MS · 2005. 6. 21. · MS advertises:I Diketene, that terrible stuff.. . the workof moonlighting...
5
MS advertises:I Diketene, that terrible stuff. . . the work of moonlighting astronomers... a product for draftsmen and possibly others A new chemical Chicago Diketene (CH2COCH2CO) is terrible stuff. It brings tears to lI the eyes even in small whiffs, smells awful, once killed a shaved guinea pig bathed with it, and may polymerize violently when catalyzed by casual contamination. For carelessness with it, one ought to go to jail. To keep it out of inexpert hands and for other more or less obvious reasons, we sell no less than 39,000 pounds at a crack and are proud of our achievement in bringing it to market. It comes in its own stainless steel tank truck, insulated heavily enough to stay safely near the - 7.5°C freezing point for up to 72 hours. Obviously anybody willing to have this truck pull up to the gate with the driver complaining of unseasonable heat on the road the past 21/2 days and asking where to connect up to the refrigerated storage tanks will have given the matter considerable thought in advance. Very likely, despite the touchy nature of Diketene and because it works directly with- out troublesome by-products, he will have chosen it as a re- placement for methyl or ethyl acetoacetate. To explain to a liberal-arts wife the now threatened role of these acetoacetates in civilization offers difficulty. To point out that in CH3COCH2COOC2Hs the methylene group with an acetyl group on one side and a carbethoxy group on the other is highly activated for conversion to mono- and dialkyl C-substitution products and that these and the parent com- pounds with their two different carbonyl-containing groups joined to the methylene group can undergo hydrolytic cleav- age-all this begs the question and plants in her mind a little seed of doubt as to whether you are really as dependable as everybody says you are. Instead, you might sum up that ethyl acetoacetate has been a sort of chemical Chicago, from which one can go in any of many directions. For historical perspec- tive, you might point out that ethyl acetoacetate has had to be made by an expensive sodium-ethyl acetate route, now to be by-passed as rising standards of safety and materials-handling sophistication make Diketene a practical commodity of com- merce. On the other hand, that's a lot of pointing out and summing up to do. Perhaps it is enough to say that Diketene is used to make drugs, dyes, and agricultural chemicals (which is prob- ably true, even if you have nothing specific in mind). When she asks whether they really need all those agricultural chem- icals, gently tum her attention to the problem of what to get the kids for Christmas. We have spent as much as $500 moving a 2-gallon free sample of Diketene 1500 miles from Eastman Chemical Products, Inc., Kings- port, Tenn. (Subsidiary of Eastman Kodak Company) and can't afford too much of that, but this is the place with which to establish mutual earnestness ofpurpose. Radiometry of the epidermis Policemen often moonlight. Many male schoolteachers moon- light. Work by the light of the moon to supplement one's income can be honorable, stimulating, and even necessary. When an astronomer (whose professional concerns encompass moonlight) wants to moonlight, he acquires some KODAK IRTRAN 4 Optical Material from Apparatus and Optical Divi- sion, Eastman Kodak Company, Rochester 4, N. Y. and fab- ricates it into a small converging lens. This transmits infrared from 1 to 20,u, a band wherein falls nearly all the energy emitted by sources around 300°K. Knowing that the human epidermis is normally a 310°K emitter, he builds the lens into a portable instrument for measuring temperature variation over small epidermal areas without actual contact and the error so intro- duced. He arranges for the lens to image a small area on a 15 NOVEMBER 1963 thermistor in a bridge circuit with microammeter. The lens makes the response independent of exact distance. After permitting use of this instrument in clinical practice for several months, the moonlighting astronomer sounds like this: A female who had Raynaud's disease was scanned 5 days after 2 fingers had been amputated to the first joint. At the site of amputation the indicated temperature was lower than 2 cm back from the end of the wound. The surgeon wouldn't use a skin thermometer for fear of causing an infection in the open wound. A female presented herself with a small mass at the outer quadrant of the right breast; palpable with difficulty. It showed a 0.7°F rise in the area. She was hospitalized and a biopsy per- formed. An adenocarcinoma was found and removed. An elderly male with a deformed, ulcerated lesion of the right ear cartilage was examined. An 0.5°F increase over the involved area was noted. It was resected and a basal cell car- cinoma was found. A female came in with psoriasis which gave rises of about 1°F over