Natural Resources for our Healthy Natural Resources for our Healthy and Prosperous Generationand Prosperous Generation

Subagus WahyuonoSubagus WahyuonoFaculty of Pharmacy, Universitas

Gadjah Mada, Yogyakarta, Indonesia

IndonesiaIndonesia

Indonesia is an archipelago comprising of approximately 17,508 islands. It encompasses 37 provinces with about 250 million people, making Indonesia is the world's fourth most populous country

West CentralEast

We are blessed by the richnest of biodiversity on We are blessed by the richnest of biodiversity on the world. This is one of Biodiversity Hot spots in the world. This is one of Biodiversity Hot spots in

IndonesiaIndonesia

Papaver somniverum

Salix alba

Nicotiana tabacum

Taxus brevifolia

Garlic

Diospyros kaki

(kesemek)

Traditional Medicine has been Traditional Medicine has been Practiced in IndonesiaPracticed in Indonesia

TRM practiceTRM practice Raw materials Raw materials traditionally usedtraditionally used

Jamu Godog Jamu Godog

Registered Jamu Registered Jamu preparationpreparation

1st lady1st lady

Herbal Herbal Product Product

SymbolsSymbols

INTEGRATEDINTEGRATED MEDICINEMEDICINE

TRADITIONALTRADITIONAL

MEDICINEMEDICINE

WESTERN MODERN WESTERN MODERN MEDICINEMEDICINE

HARMONIZATIONHARMONIZATION

STANDARDIZATIONSTANDARDIZATION

Way to “Health for All ”

• 105 species were collected according to local Medicine Man, consisting of:– 3 families

(Lycopodiaceae, Gleicheniaceae, Polypodiaceae) of Pteridophyte

– 42 families of Spermatophyte

Searching Potential Searching Potential Biodiversity from Central Biodiversity from Central Kalimantan, guided by Kalimantan, guided by local medicine manlocal medicine man

• Yellow roots (Male)• Arcangelisia flava (L.) Merr.

(Fam. Menispermaceae)• Cure Liver deseases

• Yellow roots (Female)• Fibraurea chloroleuca

Miers. (Fam. Menispermaceae)

• Cure Liver deseases

N O

O

O

OCH3

OCH3

8-oxoprotoberberineHeLa Cells (20.08%)

inhibited in vitro by this compound (500 µg/ml).

• Renta (Local name) • Combretum acuminatum

Roxb. (Fam. Combretaceae)• Protection for pregnant

woman from Magic.

• Sinduk (Local name) (Garlic odor when the leaves craushed)

• Scorodocarpus borneensis Becc. (Fam. Olacaceae)

• Stomachache, antiflatullent

• Saluang belong Male (local Name)

• Dictamnus albus L. (Fam. Rutaceae)

• Sexual enhancement for Men

• Pasak bumi/Tongkat Ali• Eurycoma longifolia

Jack. (Fam. Simaroubaceae)

• Sexual enhancement for men

• Serai hutan (Local name)• Celtis cinnamomea Lindl.

ex Plancho (Fam. Ulmaceae)

• Smell likes Lemon Grass (Gramineae)

• Tapak barito (Local Name)

• Ficus deltoidea Jack. (Fam. Moraceae)

• Habitus : epifit• Sexual enhancement for

women

Principal Active Compounds

THE ROLES OF THE ROLES OF NATURAL RESOURCESNATURAL RESOURCES FOR FOR HUMAN HEALTH AND PROSPERITYHUMAN HEALTH AND PROSPERITYFlora, Animals

MicroorganismsMarine chemistry

Human biochemistry

DRUGSDRUGS(Curative)(Curative)

PHYTOPHARMAKA (Plants)

(Curative)

Chemopreventive, Chemoprotective

(Prevention)

Methyl gallateMethyl gallate

CurativeCurative v/s v/s PPreventireventiveve

Secretion

Procarcinogen

Metabolic activation

Ultimate Carcinogen

Normal cells

Initiation (1-2 days)

Initiated cells

Promotion (> 10 thn)

Preneoplastic cells

Neoplastic cells

Progression (> 1 thn)

Multi-stage of Multi-stage of carcinogenesiscarcinogenesis

Detoxification

KuratifKuratif

PRO-TECTPRO-TECT : : A product provides A product provides aa broad spectrum flavonoid complex broad spectrum flavonoid complex

Pro-tectPro-tect : Provides broad spectrum antioxidant nutrition of flavonoid.

Pro-tectPro-tect : Provides flavonoids present in the 8 standardized-qualified extracts

FlavonoidFlavonoid : a phenolic type of compound present in plants, responsible for the bright colors of fruits, vegetables, useful for health promotion.

Pro-Tect contains :Pro-Tect contains : Pycnogenol dan grape seed extract Redbilberry extract Grape skin extract Green tea extract Ginkgo biloba extract Milk thistle (Sylibum marianum) extract Citrus bioflavonoids

Red Billberry

Gyngko biloba

Silibum marianum

Silimarin

Lutein (a carrotenoid type of compound)

Utilize the waste of carrot (Daucus carota) leaves

Proton NMR

Lutein

Scientific data is Scientific data is a must a must

OPTIMATION OF KESEMEK (Diospyros kaki Thunb.) LEAVES AS SUPPLEMEN PRODUCT TO PROMOTE

HEALTH

• This sp. grows well in the northern of TNGM (Merapi Mt National Park)• The fruits have economic values for people• The leaves are discarded• How to optimize economic values of the plant benefit for people surrondings

Similarity Index 79,2 %

Similarity index 20,8 %

Herbs Garden

Herbal Medicine Products

Modern Medicine, Taxol

But please not this kind But please not this kind of product.....of product.....

Thank you for your attention

Research LaboratoryDept. of Pharmaceutical Biology

Faculty of Pharmacy, GMUUnit-2, 1st floor

E-mail: Subagusw@yahoo.com