MSاسکلروزیس مولتیپل

Client with Multiple Sclerosis DescriptionChronic demyelinating disease of CNS associated with -abnormal immune response to environmental factorInitial onset followed by total remission making diagnosis difficult

-Most persons have disease with periods of exacerbations and remissions

Progression of disease with increasing loss of function - -Incidence is highest in young adults (20 – 40); onset

between 20 – 50Affects females more than males-

-More common in temperate climatesOccurs mainly in Caucasians -

Pathophysiology Autoimmune response to prior viral infection Inflammation destroys myelin leading to axon dysfunction Myelin sheaths of white matter of spinal cord, brain, optic nerve

destroyed in patches called plaquesDemyelination slows and distorts nerve conduction resulting in

absence of impulse transmission Neurons in spinal cord, brain stem, cerebrum, cerebellum, and

optic nerve affected Recurrent demyelination and plaque formation result in

scarring of glia and degeneration of axons Disease follows different courses, most common is the

relapsing-remitting type Stressors trigger MS: febrile states, pregnancy, physical

exertion and fatigue; and these also can trigger relapses

Manifestations 1. Fatigue2. Optic nerve involvement: blurred vision,

haziness3. Brain stem involvement: nystagmus, dysarthria

(scanning speech), cognitive dysfunctions, vertigo, deafness

4. Weakness, numbness in leg(s), spastic paresis, bladder and bowel dysfunction

5. Cerebellar: nystagmus, ataxia, hyptonia6. Blindness

Collaborative Care

Focus is on retaining optimum functioning, limiting disability

Diagnostic Tests • Neurological exam, careful history• Lumbar puncture with CSF analysis: increased

number of T lymphocytes; elevated level of immunoglobulin G (IgG)

• Cerebral, spinal optic nerve MRI: shows multifocal lesions

• CT scan of brain: changes• PET: measures brain activity• Evoked response testing of visual, auditory,

somatosensory impulses show delayed conduction

Medications

ACTH Glucocorticosteroids Immunosuppressants: azathioprine (Imuran),

cyclophosphamide (Cytoxan) Cychophosphamide Antispasmodics to treat muscle spasms Medications to deal with bladder problems:

anticholinergics or cholinergics depending on problem experienced by client

Rehabilitation

• Physical therapy to maintain abilities and deal with spasticity

Health Promotion

• Client needs to develop strategies to deal with fatigue, exacerbations

• Prevention of respiratory and urinary tract infections

Nursing Diagnoses

• Fatigue• Self care deficits

Home Care

• Education• Referral to support group and resources• Referral to home health agencies when

condition requires

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