the involved areas. It was inflamed. It is notable that temperature elevations are not obtained over static cases of psoriasis. A 17-year-old female with a soft mass in the left breast pre- sented herself. The reading was 0.5°F cooler than the surround- ing tissue. One week later surgery showed that it was benign. A male was burned on the right leg. The leg was bandaged. On the third day an elevation in body temperature was noted, suggesting an infection. On scanning the bandage a reading at the knee showed a 2°F rise. On removal of the bandage the infection site was verified. The only way currently to learn anything further about this line of development is to inquire of The Dudley Observatory (Chartered 1852), 140 South Lake Avenue, Albany, N. Y. Wash away all but the image (and erase as much of that as you like) For certain drafting-room procedures that may fail to interest the general reader, we now place upon the market a silver- sensitized photographic film that may indeed appeal to him for applications that have yet to occur to us. emulsion impregnated with developer at factory - very tough, dimensionally stable ' ESTAR Base (polyester) .004" , r.1 - prvoul prpre L An.- fron very previously prepared CP An o) line negative 1200 ft.-candles. 75 sec. activator liquid which we furnish to bathe it for anywhe: n 1/2 to 2 minutes at 65°- 85°F turns the exposed are. black"-- I''' re as and then plain warm water (80- 100eF) flushes away the un- blackened emulsion in a minute or so. A Lamenable to pen, pencil, etc. ZThis thickness drawn much exaggerated. Easily removable wet but not dry. Far finer detail results and much less exposure is required than with bichromated gelatin. Bichromated gelatin is very ancient. Time to forget it, perhaps? If you ever remembered. For the name of a dealer who quotes sizes and prices on this KODAK Wash-Off Drafting Film, write Eastman Kodak Company, Photo Reproduction Division, Rochester 4, N. Y. 983
Transcript of MS · 2005. 6. 21. · MS advertises:I Diketene, that terrible stuff.. . the workof moonlighting...
MS advertises:IDiketene, that terrible stuff. . . the work of moonlighting astronomers...a product for draftsmen and possibly others
A new chemical ChicagoDiketene (CH2COCH2CO) is terrible stuff. It brings tears to
lIthe eyes even in small whiffs, smells awful, once killed a shavedguinea pig bathed with it, and may polymerize violently whencatalyzed by casual contamination. For carelessness with it,one ought to go to jail.To keep it out of inexpert hands and for other more or less
obvious reasons, we sell no less than 39,000 pounds at a crackand are proud of our achievement in bringing it to market. Itcomes in its own stainless steel tank truck, insulated heavilyenough to stay safely near the - 7.5°C freezing point for up to72 hours. Obviously anybody willing to have this truck pull upto the gate with the driver complaining of unseasonable heaton the road the past 21/2 days and asking where to connect upto the refrigerated storage tanks will have given the matterconsiderable thought in advance. Very likely, despite thetouchy nature of Diketene and because it works directly with-out troublesome by-products, he will have chosen it as a re-placement for methyl or ethyl acetoacetate.To explain to a liberal-arts wife the now threatened role of
these acetoacetates in civilization offers difficulty. To pointout that in CH3COCH2COOC2Hs the methylene group withan acetyl group on one side and a carbethoxy group on theother is highly activated for conversion to mono- and dialkylC-substitution products and that these and the parent com-pounds with their two different carbonyl-containing groupsjoined to the methylene group can undergo hydrolytic cleav-age-all this begs the question and plants in her mind a littleseed of doubt as to whether you are really as dependable aseverybody says you are. Instead, you might sum up that ethylacetoacetate has been a sort of chemical Chicago, from whichone can go in any of many directions. For historical perspec-tive, you might point out that ethyl acetoacetate has had to bemade by an expensive sodium-ethyl acetate route, now to beby-passed as rising standards of safety and materials-handlingsophistication make Diketene a practical commodity of com-merce.On the other hand, that's a lot of pointing out and summing
up to do. Perhaps it is enough to say that Diketene is used tomake drugs, dyes, and agricultural chemicals (which is prob-ably true, even if you have nothing specific in mind). Whenshe asks whether they really need all those agricultural chem-icals, gently tum her attention to the problem of what to getthe kids for Christmas.We have spent as much as $500 moving a 2-gallon free sample of
Diketene 1500 miles from Eastman Chemical Products, Inc., Kings-port, Tenn. (Subsidiary ofEastman Kodak Company) and can't affordtoo much of that, but this is the place with which to establish mutualearnestness ofpurpose.
