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Transcript of Muscular Dystrophy Kate DeAngelis AP Biology 1/6/09 Kate DeAngelis AP Biology 1/6/09 Charles...
![Page 1: Muscular Dystrophy Kate DeAngelis AP Biology 1/6/09 Kate DeAngelis AP Biology 1/6/09 Charles DeAngelis:](https://reader036.fdocuments.net/reader036/viewer/2022082806/551b8491550346942b8b49d1/html5/thumbnails/1.jpg)
Muscular DystrophyMuscular Dystrophy
Kate DeAngelisAP Biology
1/6/09
Kate DeAngelisAP Biology
1/6/09
![Page 2: Muscular Dystrophy Kate DeAngelis AP Biology 1/6/09 Kate DeAngelis AP Biology 1/6/09 Charles DeAngelis:](https://reader036.fdocuments.net/reader036/viewer/2022082806/551b8491550346942b8b49d1/html5/thumbnails/2.jpg)
Intro to Muscular DystrophyIntro to Muscular Dystrophy
Aka: MD or inherited myopathy Discovered by: Sir Charles Bell in
1830.
Aka: MD or inherited myopathy Discovered by: Sir Charles Bell in
1830.
![Page 3: Muscular Dystrophy Kate DeAngelis AP Biology 1/6/09 Kate DeAngelis AP Biology 1/6/09 Charles DeAngelis:](https://reader036.fdocuments.net/reader036/viewer/2022082806/551b8491550346942b8b49d1/html5/thumbnails/3.jpg)
Mode of InheritanceMode of Inheritance X-linked recessive: trait is carried on one of the two-paired
genes on the X chromosome Duchenne MD
Autosomal recessive: both parents must be carriers of the affected gene Type 2 Limb-girdle MD Congenital MD
Autosomal dominant: carrier of one affected gene will manifest the trait Type 1 Limb-girdle MD Myotonic dystrophy And others
X-linked recessive: trait is carried on one of the two-paired genes on the X chromosome Duchenne MD
Autosomal recessive: both parents must be carriers of the affected gene Type 2 Limb-girdle MD Congenital MD
Autosomal dominant: carrier of one affected gene will manifest the trait Type 1 Limb-girdle MD Myotonic dystrophy And others
![Page 4: Muscular Dystrophy Kate DeAngelis AP Biology 1/6/09 Kate DeAngelis AP Biology 1/6/09 Charles DeAngelis:](https://reader036.fdocuments.net/reader036/viewer/2022082806/551b8491550346942b8b49d1/html5/thumbnails/4.jpg)
Clinical DescriptionClinical Description Muscle weakness; apparent lack of
coordination; progressive crippling Frequent falls; large calf muscles;
difficulty getting up from lying down; waddling gait; mild mental retardation
Most commonly found in males Some cases are fatal
Muscle weakness; apparent lack of coordination; progressive crippling
Frequent falls; large calf muscles; difficulty getting up from lying down; waddling gait; mild mental retardation
Most commonly found in males Some cases are fatal
![Page 5: Muscular Dystrophy Kate DeAngelis AP Biology 1/6/09 Kate DeAngelis AP Biology 1/6/09 Charles DeAngelis:](https://reader036.fdocuments.net/reader036/viewer/2022082806/551b8491550346942b8b49d1/html5/thumbnails/5.jpg)
TreatmentTreatment Exercise and strength conditioning Medications used to help manage muscle spasms
and pain Assistive devices
Walkers Canes Wheelchair
Surgery: release the contractures that may develop
Not cure yet :(
Exercise and strength conditioning Medications used to help manage muscle spasms
and pain Assistive devices
Walkers Canes Wheelchair
Surgery: release the contractures that may develop
Not cure yet :(
![Page 6: Muscular Dystrophy Kate DeAngelis AP Biology 1/6/09 Kate DeAngelis AP Biology 1/6/09 Charles DeAngelis:](https://reader036.fdocuments.net/reader036/viewer/2022082806/551b8491550346942b8b49d1/html5/thumbnails/6.jpg)
DetectionDetection
Genetic counseling Muscle biopsies Electromyography or nerve
conduction tests Blood enzyme tests
Genetic counseling Muscle biopsies Electromyography or nerve
conduction tests Blood enzyme tests
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Legal IssuesLegal Issues Some cases are fatal Physicians may be biased to
certain treatments Most treatments improve the
quality of the patients life, but do not prevent loss of muscle function
Some cases are fatal Physicians may be biased to
certain treatments Most treatments improve the
quality of the patients life, but do not prevent loss of muscle function
![Page 8: Muscular Dystrophy Kate DeAngelis AP Biology 1/6/09 Kate DeAngelis AP Biology 1/6/09 Charles DeAngelis:](https://reader036.fdocuments.net/reader036/viewer/2022082806/551b8491550346942b8b49d1/html5/thumbnails/8.jpg)
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