Name : ZEYNEP

Surname : ŞIKLAR

E-mail : zeyneps@ankara.edu.tr

Phone Number : 0312 595 66 35

Title : PROF. DR.

Unit : FACULTY OF MEDICINE

Department : Department of Pediatric Endocrinology

NAME & SURNAME Zeynep ŞIKLAR

ACADEMIC TITLE Prof. Dr.

DEPARTMENT Pediatric Endocrinology

BUSINESS ADDRESS Ankara Universitiy School of Medicine Department of Pediatric Endocrinology

BUSINESS PHONE +90 312 5956791 +90 312 5957235

BUSINESS FAX: +90 312 3191440

CELL PHONE -

E-MAIL : zeynepsklr@gmail.com zeyneps@ankara.edu.tr

ACADEMIC CAREER Education Medical School : Istanbul Universitiy School of Medicine 1980-1986 Post Graduate Education : Residency in pediatrics: Ankara Education and Research Hospital, 1987- 1991 Residency in pediatric endocrinology: Ankara University School of Medicine 2001-2003 Receiving Associate Professor title: 1998 Academic Positions Specialist in Pediatric Endocrinology, Ankara Universitiy School of Medicine Department of Pediatric Endocrinology 2003-2008 Associate Professor : Ankara Universitiy School of Medicine Department of Pediatric Endocrinology 2008-2010 Professor: Ankara Universitiy School of Medicine Department of Pediatric Endocrinology 2010- to be continued

mailto:zeynepsklr@gmail.commailto:zeyneps@ankara.edu.tr

ADMINISTRATIVE RESPONSIBILITIES

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INTERNATIONAL EXPERIENCE

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CURRENT PROFESSIONAL MEMBERSHIPS

ESPE (European Society of Pediatric Endocrinology), Turkish Pediatric Endocrinology and Diabetes Society

AWARDS AND GRANTS

RESEARCH AREA Growth, Bone, Disorders of Sexual Development, Puberty, Obesity

INTERNATIONAL PUBLICATIONS

INTERNATIONAL PUBLICATIONS

1. Tanyer G, Şıklar Z, Dallar Y, Yıldırmak Y, Tıraş Ü. Multiple dose IVIG treatment in neonatal immune hemolytic jaundice. J Tropical Pediatrics 2001;47: 50-3.

2. Şıklar Z, Tezer H, Dallar Y, Tanyer G. Borderline congenital hypothyroidism in the neonatal period. J Ped Endocrinol Metab 2002; 15 (6): 817-21.

3. Kocaturk PA, Şıklar Z, Kavas GO, Dallar Y, Tanyer G. Zinc treatment affects superoxide dismutase activity in growth retardation. Biol Trace Elem Res 2002; 90(1-3):39-46.

4. Şıklar Z, Tuna C, Dallar Y, Tanyer G. Zinc deficiency: a contributing factor of short stature in growth hormone deficient children. J Trop Pediatr. 2003; 49(3):187-8.

5. Erdeve O, Şıklar Z, Kocaturk PA, Dallar Y, Kavas GO. Antioxidant superoxide dismutase activity in obese children. Biol Trace Elem Res. 2004;98(3):219-28.

6. Kocaturk PA, Kavas GO, Erdeve O, Şıklar Z. Superoxide dismutase activity and zinc and copper concentrations in growth retardation. Biol Trace Elem Res. 2004;102(1-3):51-9.

7. Şıklar Z, Sanli E, Dallar Y, Tanyer G. Diurnal variation of height in children. Pediatr Int. 2005;47(6):645-8.

8. Darendeliler F, Berberoglu M, Ocal G, Adiyaman P, Bundak R, Gunoz H, Bas F, Darcan S, Goksen D, Arslanoglu I, Yildiz M, Ercan O, Ercan G, Ozerkan E, Can S, Bober E, Adal E, Sarikaya S, Dallar Y, Şıklar Z, Bircan I, Bideci A, Yuksel B, Buyukgebiz A. Response to growth hormone with respect to pubertal status on increased dose in idiopathic growth hormone deficiency: an analysis of Turkish children in the KIGS database (Pfizer International Growth Study). J Pediatr Endocrinol Metab. 2005;18(10):949-54.

9. Evliyaoglu O, Berberoglu M, Adiyaman P, Aycan Z, Ergur A, Şıklar Z, Ocal G, Fitoz S. Incidence of iodine deficiency in patients presenting with goitre—discrepancy between clinical and ultrasonographic evaluation of the thyroid: comparison of patients with and without autoimmune thyroiditis--clinical, hormonal and urinary iodine excretion studies. J Pediatr Endocrinol Metab. 2006;19(1):39-44.

10. Berberoglu M, Evliyaoglu O, Adiyaman P, Ocal G, Ulukol B, Simsek F, Şıklar Z, Torel A, Ozel D, Akar N. Plasminogen activator inhibitor-1 (PAI-1) gene polymorphism (-675 4G/5G) associated with obesity and vascular risk in children. J Pediatr Endocrinol Metab. 2006;19(5):741-8.

11. Şıklar Z, Öçal G, Adıyaman P, Ergur A, Berberoğlu M. Functional ovarian hyperandrogenism and polycystic ovary syndrome in prepubertal girls with obesity and/or premature pubarche. J Pediatr Endocrinol Metab 2007; 20 (4): 475-481.

12. Kara C, Ocal G, Berberoğlu M, Şıklar Z, Adiyaman P. Persistently raised thyroid stimulating hormone in adequately treated congenital hypothyroidism on long-term follow-up. J Pediatr Endocrinol Metab. 2008 Mar;21(3):251-6.

13. Ergür AT, Ocal G, Berberoglu M, Tekin M, Kiliç BG, Aycan Z, Kutlu A, Adiyaman P, Şıklar Z, Akar N, Sahin A, Akçayöz D. Paternal X could relate to arithmetic function; study of cognitive function and parental origin of X chromosome in Turner syndrome. Pediatr Int. 2008; 50(2):172-4.