Radiometry of the epidermisPolicemen often moonlight. Many male schoolteachers moon-light. Work by the light of the moon to supplement one'sincome can be honorable, stimulating, and even necessary.When an astronomer (whose professional concerns encompassmoonlight) wants to moonlight, he acquires some KODAKIRTRAN 4 Optical Material from Apparatus and Optical Divi-sion, Eastman Kodak Company, Rochester 4, N. Y. and fab-ricates it into a small converging lens. This transmits infraredfrom 1 to 20,u, a band wherein falls nearly all the energy emittedby sources around 300°K. Knowing that the human epidermisis normally a 310°K emitter, he builds the lens into a portableinstrument for measuring temperature variation over smallepidermal areas without actual contact and the error so intro-duced. He arranges for the lens to image a small area on a15 NOVEMBER 1963
thermistor in a bridge circuit with microammeter. The lensmakes the response independent of exact distance.
After permitting use of this instrument in clinical practicefor several months, the moonlighting astronomer sounds likethis: A female who had Raynaud's disease was scanned 5 days
after 2 fingers had been amputated to the first joint. At the siteof amputation the indicated temperature was lower than 2 cmback from the end of the wound. The surgeon wouldn't use askin thermometer for fear of causing an infection in the openwound.A female presented herself with a small mass at the outer
quadrant of the right breast; palpable with difficulty. It showeda 0.7°F rise in the area. She was hospitalized and a biopsy per-formed. An adenocarcinoma was found and removed.An elderly male with a deformed, ulcerated lesion of the
right ear cartilage was examined. An 0.5°F increase over theinvolved area was noted. It was resected and a basal cell car-cinoma was found.A female came in with psoriasis which gave rises of about
1°F over the involved areas. It was inflamed. It is notable thattemperature elevations are not obtained over static cases ofpsoriasis.A 17-year-old female with a soft mass in the left breast pre-
sented herself. The reading was 0.5°F cooler than the surround-ing tissue. One week later surgery showed that it was benign.A male was burned on the right leg. The leg was bandaged.
On the third day an elevation in body temperature was noted,suggesting an infection. On scanning the bandage a reading atthe knee showed a 2°F rise. On removal of the bandage theinfection site was verified.
The only way currently to learn anything further about this line ofdevelopment is to inquire of The Dudley Observatory (Chartered1852), 140 South Lake Avenue, Albany, N. Y.
Wash away all but the image(and erase as much of that as you like)For certain drafting-room procedures that may fail to interestthe general reader, we now place upon the market a silver-sensitized photographic film that may indeed appeal to him
for applications that have yetto occur to us.
emulsion impregnated withdeveloper at factory
- very tough, dimensionally stable 'ESTAR Base (polyester) .004" ,
r.1- prvoul prpreL
An.-fronvery
previously prepared CP An o)line negative 1200 ft.-candles. 75 sec.
activator liquid which we furnish to bathe it for anywhe:n 1/2 to 2 minutes at 65°- 85°F turns the exposed are.
black"--
I I'''reas
and then plain warm water (80-100eF) flushes away the un-blackened emulsion in a minute or so.
