National Alliance for Medical Image Computing http://na-mic.org

Core 3-1 Schizophrenia

NA-MICNational Alliance for Medical Image Computing http://na-mic.org

Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School

Surgical Planning Laboratory, MRI Division, Department of Radiology Brigham & Women’s Hospital, Harvard Medical School

National Alliance for Medical Image Computing http://na-mic.org

Data• All the legacy data has been converted to one single file format,

nrrd.• Total of 188 morphological cases and 80 diffusion cases have

been uploaded. • Each case has a unique BIRN identifier. Information about

diagnosis, data parameters and labels associated with Region of Interests (ROI) are on the BIRN site in the following Excel files:

- morph-NAMIC.xls : Gives diagnosis, age, gender as well as the ROIs drawn for each morphological case.

- morph-ROI-description.xls: Gives for each ROI set, the label corresponding to specific structures.

- diffusion-NAMIC.xls: Gives diagnosis, age, gender, ROIs drawn and when existing, the corresponding morphological data ID number.

- diffusion-ROI-description.xls: Gives or each ROI set, the label corresponding to specific structures.

National Alliance for Medical Image Computing http://na-mic.org

Data Sets Already Uploaded

MRI Data: • Raw SPGR (124 slices of 1.5 mm thickness, voxel dimensions 0.9375 x 0.9375 x 1.5

mm): (N=26 SZ; N=28 AFF; N=29 Ctrl).• ROIs- Amygdala-Hippocampus: (N=16 SZ and N=15 Ctrl). - STG: (N=17 SZ; N=16 AFF; N=18Ctrl).- MTG & ITG: (N=23 SZ; N=28 Ctrl).- Caudate: (N=15 SPD; N=14 Ctrl).- Insular Cortex & Temporal Pole: (N=26 SZ; N=28 AFF; N=29 Ctrl).DTI Data:• Raw DWI data (8 images- six gradient directions plus 2 T2W, FOV 220mm, 256 x

256 image matrix, 4 mm slice thickness, 1 mm interslice distance).• ROIs- Cingulum Bundle: (N=31 SZ; N=42 Ctrl).- Fornix: (N=24 SZ; N=31 Ctrl).

National Alliance for Medical Image Computing http://na-mic.org

MRI Data

National Alliance for Medical Image Computing http://na-mic.org

A B

STG

MTG

ITG

STG

MTG

ITG

ab

c de

fg

h

STG, MTG, and ITG Segmented ROIs

(Onitsuka et al., AJP In Press)

National Alliance for Medical Image Computing http://na-mic.org

(Kasai et al., Arch Gen Psychiatry, 2003)

Insular Cortex and Temporal Pole ROI

National Alliance for Medical Image Computing http://na-mic.org

Caudate Nucleus ROI

(Koo et al., In Preparation)

National Alliance for Medical Image Computing http://na-mic.org

DTI Data

National Alliance for Medical Image Computing http://na-mic.org

Cingulum Bundle

ROI was drawn on 8 consecutive slices. The fiber tract is much longer, however, but not easy to delineate.

(Kubicki et al., 2003)

National Alliance for Medical Image Computing http://na-mic.org

Fornix

ROI drawn on 1slice perpendicular to the plane.

(Kuroki et al., in press)

National Alliance for Medical Image Computing http://na-mic.org

Rules for accessing and using the data

• IRB training (human subject’s protection)

• Data sharing (do not give data to other people)

• ROI data publication acknowledgement

• Grant acknowledgement- NIGHS/NI - U54 GM 072977 to Ron Kikinis- NIH - P41 RR13218 to Ron Kikinis; RO1 NS39335 to Stephan Maier; R01 MH 50747 to Martha

Shenton; K05 MH 70047 to Martha Shenton; R01 MH 40799 to Robert McCarley; R03 MH 068464 to Marek Kubicki.

- VA- Merit Awards to Martha Shenton and to Robert McCarley and a Research Enhancement Award Program (VA REAP) to Robert McCarley and to Martha Shenton.