14. Sadeghi F, Yurur-Kutlay N, Berberoglu M, Cetinkaya E, Aycan Z, Kara C, Ilgin Ruhi H, Ocal G, Şıklar Z, Elhan A, Tukun A. Identification of frequency and distribution of the nine most frequent mutations among patients with 21-hydroxylase deficiency in Turkey. J Pediatr Endocrinol Metab. 2008; 21(8):781-7.

15. Şıklar Z, Citak FE, Uysal Z, Oçal G, Ertem M, Engiz O, Adiyaman P, Ileri T,Gözdaşoğlu S, Berberoğlu M. Evaluation of glucose homeostasis in transfusion-dependent thalassemic patients. Pediatr Hematol Oncol. 2008 Sep;25(7):630-7.

16. Tezer H, Şıklar Z, Dallar Y, Doğankoç Ş. Early and severe presentation of vitamin D deficiency and nutritional rickets among hospitalized infants and the effective factors. Turk J Pediatr 2009; 51: 110-115.

17. Şıklar Z, Berberoglu M, Öçal G, Bilir P, Erdeve SS.

The Endocrinologist 2009; 19(6):285-287.

18. Şıklar Z, Oçal G, Bilir P, Ergur A, Berberoğlu M. "Maternal/Neonatal" iodine status in patients with prolonged physiological jaundice. Exp Clin Endocrinol Diabetes. 2009; 117(7):312-5.

19. Coker A, Cetinkaya E, Dundar B, Şıklar Z, Buyukgebiz A, Arman A. Characterization of GH-1 mutations in children with isolated growth hormone deficiency in the Turkish population. J Pediatr Endocrinol Metab. 2009; 22(10):937-46.

20. Engiz O, Berberoğlu M, Şıklar Z, Oçal G. Risk factors for non-alcoholic fatty liver disease in obese children. Horm Res. 2009;72(1):63-4.

21. Hacihamdioğlu B, Berberoğlu M, Siklar Z, Savaş Erdeve S, Oçal G, Tutar E,Atalay S. Amiodarone-induced thyrotoxicosis in children and adolescents is a possible

http://journals.lww.com/theendocrinologist/Abstract/2009/11000/Evaluation_of_Final_Height_and_Parentally_Adjusted.12.aspxhttp://journals.lww.com/theendocrinologist/Abstract/2009/11000/Evaluation_of_Final_Height_and_Parentally_Adjusted.12.aspxhttp://journals.lww.com/theendocrinologist/Abstract/2009/11000/Evaluation_of_Final_Height_and_Parentally_Adjusted.12.aspx

outcome in patients with low iodine intake. J Pediatr Endocrinol Metab. 2010; 23(4):363-8.

22. Öcal G, Berberoğlu M, Şıklar Z, Bilir P, Uslu R, Yağmurlu A, Tükün A, Akar N, Soygür T, Gültan S, Gedik VT. Disorders of sexual development: an overview of 18 years experience in the pediatric Endocrinology Department of Ankara University. J Pediatr Endocrinol Metab. 2010; 23(11):1123-32.

23. Özçakar ZB, Kadioğlu G, Şıklar Z, Kavaz A, Nur Aksanal F, Berberoğlu M, Ekim M, Ocal G, Yalçinkaya F. The effect of colchicine on physical growth in children with familial mediterranean fever. Eur J Pediatr. 2010; 169(7):825-8.

24. Savas Erdeve S, Ocal G, Berberoglu M, Şıklar Z, Hacihamdioglu B. Is Adrenocorticotropic Hormone Deficiency Really Rare in Patients with Idiopathic Growth Hormone Deficiency and Normal Thyroid Function Tests? Horm Res Paediatr. 2011; 75(3): 200-5.

25. Siklar Z, Oçal G, Berberoglu M, Hacihamdioglu B, Erdeve SS, Egin Y, Akar N. Evaluation of Hypercoagulability in Obese Children With Thrombin Generation Test and Microparticle Release: Effect of Metabolic Parameters. Clin Appl Thromb Hemost. 2011 Nov-Dec;17(6):585-9.

26. Siklar Z, Berberoglu M, Savas Erdeve S, Hacihamdioglu B, Ocal G, Egin Y, Akar N. Contribution of clinical, metabolic, and genetic factors on hypertension in obese children and adolescents. J Pediatr Endocrinol Metab. 2011;24(1-2):21-4.

27. Ocal G, Berberoğlu M, Sıklar Z, Ruhi HI, Tükün A, Camtosun E, Erdeve SS,Hacıhamdioğlu B, Fitöz S. The clinical and genetic heterogeneity of mixed gonadal dysgenesis: does "disorders of sexual development (DSD)" classification based on new Chicago consensus cover all sex chromosome DSD? Eur J Pediatr. 2012 May 30.

28. Baş F, Darendeliler F, Aycan Z, Cetinkaya E, Berberoğlu M, Sıklar Z, Ocal G, Timirci O, Cetinkaya S, Darcan S, Gökşen Şimşek D, Bideci A, Cinaz P, Böber E, Demir K, Bereket A, Turan S, Atabek ME, Tütüncüler F, Isbir T, Bozkurt N, Kabataş Eryılmaz S, Uzunhan O, Küçükemre Aydın B, Bundak R. The exon 3-deleted/full-length growth hormone receptor polymorphism and response to growth hormone therapy in growth hormone deficiency and turner syndrome: a multicenter study. Horm Res Paediatr. 2012;77(2):85-93.

29. Savas Erdeve S, Berberoglu M, Yurur-Kutlay N, Siklar Z, Hacihamdioglu B, Tukun A, Ocal G. Characteristics and prevalence of non-classical congenital adrenal hyperplasia with a V2811 mutation in patients with premature pubarche. J Pediatr Endocrinol Metab. 2011;24(11-12):965-70.

30. Savas Erdeve S, Ocal G, Berberoglu M, Siklar Z, Hacihamdioglu B, Evliyaoglu O, Fitoz S. The endocrine spectrum of intracranial cysts in childhood and review of the literature. J Pediatr Endocrinol Metab. 2011;24(11-12):867-75.