A
Lamenable to pen,pencil, etc.
ZThis thickness drawn much exaggerated.Easily removable wet but not dry.
Far finer detail results and much less exposure is requiredthan with bichromated gelatin. Bichromated gelatin is veryancient. Time to forget it, perhaps? If you ever remembered.For the name ofa dealer who quotes sizes andprices on this KODAK
Wash-Off Drafting Film, write Eastman Kodak Company, PhotoReproduction Division, Rochester 4, N. Y.
983
I ININi
m i a o- . - i0l1,
*1- --1
Curves and (lata above illustrate procedures used, and provide con-clusive proof of the outstanding performance offered by the Bausch &Lomb) Model 5 Relative Spectroradiometer,/Spectroreflectometer.comparing with instruments costing up to $5000 more.What is your problem? Double-beam comparison of spectral energy
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Winter GordonResearch Conferences
TIc Winter Gordon Research Con-terences \,ill be held fronm 27 JaInUaryto 7 Februarv 1964 at the MiramarHotcl. Sainta Barbara. California Thepurpose of the Gordon Research Con-I erences, w hich is to stimiiulate researchin Unixersities. research fouLndaitions, andindustrial labortatories, is achieved byan inform,al tvpe of mleeting consistillnot scheduleld lectuLres and discussiongroups. SuLfficient timle is available tostimulate informal discussions amongithe imiemlbers of each conference. Meet-ings are held in the morning and inthe cvening, Monday through Friday.xxith the exception of Friday eveningThe afternooons are available for rec-reation. reading, or participation in dis-CuLSSioIn grouLps as the individual de-sires. This type ot meeting is a valuablemeans of disseminating information andideas to an cxtent that could not beachieved through the usual ch'annels ofpublication and presentation at scieni-tific meetings. It is hoped that eachconference x ill extend the frontiers ofscience by fostering a free and infor-mal cxchangc of ideas aimong personsaIctively interested in the suibjects uinderdiscuIssioll. The suImlimier conferences areheld in New Hampshire [Science 139.10))6 (f 963)].
Re-'i.stration anid Reservatiotns. At-tendarice aIt the conferences, limited toapproximately 100, is by application.IndividuLIls interested in attendinio theconferences are requLested to send theirapplications to the office of the di-rector. Applicaitions muLIst be suLbmlliti[Cin dUplicate on the standard torm.xxhich may be obtained froml the officeot the director. The aipplications xvillbe reviexAxed by the Conference Coml-miittee. This comimilittee, in selecting theparticipants, wvill distribute the attend-ance as widely as possible among theinstituitions and laboratories represeintedby the applications. A registration cardwill be mlailed to those selected. Ad-vance registration by mail is requlired:this is comipleted when the registraitiotcard xxith acdeposit of $15, is receivedin the oflice of the director. A registra-tion card not accomipanied by the de-posit \vill not be accepted; this advancedleposit is not requlired of scientists fromtoreiizn coulitries.A fixed fee of $11 5 has been estab-
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SCIENCE, VOL. 142
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SCIENCE, VOL. 142
AGING . .Some Social and Biological AspectsA symposium presented at the AAAS
Chicago MeetingDecember 1959. Published November 1960.
Nathan V. Shock, Editor6 x 9, 436 pp., 65 illus., cloth
$8.50 AAAS nieinbers' cash orders $7.50
CONTENTSImplications for society: J. W. McConnell, J. T. Freeman,
R. J. Havighurst, C. D. Leake, S. SpectorAging in tissues and cells: B. Glass, J. D. Ebert, G. H.
Bourne, A. WhiteAging in the total organism: M. Landowne, G. Pincus, P.
