheets andflash animation of various pathways, reflexes, and circuits are also included.


EpilepticSeizures andthe EEGMeasurement,Models, Detectionand PredictionAndrea Varsavsky andIven MareelsThe University of Melbourne,Victoria, Australia

Mark CookSt. Vincent's Hospital and the University of Melbourne,Victoria, Australia

A study of epilepsy from an engineering perspective,this volume begins by summarizing the physiologybehind the measurement, analysis, and modeling ofthe epileptic brain. It introduces the EEG and explainsthe type of brain activity likely to register in EEG meas-urements. The authors focus on the problem ofseizure detection, survey the physiologically baseddynamic models of brain activity, and address the fundamental question of whether seizures can be predicted.

Catalog no. K10604, December 2010, 370 pp.ISBN: 978-1-4398-1200-6, $145.95 / £93.00Also available as an eBook






ConcussiveBrain TraumaNeurobehavioralImpairment &Maladaptation,Second EditionRolland S. ParkerNew York University School ofMedicine, USA

This second edition of a bestseller provides compre-hensive coverage of neurobehavioral disorders in chil-dren and adults following impact and accelerationaccidents. Drawing on his training, education, andexperience in human physiology, neuroanatomy, andendocrinology, the author gives readers a solid foun-dation for understanding, diagnosing, and treatingconcussive brain trauma. The book discusses person-ality and subjective complaints and symptoms andincludes six new chapters and new material on dysregulation of the internal environment.


Diet, Brain,BehaviorPracticalImplicationsEdited by

Robin B. KanarekTufts University, Medford,Massachusetts, USA

Harris R. LiebermanUSARIEM, Natick,Massachusetts, USA

Both the scientific community and the general popu-lation have expressed a heightened interest in theeffect of nutrients on behavior. Topics discussed in thisvolume include mental energy and fatigue, obesityand its effect on behavior, weight loss methods, andthe effects of dietary supplements on brain function-ing and behavior. The book also examines the rewarddeficiency hypothesis, proper fluid intake, the effectsof eating breakfast on performance, and diet and painsensitivity.

Catalog no. K11143, October 2011, 335 pp.ISBN: 978-1-4398-2156-5, $149.95 / £95.00Also available as an eBook

Bestseller!

UnderstandingAutismFrom BasicNeuroscience toTreatmentEdited by

Steven O. MoldinUniversity of Southern California,Washington, D.C., USA

John L. R. RubensteinUniversity of California, San Francisco, USA

Integrating basic and clinical neuroscience perspec-tives, this work presents a comprehensive outlook oncurrent autism research. The book covers a broadrange of fields, including epidemiology, genetics, andclinical neuroscience and neural systems. An underly-ing theme focuses on future genomic research andthe text also explores social, economic, and advocacyissues. The research contained herein will stimulatenew directions for advancement and the develop-ment of new drug treatment.


MaldyniaMultidisciplinaryPerspectives on theIllness of ChronicPainEdited by

James GiordanoCenter for NeurotechnologyStudies, Potomac Institute forPolicy Studies, Arlington,Virginia, USA and Human Science Center, Ludwig-Maximilians University, Munich Germany

An in-depth examination of chronic pain, this bookexplores pain as a bio-cultural phenomenon thatnecessitates reexamination of medical philosophy,ethics, education, and practice. It provides a historicalaccount of pain and then frames it with contemporaryneurobiological perspectives. The book illustrates howwhat we know about pain could influence medicaleducation and practice and demonstrates how knowl-edge of the history and present considerations of painmight help to construct meaningful, patient-centeredmedicine.






21



NeuroanatomicalBasis of ClinicalNeurologyEdited by

Orhan ArslanUniversity of South Florida,Tampa, USA

Superbly illustrated, this vol-ume bridges the gap between the disciplines of neu-roanatomy and neurology, aiding the understandingof neurologic disorders by investigating their anatom-ic basis. The extensive coverage of the peripheral andcentral nervous systems in the context of neurologicaldisorders and conditions sets it apart from other neu-roanatomy texts. The author has skillfully integratedtext and diagrams, highlighting and clarifying thenumerous functionally important pathways in thecentral and peripheral nervous systems.