31. G. Ocal, M. Berberoglu, Z. Siklar, H.I. Ruhi, A. Tükün, E. Çamtosun, S. S. Erdeve, B. Hacihamdioglu, S. Fitöz. The clinical and genetic heterogeneity of mixed gonadal dysgenesis: does ‘disorders of sexual development (DSD) ’classification based on new Chicago consensus cover all sex chromosome DSD? Eur J Pediatr 2012;171: 1497-1502.

32. Hacıhamdioğlu B, Oçal G, Berberoğlu M, Savaş Erdeve S, Camtosun E, Kocaay P,Fitoz S, Ceyhan K, Dindar H, Yağmurlu A, Kır M, Unal E, Sıklar Z. The evaluation of thyroid carcinoma in childhood and concomitance of autoimmune thyroid disorders. J Pediatr Endocrinol Metab. 2014 Sep;27(9-10):901-8.

33. Simsek DG, Aycan Z, Özen S, Cetinkaya S, Kara C, Abalı S, Demir K, Tunç O, Uçaktürk A, Asar G, Baş F, Cetinkaya E, Aydın M, Karagüzel G, Orbak Z, Sıklar Z, Altıncık A, Ökten A, Özkan B, Ocal G, Semiz S, Arslanoğlu İ, Evliyaoğlu O, Bundak R, Darcan Ş. Diabetes care, glycemic control, complications, and concomitant autoimmune diseases in children with type 1 diabetes in Turkey: a multicenter study. J Clin Res Pediatr Endocrinol. 2013;5(1):20-6.

34. Şıklar Z, Berberoğlu M. Syndromic disorders with short stature. J Clin Res Pediatr Endocrinol. 2014;6(1):1-8.

35. Tacyildiz N, Ozyörük D, Yavuz G, Unal EC, Dinçaslan H, Tanyıldız GO, Gördü Z, Sıklar Z, Berberoğlu M, Ocal G. Rare childhood tumors in a Turkish pediatric oncology center. Indian J Med Paediatr Oncol. 2013 Oct;34(4):264-9.

36. Hacıhamdioğlu B, Öçal G, Berberoğlu M, Sıklar Z, Fitöz S, Tutar E, Nergisoğlu G, Savaş Erdeve S, Çamtosun E. Preperitoneal fat tissue may be associated with arterial stiffness in obese adolescents. Ultrasound Med Biol. 2014 May;40(5):871-6.

37. Aydın BK, Aycan Z, Sıklar Z, Berberoğlu M, Ocal G, Cetinkaya S, Baş VN, Kendirci HN, Cetinkaya E, Darcan S, Gökşen D, Evliyaoğlu O, Sükür M, Baş F, Darendeliler F. Adherence to growth hormone therapy: results of a multicenter study. Endocr Pract. 2014 Jan-Feb;20(1):46-51.

38. Hacıhamdioğlu B, Kendirli T, Oçal G, Sıklar Z, Savaş Erdeve S, Ince E, Berberoğlu M. Pathophysiology of critical illness hyperglycemia in children. J Pediatr Endocrinol Metab. 2013;26(7-8):715-20.

39. Flanagan SE, Xie W, Caswell R, Damhuis A, Vianey-Saban C, Akcay T, Darendeliler F, Bas F, Guven A, Siklar

Z, Ocal G, Berberoglu M, Murphy N, O'Sullivan M, Green A, Clayton PE, Banerjee I, Clayton PT, Hussain K, Weedon MN, Ellard S. Next-generation sequencing reveals deep intronic cryptic ABCC8 and HADH splicing founder mutations causing hyperinsulinism by pseudoexon activation. Am J Hum Genet. 2013 Jan 10;92(1):131-6

40. and Pediatric hormonal disturbances after hematopoietic stem cell transplantation. Expert Review of Endocrinology & Metabolism January 2013, Vol. 8, No. 1 , Pages 81-90

41. Şıklar Z, Kocaay P, Çamtosun E, İsakoca M, Hacıhamdioğlu B, Savaş Erdeve Ş, Berberoğlu M. The Effect of Recombinant Growth Hormone Treatment in Children with Idiopathic Short Stature and Low Insulin-Like Growth Factor-1 Levels. J Clin Res Pediatr Endocrinol. 2015 Dec 5;7(4):301-6. doi: 10.4274/jcrpe.2111

42. Delil K, Karabulut HG, Hacıhamdioğlu B, Şıklar Z, Berberoğlu M, Öçal G, Tükün A, Ilgın Ruhi H. Investigation of SHOX Gene Mutations in Turkish Patients with Idiopathic Short Stature. J Clin Res Pediatr Endocrinol. 2015 Dec 18. doi: 10.4274/jcrpe.2307. [Epub ahead of print] PubMed PMID: 26758084.

43. Çamtosun E, Flanagan SE, Ellard S, Şıklar Z, Hussain K, Kocaay P, Berberoğlu M. A Deep Intronic HADH Splicing Mutation (c.636+471G>T) in a Congenital Hyperinsulinemic Hypoglycemia Case: Long Term Clinical Course. J Clin Res Pediatr Endocrinol. 2015 Jun;7(2):144-7. doi: 10.4274/jcrpe.1963. PubMed PMID: 26316438; PubMed Central PMCID: PMC4563187.

44. Yildiz AE, Ceyhan K, Sıklar Z, Bilir P, Yağmurlu EA, Berberoğlu M, Fitoz S. Intrathyroidal Ectopic Thymus in Children: Retrospective Analysis of Grayscale and Doppler Sonographic Features. J Ultrasound Med. 2015 Sep;34(9):1651-6. doi: 10.7863/ultra.15.14.10041. Epub 2015 Aug 12. PubMed PMID: 26269296.

45. Topcu V, Ilgin-Ruhi H, Siklar Z, Karabulut HG, Berberoglu M, Hacihamdioglu B, Savas-Erdeve S, Aycan Z, Peltek-Kendirci HN, Ocal G, Tukun FA. Investigation of androgen receptor gene mutations in a series of 21 patients with 46,XY disorders of sex development. J Pediatr Endocrinol Metab. 2015 Nov 1;28(11-12):1257-63. doi: 10.1515/jpem-2014-0500. PubMed PMID: 26197461.

