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WHO AM I?

I am a Medical Herbalist, trained in the UK, in

integrated medicine in clinics, hospitals and

university environments

I treat cancer, pre cancerous and chronic auto immune

conditions such as MS, Alzheimer's, thyroid and

women’s problems in a (w) holistic protocol, on a

science evidenced basis with plant drugs

Disclosure - No commercial ties

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YOU NEED TO TAKE CHARGE

Because:

We live in age of chronic auto immune disease

Conventional medicine is designed for acute

conditions only

Many chronic diseases arise from

faulty diet, lack of exercise, alcohol

nicotine and stress i.e lifestyle

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MS - STATISTICS

Women vs. men

Average age 40

No major ethnic differences

Previously confined to Northern latitudes

Meat & Potato diets vs. primarily vegetable diets

Low Vitamin D & low thyroid function

Am J Manag Care. 2013 Feb;19(2 Suppl):S15-20.

Overview of the epidemiology, diagnosis, and disease progression associated with multiple sclerosis.Tullman MJ.

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MS TRADITIONAL PATHOLOGY

Demyelinating lesions in the brain

BUT increasingly there is a re-application of our

knowledge towards:

VIRUSES AND BACTERIA

Human endogenous retroviruses and multiple sclerosis: innocent bystanders or disease determinants?

Antony JM, ET AL.

Human herpesvirus 6 is latent in peripheral blood of patients with relapsing-remitting multiple sclerosis.

Rotola A,ET AL.

J Neurol Neurosurg Psychiatry. 1999 Oct;67(4):529-31. iochim Biophys Acta. 2011 Feb;1812(2):162-76.

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RESEARCH DRIVEN BY BIG PHARMA

During the last 20 years research has been focussed on genetics and

spinning off extra use out of drugs such as immomodulating agents

As these on the balance of probability showed the quickest and most

profitable routes for MS treatments for Big Pharma – it has not

delivered the expected benefits and results nor substantiated in research

In the 1980’s a Medical Herbalist and Chemistry Professor Kerry Bone was

wrote most of our chronic auto immune disease arose in the gut.

Now this is being recognised in research arising from the Planck institute

in Germany

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OHIP PROTOCOLS

Negative impact of statins on oligodendrocytes and myelin formation in

vitro and in vivo. Klopfleisch S, et al. J Neurosci. 2008

Glatiramer Acetate only slows progression in some cases

Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome.

Fingomolid known to cause heart block

Dimethyl fumarate for treatment of multiple sclerosis: mechanism of action, effectiveness, and side effects.

Linker RA, Gold R. Curr Neurol Neurosci Rep. 2013 Nov;13(11):394. doi: 10.1007/s11910-013-

0394-8.

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2. 0HIP

Surgery The thinking behind this hypotheses was that in

MS narrowed arteries and veins led to poor

oxygenation of the brain and thus

demyelinating lesions.

Venous angioplasty in multiple sclerosis: neurological outcome at two years in a cohort of

relapsing-remitting patients.

Salvi F, Bartolomei I, Buccellato E, Galeotti R, Zamboni P.

Funct Neurol. 2012 Jan-Mar;27(1):55-9.

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3 OHIP

Recently Health Canada showed this treatment protocol is

not effective nor confined to MS.

Can J Neurol Sci. 2013 Mar;40(2):203-9. An observational study of venoplasty in patients with

multiple sclerosis.Pryse-Phillips W, et alDept of Medicine, Memorial University of Newfoundland,

IS IT SUPRISING NO!

WHY DO ARTERIES AND VEINS GET CLOGGED?

Principally thru poor diet and lack of exercise over years

Ipso facto link to bacterial and viral causes & epidemiology

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THE ROLE OF THE GUT

… ……Is fundamental to understanding the causes of chronic auto

immune disease

If the principal causes are bacteria and viruses:

Why do some people have the susceptibility to develop MS?

• Poor Gut health

• Poor immune function

• Reflected in the pattern of epidemiology – low vitamin D, high

grain/sugar diets, poor thyroid function etc

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THE MICROBIOME

PLoS One. 2013 Apr 16;8(4):e60647. doi: 10.1371/journal.pone.0060647..

Cortisol awakening response is linked to disease course and progression

in multiple sclerosis.

Kern S, et al Center for Clinical Neuroscience, Dresden, Germany.

Molecular biology, epidemiology, and pathogenesis of progressive

multifocal leukoencephalopathy, the JC virus-induced demyelinating

disease of the human brain.

Ferenczy MW, et al Clin Microbiol Rev. 2012 Jul;25(3):471-506.

Commensal microbiota and myelin autoantigen cooperate to trigger

autoimmune demyelination.

Berer K, et al. Nature. 2011

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KEY FINDINGS:

Dietary Deficiencies =

Viruses}

Bacteria}

combine to create most chronic auto immune

diseases

cancer, alzheimers, parkinsons, MS, arthritis

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BERER K, ET AL. NATURE. 2011

Ms Berer’s research is provided A LEAP FOR MANKIND

The most exciting development in the last 20 years

She and her team showed how bacteria in the gut over time

alter and create antigens which infect the gut and move

into the myelinating sheath and travel to the brain.