Catalog no. PA578X, August 2001, 432 pp.ISBN: 978-1-85070-578-9, $77.95 / £49.99Also available as an eBook

AutismOxidative Stress,Inflammation, andImmuneAbnormalitiesAbha Chauhan, Ved Chauhan, and W. Ted BrownNew York State Institute for BasicResearch in DevelopmentalDisabilities, Staten Island, USA

The CDC issued an alert indicating that autism mayimpact one out of every 150 children. While the syn-drome is still officially labeled as idiopathic, researchshows the cause of autism may possess genetic, envi-ronmental, and possibly immunological factors andthat it has at least a correlation to oxidative stress. Thisbook collects work from researchers who report onevidence indicating links between autism and a num-ber of oxidative stress-related abnormalities. The textalso reports on potential avenues for new therapeuticintervention strategies.


Forthcoming!

Parkinson'sDiseaseSecond EditionEdited by

Ronald F. PfeifferUniversity of Tennessee HealthScience Center, Memphis, USA

Zbigniew K. WszolekMayo Clinic, Jacksonville, Florida, USA

Manuchair EbadiUniversity of North Dakota, Grand Forks, USA

In recent years, considerable advances have beenmade in our knowledge and understanding ofParkinson's disease (PD). In particular, there has beenan explosion of information regarding genetic contri-butions to the etiology of PD and an increased aware-ness of the incidence and importance of the non-motor features of the disease. Theories regarding thepathogenesis and pathophysiology of PD have alsobeen refined, and new treatment modalities andadvances have been implemented. Reflecting thesechanges, this second edition features new chaptersdevoted to these areas and new treatment modalities.

Catalog no. K10361, October 2012, c. 1336 pp.ISBN: 978-1-4398-0714-9, $249.95 / £159.00Also available as an eBook

EpilepsyMechanisms, Models,and TranslationalPerspectivesEdited by

Jong M. RhoAlberta Children's Hospital,Calgary, Canada

Raman SankarUniversity of California School ofMedicine, Los Angeles, USA

Carl E. StafstromUniversity of Wisconsin, Madison, USA

Written for researchers and clinicians in neurology andneuroscience, this text offers a bridge across the so-called translational divide to cover innovative treat-ment strategies that, while based on scientific principles, have yet to be tested rigorously in clinicalsettings. The text features the contributions of leadingresearchers in adult and pediatric epilepsy who covera range of topics including gene therapy, metabolicregulation, and neuroprotective strategies. It high-lights therapies with the greatest potential and identi-fies challenges common to researchers.

Catalog no. 8559X, June 2010, 684 pp.ISBN: 978-1-4200-8559-4, $199.95 / £127.00Also available as an eBook







Automated EEG-Based Diagnosisof NeurologicalDisordersInventing the Futureof NeurologyHojjat AdeliThe Ohio State University,Columbus, USA

Samanwoy Ghosh-DastidarArdmore, Pennsylvania, USA

Based on the authors' groundbreaking research, thisbook presents a novel approach for automated EEG-based diagnosis of neurological disorders such asepilepsy. The method is based on the adroit integra-tion of three computing and problem-solving paradigms: neural networks, wavelets, and chaos theory. The text introduces each of these computingparadigms along with a number of sophisticatedmathematical algorithms. It concludes with applica-tions of the method to epilepsy and to Alzheimer's disease.


Coffee, Tea,Chocolate, andthe BrainEdited by

Astrid NehligInserm, Strasbourg, France

With contributions from world experts in the field, thisvolume analyzes current research findings on caffeinecompounds and their interaction with the brain andcentral nervous system. The book discusses the effectsof coffee, tea, and chocolate on memory, cognitiveperformance, Parkinson's disease, stroke, oxidativestress, headache and sleep disorders, addictiondependence, and more. It also explores the relation-ships between caffeine and seizures, blood flow, alert-ness, and cravings. This reference is an essentialresource for all students and researchers of nutrition,psychology, neuroscience, pharmacology, and otherhealth-related sciences.

Catalog no. TF1650, April 2004, 248 pp.ISBN: 978-0-415-30691-1, $135.95 / £87.00Also available as an eBook

Manual ofStroke Modelsin RatsEdited by

Yanlin Wang-FischerPalatin Technologies, Cranbury,New Jersey, USA

While new insights into the mechanisms and thetreatment of stroke have been obtained from animalexperiments over the past several years, this is the firstbook in more than two decades to compile researchin this essential area. Cutting-edge researchers offerdetailed explanations of the methods and techniquesfor accomplishing different stroke models in rats. As ofnow, no specific neuroprotective treatment forischemic stroke is available. This book provides a start-ing point for those researchers employing stroke mod-els to develop new drugs to counteract this problem.

