NEONATAL RESPIRATORY MECHANICS
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Transcript of NEONATAL RESPIRATORY MECHANICS
![Page 1: NEONATAL RESPIRATORY MECHANICS](https://reader035.fdocuments.net/reader035/viewer/2022081605/58f9b121760da3da068bbdb5/html5/thumbnails/1.jpg)
NEONATAL RESPIRATORY MECHANICS
Dr. Murtaza KamalMBBS, MD, DNB
Division of NeonatologyDepartment of Pediatrics
Safdarjung Hospital & VMMC, New DelhiDOP-07/11/2015
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What is expected of us post talk??
Compliance Resistance Time Constant Lung Volumes Oxygenation CO2 removal Clinical implications
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COMPLIANCE
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Compliance
Measurement of distensibility
C= Volume change (V) / Pressure change(P)
Volume change per unit pressure
Lung which is more compliant is more distensible and vice versa
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Clinical Implications
In RDS
Less compliant lungs Requires more pressure to ensure
tidal volume delivery
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Clinical Implications (cont.)
Role of Surfactant
Improves compliance Results in a rapid decline in
pressures required to deliver the tidal volumes after surfactant administration
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Lets try this
3kg neonate, tidal volume delivered-14ml, pressure required to drive this volume is PIP of 18 and PEEP of 4
Calculate compliance=??
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So we got… Compliance=
Tidal volume/ Pressure gradient=14/ (PIP-PEEP)=14/14=1ml/cm Hg
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Clinical Implications (cont.)
Collapsed/ overstretched lungs poor compliance
PEEP Pressure required to open the lungs and keep it inflated
High PIP (excess pressure) which over distends the lungs, does not result in better volume delivery
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Clinical Implications (cont.) These lung
propertiesTypical sigmoid shape curve to pressure-volume loop
Operate on the rapid slope (middle segment) during ventilation
Fig.1
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RESISTANCE
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Resistance
The oppositional force for air flow into the lungs
Higher the resistance, greater is the pressure required to drive the gases into the lungs
Depends on: Airway diameter Airway length Viscosity of gas
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Resistance Resistance is directly proportional to:
Length Viscosity 1/r4
Pressure required to drive 1L/min of gas flow into the lungs
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Clinical Implications
As length increases- resistance increases
Eg: long ET tube flow sensor or capnograph
Trim the ET tube to 2.5cm outside the upper lip
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Clinical Implications (cont.) A small decrease in airway diameter
causes a large change in resistance
Removal of airway secretions and largest diameter ET tube that fits the glottis to be chosen
Higher air flows increases the resistance by causing turbulence to gas flow
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TIME CONSTANT
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Time Constant
Time taken to empty the gases from lungs
It nearly takes 3-5 time constants to completely empty the lungs
Time constant(sec)= Compliance x Resistance
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Time Constant
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Time Constant
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Clinical Implications
RDS: Low compliance, normal resistance Hence time constant-> less Time required to inflate (Ti) or
deflate (Te) the lungs ->Hence short
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Clinical Implications(cont.)
MAS Resistance is high, Compliance
decreases little bit Hence, time constant increases Time required to inflate (Ti) or deflate
(Te) the lungs hence is long A short set expiratory time on
ventilator can lead to inadequate lung emptying and hence gas trapping
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Clinical Implications(cont.)
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LUNG VOLUMES
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Lung Volumes of our Importance
Tidal volume
Minute volume
Functional residual volume
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TIDAL VOLUME
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Tidal Volume
Volume of the gas going in and out with each breath
5-8ml/kg
Ideally inspiratory and expiratory tidal volumes are equal
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Clinical Implications
Whenever peritubal leak during MV, air leaks more during inspiration (higher PIP and wider airways)
Hence, in modes of ventilation where tidal volume is being targeted, it is better to measure the expiratory volume (volume of gas that actually goes to the lungs)
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DEAD SPACE
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Dead Space Respiratory component-
Terminal bronchiole, Alveolar sacs Alveoli
Anatomical dead space- Part of tidal volume which is not a part of gas exchange (airways) 2ml/kg
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Dead Space
Some gas in alveoli, due to ill perfusion, is not a part of gas exchange
Physiological dead space- Anatomical+ ill perfused alveoli
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So Tidal Volume is…
Alveolar tidal volume+ Anatomical dead space+ ill perfused alveoli’s vol
Alveolar tidal volume+ Physiological dead space
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MINUTE VOLUME
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Minute Volume
Total volume of the gas moving in and out of the lungs per minute
MV=TV X RR
200-480 ml/kg/min
Alveolar MV= ??
