Nanotechnology - National Cancer Institute...N. no Silver Toothpaste Nano Alpha Arbutin Anti...
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Nanotechnology
Transcript of Nanotechnology - National Cancer Institute...N. no Silver Toothpaste Nano Alpha Arbutin Anti...
Nanotechnology
Outline
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What is nano?
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Examples of nanomaterials
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Nanoparticles in daily life
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Nanoparticles
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Products
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Products
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Companies and nanotechnology
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Nanomaterials
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Nanoparticle exposure
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Nanoparticles for medicine
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Medical applications
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Evolving landscapes
Medical applications
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Clinical grade products
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Nanoproducts
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Immunotherapy
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Benefits: Gene therapy
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Benefits: Vaccines
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Benefits: Lymphatic delivery
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Benefits: Image guided surgery
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Toxicity
Nanoparticles
Terminology
Immune system
Particle size
Nanoparticles
Structure activity relationship
Immune system
Bidirectional communication
Protein binding
Biodistribution
MPS uptake
Macrophage polarization
Hemolysis
Hemolysis
Coagulation system
Undesirable effects
Zeta potential
Platelets
Endothelial cells
Complement activation
Fibrous carriers
IL-1 induction
Cationic liposomes
Chemokine induction
IFN induction
IFN induction
API immunotoxicity
Platform selection
Infusion reactions
2nd generation liposomes
Allergenicity
Immunogenicity
Anti-PEG antibody
Anti-inflammatory properties
Immunosuppression
Take home message
Nanotechnology characterization lab
Future directions
NCL team
NCL immunology team