Catalog no. 9578, August 2008, 352 pp.Soft CoverISBN: 978-0-8493-9578-9, $115.95 / £73.99Also available as an eBook

AugmentingCognitionIdan SegevThe Hebrew University,Jerusalem, Israel

Henry MarkramSwiss Federal Institute ofTechnology, Lausanne,Switzerland

Augmenting cognition is a rapidly emerging field inneuroscience, concerned with the translation of whatis known about cognitive function and dysfunction toapproaches for enhancing and rehabilitating thebrain. Modern medicine has few options to treatthose with cognitive deficiencies, and as we learnmore about the biology of these conditions, we con-sider the design of a new class of therapies to restoreand augment cognition. This book describes a num-ber of the foundational areas of cognitive enhance-ment, with chapters devoted to the use of stem cells,savants, post-traumatic stress disorder, deep-brainstimulation, drugs, virtual reality, the role of sleep, andthe brain-computer interface.

Catalog no. N10260, November 2011, 250 pp.ISBN: 978-1-4398-3993-5, $89.95 / £57.99





23

Neuroscience


Forthcoming!

NeuroadaptiveSystemsTheory andApplicationsEdited by

Magdalena Fafrowicz,Tadeusz Marek,Waldemar Karwowski,and Dylan SchmorrowNeuroadaptive Systems: Theory and Applicationsis one of the first texts to address this emerging fieldand to present the state-of-the-art developments incurrent research. The scope of coverage includes neu-roscience and human factors as well as brain activitymeasurement. Topics include operator functionalstate (OFS) and neuroadaptive systems, psychologicalconstructs versus neuronal mechanisms, object recog-nition versus object-directed grasping, mental fatigue,sleeplessness, neural mechanisms of control, andattentional network- and error-related negativity asso-ciated with sleep deprivation.

Contents:

Theoretical Issues

Augmented Cognition

Neuroscience and Human Factors

Psychological Constructs vs. Neuronal Mechanisms -Different Perspectives for Advanced Technologies

Research

Attention - Individual Differences - GeneticPerspective

Object Recognition vs. Object-Directed Grasping

Neural Signatures Of Learning to Direct Training

Mental Fatigue, Sleeplessness and NeuralMechanisms of Control

EEG Cognitive Assessment Using Eye Fixations

Error Related Negativity and Sleep Deprivation

Attentional Network and Sleep Deprivation

Motor Activity, Cortical Potentials and MuscularPerformance

Applications

Driving and Safety - Neuronal Perspective

Advanced Tactical Aircraft Simulator - QualityTraining Effectiveness Assessment (Atas-Qte)

User-In-The-Loop Adaptive System Design

Interactive Neurotechnology Platform

Robots and 3d Shapes Perception

A Neuro-Fuzzy Approach to Modeling of HumanMotor Control

Catalog no. K12687, October 2012, c. 410 pp.ISBN: 978-1-4398-5745-8, $129.95 / £82.00Also available as an eBook

New!

NeuropeptidesinNeuroprotectionandNeuroregenerationEdited by

Fred NybergUniversity of Uppsala, Sweden

This volume discusses neuropeptides and their role inneurodegeneration and neuroprotection. It describesimportant features of the endogenous neuropeptidesystems regarding their formation, receptor signaling,and inactivation. The contributors examine topics ofenormous interest in the field—including the designand development of peptide-like drugs, pep-tidomimetics, mechanisms of peptide transport overbiological barriers, oxidative stress, and cognitiveenhancement. It also clarifies the basic molecularmechanisms of the neuronal and nitropeptidergicprocesses that are important in cognition.

Catalog no. K11501, June 2012, 319 pp.ISBN: 978-1-4398-3062-8, $149.95 / £95.00Also available as an eBook

New!