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Clinical Implications
MV, esp the alveolar MV, is determinant of CO2 removal
Co2 removal hastened either by increasing the TV or rate
Better to increase the TV more energy efficient (Increasing TV--dead space is constant but increasing rate– increases dead space too)
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FUNCTIONAL RESIDUAL CAPACITY
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FRC
Volume of the gas present in the lungs at the end of expiration
Allows gas exchange to be a continuous process
25-30ml/kg
RDS-FRC low MAS-FRC high
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Clinical Implications PVR- Least at normal FRC PVR increases as FRC increases of decreases
Indicators of normal FRC: 6-8 intercostal spaces on CXR Fall in FiO2 when increasing the PEEP
when a neonate is on CPAP or MV
CPAP and surfactant—Interventions done to allow normal FRC in neonatal lungs
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OXYGENATION
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Oxygenation
Parameters determining oxygenation are:
Mean Airway pressure (directly proportional)
FiO2 (directly proportional)
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Mean Airway Pressure
The average pressure exerted on the airway and the lungs from the beginning of inspiration until the beginning of next inspiration
Most powerful influence on oxygenation
MAP=K(PIP*Ti)+(PEEP*Te) / Ti+Te
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Pressure-Time Graph
MAP is the area under the curve for one respiratory cycle
Slope of pressure rise is dependent on flow
K depends on the slope
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High MAP will lead to…
Decreased cardiac output Pulmonary hypoperfusion Increased risk of barotrauma
(Levels>12cm H2O contributes to barotrauma)
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Clinical Implications MAP can be increased by:
Increasing PIP Increasing PEEP Increasing I/E ratio Increase the flow rate( converts the
sign wave pressure time graph to a square wave)
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So for increasing oxygenation…
Prefer increasing MAP when: Lung disease is severe (Pneumonia) Lung volume is small (RDS)
Prefer increasing FiO2 when: Lung volume is increased(MAS) When there is air leak
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So lets scratch our heads now…
PIP=22 PEEP=4 Rate=40/min IT=.4 sec
Calculate MAP-??
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Lets get it… Rate =40/min So, one cycle of breath=60/40=1.5 sec IT=0.4sec So, ET=1.5-0.4=1.1sec So, MAP=K(PIP*Ti)+(PEEP*Te) / Ti+Te
=1(22*0.4)+(4*1.1)/1.5 =1(8.8)+(4.4)/1.5 =13.2/1.5 =8.8cm H20
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C02 ELIMINATION
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CO2 Elimination
Depends on MV (alveolar minute volume more specifically) and RR
CO2 elimination directly proportional to alveolar tidal volume and respiratory rate
=(PIP-PEEP)*RR
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Achieve CO2 elimination by:
Decreasing dead space Excess ET tube Secretions Partial block
Increasing PIP Increasing rate Decreasing PEEP (only if there is lung
hyperinflation)
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LETS TRY OUT THESE…
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Question 1
1]True about RDS is? A] Low compliance, High resistance B]High compliance, Low resistance C]Low compliance, Normal
Resistance D]High compliance, High resistance
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Question 2
2]Which of the following will affect PaCO2 maximum?
A]Secretions in the ET tube B]Respiratory Rate C]Tidal volume D]Dead space
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Question 3
3] Which is a wrong match? A] FRC—PVR B] PaO2—MAP C] PaCO2—TV D] MAP—FiO2
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KEY CONCEPTS
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Key Concepts
Compliance is distensibility, resistance is the oppositional force and time constant is the time required to empty the lungs
Lung tissue determine the compliance, airways determine the resistance and both compliance and resistance determine the time constant
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Key Concepts(cont…)
Ventilation is intermittent but gas exchange is continuous. Alveolar Minute Volume is a measure of ventilation and FRC influences gas exchange
MAP and FiO2 regulate oxygenation while alveolar tidal volume and respiratory rate regulate PaCO2 when a neonate is on MV
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