MRI-PET joint kinetic model-driven reconstruction · 2016. 9. 26. · PET-MRI: Vp, CBF, PS, EEV,...
Transcript of MRI-PET joint kinetic model-driven reconstruction · 2016. 9. 26. · PET-MRI: Vp, CBF, PS, EEV,...
![Page 1: MRI-PET joint kinetic model-driven reconstruction · 2016. 9. 26. · PET-MRI: Vp, CBF, PS, EEV, K1, k2, k3, k4 4+5 = 8! Gd-DTPA and FDG. Gd-DTPA and H2O-PET. MRI-PET joint kinetic](https://reader033.fdocuments.net/reader033/viewer/2022053115/6091b781b8fb2c08461f72c3/html5/thumbnails/1.jpg)
School of somethingFACULTY OF OTHER
MRI-PET joint kinetic
model-driven reconstruction
Steven Sourbron
Division of Biomedical ImagingLeeds Institute of Cardiovascular and Metabolic Medicine
PET-MR workshop, BC ISMRM, Leeds 2016
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Overview
PET: Kinetic model driven reconstruction
MRI: Kinetic model driven reconstruction
PET-MRI: Opportunities for joint kinetic model driven
reconstruction
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PET: KINETIC MODEL DRIVEN
RECONSTRUCTION
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PET kinetic data
Muzi et al. MRI 2012; 30: 1203.
QIN: Quantitative assessment of dynamic PET imaging data in Cancer Imaging.
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PET AIF
Muzi et al. MRI 2012; 30: 1203.
QIN: Quantitative assessment of dynamic PET imaging data in Cancer Imaging.
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PET kinetic models
Muzi et al. MRI 2012; 30: 1203.
QIN: Quantitative assessment of dynamic PET imaging data in Cancer Imaging.
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PET – model-driven (Direct)
reconstruction
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PET - Direct reconstruction
Dynamic Data
(Sinograms)
S(θ,ti); i=1,…,200
Dynamic Images
(Concentrations)
C(r,ti); i=1,…,200
Reconstruct
Parametric Maps
K1(r), k2(r), k3(r),
…
Compartment
Model
Direct
Reconstruction
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PET - direct reconstruction
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MRI: KINETIC MODEL DRIVEN
RECONSTRUCTION
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Dynamic MRI (1984)
Runge et al. Intravascular
Contrast Agents Suitable for
Magnetic Resonance Imaging.
Radiology 1984; 153: 171-176
Precontrast
16min
6min
67min
1984: first direct
recon in PET!
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MRI kinetic models
CBF
PSPS
CBV
EEV
AIF
CBF
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MRI Signal modelling
FLASH with FA from 10° to 90°
Sig
nal c
han
ge (
a.u
.)
Concentration (/100 mM)
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MRI AIF measurement
Arterial Input Function
Reference concentration for
quantitative analysis
(“Virtual” blood sampling)
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Partial-volume
Correction
AIF & partial-volume correction
Max S-S0
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AIF measurement errors
Problem: Inflow effects (velocity sensitive signal)
Possible solutions
• Sequence optimisation (in 2D: lower FA, in 3D: increase FA)
• In 3D: distal AIF / saturation slabs / heart in FOV
• Reduce peak concentration (lower dose/flow rate)
• Correct using flow measurements
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MRI direct reconstruction
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MRI direct reconstruction
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PET-MRI: JOINT KINETIC MODEL
DRIVEN RECONSTRUCTION
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Opportunities (I)
Exploiting AIF similarities
CBF
PSPS
CBV
EEV
AIF
CBF
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Opportunities (I)
Exploiting AIF similarities
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Opportunities (II)
Exploiting tissue similarities
CBF
PSPS
Vp
EEV
AIF
CBF
MRI: Vp, CBF, PS, EEV PET: Vp, K1, k2, k3, k4
PET-MRI: Vp, CBF, PS, EEV, K1, k2, k3, k4
4+5 = 8!
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Gd-DTPA and FDG
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Gd-DTPA and H2O-PET
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MRI-PET joint kinetic model-
driven reconstruction
?