Nanoparticle Safety UTSI November 2011. Introduction - Nanoparticles Nanoparticles have at least...
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Transcript of Nanoparticle Safety UTSI November 2011. Introduction - Nanoparticles Nanoparticles have at least...
Introduction - Nanoparticles Nanoparticles have at least one
dimension between 1 and 100 nanometers (nm)
They have existed in nature since time beganExample – fine particles associated with combustion or volcanic eruptions
Only recently (past 20 years) have they been engineered
Introduction - Examples of Engineered Nanoparticles Carbons
examples - Fullerenes, nanotubes Oxides
examples - Titanium dioxide, silicon dioxide Metals
examples - Gold, zinc, nickel, copper Semiconductors
examples - CdSe, CdS, InAs, InP Polymers/organics
examples- liposomes
Introduction -Nanoparticles Nano-scale materials may have different
properties as compared to the bulk material
For example gold is malleable in the bulk form but is brittle and appears red in color at the nano-scale
Introduction – MonitoringMeasurement of most hazardous air contaminants is done on a mass-to-volume ratio
Example milligrams/cubic meter of air
This type of measurement is not always acceptable when evaluating nano-scale substances with respect to hazard
Introduction-Monitoring Other nanoparticle characteristics, that
can’t be easily measured in the workplace, may be more important in hazard assessment for, such as Surface area Number of particles Electrical charge of the particle Agglomeration of particles Particle size Solubility
Introduction Nano-scale particles haven’t been fully
evaluated with respect to toxicity, especially for chronic exposures.
Therefore, it’s necessary to have an increased level of safety to offset uncertainties with respect to risk
Controls Traditional controls such as ventilation,
respirators, gloves, etc. work well against nanoparticles according to the National Institute for Occupational Safety and Health (NIOSH).
Disposable nitrile gloves are recommended for use with nanoparticles in the UTSI lab
Material Safety Data Sheets Materials Safety Data Sheets (MSDS) are
available for various materials. However, the MSDS don’t address nano-
scale particles of the substance Therefore, professional judgment must
be used when conducting hazard evaluations with nano-scale particles.
Hazard Assessment Most nano-scale dusts can act as a
mechanical irritant to the skin, and mucous membranes (eyes, nose and throat).
Nanoparticles in a liquid are not capable of becoming airborne and therefore present less of a hazard
Hazard Assessment - Dermal The nanoparticles used at UTSI are
sandwiched between transparent adhesive plastic tape.
This should make exposure essentially zero
However, disposable gloves are recommended as a general precaution.
Hazard Assessment - Ingestion Ingestion is highly unlikely for the nano-
scale alloy particles used at UTSI
Steps to prevent ingestion include: Use gloves while handling the materials Remove gloves and wash hands following
work in the lab Don’t allow hand-to-mouth contact (e.g.
eating, drinking) while working in the lab.
Hazard Assessment - Inhalation Inhalation can be the most significant
route of entry into the body for an airborne material.
Particles less than 5 microns (5000 nm) in size can penetrate deeply into the lungs where some clearance mechanism (cilia) are not present
In addition, smaller particles are likely to stay airborne for a longer period of time
Hazard Assessment - Inhalation It’s unlike that any of the nano-scale
alloys used at UTSI would be inhaled through routine handling
However, it’s prudent to limit unnecessary inhalation
Hazard Assessment – Accidental Release In the event an accidental release of the
nanoparticles occurs: Avoid breathing the dust Use gloves to clean up the spilled
material Use wet methods (damp paper towel or
other material) to collect the spill Avoid creating a dust
Hazard Assessment –Accidental Release Clean up materials, including personal
protective equipment, from a spill may be discarded via regular trash
They aren’t considered a hazardous waste.
It’s suggested they be placed in a sealed plastic bag and kept damp if possible
OSHA Compliance Labeling – Containers of the nano-particles
must be labeled The OSHA HazCom labeled should contain:
Name of the substance (example: iron oxide) A hazard warning (example: caution, dust
may be irritating) Name of the responsible individual (or
company) who is familiar with the substance
OSHA Compliance Employees who are likely to come in contact
with the material should receive training
The information in this PowerPoint presentation should meet the requirements for training.
Results of training must be documented, which can be done by a quiz, sign-in sheet or by other means.
OSHA Compliance Material Safety Data Sheet should be
made available to the workers
Employee’s should know the location of UTSI’s Hazard Communication Plan (also called HazCom or Right to Know Plan)
OSHA Compliance Individuals who are likely to come in
contact with the material should know: How to detect the presence or release of
a the nanoparticles (such as visual appearance)
Methods of self –protection (such as gloves or the use of wet methods for clean up and not eating food or drinking in the lab)
Europium Sulfide The chemical, physical and toxicological
properties of europium have not been thoroughly investigated and recorded.
Europium Sulfide Unable to find an MSDS for Europium
Sulfide on the Internet However, it should behave similar to
Europium chloride. Information the next two pages
regarding europium were taken from:
http://www.espirareearth.com/MSDS/Europium%20Chloride.htm
Europium Sulfide Europium metals are moderately to
highly toxic. Symptoms of toxicity include writhing,
ataxia, labored respiration, walking on the toes with arched back and sedation.
Low toxicity by ingestion exposure. Again, exposure is extremely unlikely in
the UTSI lab and none of these symptoms are anticipated.
Europium Intraperitoneal route is highly toxic Subcutaneous route is poisonous to
moderately toxic. The production of lung and skin
granulomas after exposure to them requires extensive protection to prevent such exposure
Iron Oxide Iron oxide is fairly innocuous and
shouldn’t present a distinct health hazard. The primary hazard would be irritation of skin or mucous membranes upon contact
A copy of the MSDS can be found at:
http://fscimage.fishersci.com/msds/09765.htm
Iron-Cobalt Alloy
The primary health effect of an iron-cobalt alloy is irritation of the skin or mucous membranes upon contact
A material safety data sheet for iron-cobalt alloy can be found at:
http://www.alloycastproducts.com/docs/MSDS.pdf
Cobalt Alloys Cobalt can be hazardous by ingestion or
inhalation. An MSDS for cobalt can be found at:
http://www.sciencelab.com/msds.php?msdsId=9923518
It’s unlike that exposure will occur in the UTSI lab.