The team also replicated this effect in mice providing the

first scientific clues that gut health is instrumental in

human health for chronic disease

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WHAT CAN WE DO WITH THIS KNOWLEDGE?

Explains why Plant medicine is so effective at inhibiting progression as many work in and through the gut

Plant drug medicine has multi level properties - drugs do not

Plants can mimic how bacteria/viruses behave

As long ago as 1952 a Dutch scientist compared Plant viruses to MS suggesting it was a virus.

Which means plants develop secondary defensive metabolites to those bacteria and diseases.

PREVENT/INHIBIT MS BY USING PLANTS, DIET, EXERCISE

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IMMUNITY

Plants had millions of yrs. to develop their immune systems

We have had about 10,000 years as omnivores

The plant immune system through secondary metabolites

strengthens and modifies our immune capabilities

IMMUNITY CAN BE BUILT UP USING PROPER

FOODS AND SPICES

Ann NY Acad Sci, 2004 Dec;1030:434-41.

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STRATEGIES FOR PREVENTION/INHIBITION

DIET DIET DIET

EXERCISE

AVOID STRESS

USE YOUR BRAIN

USE PLANT MEDICINE

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USE PLANT MEDICINE

Many pathways of inflammation in MS – Plants available for all of them

Bacterial and Viral properties available in many plants not available in drug-

Elderberry = anti Sars

Immodulatory agents – Eccinachea spp

Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Shulzhenko N, et al Matzinger P. Nat Med. 2011 Nov 20;17(12):1585-93. doi: 10.1038/nm.2505.

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SPICES WHICH INHIBIT NFKB

Basil black pepper

Caraway cardamom

chili pepper cinnamon

Clove coriander

Cumin fennel

Fenugreek flaxseed

Garlic ginger

Holy basil lemongrass

Licorice mint mustard seed nutmeg

Oregano parsley rosemary saffron Tamarind Turmeric

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THYROID CONTROLS METABOLISM

. Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis.

Gottschalk M, et alF, Weber F. Arch Neurol. 2005

. Dysregulation of the hypothalamo-pituitary-adrenal axis is related to the clinical course of MS.

Then Bergh F, et al. Neurology. 1999

• Sub clinical Hypothyroidism is endemic in Ontario

Plants can repair the thyroid and common deficiencies are zinc & selenium

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DIET

AVOID PROCESSED FOODS

LOVE YOUR VEGGIES

INNOVATE AND EAT A WIDE RANGE OF FOOD STUFFS

Value moderation

ELIMINATE SUGAR FROM YOUR DIET

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YOU ARE WHAT YOU EAT!

What you eat is totally under your control and preventable medicine

There will never be a drug for bacteria as they mutate like viruses

Plants have anti bacterial and anti viral properties!

If dimethyl fumarate works ( not a lot of evidence so far )

One of the conclusions should be: there is a predisposition to MS if you do not eat sufficient fruits and vegetables as the regular consumption of fumaric acid acts as a preventative to bacteria - in large doses it is poison!

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GUT HEALTH DEPENDS ON WHAT YOU EAT

. Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans.

Muegge BD, Kuczynski J, Knights D, Clemente JC, González A, Fontana L, Henrissat B, Knight R, Gordon JI.

Science. 2011 May 20;332(6032):970-4. doi: 10.1126/science.1198719.

. Regulation of innate and adaptive immunity by the commensal microbiota.

Jarchum I, Pamer EG.

Curr Opin Immunol. 2011 Jun;23(3):353-60. doi: 10.1016/j.coi.2011.03.001. Epub 2011 Apr 3.

. Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease.

Ochoa-Repáraz J, Mielcarz DW, Begum-Haque S, Kasper LH.

Ann Neurol. 2011 Feb;69(2):240-7. doi: 10.1002/ana.22344.

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NUTRIENT DEFICIENCIES

Our locally grown vegetables do not have sufficient zinc,

selenium

Most people do not eat enough fish- iodine

Most people eat too much processed flour based food –

inhibiting bromine.

All of which is interesting considering that is how

recognised neurological diseases starts in the gut.

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SUGAR

Grains translate to sugars in the body:

Sugar is inflammatory to the body ( inflammation being part of MS

pathological processes )

Sugar provides a better less hostile environment in the gut for bacteria and

viruses to grow and live ( bacteria and viruses part of the pathological

processes of MS )

High circulating sugar levels impede the function of the brain, liver,

kidneys, pancreas and thyroid. The receptors leading to further

biochemical processes in the body are altered.

Obesity and other concomitant diseases

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SUGAR IS WHITE SWEET AND DEADLY!*

The presence of sugar in processed foods has grown exponentially since 1900 – so has the diagnosis of MS

Globally, sugar consumption has tripled in the past 50 years. But, it turns out, the greatest threat to human health is one type of sugar in particular: fructose.