NeurotechnologyPremises, Potential,and ProblemsEdited by

James GiordanoCenter for NeurotechnologyStudies, Potomac Institute forPolicy Studies, Arlington,Virginia, USA and HumanScience Center, Ludwig-Maximilians University, Munich, Germany

New technologies that allow us to investigate mecha-nisms and functions of the brain have shown consider-able promise in treating brain disease and injury. Theseemerging technologies also provide a means to assessand manipulate human consciousness, cognitions,emotions, and behaviors, bringing with them thepotential to transform society. This volume explores thetechnical, moral, legal, and sociopolitical issues thatarise in and from today’s applications of neuroscienceand technology and discusses their implications for thefuture. Topics include neurotechnology in education,neuroimaging and tissue implantation technology neuroprostheses, cyborg technology, and more.






Neuroscience

New!

Neurons andthe DHAPrincipleRaymond C. ValentineUniversity of California at Davis,Professor Emeritus, USA andVisiting Scholar, University ofCalifornia, Santa Barbara, USA

David L. ValentineUniversity of California, Santa Barbara, USA

Recent discoveries have highlighted the role ofomega-3 fatty acid DHA in brain health and degener-ation as well as the molecular biology of this fatty acidin neurons. This research has led to a new theory ofneurodegeneration. This book provides in-depth cov-erage of the molecular biology of the omega-3 fattyacid DHA in neurons. Using examples from the worldof animal cells, the book illustrates the role of DHA inthe brain. It examines DHA benefits and risks and dis-cusses the link between DHA and the effects of aging.

Catalog no. K13471, November 2012, c. 272 pp.ISBN: 978-1-4398-7486-8, $159.95 / £95.00Also available as an eBook

MicrofabricatedCorticalNeuroprosthesesEdited by

André Mercanzini andPhilippe RenaudFaculty of Engineering, SwissFederal Institute of TechnologyLausanne (EPFL), Switzerland

Despite their demonstrated effectiveness, the long-term use of microscale neuroprosthetic devices is frequently compromised by the postimplantation tissue reaction that can form around the device. Thisbook studies ways to improve the tissue reaction toimplanted neuroprosthesis by use of a controlled drugrelease mechanism, quantified by novel measurementtechniques. The author, a holder of two U.S. patentson microassembly, also examines ways to improveneural stimulation and recording capability.

Catalog no. N10256, January 2011, 250 pp.ISBN: 978-1-4398-3754-2, $89.95 / £57.99

Time SeriesModeling ofNeuroscienceDataTohru OzakiInstitute of StatisticalMathematics, Tokyo, Japan

Due to recent advances in methodology that offer sig-nificant improvements over conventional methods,there is increasing interest in the use of time seriesmodels for the study of neuroscience data such asEEG, MEG, fMRI, and NIRS. This book presents anoverview of time series models for the study of neuro-science data. Accessible to applied statisticians as wellas quantitatively trained neuroscientists, the book issupported by many real examples to illustrate themethods and provides useful instructions for compu-tational problems, enabling readers to develop theirown computational toolbox to apply the methods toreal data.

Catalog no. C4602, January 2012, 574 pp.ISBN: 978-1-4200-9460-2, $99.95 / £63.99Also available as an eBook

TRP ChannelsEdited by

Michael X. ZhuThe University of Texas HealthScience Center at Houston, USA

Providing detailed methods for the study of transientreceptor potential (TRP) channels and their role in awide variety of cellular functions, this book includesexpression and functional studies of TRP channels inheterologous systems as well as structural and func-tional studies of TRP channels. The author alsoexplores various methods for detailed analysis of bio-physical properties of TRP channels. In addition, thetext covers high-throughput screening assays for TRPchannels and offers novel and effective approaches tostudy endogenous TRP channel function in native systems.






25

Neuroscience


The FemaleBrainSecond EditionCynthia L. DarlingtonUniversity of Otago, Dunedin,New Zealand

The first edition of this bestseller laid the groundworkfor understanding the female brain, examining theevidence of structural and functional differencesbetween the brains of males and females. Addressinga wealth of current research, the second edition con-tinues in this vein, leading readers through the basicprinciples of anatomy and physiology and on to thecomplex behavioral functions which constitute theworkings of the normal and abnormal female brain.Filled with rigorous scientific analysis in an easilyaccessible format, the book delineates gender-baseddifferences between brains and explains why theyshould be considered when designing research andclinical studies.