46. Sıklar Z, Berberoğlu M, Çamtosun E, Kocaay P. Diagnostic characteristics and metabolic risk factors of cases with polycystic ovary syndrome during adolescence. J Pediatr Adolesc Gynecol. 2015 Apr;28(2):78-83. doi: 10.1016/j.jpag.2014.05.006. Epub 2014 May 28. PubMed PMID: 25850587.

47. Poyrazoğlu Ş, Akçay T, Arslanoğlu İ, Atabek ME, Atay Z, Berberoğlu M, Bereket A, Bideci A, Bircan İ, Böber

http://informahealthcare.com/action/doSearch?Contrib=Zeynep+Siklar%5C*+and+http://informahealthcare.com/action/doSearch?Contrib=Zeynep+Siklar%5C*+and+http://informahealthcare.com/action/doSearch?Contrib=Merih+Berberoglu

E, Can Ş, Cesur Y, Darcan Ş, Demir K, Dündar B, Ersoy B, Esen İ, Güven A, Kara C, Keskin M, Kurtoğlu S, Memioğlu N, Özbek MN, Özgen T, Sarı E, Şıklar Z, Şimşek E, Turan S, Yeşilkaya E, Yüksel B, Darendeliler F. Current practice in diagnosis and treatment of growth hormone deficiency in childhood: a survey from Turkey. J Clin Res Pediatr Endocrinol. 2015 Mar;7(1):37-44. doi: 10.4274/jcrpe.1794. PubMed PMID: 25800474; PubMed Central PMCID: PMC4439890.

48. Baş F, Uyguner ZO, Darendeliler F, Aycan Z, Çetinkaya E, Berberoğlu M, Şiklar Z, Öcal G, Darcan Ş, Gökşen D, Topaloğlu AK, Yüksel B, Özbek MN, Ercan O, Evliyaoğlu O, Çetinkaya S, Şen Y, Atabek E, Toksoy G, Aydin BK, Bundak R. Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study. Endocrine. 2015 Jun;49(2):479-91. doi: 10.1007/s12020-014-0498-1.

49. Öcal G, Berberoğlu M, Sıklar Z, Aycan Z, Hacıhamdioglu B, Erdeve ŞS, Çamtosun E, Kocaay P, Ruhi HI, Kılıç BG, Tukun A. Clinical review of 95 patients with 46,XX disorders of sex development based on the new Chicago classification. J Pediatr Adolesc Gynecol. 2015 Feb;28(1):6-11. doi: 10.1016/j.jpag.2014.01.106. Epub 2014 Nov 12. PubMed PMID: 25444050.

50. Şıklar Z, Berberoğlu M. Current Status of Childhood Hyperinsulinemic Hypoglycemia in Turkey. J Clin Res Pediatr Endocrinol. 2016 Dec 1;8(4):375-380. doi: 10.4274/jcrpe.2991. PubMed PMID: 27181376; PubMed Central PMCID: PMC5197994.

51. Şıklar Z, Genens M, Poyrazoğlu Ş, Baş F, Darendeliler F, Bundak R, Aycan Z, Savaş Erdeve Ş, Çetinkaya S, Güven A, Abalı S, Atay Z, Turan S, Kara C, Can Yılmaz G, Akyürek N, Abacı A, Çelmeli G, Sarı E, Bolu S, Korkmaz HA, Şimşek E, Çatlı G, Büyükinan M, Çayır A, Evliyaoğlu O, İşgüven P, Özgen T, Hatipoğlu N, Elhan AH, Berberoğlu M. The Growth Characteristics of Patients with Noonan Syndrome: Results of Three Years of Growth Hormone Treatment: A Nationwide Multicenter Study. J Clin Res Pediatr Endocrinol. 2016 Sep 1;8(3):305-12. doi: 10.4274/jcrpe.3013. PubMed PMID: 27125300; PubMed Central PMCID: PMC5096494.

52. Şıklar Z, Karataş D, Doğu F, Hacıhamdioğlu B, İkincioğulları A, Berberoğlu M. Regulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis. J Clin Res Pediatr Endocrinol. 2016 Sep 1;8(3):276-81. doi: 10.4274/jcrpe.2766. PubMed PMID: 27086659; PubMed Central PMCID: PMC5096490.

53. Şıklar Z, Kocaay P, Çamtosun E, İsakoca M, Hacıhamdioğlu B, Savaş Erdeve Ş, Berberoğlu M. The Effect of Recombinant Growth Hormone Treatment in Children with Idiopathic Short Stature and Low Insulin-

Like Growth Factor-1 Levels. J Clin Res Pediatr Endocrinol. 2015 Dec;7(4):301-6. doi: 10.4274/jcrpe.2111. PubMed PMID:26777041; PubMed Central PMCID: PMC4805225.

54. Delil K, Karabulut HG, Hacıhamdioğlu B, Şıklar Z, Berberoğlu M, Öçal G, Tükün A, Ruhi HI. Investigation of SHOX Gene Mutations in Turkish Patients with Idiopathic Short Stature. J Clin Res Pediatr Endocrinol. 2016 Jun 5;8(2):144-9. doi: 10.4274/jcrpe.2307. PubMed PMID: 26758084; PubMed Central PMCID: PMC5096468.

55. Yildiz AE, Ceyhan K, Sıklar Z, Bilir P, Yağmurlu EA, Berberoğlu M, Fitoz S. Intrathyroidal Ectopic Thymus in Children: Retrospective Analysis of Grayscale and Doppler Sonographic Features. J Ultrasound Med. 2015 Sep;34(9):1651-6. doi: 10.7863/ultra.15.14.10041. PubMed PMID: 26269296.

56. Topcu V, Ilgin-Ruhi H, Siklar Z, Karabulut HG, Berberoglu M, Hacihamdioglu B, Savas-Erdeve S, Aycan Z, Peltek-Kendirci HN, Ocal G, Tukun FA. Investigation of androgen receptor gene mutations in a series of 21 patients with 46,XY disorders of sex development. J Pediatr Endocrinol Metab. 2015 Nov 1;28(11-12):1257-63. doi: 10.1515/jpem-2014-0500. PubMed PMID: 26197461.

