Neuroinflamação e neurodegeneração€¦ · Contributions of the D-serine pathway to...
Transcript of Neuroinflamação e neurodegeneração€¦ · Contributions of the D-serine pathway to...
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Neuroinflamação e neurodegeneração
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Altern Med Rev 1998;3(6):432-447
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Vascular risk factor detection and control may prevent Alzheimer’s disease
Ageing Research Reviews 9 (2010) 218–225
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Glycine and N-Methyl-D-Aspartate Receptors: Physiological Significance and Possible TherapeuticApplications
PHARMACOLOGICAL REVIEWS Vol. 50, No. 4
NMDA receptors
Neurology 76 May 17, 2011
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Hipótese glutamatérgica da esquizofrenia
Rev Bras Psiquiatr 2003;25(3):177-83
Contributions of the D-serine pathway to schizophrenia
Neuropharmacology 62 (2012) 1484e1503
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Glycine and its synaptic interactions
Neurology 77 August 16, 2011
Glutamate signaling in the pathophysiology and therapy of schizophrenia
Pharmacology, Biochemistry and Behavior 100 (2012) 665–677
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Adenosine, energy metabolism and sleep homeostasis
Sleep Medicine Reviews 15 (2011) 123e135
Overview of glutamatergic neurotransmission in the nervous system
Pharmacology, Biochemistry and Behavior 100 (2012) 656–664
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Glutamate abnormalities in obsessive compulsive disorder: Neurobiology,pathophysiology, and treatment
Pharmacology & Therapeutics 132 (2011) 314–332
Glutamate abnormalities in obsessive compulsive disorder: Neurobiology,pathophysiology, and treatment
Pharmacology & Therapeutics 132 (2011) 314–332
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From pancreatic islets to central nervous system, the importance of glutamatedehydrogenase for the control of energy homeostasis
Neurochemistry International 59 (2011) 510–517
Trycats
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Inflammatory Biomarkers and Depression
Neurotox Res
The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation inducesindoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased
synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 (2011) 702–721
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A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness
Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 (2011) 676–692
Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways
Progress in Neuro-Psychopharmacology & Biological Psychiatry 42 (2013) 101–114
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Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways
Progress in Neuro-Psychopharmacology & Biological Psychiatry 42 (2013) 101–114
Excitotoxicidade
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The role of glutamate in neuronal ischemic injury: the role of spark in fire
Neurol Sci
Anedonia
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The possible role of the kynurenine pathway in anhedonia in adolescents
J Neural Transm
Stress
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Metabotropic and ionotropic glutamate receptors as neurobiological targets inanxiety and stress-related disorders: Focus on pharmacology and preclinical
translational models
Pharmacology, Biochemistry and Behavior 100 (2012) 775–800
Parkinson
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Novel anti-inflammatory therapy for Parkinson’s disease
TRENDS in Pharmacological Sciences Vol.24 No.8 August 2003
Pathogenesis of Parkinson’s Disease
Movement Disorders, Vol. 28, No. 1, 2013
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Does cellular iron dysregulation play a causative role in Parkinson’s disease?
Ageing Research Reviews 3 (2004) 327–343
Alzheimer
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Mechanisms Underlying Inflammation in Neurodegeneration
Cell 140, 918–934, March 19, 2010
New therapeutic targets in Alzheimer’s disease: brain deregulation of calcium and zinc
Cell Death and Disease (2011) 2, e176;
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Neuroprotective Effect of Natural Products Against Alzheimer’s Disease
Neurochem Res
Molecular mechanisms for Alzheimer’s disease: implications for neuroimaging and therapeutics
Journal of Neurochemistry, 2006, 97, 1700–1725
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Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer’s disease
Brain Research Bulletin 87 (2012) 144– 153
The failure of mitochondria leads to neurodegeneration: Do mitochondria need ajump start?
Advanced Drug Delivery Reviews 61 (2009) 1316–1323
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Glutamate-Based Antidepressants: Preclinical Psychopharmacology
BIOL PSYCHIATRY 2013;]:]]]–]]]
Modulando glutamato
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The promise of N-acetylcysteine in neuropsychiatry
Trends in Pharmacological Sciences xx (2013) 1–11
The promise of N-acetylcysteine in neuropsychiatry
Trends in Pharmacological Sciences xx (2013) 1–11
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N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind RandomizedPlacebo-Controlled Trial
BIOL PSYCHIATRY 2008;64:468–475 1g
N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia—A Double-Blind, Randomized,Placebo-Controlled Trial
BIOL PSYCHIATRY 2008;64:361–368 1g
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N-Acetylcysteine, a Glutamate Modulator, in the Treatment of Trichotillomania
Arch Gen Psychiatry. 2009;66(7):756-763
Chronic N-Acetylcysteine during Abstinence or Extinction after Cocaine Self-Administration Produces Enduring Reductions in Drug Seeking
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS vol. 337, no. 2
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N-acetyl cysteine add-on treatment for bipolar II disorder: a subgroupanalysis of a randomized placebo-controlled trial
Journal of Affective Disorders 129 (2011) 317–320
Hipótese glutamatérgica da esquizofrenia
Rev Bras Psiquiatr 2003;25(3):177-83
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Depressão
Depression and treatment response: dynamic interplay of signaling pathways and altered neural processes
Cell. Mol. Life Sci. (2013) 70:39–53
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An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways
Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 (2011) 784–794
Oxidative/nitrosative stress and antidepressants: Targets for novel antidepressants
Progress in Neuro-Psychopharmacology & Biological Psychiatry xxx (2012) xxx–xxx
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Nitric oxide and major depression
Nitric Oxide 24 (2011) 125–131
Signaling pathways underlying the rapid antidepressant actions of ketamine
Neuropharmacology 62 (2012) 35e41
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Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression
BIOL PSYCHIATRY 2010;67:139–145
Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression
BIOL PSYCHIATRY 2010;67:139–145
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Ketamine for Depression: Where Do We Go from Here?
BIOL PSYCHIATRY 2012;72:537–547
Novel therapeutic targets in depression: Minocycline as a candidate treatment
Behavioural Brain Research 235 (2012) 302– 317
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Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study
Progress in Neuro-Psychopharmacology & Biological Psychiatry 37 (2012) 222–226
Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study
Progress in Neuro-Psychopharmacology & Biological Psychiatry 37 (2012) 222–226
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Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects
Journal of Psychopharmacology 26(12) 1512–1524
Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects
Journal of Psychopharmacology 26(12) 1512–1524
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The role of zinc in neurodegenerative inflammatory pathways in depression
Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 (2011) 693–701
The role of zinc in neurodegenerative inflammatory pathways in depression
Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 (2011) 693–701
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Plasma magnesium levels and treatment outcome in depressed patients
Nutritional Neuroscience 2012 VOL. 15 NO. 2
Serum zinc level in depressed patients during zinc supplementation of imipraminetreatment
Journal of Affective Disorders 126 (2010) 447–452
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Serum zinc level in depressed patients during zinc supplementation of imipraminetreatment
Journal of Affective Disorders 126 (2010) 447–452
Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression:A randomized, double-blind, placebo-controlled trial (1g_
European Neuropsychopharmacology(]]]]) ], ]]]–]]]
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Neuroinflamação
• Omega-3 e GLA.
• Polifenóis ou antiinflamatórios.
• Magnésio.
• Antioxidantes.
• Sinergia.
• Drogas