OncoScreenPML RARA bcr1 and bcr3 Screening Kit

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PML RARA bcr1 and bcr3 Screening Kit

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Historically, Acute promyelocytic leukemia (APL or AML-M3) is one of the most lethal forms of acute myeloid leukemia with distinct clinical and histopathologic features.

Acute promyelocytic leukemia is characterized by a unique chromosomal translocation involving the retinoic acid receptor-alpha gene on chromosome 17 (RARA). In greater than 99% of cases of APL, retinoic acid receptor-alpha (RARA) gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q12)

Depending on the location of breakpoints within the PML site, intron 6, exon 6 and intron 3, the respective PML-RARa transcript subtypes referred to as long (L or bcr1), variant (V or bcr2) and short (S or bcr3), may be formed representing 55%, 5% and 40% of the cases respectively.The presence of PML/RARA t(15;17) translocation is necessary for response to all-trans-retinoic acid and arsenic trioxide. Thus, the PML/RARA t(15;17) assay is useful for diagnosis and predicting treatment response. It is also helpful for monitoring therapeutic response and MRD and for detecting early relapse.

Kit contents:

· Reagents required for Real Time PCR · Validated reaction controls · Plastic wares for RT PCR Tests

PML RARA and Cancer

Kit Features

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· Easy workflow with ready-to-use solutions for “Direct to customer” clinical lab tests · Detection of the PML/RARA t(15;17) (q21;q22) translocation, a tool to detect for Acute promyelocytic leukemia (APL or AML-M3) · Real-time quantitative gene analysis of control gene and fusion gene transcript bcr1 (PMLex6/RAR ex3L-form (=BCR1) ) and fusion gene

transcript bcr3 (PMLex6/RAR ex3S-form (=BCR3))· One-step High Performance quantitative detection – no need to perform separate cDNA synthesis and qPCR· Results aligned with control standards included with the kit.· Low contamination risk – no post-PCR product handling· Fast – results in under 80 minutes after PCR start· Multiplexed – Control and target genes assessed in the same reaction· Includes all the reagent required to perform RNA to Result analysis no additional reagents needed. (Including Mastermix)

Ordering informationProduct Cat. no.

Reaction size/kit

100

50

The Kit is intended for research use only. The Kit performance is functionally tested, and is currently under validation for Diagnostic purpose.

Price

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Please InquireOncoScreen PML RARA bcr1 Screening Kit- For the quantification of PML RARA bcr1(L form) Fusion transcript OPLQ50

OPLQ100

OPSQ50

OPSQ100 100

50

Please Inquire

Please Inquire

OncoScreen PML RARA bcr1 Screening Kit- For the quantification of PML RARA bcr1(L form) Fusion transcript

OncoScreen PML RARA bcr3 Screening Kit-For the quantification of PML RARA bcr3(S form) Fusion transcript

OncoScreen PML RARA bcr3 Screening Kit-For the quantification of PML RARA bcr3(S form) Fusion transcript

One Step Quantitative RT PCR Our PML RARA bcr1 and bcr3 one step detection kits have been formulated for highly reproducible first-strand cDNA synthesis and subsequent real-time PCR . A combination of

validated primers, hydrolysis probes, and hot-start DNA polymerase ensures that the kits lead to highly-specific and ultra-sensitive results in a single step.

One Step Quantitative RT PCR

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OncoScreen PML RARA bcr1 and bcr3 Screening Kit- For quantification of both PML RARA bcr1(L form) & bcr3(S form) Fusion transcript

OPLSQ50 50 Please Inquire