57. Johnson MB, De Franco E, Lango-Allen H, Al Senani A, Elbarbary N, Siklar Z, Berberoglu M, Imane Z, Haghighi A, Ullah I, Alyaarubi S, Gardner D, Ellard S, Hattersley AT, Flanagan SE. Recessively Inherited Lrba Mutations Cause Autoimmunity Presenting as Neonatal Diabetes. Diabetes. 2017 May 4. pii: db170040. doi: 10.2337/db17-0040. [Epub ahead of print] PubMed PMID: 28473463.

58. Çullas İlarslan NE, Şıklar Z, Berberoğlu M. Childhood sustained hypercalcemia: A diagnostic challenge. J Clin Res Pediatr Endocrinol. 2017 Apr 26. doi: 10.4274/jcrpe.4247. [Epub ahead of print] PubMed PMID: 28443817.

59. Şıklar Z, Berberoğlu M. Current Status of Childhood Hyperinsulinemic Hypoglycemia in Turkey. J Clin Res Pediatr Endocrinol. 2016 Dec 1;8(4):375-380. doi: 10.4274/jcrpe.2991. Epub 2016 May 16. Review. PubMed PMID: 27181376; PubMed Central PMCID: PMC5197994.

60. Kocaay P, Şiklar Z, Ellard S, Yagmurlu A, Çamtosun E, Erden E, Berberoglu M, Flanagan SE. Coexistence of Mosaic Uniparental Isodisomy and a KCNJ11 Mutation Presenting as Diffuse Congenital Hyperinsulinism and Hemihypertrophy. Horm Res Paediatr. 2016;85(6):421-5. doi: 10.1159/000446153. Epub 2016 May 14. PubMed PMID: 27173951; PubMed Central PMCID: PMC5079068.

61. Şıklar Z, Karataş D, Doğu F, Hacıhamdioğlu B, İkincioğulları A, Berberoğlu M. Regulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis. J Clin Res Pediatr Endocrinol. 2016 Sep 1;8(3):276-81. doi: 10.4274/jcrpe.2766. Epub 2016 Apr

18. PubMed PMID: 27086659; PubMed Central PMCID: PMC5096490.

62. Taylan F, Costantini A, Coles N, Pekkinen M, Héon E, Şıklar Z, Berberoğlu M, Kämpe A, Kıykım E, Grigelioniene G, Tüysüz B, Mäkitie O. Spondyloocular Syndrome: Novel Mutations in XYLT2 Gene and Expansion of the Phenotypic Spectrum. J Bone Miner Res. 2016 Aug;31(8):1577-85. doi: 10.1002/jbmr.2834. Epub 2016 Apr 4. PubMed PMID: 26987875.

63. Atay Z, Yesilkaya E, Erdeve SS, Turan S, Akin L, Eren E, Doger E, Aycan Z, Abali ZY, Akinci A, Siklar Z, Ozen S, Kara C, Tayfun M, Sari E, Tutunculer F, Karabulut GS, Karaguzel G, Cetinkaya S, Saglam H, Bideci A, Kurtoglu S, Guran T, Bereket A. The Etiology and Clinical Features of Non-CAH Gonadotropin-Independent Precocious Puberty: A Multicenter Study. J Clin Endocrinol Metab. 2016May;101(5):1980-8. doi: 10.1210/jc.2015-3500. Epub 2016 Mar 10. PubMed PMID: 26964727.

64. Şıklar Z, Kocaay P, Çamtosun E, İsakoca M, Hacıhamdioğlu B, Savaş Erdeve Ş, Berberoğlu M. The Effect of Recombinant Growth Hormone Treatment in Children with Idiopathic Short Stature and Low Insulin-Like Growth Factor-1 Levels. J Clin Res Pediatr Endocrinol. 2015 Dec;7(4):301-6. doi: 10.4274/jcrpe.2111. PubMed PMID:26777041; PubMed Central PMCID: PMC4805225.

65. Savaş-Erdeve Ş, Şıklar Z, Hacıhamdioğlu B, Kocaay P, Çamtosun E, Öcal G, Berberoğlu M. Gonadotropin-Releasing Hormone Analogue Treatment in Females with Moderately Early Puberty: No Effect on Final Height. J Clin Res Pediatr Endocrinol. 2016 Jun 5;8(2):211-7. doi: 10.4274/jcrpe.2356. Epub 2015 Dec 18. PubMed PMID: 26758571; PubMed Central PMCID: PMC5096478.

66. Sıklar Z, Berberoğlu M, Çamtosun E, Kocaay P. Diagnostic characteristics and metabolic risk factors of cases with polycystic ovary syndrome during adolescence. J Pediatr Adolesc Gynecol. 2015 Apr;28(2):78-83. doi: 10.1016/j.jpag.2014.05.006. PubMed PMID: 25850587.

67. Poyrazoğlu Ş, Akçay T, Arslanoğlu İ, Atabek ME, Atay Z, Berberoğlu M, Bereket A, Bideci A, Bircan İ, Böber E, Can Ş, Cesur Y, Darcan Ş, Demir K, Dündar B, Ersoy B, Esen İ, Güven A, Kara C, Keskin M, Kurtoğlu S, Memioğlu N, Özbek MN, Özgen T, Sarı E, Şıklar Z, Şimşek E, Turan S, Yeşilkaya E, Yüksel B, Darendeliler F. Current practice in diagnosis and treatment of growth hormone deficiency in childhood: a survey from Turkey. J Clin Res Pediatr Endocrinol. 2015 Mar;7(1):37-44. doi: 10.4274/jcrpe.1794. PubMed PMID: 25800474; PubMed Central PMCID: PMC4439890.

68. Johnson MB, De Franco E, Lango-Allen H, Al Senani A, Elbarbary N, Siklar Z, Berberoglu M, Imane Z, Haghighi A, Ullah I, Alyaarubi S, Gardner D, Ellard S, Hattersley AT, Flanagan SE. Recessively Inherited Lrba Mutations Cause Autoimmunity Presenting as Neonatal Diabetes. Diabetes. 2017 May 4. pii: db170040. doi: 10.2337/db17-0040. [Epub ahead of print] PubMed PMID: 28473463.