Atlas of HumanCentral NervousSystemDevelopmentFive-Volume SetShirley A. Bayer andJoseph AltmanIndianapolis, Indiana, USA

This award-winning series provides a complete recordof the development of the human central nervous sys-tem from spinal cord gestation through the thirdtrimester. The contents are organized by coronal,sagittal, and horizontal planes of sectioning, ensuringpictorial representation of nearly every structure in thedeveloping brain. Each volume provides two-pagespreads containing high-resolution black and whiteimages opposite ghost images with unabbreviatedlabels that clearly identify each structure. The final vol-ume summarizes major events of CNS developmentand offers a theoretical account of the morphogenet-ic processes involved.

Catalog no. 68008, July 2007ISBN: 978-1-4200-6800-9, $850.00 / £541.00

Micronutrientsand BrainHealthEdited by

Lester Packer, Helmut Sies, Manfred Eggersdorfer,and Enrique CadenasUnder the direction of leading experts in oxidativestress, this book addresses cutting-edge areas ofresearch regarding micronutrients and the brain. Itdiscusses age-related metabolic pathways, mitochon-drial nutrients, and neurodegeneration. Additionalchapters cover flavonoids, cell signaling, and neuronalfunctions, as well as the role of choline, amino acids,metals, and other micronutrients in brain health. Thetext places a particular emphasis on lipoic acid, whichis shown to be a therapeutic agent.


The Spinal Cord fromGestationalWeek 4 to the4th PostnatalMonthShirley A. Bayer andJoseph AltmanIndianapolis, Indiana, USA

This first volume in the Atlas of Human Central NervousSystem Development series sets the stage with com-plete coverage of the spinal cord from gestationalweek 4 to the 4th postnatal month. 3D color imagesprovide a holistic view of the structural changes dur-ing spinal cord morphogenesis. Providing quantitativesummaries of several ontogenetic trends, it features allthe stages of spinal cord development, offers freshinsights into the steps involved in the morphogenesisof the mature spinal cord, and shows the humanspinal cord at its most primitive stage—consistingmainly of neuroepithelial stem cells.







Neuroscience

The HumanBrain duringthe ThirdTrimesterShirley A. Bayer andJoseph AltmanIndianapolis, Indiana, USA

Since the brain in the third trimester is nearing matu-rity, this atlas can serve as a comprehensive guide tostructures in the adult brain. High magnification viewsof different areas of the cerebral cortex and cerebellarcortex show the degree of maturation of these largestructures in the third trimester brain. This atlas revealsthe maturation of the brain's settled and enduringneural populations. It also uncovers information aboutimmature features of the perinatal brain that havenever before been identified.


The HumanBrain Duringthe Late FirstTrimesterShirley A. Bayer andJoseph AltmanIndianapolis, Indiana, USA

The fourth volume in the Atlas of Human CentralNervous System Development series explores featuresof the perinatal brain, examining brain developmentduring the late first trimester (GW11-GW7.5). Themajor theme of this volume is the identification ofstretches and patches (mosaics) of the NEP matrixalong the hypertrophied telencephalic, diencephalic,mesencephalic, and rhombencephalic superventri-cles. The book also identifies many putative migrato-ry paths of young nerons on their way to their settlingsites.


The HumanBrain duringthe SecondTrimesterShirley A. Bayer andJoseph AltmanIndianapolis, Indiana, USA

“ … an excellent exposition of the fetal humanbrain development which contains valuable infor-mation not readily accessible elsewhere ... will be aworthwhile addition to the libraries of neuro-sciences whose pursuits require ready access to anauthoritative atlas on development of the humanbrain in the second trimester. This user-friendlyatlas will also be useful to residents, and evengraduate students needing to learn about thehuman brain development."

—Journal of Chemical Neuroanatomy


The HumanBrain duringthe Early FirstTrimesterShirley A. Bayer andJoseph AltmanIndianapolis, Indiana, USA

This is the fifth and concluding volume in the Atlas ofHuman Central Nervous System Development. Withhigh-resolution black and white photos as well asghost image photos with unabbreviated labels, it sur-veys structural processes that occur during develop-ment. Experimental H-thymidine radiography is usedto identify previously unknown structures. The book isdivided into two main sections: sagittal and frontalplane specimens. This volume also contains a summa-ry analysis of some of the morphogenetic processesinvolved in human brain development.