Handler, E. W. BusseTheories of aging: N. W. Shock, H. Selye, P. Prioreschi,
B. L. Strehler, J. E. Birren, S. E. StumpfOral aspects of aging: R. F. Sognnaes, A. A. Dahlberg,
J. Nalbandian, J. Klingberg, L. Cancellaro, E. 0.Butcher, J. R. Ring
Financing medical costs after age 65: J. T. FreemanDiscussions. Index
British agents: Bailey Bros. & Swinfen, Ltd.Hyde House, West Central StreetLondon W.C.1
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Write for your FREE COPY of newcatalog to Department S-33.
studies of polymers with defined dis-tribution."
30 Jan. A. J. Havlik and R. Simha,"Equation of state of polymer liquids;glass transitions"; A. A. Berlin, (sub-ject to be announced); G. Natta, G.Mazzanti and G. Dall'Asta, "Polymer-ization of cyclic olefins."
31 Jan. K. Fukui, "Toward a theo-retical strategy for the chemistry ofpolymerization"; S. E. Bresler, (sub-ject to be announced); J. F. Smith, "Ap-plication of computer techniques to theprediction of copolymer compositions."
Electrochemistry: Electrode Reactions
Ralph N. Adams and Richard Buckare chairman and vice chairman, re-spectively.
3-7 Feb. Paul Delahay, "Double lay-er and electrode kinetics"; LucienGierst, "Cation effects on electrodekinetics"; A. C. Riddiford, "Rotateddisk electrodes"; Philip J. Boddy, "An-ion effects on potential distribution at agermanium electrode"; Donald Smith,"Electrochemical studies of rapid ho-mogeneous chemical reactions employ-ing AC techniques"; Allen J. Bard,"Coulometry applied to electrode mech-anism studies"; Henry Taube, "Elec-tron exchange reactions"; G. C. Barker,"Photo currents at mercury electrodes";Manfred Breiter, "Kinetics of hydro-gen and deuterium discharge on plati-num"; Leon Dorfman, "Pulse radiolysisstudies of the electron in polar liquids";N. Sutin, "Electron exchange reac-tions"; H. Gerischer, "Semiconductorelectrodes"; E. Yeager, "Kinetics ofthe oxygen electrode at various sur-faces"; W. H. Reinmuth, "Impluse re-laxation techniques"; Robert Oster-young, "Adsorption studies at solidelectrodes"; S. Bruckenstein, "Ring-disk electrode techniques."
W. GEORGE PARKSUniversity of Rhode Island,Kingston
Other Meetings
November
24-27. American Acad. for CerebralPalsy, Dallas, Tex. (J. D. Russ, 1520Louisiana Ave., New Orleans, La.)
25-27. Geological Soc. of America,76th meeting, New York, N.Y. (F. Betz,Jr., 419 W. 117 St., New York 27)
29-30. American Mathematical Soc.,Cleveland, Ohio. (AMS, 190 Hope St.,Providence 6, R.I.)
31-1. American College of ChestPhysicians, Portland, Ore. (M. Kornfeld,112 E. Chestnut, Chicago 11, Ill.)9- S
988
Nev/ AAAS Symposium Volumes
Spermatozoan MotilityEdited by David W. Bishop. 322pages. 113 illustrations. Refer-ences. Index. 28 tables. August1962. $7.50 ($6.50 prepaid forAAAS members).
Great Lakes BasinEdited by Howard J. Pincus. 320pages. 92 illustrations. 46 tables.Abstracts. References. Index. Au-gust 1962. $7.50 ($6.50 prepaidfor AAAS members).
Fundamentals ofKeratinization
Edited by E. 0. Butcher and R. F.Sognnaes. 202 pages. 136 illustra-tions. Summaries. References. In-dex. May 1962. $6.50 ($5.75 pre-paid for AAAS members).
Biophysics of Physiologicaland Pharmacological Actions
Edited by Abraham M. Shanes.612 pages. 212 illustrations, Refer-ences. Index. December 1961.$13.50 ($11.75 prepaid for AAASmembers).
Order today, from
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SCIENCE, VOL. 142