69. Çullas İlarslan NE, Şıklar Z, Berberoğlu M. Childhood sustained hypercalcemia: A diagnostic challenge. J Clin Res Pediatr Endocrinol. 2017 Apr 26. doi: 10.4274/jcrpe.4247. [Epub ahead of print] PubMed PMID: 28443817.

70. Şıklar Z, Berberoğlu M. Current Status of Childhood Hyperinsulinemic Hypoglycemia in Turkey. J Clin Res Pediatr Endocrinol. 2016 Dec 1;8(4):375-380. doi: 10.4274/jcrpe.2991. Epub 2016 May 16. Review. PubMed PMID: 27181376; PubMed Central PMCID: PMC5197994.

71. Taylan F, Costantini A, Coles N, Pekkinen M, Héon E, Şıklar Z, Berberoğlu M, Kämpe A, Kıykım E, Grigelioniene G, Tüysüz B, Mäkitie O. Spondyloocular Syndrome: Novel Mutations in XYLT2 Gene and Expansion of the Phenotypic Spectrum. J Bone Miner Res. 2016 Aug;31(8):1577-85. doi: 10.1002/jbmr.2834. Epub 2016 Apr 4. PubMed PMID: 26987875.

72. Şıklar Z, Tanyer G, Dallar Y, Günay S. Pica and intoxication in childhood. Clinical Pediatrics 2000; 39 10: 624-5.

73. Şıklar Z, Tanyer G, Dallar Y, Aksoy FG. Hajdu-Cheney Syndrome with growth hormone deficiency and neuropathy: a case report. J Ped Endocrinol Metab 2000; 13 (7): 951-4.

74. Şıklar Z, Bostanci I, Atli O, Dallar Y. An infantile Cushing syndrome due to misuse of topical steroid. Pediatr Dermatol. 2004; 21(5):561-3.

75. Erdeve O, Dallar Y, Şıklar Z. Is hypertriglyceridaemia a new concept for visceral leishmaniasis? Ann Trop Paediatr. 2004;24(4):369.

76. Aycan Z, Berberoglu M, Adiyaman P, Ergur AT, Ensari A, Evliyaoglu O, Şıklar Z, Ocal G. Latent autoimmune diabetes mellitus in children (LADC) with autoimmune thyroiditis and Celiac disease. J Pediatr Endocrinol Metab. 2004;17(11):1565-9.

77. Şıklar Z, Öçal G, Berberoğlu M, Adıyaman P, Ergur AT, Evliyaoğlu O, Sak SD. Importance of thyroglobulin levels for diagnosis and monitoring of follicular thyroid carcinoma in an adolescent with severe iodine deficiency. J Pediatr Endocrinol Metab. 2006; 19 (9): 1175-1178.

78. Erdeve Ö, Atasay B, Arsan S, Şıklar Z, Öçal G, Berberoğlu M. Hypocalcemic seizure due to congenital

rickets in the first day of life. Turk J Pediatr 2007; 49: 301-303.

79. Şıklar Z, Öcal G, Berberoğlu M, Adıyaman P, Ergur A, Çetinkaya E, Fitöz S, Dindar H, Yağmurlu A. Diagnostic value of contrast enhanced MR angiography in a child with MIBG-negative recurrent pheochromocytoma. The Endocrinologist. 2008; 18 (1): 19-22.

80. Teber S, Sezer T, Kafali M, Kendirli T, Şıklar Z, Berberoglu M, Ocal G, Deda G. Hypophosphatasia associated with pseudotumor cerebri and respiratory insufficiency. Indian J Pediatr. 2008; 75(2):186-8.

81. Engiz O, Berberoglu M, Şıklar Z, Bilir P, Ocal G. Treatment of autonomous ovarian follicular cyst with long-term anastrozole therapy. Indian J Pediatr. 2009; 76 (9): 950-1.

82. Şıklar Z, Berberoğlu M, Uysal Z, Cıtak FE, Bilir P, Ertem M, Engiz O, Oçal G. Cytokines as a Common Components of Two Different Disorders: Metabolic Syndrome and Hemophagocytic Lymphohystiositosis. Exp Clin Endocrinol Diabetes. 2009;117 (2): 57-9.

83. Engiz O, Ocal G, Şıklar Z, Erdogan M, Kologlu M, Percinel S, Bilir P, Berberoglu M. Early prophylactic thyroidectomy for RET mutation-positive MEN 2B. Pediatr Int. 2009; 51(4):590-3.

84. Ocal G, Berberoğlu M, Şıklar Z, Bilir P. Gender dysphoria and gender change in an adolescent with 45,X/46,XY mixed gonadal dysgenesis. Exp Clin Endocrinol Diabetes. 2009; 117(6):301-4.

85. Hacihamdioğlu B, Berberoğlu M, Şıklar Z, Savaş Erdeve S, Oçal G, Tutar E, Atalay S. Amiodarone-induced thyrotoxicosis in children and adolescents is a possible outcome in patients with low iodine intake. J Pediatr Endocrinol Metab. 2010; 23(4):363-8.

86. Savas Erdeve S, Aycan Z, Berberoglu M, Şıklar Z, Hacihamdioglu B, Sipahi K, Akar N, Ocal G. A novel mutation of 5alpha-steroid reductase 2 deficiency (CD 65ALA-PRO) with severe virilization defect in a Turkish family and difficulty in gender assignment. Eur J Pediatr. 2010; 169(8):991-5.

87. Siklar Z, Ellard S, Okulu E, Berberoğlu M, Young E, Savaş Erdeve S, Mungan IA, Hacihamdioğlu B, Erdeve O, Arsan S, Oçal G. Transient neonatal diabetes with two novel mutations in the KCNJ11 gene and response to sulfonylurea treatment in a preterm infant. J Pediatr Endocrinol Metab. 2011;24(11-12):1077-80.

