Multimodality Imaging of Right Atrial Masses

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IMAGES IN CARDIOLOGY Multimodality Imaging of Right Atrial Masses Patricia Campbell, MD, Robert F. Padera, MD, PHD, Michael M. Givertz, MD Boston, Massachusetts Right atrial mass subcostal view Right atrial masses Right PA Absent left PA Main Filling defect from right atrial mass Right atrial mass Bioptome H&E Stain WT-1 Stain C D B A E C1 D Right atrial mass Bioptome From the Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts. Manuscript received April 22, 2009, accepted April 29, 2009. A 76-year-old man presented with 2 months of dyspnea, early satiety, and lower extremity edema. Ten years previously, he underwent left extrapleural pneumonectomy for mesothe- lioma but had chest wall and mediastinal recurrences that required systemic chemotherapy and local radiation. Transthoracic echocardiography revealed right atrial dilation with a 4.9 6.4 cm mass attached to the anterior and inferior right atrial walls (A). Cardiac magnetic resonance imaging demonstrated 2 right atrial masses with gadolinium enhancement indicating vascularity: a 5.2 4.7 cm mass on the superior free wall, and a 4 4 cm mass partially obstructing inferior venal caval inflow on the lateral free wall (B). Right ventriculography (C) and echocardiographic- guided biopsy (pulmonary artery) (D) were performed (Online Videos 1, 2, 3 and 4). Histopathol- ogy confirmed the diagnosis of epithelioid-type mesothelioma (hematoxylin and eosin [H&E] stain, E, left; WT-1 stain positive for calretinin, E, right). The patient was not a candidate for surgical resection and died of progressive metastatic mesothelioma. Journal of the American College of Cardiology Vol. 55, No. 8, 2010 © 2010 by the American College of Cardiology Foundation ISSN 0735-1097/10/$36.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2009.04.106

Transcript of Multimodality Imaging of Right Atrial Masses

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Journal of the American College of Cardiology Vol. 55, No. 8, 2010© 2010 by the American College of Cardiology Foundation ISSN 0735-1097/10/$36.00P

IMAGES IN CARDIOLOGY

Multimodality Imaging of Right Atrial MassesPatricia Campbell, MD, Robert F. Padera, MD, PHD, Michael M. Givertz, MD

Boston, Massachusetts

Right atrial masssubcostal view →

Right atrialmasses

→↓

Right PA →

← Absent left PA

Main

Filling defect fromright atrial mass →

Right atrial mass �

Bioptome �

H&E Stain WT-1 Stain

C D

BA

E

C1

D Right atrialmass

Bioptome

rom the Cardiovascularivision, Brigham andomen’s Hospital, Harvardedical School, Boston,assachusetts.anuscript receivedpril 22, 2009, acceptedpril 29, 2009.

A76-year-old man presented with 2 months of dyspnea, early satiety, and lower extremityedema. Ten years previously, he underwent left extrapleural pneumonectomy for mesothe-lioma but had chest wall and mediastinal recurrences that required systemic chemotherapy

and local radiation. Transthoracic echocardiography revealed right atrial dilation with a 4.9 � 6.4cm mass attached to the anterior and inferior right atrial walls (A). Cardiac magnetic resonanceimaging demonstrated 2 right atrial masses with gadolinium enhancement indicating vascularity: a5.2 � 4.7 cm mass on the superior free wall, and a 4 � 4 cm mass partially obstructing inferiorvenal caval inflow on the lateral free wall (B). Right ventriculography (C) and echocardiographic-guided biopsy (pulmonary artery) (D) were performed (Online Videos 1, 2, 3 and 4). Histopathol-ogy confirmed the diagnosis of epithelioid-type mesothelioma (hematoxylin and eosin [H&E] stain,E, left; WT-1 stain positive for calretinin, E, right). The patient was not a candidate for surgicalresection and died of progressive metastatic mesothelioma.

ublished by Elsevier Inc. doi:10.1016/j.jacc.2009.04.106