Neural responses in the auditory nervous system depend not ... · Web view(2011) Effect of auditory...
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SEMINARIO 29 DE NOVIEMBRE DE 2013 Functional mechanisms that mediate stimulus-specific adaptation in the auditory brain Manuel S. Malmierca Auditory Neurophysiology Laboratory. Institute of Neuroscience of Castilla y León, University of Salamanca Salamanca, Spain C/ Pintor Fernando Gallego, 1 37007 Salamanca, Spain Stimulus-specific adaptation (SSA) is the reduction in the responses to a common sound relative to the same sound when rare. It has been described in auditory cortex (AC; Ulanovsky et al., 2003) and in the auditory midbrain and thalamus (IC and MGB). In this talk I will show our recent findings on recordings from single neurons in the IC and MGB of rats to an oddball paradigm, as well as the effect of reversible cortical deactivation and the manipulation at synaptic level as these responses. Our data indicates: 1) Most neurons in the non-lemnical divisions of the IC and MGB show strong SSA (Malmierca et al. 2009, Antunes et al., 2010); 2) the magnitude of adaptation in many IC neurons increased proportionally with frequency contrast and low probability of occurrence for deviant tones (Ayala and Malmierca, 2012). 3) SSA varies within the neuronal receptive field (Duque et al., 2012). 4) GABAergic and/or glycinergic inhibition play a role in shaping SSA in the IC (Pérez-González et al., 2012) and MGB (Duque et al., 2013). 5) AC modulates the responses of neurons in a gain control manner but SSA in the IC (Anderson and Malmierca, 2013) and MGB (Antunes et al., 2011) is not inherit from the AC (Antunes et al., 2011). Taken together our results suggest that SSA can be generated in a bottom-up manner throughout the auditory pathway and they are congruent with the notion that subcortical SSA can contribute upstream to the generation of MMN. In the future, we wish to know the cellular mechanisms that generate SSA and also to understand how neurons that exhibit SSA
Transcript of Neural responses in the auditory nervous system depend not ... · Web view(2011) Effect of auditory...
SEMINARIO 29 DE NOVIEMBRE DE 2013
Functional mechanisms that mediate stimulus-specific adaptation in theauditory brain
Manuel S. Malmierca
Auditory Neurophysiology Laboratory. Institute of Neuroscience of Castilla y León, University of Salamanca Salamanca, Spain
C/ Pintor Fernando Gallego, 137007 Salamanca, Spain
Stimulus-specific adaptation (SSA) is the reduction in the responses to a common sound relative to the same sound when rare. It has been described in auditory cortex (AC; Ulanovsky et al., 2003) and in the auditory midbrain and thalamus (IC and MGB).In this talk I will show our recent findings on recordings from single neurons in the IC and MGB of rats to an oddball paradigm, as well as the effect of reversible cortical deactivation and the manipulation at synaptic level as these responses. Our data indicates: 1) Most neurons in the non-lemnical divisions of the IC and MGB show strong SSA (Malmierca et al. 2009, Antunes et al., 2010); 2) the magnitude of adaptation in many IC neurons increased proportionally with frequency contrast and low probability of occurrence for deviant tones (Ayala and Malmierca, 2012). 3) SSA varies within the neuronal receptive field (Duque et al., 2012). 4) GABAergic and/or glycinergic inhibition play a role in shaping SSA in the IC (Pérez-González et al., 2012) and MGB (Duque et al., 2013). 5) AC modulates the responses of neurons in a gain control manner but SSA in the IC (Anderson and Malmierca, 2013) and MGB (Antunes et al., 2011) is not inherit from the AC (Antunes et al., 2011). Taken together our results suggest that SSA can be generated in a bottom-up manner throughout the auditory pathway and they are congruent with the notion that subcortical SSA can contribute upstream to the generation of MMN.In the future, we wish to know the cellular mechanisms that generate SSA and also to understand how neurons that exhibit SSA code for other, more complex patterns of regularity beyond the oddball paradigm such us expected and unexpected sounds in different context.
Financial support was provided by the Spanish MICINN (BFU2009-07286), MICINN-EU (EUI2009-04083).
Anderson LA, Malmierca MS (2013) The effect of auditory cortex deactivation on stimulus-specific adaptation in the inferior colliculus of the rat. The European journal of neuroscience 37 (1):52-62.
Antunes FM, Malmierca MS (2011) Effect of auditory cortex deactivation on stimulus-specific adaptation in the medial geniculate body. The Journal of neuroscience 31 (47):17306-17316.
Antunes FM, Nelken I, Covey E, Malmierca MS (2010) Stimulus-specific adaptation in the auditory thalamus of the anesthetized rat. PloS one 5 (11):e14071. doi:10.1371/journal.pone.0014071
Ayala YA, Malmierca MS (2013) Stimulus-specific adaptation and deviance detection in the inferior colliculus. Frontiers in neural circuits 6:89. doi:10.3389/fncir.2012.00089
Duque D, Malmierca MS, Caspary DM (2013) Modulation of stimulus-specific adaptation by GABAA receptor activation or blockade in the medial geniculate body of the anesthetized rat. J Physiol, 2013/10/09 edn. doi:jphysiol.2013.261941 [pii] 10.1113/jphysiol.2013.261941
Duque D, Perez-Gonzalez D, Ayala YA, Palmer AR, Malmierca MS (2012) Topographic distribution, frequency, and intensity dependence of stimulus-specific adaptation in the inferior colliculus of the rat. The Journal of neuroscience 32 (49):17762-17774.
Malmierca MS, Cristaudo S, Perez-Gonzalez D, Covey E (2009) Stimulus-specific adaptation in the inferior colliculus of the anesthetized rat. The Journal of neuroscience 29 (17):5483-5493.
Perez-Gonzalez D, Hernandez O, Covey E, Malmierca MS (2012) GABA(A)-mediated inhibition modulates stimulus-specific adaptation in the inferior colliculus. PloS one 7 (3):e34297. doi:10.1371/journal.pone.0034297
Ulanovsky N, Las L, Nelken I (2003) Processing of low-probability sounds by cortical neurons. Nature neuroscience 6 (4):391-398. doi:10.1038/nn1032