88. Oçal G, Flanagan SE, Hacihamdioğlu B, Berberoğlu M, Siklar Z, Ellard S, Savas Erdeve S, Okulu E, Akin IM, Atasay B, Arsan S, Yağmurlu A. Clinical characteristics of recessive and dominant congenital hyperinsulinism due to mutation(s) in the ABCC8/KCNJ11 genes encoding the ATP-sensitive potasium channel in the pancreatic beta cell. J Pediatr Endocrinol Metab. 2011;24(11-12):1019-23

89. Bektas Ö, Yılmaz A, Kendirli T, Sıklar Z, Deda G. Hashimoto encephalopathy causing drug-resistant status epilepticus treated with plasmapheresis. Pediatr Neurol. 2012 Feb;46(2):132-5. PubMed PMID: 22264710.

90. Savas-Erdeve S, Berberoglu M, Siklar Z, Hacihamdioglu B, Ocal G, Ertem M, Ileri T, Ince EU, Uysal Z. Primary adrenal insufficiency in a child after busulfan and cyclophosphamide-based conditioning for hematopoietic stem cell transplantation. J Pediatr Endocrinol Metab. 2011;24(9-10):853-5.

91. Çakır U, Alan S, Erdeve Ö, Atasay B, Şıklar Z, Berberoğlu M, Arslan S. Late neonatal hypocalcemic tetany as a manifestation of unrecognized maternal primary hyperparathyroidism. Turk J Pediatr. 2013 Jul-Aug;55(4):438-40.

92. Sıklar Z, Berberoğlu M, Ceylaner S, Çamtosun E, Kocaay P, Göllü G, Sertçelik A, Öcal G. A novel heterozygous mutation in steroidogenic factor-1 in pubertal virilization of a 46,XY female adolescent. J Pediatr Adolesc Gynecol. 2014 Apr;27(2):98-101

93. Çamtosun E, Şıklar Z, Kocaay P, Ceylaner S, Flanagan SE, Ellard S, Berberoğlu M. Three cases of Wolfram syndrome with different clinical aspects. J Pediatr Endocrinol Metab. 2015 Mar;28(3-4):433-8. doi: 10.1515/jpem-2014-0139. PubMed PMID: 25210753.

94. Tuna Kirsaclioglu C, Kuloglu Z, Kansu A, Ensari A, Siklar Z, Berberoğlu M, Ocal G. Gastric carcinoid tumor in a 14-year old girl. Scand J Gastroenterol. 2014 Nov;49(11):1391-3. doi: 10.3109/00365521.2014.953574. PubMed PMID: 25180819.

95. Kahvecioglu D, Atasay B, Berberoglu M, Yildiz D, Cakir U, Akduman H, Erdeve O, Siklar Z, Magdelaine C, Lienhardt-Roussie A, Akar M, Ozbek MN, Arsan S. A novel mutation in the calcium sensing receptor gene in a neonate with severe hyperparathyroidism. . Genet Couns. 2014;25(3):331-5. PubMed PMID: 25365856.

96. Kocaay P, Şıklar Z, Çamtosun E, Kendirli T, Berberoğlu M. ROHHAD Syndrome: Reasons for Diagnostic Difficulties in Obesity. J Clin Res Pediatr Endocrinol. 2014 Dec;6(4):254-7. doi: 10.4274/Jcrpe.1432.

97. Şıklar Z, Berberoğlu M. Syndromic disorders with short stature. J Clin Res Pediatr Endocrinol. 2014;6(1):1-8. doi: 10.4274/Jcrpe.1149. Review. PubMed PMID: 24637303; PubMed Central PMCID: PMC3986733.

98. Çamtosun E, Flanagan SE, Ellard S, Şıklar Z, Hussain K, Kocaay P, Berberoğlu M. A Deep Intronic HADH Splicing Mutation (c.636+471G>T) in a Congenital Hyperinsulinemic Hypoglycemia Case: Long Term Clinical Course. J Clin Res Pediatr Endocrinol. 2015 Jun;7(2):144-

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99. Çamtosun E, Şıklar Z, Ceylaner S, Kocaay P, Berberoğlu M. Delayed Diagnosis of a 17-Hydroxylase/17,20-Lyase Deficient Patient Presenting as a 46,XY Female: A Low Normal Potassium Level Can Be an Alerting Diagnostic Sign. J Clin Res Pediatr Endocrinol. 2017 Jun 1;9(2):163-167. doi: 10.4274/jcrpe.3839. Epub 2016 Dec 23. PubMed PMID: 28008861; PubMed Central PMCID: PMC5463290.

100. Ödek Ç, Kendirli T, Kocaay P, Azapağası E, Uçar T, Şıklar Z, Berberoğlu M. Acute reversible cardiomyopathy and heart failure in a child with acute adrenal crisis. Paediatr Int Child Health. 2017 May;37(2):148-151. doi: 10.1080/20469047.2015.1120410. Epub 2016 Jan 29. PubMed PMID: 27077627.

101. Koç Yekedüz M, Şıklar Z, Burgu B, Kuloğlu Z, Kocaay P, Çamtosun E, İsakoca M, Kansu A, Soygür T, Berberoğlu M. Response to Anastrozole Treatment in a Case with Peutz-Jeghers Syndrome and a Large Cell Calcifying Sertoli Cell Tumor. J Clin Res Pediatr Endocrinol. 2017 Jun 1;9(2):168-171. doi: 10.4274/jcrpe.3625. Epub 2016 Nov 20. PubMed PMID: 27873740; PubMed Central PMCID: PMC5463291.

102. Kocaay P, Şiklar Z, Ellard S, Yagmurlu A, Çamtosun E, Erden E, Berberoglu M, Flanagan SE. Coexistence of Mosaic Uniparental Isodisomy and a KCNJ11 Mutation Presenting as Diffuse Congenital Hyperinsulinism and Hemihypertrophy. Horm Res Paediatr. 2016;85(6):421-5. doi: 10.1159/000446153. Epub 2016 May 14. PubMed PMID: 27173951; PubMed Central PMCID: PMC5079068.