Laboratory Animal Pocket Reference SeriesThirteen-Volume Set

Edited by

Mark A. SuckowUniversity of Notre Dame, Indiana, USA

Amply illustrated with figures and tables, each book in this 13-volumeseries is a single-source reference that allows for the humane, healthy, andefficient handling of laboratory animals. These reader-friendly volumesdetail basic information and common procedures for individuals per-forming research with laboratory animals, including duties of animal facil-ity management, animal husbandry, regulatory compliance, and technical procedures. They also discusspossible sources and suppliers of animals, feed, sanitation supplies, cages, and research and veterinarysupplies. The newest additions to the series (The Laboratory Rabbit, The Laboratory Xenopus sp., TheLaboratory Swine, and The Laboratory Zebrafish) are now in color.

27

Lab Animal Science


Buy the Set & Save!

Catalog no. 2560, ISBN: 978-0-8493-2560-1 $649.95 / £414.00

Also available as stand-alone references

New!

The Laboratory MouseSecond EditionCatalog no. K12511, September 2012, 256 pp.Soft Cover, ISBN: 978-1-4398-5421-1, $59.95 / £38.99

Forthcoming!

The Laboratory RatSecond EditionCatalog no. K11462, December 2012, c. 368 pp.Soft Cover, ISBN: 978-1-4398-2986-8, $59.95 / £38.99Also available as an eBook

The Laboratory FerretCatalog no. K12861, March 2012, 123 pp.Soft Cover, ISBN: 978-1-4398-6181-3, $59.95 / £38.99Also available as an eBook

The Laboratory ZebrafishCatalog no. K10378, December 2010, 274 pp.Soft Cover, ISBN: 978-1-4398-0743-9, $59.95 / £38.99

The Laboratory Xenopus sp.Catalog no. 91093, December 2009, 180 pp.Soft Cover, ISBN: 978-1-4200-9109-0, $59.95 / £38.99

The Laboratory CanineCatalog no. 2893, October 2006, 184 pp.Soft Cover, ISBN: 978-0-8493-2893-0, $59.95 / £38.99

The Laboratory Nonhuman PrimateCatalog no. 2562, September 2001, 288 pp.Soft Cover, ISBN: 978-0-8493-2562-5, $59.95 / £38.99Also available as an eBook

The Laboratory SwineCatalog no. 1035, December 1999, 152 pp.Soft Cover, ISBN: 978-0-8493-1035-5, $55.95 / £35.99Also available as an eBook

The Laboratory Small RuminantCatalog no. 2568, March 1999, 176 pp.Soft Cover, ISBN: 978-0-8493-2568-7, $59.95 / £38.99

The Laboratory Hamster and GerbilCatalog no. 2566, December 1998, 168 pp.Soft Cover, ISBN: 978-0-8493-2566-3, $59.95 / £38.99

The Laboratory Guinea PigCatalog no. 2564, November 1997, 192 pp.Soft Cover, ISBN: 978-0-8493-2564-9, $57.95 / £36.99

The Laboratory CatCatalog no. 2567, November 1997, 160 pp.Soft Cover, ISBN: 978-0-8493-2567-0, $59.95 / £38.99

The Laboratory RabbitCatalog no. 2561, February 1997, 160 pp.Soft Cover, ISBN: 978-0-8493-2561-8, $55.95 / £35.99
















Lab Animal Science

Laboratory Mouse andLaboratory Rat ProceduralTechniquesManuals and DVDsJohn J. Bogdanske, Scott Hubbard-Van Stelle,Margaret Rankin Riley, and Beth M. SchiffmanResearch Animal Resources Center (RARC), University of Wisconsin, Madison, USA

“Currently, there is a paucity of training materialfor experimental techniques in laboratoryrodents, particularly audiovisual material. Themanuals and accompanying DVDs will be ofgreat interest to students, technicians, veterinari-ans, and investigators. Importantly, the straight-forward approach taken in both the printedmanual and DVD will be seen as an excellent toolfor non-English speaking personnel.”

—Mark A. Suckow, DVM, Dipl. ACLAM, Director, Freimann Life Science Center, University

of Notre Dame, & Past President of AALAS

“Students of animal technology can watchthese videos to 'get the picture' and then prac-tice with an experienced individual. It is a goodrefinement step of the 3Rs … . I will be veryexcited to have these manuals to use as trainingitems with my students and as referenceresources in our animal facility.”

