Neoplasms of the Nose and Paranasal Sinuses - gmch.gov.in lectures/ENT/Nose-sinus-0006.pdf · and...
Transcript of Neoplasms of the Nose and Paranasal Sinuses - gmch.gov.in lectures/ENT/Nose-sinus-0006.pdf · and...
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Neoplasms of the Nose and Paranasal Sinuses
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Sinonasal Neoplasms
3% of aerodigestive malignancies1% of all malignancies2 to 1 malesSixth to seventh decadesSymptomatology same
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Sinonasal Neoplasms
Nasal cavity (benign = malignant)Benign - inverting papillomaMalignant - SCCA
Sinuses (malignant)SCCAMaxillary most common
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Epidemiology
Occupational exposure in >40%nickel workers - SCCAhardwood dust & leather tanning - adenoca
Viral - HPVCigarettes & alcohol
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Presentation
Similar symptoms to common problems6 to 8 month delay in diagnosisCranial neuropathies & proptosis
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PresentationOral - 30%tooth pain, trismus, palatal fullness,
erosion
Nasal - 50%obstruction, epistaxis, discharge, erosion
Ocular - 25%diplopia, proptosis, tearing, pain, fullness
FacialV2 numbness, asymmetry, pain
Auditory - CHL
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Advanced Disease
Classic Triadfacial asymmetrytumor bulge in oral cavitynasal mass
All three - 40-60%One - 90%
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Diagnosis
Physical examNasal endoscopyBiopsyRadiology
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Computed Tomography
Bone erosionorbit, cribiform plate, fovea, post max sinus wall, PTPF, sphenoid, post wall of frontal sinus
85% accuracy? Tumor vs. inflammation vs. secretions
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MRI Superior to CT
multiplanar no ionizing radiation
Inflammatory tissue & secretions - intense T2 Tumor - intermediate T1 & T2 94% accuracy 98% accuracy with gadolinium
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INVERTED PAPILLOMAS
Fungiform (50%) - septumCylindrical (3%) - lateral nasal wallInverting (47%) - lateral nasal wallrecurs, locally destructive, malignant
potentialmen, 6th-7th decades, unilateralSCCA - 2-13%Recurrence - 0-80%
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Osteomas
Benign, slow-growing15 to 40 yearsfrontal > ethmoid > maxillarylocal excision
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Fibrous Dysplasia
Normal bone replaced by collagen, fibroblasts, and osteoid material< 20 yearsground-glass appearanceTreatment excision?
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Neurogenic tumorsSchwannomassurface of nerve fibersno malignant degenerationalong trigeminal & ANS
Neurofibromaswithin nerve fibersvon Recklinghausen’s diseasemalignant degeneration in 15%
Complete excision
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SCCA
Most common - 80%Max > nasal cavity > ethmoidsMalesSixth decade90% have eroded walls of sinuses
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Adenoid Cystic Carcinoma
Palate > major salivary glands > sinusesResistant to txMultiple recurrences, distant metsPerineural spreadLong-term followup necessary
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Mucoepidermoid Carcinomarare, widespread local invasion
Adenocarcinoma2nd most common, 5-20%ethmoidsoccupational exposures
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Hemangiopericytoma Uncommon pericytes of Zimmerman 80% of sinonasal tumors in ethmoids resembles nasal polyps average in 55 yo excision, XRT for (+) margins
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Melanoma1% originate in sinonasal cavity5th-8th decadesanterior septummaxillary antrumpolypoid mass, pigmentation?5 yr = 38%10 yr = 17%
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Olfactory NeuroblastomaNeural crest originno urinary VMA or HVAbimodal distribution at 20 and 50locally aggressiverosettes are hallmarkKadish staginglocal recurrence 50-75%metastasis 20-30%
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Osteogenic Sarcomamost common primary bone tumoronly 5% in H & N, mandible most involvedsunray appearance
Fibrosarcomararely seen in sinuses
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Chondrosarcoma3rd-5th decadeshistologic dx difficultslow erosion of skull base, (+) margins
Rhabdomyosarcomamost common in children35-45% in H&N, 8% in sinusesembryonal, alveolar, pleomorphictriple tx
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Lymphomabimodal presentationNHLirradiation +/- chemo
Extramedullary plasmacytoma40% in paranasal sinuses/nose“benign”must r/o myelomaexcision or irradiation
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Metastatic tumors
Renal cell carcinomalungsbreastsurogenital tractgastrointestinal tractPalliation necessary
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Ohngren’s Line
SuprastructureInfrastructure
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Staging of Maxillary Sinus Tumors
T1: limited to antral mucosa without bony erosion
T2: erosion or destruction of the infrastructure, including the hard palate and/or middle meatus
T3: Tumor invades: skin of cheek, posterior wall of sinus, inferior or medial wall of orbit, anterior ethmoid sinus
T4: tumor invades orbital contents and/or: cribriform plate, post ethmoids or sphenoid, nasopharynx, soft palate, pterygopalatine or infratemporal fossa or base of skull
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Surgery
Unresectable tumors:Superior extension: frontal lobesLateral extension: cavernous sinusPosterior extension: prevertebral fasciaBilateral optic nerve involvement
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Treatment
T3 and T460% local recurrenceSurgeryIrradiationChemotherapy
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Surgical resection
Endoscopic excisionWLEmedial maxillectomytotal maxillectomyradical maxillectomy +/- exenterationcraniofacial resection
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Neck Dissection
Retropharyngeal and jugulodigastric nodes10% (+) necksneck dissectionpalpable nodesradiographic evidence of disease
40% cervical mets at 4 yrs
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Radiation therapy
Primary tx only for palliation10-15% improved 5 year survivalXRT = 23% vs. Surgery + XRT = 44%preoperative vs. postoperativeprotection of CNS and globeXRT 12-20% unilateral visual loss, 0-8%
bilateral visual lossSurgery 10-20% useless globes, 2X with
XRT
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Chemotherapy
Palliation, unresectable disease(+) margins, perineural spread, surgical
refusal, ECSIntraarterial chemotherapyRobbins - 86% response of T4 lesionsLee - 91% satisfactory response
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