103. Garg N, Bademci G, Foster J 2nd, Sıklar Z, Berberoglu M, Tekin M. MORFAN Syndrome: An Infantile Hypoinsulinemic Hypoketotic Hypoglycemia Due to an AKT2 Mutation. J Pediatr. 2015 Aug;167(2):489-91. doi: 10.1016/j.jpeds.2015.04.069.Epub 2015 May 23. PubMed PMID: 26003998.

104. Z Şıklar, U Mıhçıoğlu, G Tanyer, Y Dallar, Y Aral, F Aksoy. Investigation of empty sella syndrome in childhood hypothalamic pituitary dysfunction. Turk J Endocrinol Metab. 1998; 2: 119-124.

105. Z Şıklar, G Öçal, M Berberoğlu, P Adıyaman, A Ergur. Usefullnes of combined evaluation of IGF I and IGFBP3 for optimizing the growth hormone therapy as a safety index for carcinogenesis. Turk J Endocrinol Metab 2006; 3: 93-96.

106. Şıklar Z, Berberoğlu M, Adıyaman P, Salih M, Tükün A, Çetinkaya E, Aycan Z, Evliyaoğlu O, Ergur A, Öçal G. Disorders of gonadal development: A broad clinical, cytogenetic and histopathologic spectrum.

Pediatric Endocrinology reviews (PER). 2007; 4 (3): 210-217.

107. Berberoglu M, Şıklar Z, Darendeliler F, Poyrazoglu Ş, Darcan Ş, Isguven P, Bideci A, Öcal G, Bundak R, Yuksel B, Arslanoglu İ. Evaluation of Permanent Growth Hormone Deficiency (GHD) in Young Adults with Childhood Onset GHD: A multicenter study. J Clin Res Ped Endo 2008; 1(1):30-7.

108. Şıklar Z, Öcal G, Berberoğlu M, Bilir P. Combined Evaluation of IGF-1 and IGFBP-3 as an Index of Efficacy and Safety in Growth Hormone Treated Patients - Original Article J Clin Res Ped Endo 2009;1(5):240-243.

109. Ergür AT, Berberoğlu M, Atasay B, Şıklar Z, Bilir P, Arsan S, Söylemez F, Öcal G. Vitamin D Deficiency in Turkish Mothers and Their Neonates and in Women of Reproductive Age - Original Article J Clin Res Ped Endo 2009; 1(6):266-269.

110. Ergür AT, Oçal G, Berberoğlu M, Adıyaman P, Şıklar Z, Aycan Z, Evliyaoğlu O, Kansu A, Girgin N, Ensari A. Celiac Disease and Autoimmune Thyroid Disease in Children with Type 1 Diabetes Mellitus: Clinical and HLA-Genotyping Results. J Clin Res Pediatr Endocrinol. 2010; 2(4):151-4.

111. Ergür AT, Evliyaoğlu O, Şıklar Z, Bilir P, Öçal G, Berberoğlu M. Evaluation of thyroid functions with respect to iodine status and TRH test in chronic autoimmune thyroiditis. J Clin Res Pediatr Endocrinol. 2011;3(1):18-21.

112. Savaş-Erdeve Ş, Berberoğlu M, Oygar P, Sıklar Z, Kendirli T, Hacıhamdioğlu B, Bilir P, Oçal G. Efficiency of fluid treatments with different sodium concentration in children with type 1 diabetic ketoacidosis. J Clin Res Pediatr Endocrinol. 2011 Sep;3(3):149-53.

113. Gürbüz F, Kotan LD, Mengen E, Sıklar Z, Berberoğlu M, Dökmetaş S, Kılıçlı MF, Güven A, Kırel B, Saka N, Poyrazoğlu S, Cesur Y, Doğan M, Ozen S, Ozbek MN, Demirbilek H, Kekil MB, Temiz F, Mungan NO, Yüksel B, Topaloğlu AK. Distribution of Gene Mutations Associated with Familial Normosmic Idiopathic Hypogonadotropic Hypogonadism. J Clin Res Pediatr Endocrinol. 2012 Jul 5. doi: 10.4274/jcrpe.725.

114. N. Abseyi, Z. Sıklar, M. Berberoğlu, B. Hacihamdioglu, S.S. Erdeve, G. Oçal. Relationships between osteocalcin, glucose metabolism, and adiponectin in obese children: is there crosstalk between bone tissue and glucose metabolism? J Clin Res Pediatr Endocrinol. 2012 ;4(4):182-8.

115. Ocal G, Şıklar Z, Berberoglu M, Bilir P, Engiz Ö, Fitoz S, Arici S. Permanent Central Diabetes Insipidus with Complete Regression of Pituitary Stalk Enlargement

After 4 Years of Follow-up. J Clin Res Pediatr Endocrinol 2008; 1(1):38-42.

116. Hacıhamdioğlu B, Şıklar Z, Erdeve SS, Berberoğlu M, Deda G, Tıraş ST, Fitöz S, Öçal G. Genoa syndrome and central diabetes insipidus: a case report. J Clin Res Pediatr Endocrinol. 2010; 2(2):89-91.

117. Erdeve SS, Berberoğlu M, Şıklar Z, Evliyaoğlu O, Hiort O, Ocal G. Long-Term Follow-Up of a Pseudohypoparathyroidism Type 1A Patient with Missense Mutation (Pro115Ser) in Exon 5. J Clin Res Pediatr Endocrinol. 2010; 2 (2): 85-8.

118. Şıklar Z, Berberoğlu M, Legendre M, Amselem S, Evliyaoğlu O, Hacıhamdioğlu B, Erdeve SS, Oçal G. Two Siblings with Isolated GH Deficiency Due to Loss-of-Function Mutation in the GHRHR Gene: Successful Treatment with Growth Hormone Despite Late Admission and Severe Growth Retardation. J Clin Res Pediatr Endocrinol. 2010; 2(4):164-7.

119. Şıklar Z, Berberoğlu M, Yağmurlu A, Hacıhamdioğlu B, SavaşErdeve S, Fitöz S, Kır M, Öçal G. Synchronous occurrence of papillary carcinoma in the thyroid gland and thyroglossal duct in an adolescent with congenital hypothyroidism. J Clin Res Pediatr Endocrinol. 2012 Mar;4(1):30-3.