—Bruce W. Kennedy, Compliance Associate,Research & Graduate Studies,

California State Polytechnic University, Pomona, &Past President of AALAS

Laboratory Mouse ProceduralTechniquesManual and DVDCatalog no. K12294, November 2010, 100 pp.Soft Cover, ISBN: 978-1-4398-5042-8$59.95 / £38.99

Laboratory Rat ProceduralTechniquesManual and DVDCatalog no. K12295, November 2010, 92 pp.Soft Cover, ISBN: 978-1-4398-5044-2$59.95 / £38.99

On DVD with Full-Color

CompanionManuals

This combination of manuals and DVDs providesmuch-needed training on the proper handling ofmice and rats used in biomedical research. The DVDsinclude narrated video clips that demonstrate anddescribe each procedural technique. The manualscontain handouts with color illustrations anddescriptive text for each technique, including thepurpose and application of the procedure, recom-mended skills, and necessary supplies. The pair canbe used as a training resource and refresher for labanimal veterinarians, veterinary technicians, animalcare staff, trainers, and research investigators andstaff who work with mice and rats.

Each DVD provides:

• Narrated video clips that demonstrate anddescribe each procedural technique

• Easy navigation to desired techniques,including handling/transfer, oral gavage, blood draw, restraint, injection, and ear notching and tagging

Each manual includes:

• Full text narratives and procedural handouts withcolor illustrations of each technique included on the DVD, including purpose and applicationof the procedure, recommended skills, and necessary supplies

• Supplementary chapters that provide normativedata for the laboratory rat and mouse

Buy the set and save!Two Manuals and Two DVDs

Catalog no. K12298, November 2010192 pp., Soft Cover, ISBN: 978-1-4398-5050-3

$108.00 / £68.99

Also available individually




29

Lab Animal Science


Atlas of theNeonatal RatBrainRenuka Ramachandraand ThyagarajanSubramanianThe Pennsylvania StateUniversity Hershey MedicalCenter, USA

Changes in the rat brain are rapid in the first twoweeks after birth. Atlas of the Neonatal Rat Brain provides researchers in neurology, pharmacology,biology, and veterinary science with detailed colorimages of the normal developing rat brain. It presentsphotographic, histological illustrations of the anatom-ical features of the neonatal rat brain at postnatal (P)days P-1, P-7, and P-14.

Each plate is a photomicrograph composite thatshows the entire brain in sagittal and coronal sectionsat each stage. The P-1 section contains 30 coronalplates and 14 sagittal plates and the P-7 sectionincludes 27 coronal plates and 24 sagittal plates. Thefinal P-14 section shows 41 coronal plates and 21sagittal plates. Each set consists of contiguous sectionsfrom individual animals, and selections were based onthe structural variability represented.

The sections are Nissl stained with Cresyl violet creating photomicrographs with high resolution andclarity. The structures are directly labeled on theimages, making it easier to correlate data. Additionalimages are available as electronic resources for indi-viduals who seek images not represented in this vol-ume, and the electronic version allows labels to beremoved so the atlas can be used as a teaching tool.

Contents:

Preface

Acknowledgements

Introduction

Nomenclature

Histology

Imaging

Atlas Plates: PI Rat Brain, P7 Rat Brain, PI4 Rat Brain

Index

Catalog no. K11857, January 2011, 188 pp.ISBN: 978-1-4398-4012-2, $159.95 / £108.00Also available as an eBook

The Minipig inBiomedicalResearchEdited by

Peter A. McAnultyNon-Clinical Consultant,Roskilde, Denmark

Anthony D. DayanLondon, UK

Niels-Christian GanderupEllegaard Gottingen Minipigs A/S, Dalmose, Denmark

Kenneth L. HastingsSanofi-aventis, Bethesda, Maryland, USA

The first comprehensive single-source reference onthe minipig, this accessible manual discusses itspotential and use as a model. Written by acknowl-edged experts in the field, the book describes bestpractices in husbandry, transport, and experimenta-tion. It explains and illustrates clinical, practical, andexperimental techniques and procedures. It providesmany examples of successful use of the minipig inbasic and regulatory toxicity studies of drugs anddevices. It also discusses clinical and physiologicalfindings and laboratory values in health and disease. A48-page color insert is included.