In the US, per-capita consumption of fructose, a common food additive there – mainly in the form of high-fructose corn syrup – has increased more than 100-fold since 1970.

Processed foods lack key nutrients. 1tsp = fruits

J.Physiol 2012 590:2485-2499 Gomez-Pinella see also Lustig / Yudkin

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EXERCISE

The effects of exercise training on fitness,

mobility, fatigue, and health related quality of

life among adults with multiple sclerosis: a

systematic review to inform guideline

development.

Latimer-Cheung AE, Pilutti LA, Hicks AL, Martin Ginis KA, Fenuta A, Mackibbon KA, Motl RW.School

of Kinesiology and Health Studies, Queen's University, Kingston, Ontario.

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WHAT CAN WE DO TO PREVENT?

AVOID MAJOR STRESSORS

Do positive or negative stressful events predict the development of

brain lesions in people with multiple sclerosis?

Mult Scler. 2013 May 14.

USE YOUR BRAIN

Retrieval practice is a robust memory aid for memory-impaired

patients with MS.Sumowski JF,ET AL.Kessler Foundation

Research Center, USA.Arch Phys Med Rehabil. 2013 May 10. pii:

S0003-9993(13)00361-4. doi: 10.1016/j.apmr.2013.04.020.

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HERBAL PROTOCOLS

THE BEST ANTI VIRALS ARE PLANTS

MANY PLANTS HAVE ANTI INFLAMMATORY AND ANTI

MICROBIAL PROPERTIES

SOME PLANTS ARE SPECIFIC FOR MS AS THEY INHIBIT

THE DEMYELINATING PROCESS

SOME PLANTS ACTIVATE THE DENDRITIC IMMUNE CELLS

OF OUR BODIES

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PLANT MEDICINE

The newest drug for MS is dimethyl fumarate

Fumaric acid is found in all fresh fruits and vegetables

With no side effects!

It is also found in a plant called Fumitory and its traditional use is:

An anti inflammatory ( first pathological pathway for MS )

Hepatic stimulant for torpid livers ( poor liver function due to diet )

Anti spasmodic ( relaxing muscles )

Mild laxative and diuretic ( both issues found clinically in MS )

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OTHER PLANTS

There are a significant number of other plants which have

been shown to inhibit and address the pathological

pathways of MS – some of which you may be familiar with

are:

Turmeric, Green Tea, Withania

BUT IN PROFESSIONAL MEDICAL DOSES ONLY

IE NOT OTC PRODUCTS

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TRUE PERSONALISED MEDICINE

I treat every person according to their needs which means there is no one

single protocol

The medicine I use is not available over the counter

Some of the plants I use can regulate the thyroid but not one single plant.

Some Plants have been shown to inhibit the MS processes in the brain

USE PLANTS!

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ADDITIONAL BENEFITS

VITAMIN D & MELATONIN

Brain Behav Immun. 2013 May 7. pii: S0889-1591(13)00178-5. doi:

10.1016/j.bbi.2013.04.010. The influence of vitamin D supplementation

on melatonin status in patients with multiple sclerosis.Golan D, ET AL.Division of Neuroimmunology & Multiple Sclerosis Center, Israel; Department of Neurology,

Carmel Medical Center, Haifa, Israel.

CO Q 10

Coenzyme Q10 Supplementation Reduces Oxidative Stress and Increases

Antioxidant Enzyme Activity in Patients with Relapsing-Remitting

Multiple Sclerosis. Int J Neurosci. 2013 May 10Sanoobar M, et al.Tehran

University of Medical Sciences, Department of Clinical Nutrition, School of Nutritional Sciences

& Dietetics , tehran , Iran

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OTC SUPPLEMENTS - CAVEATS

• illegal to sell a medically efficacious dose

• most are not pharmaceutical grade

• no evidence base / extrapolation claims

• Contents /label/marketing claim

• Unnecessary with a proper diet

• No consideration of individual needs

• Failure to address polysupplementation

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EXAMPLES OF OTC ISSUES

DO NOT USE RESERVATROL A supplement widely available and used in cancer Protocols

Reservatrol exacerbates both autoimmune and viral models of multiple sclerosis Sat F. et al Am J Path 2013 Sept 25

DO NOT USE PROTEIN POWDER WHERE THERE

ARE SUGARS – AGAVE, SYNTHETIC SWEETNERS,

Just because its ‘natural’

does not mean its good for you Circulating insulin like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple

sclerosis. Growth Hormone & IGF research Vol 17 Issue 6 Dec 2007 Hosback et al

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REFERENCES

Some of the references used have been shown in the text

but if you want a full list please email me at

mrsmg@sympatico.ca

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THANK YOU

Morwenna Given

MEDICAL HERBALIST

BA MA (Oxon) BSc m.OHA BHG AHG RH

www.medicusherbis.com

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