BiodefenseResearchMethodologyand AnimalModelsSecond EditionEdited by

James R. SwearengenNational Biodefense Analysis andCountermeasures Center, Frederick, Maryland, USA

Since the publication of the first edition of this vol-ume, significant advances have been made in animalmodel development for biological research, and theramifications of the FDA’s Animal Efficacy Rule havebecome better understood in the scientific communi-ty. With each chapter completely updated, this volume spans the spectrum of coverage from basicresearch to advanced development of medical countermeasures. Topics discussed include a history ofbiological agents as weapons, concepts and strategiesinvolved in biowarfare and bioterrorism, animal mod-els in biodefense research, and infectious disease aer-obiology. The book also presents studies involving arange of specific diseases and toxins.






Lab Animal Science

Stereotaxic andChemo-architecturalAtlas of theBrain of theCommonMarmoset(Callithrix jacchus)Craig D. Hardman and Ken W. S. AshwellUniversity of New South Wales, Sydney, Australia

Written for international neuroscientists engaged inresearch of neurological disorders such as Parkinson’sdisease, Multiple Sclerosis, and Alzheimer’s disease, aswell as professionals working in laboratories conduct-ing pharmacokinetic studies, this book is the first comprehensive stereotaxic atlas of all parts of the marmoset brain, including up-to-date data on corticalareas. The book provides precise stereotaxic co-ordi-nates, functionally important chemoarchitecturalinformation, and estimates for the numbers of neu-rons within important brain regions and nuclei. It alsoprovides information for assessing the efficacy of treat-ments in marmoset models.

Catalog no. K11718, January 2012, 515 pp.ISBN: 978-1-4398-3778-8, $179.95 / £114.00Also available as an eBook

The COSTManual ofLaboratoryAnimal Careand UseRefinement, Reduction,and ResearchEdited byBryan HowardFormer Director of Animal Welfare, University of Sheffield, UKTimo NevalainenUniversity of Eastern Finland, KuopioGemma PerrettaItalian National Research Council, Santa Maria di Galeria, Italy

COST (European Cooperation in the field of Scientificand Technical Research) is an intergovernmental ini-tiative in science and research intended to promotethe coordination of nationally funded research inEurope. In this volume, four working groups discussthe housing of animals, their environmental needs,refinement of procedures, genetically modified ani-mals, and cost-benefit analysis. Based on the activitiesof these working groups, the book provides theEuropean best practices for individuals and institutionsworking with laboratory animals. The text also dis-cusses the ethical evaluation of experiments and pro-cedures involving animals.

Catalog no. K11184, October 2010, 439 pp.ISBN: 978-1-4398-2492-4, $89.95 / £57.99

CurrentResearch inAnimalPhysiologyEdited by

Victor S. LamoureuxBroome Community College,Binghamton, New York, USA

Animal physiology is the scientific study of how thebodies of animals function. How does an animalbreathe, develop, eat and digest, reproduce, controlits activities? The field encompasses the molecular,cellular, tissue, and organ systems of animals. Thisbook looks at an eclectic selection of studies in animalphysiology, including how animals adapt to theirphysical environments, how human interaction canaffect animal functioning, and much more. Animalscovered include cows, mice, eels, pigs, rabbits, cats,and dogs, as well as various insects.

Catalog no. N10605, December 2011, 318 pp.ISBN: 978-1-926692-79-1, $129.95 / £82.00Also available as an eBook

Bestseller!

The IACUCHandbookSecond EditionEdited by

Jerald SilvermanUniversity of MassachusettsMedical School, Worcester, USA

Mark A. SuckowUniversity of Notre Dame, Indiana, USA

Sreekant MurthyDrexel University, Philadelphia, Pennsylvania, USA

Since its establishment by USDA regulation in the1980s, the Institutional Animal Care and UseCommittee has evolved as the premiere US instru-ment for animal welfare supervision. This volume pro-vides a foundation for those attempting to under-stand and implement the various responsibilities ofthis committee. This edition features comprehensiveupdates for all pertinent federal laws, regulations, andpolicies, incorporating revised suggestions on best-practice compliance from experienced professionals.With concise, easy-to-find information, it remains thereference of choice for researchers and professionals.

Catalog no. 4010, October 2006, 680 pp.ISBN: 978-0-8493-4010-9, $89.95 / £57.99





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