© 2016 LABCYTE INC. All rights reserved. Labcyte®, Echo, the Labcyte logo are registered trademarks or trademarks of Labcyte Inc., in the U.S. and/or other countries.

MOVING LIQUIDS with SOUNDLabcyte Overview

Mark Fischer-Colbrie

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Liquid Handling

▸ Billions have been invested in developing advanced analytical and detection tools

▸ Antiquated liquid handling has reached its physical limits and is a bottlenecj

▸ Urgent need for improved liquid transfer

▸ Precision Medicine needs precise liquid handling

▸ Achieving $1000 Genome (and going to $100 Genome) requires miniaturization of expensive

reagents

▸ Biology is complex – complexity requires more testing and lower cost per data point

Sample Collection

Advances in Analysis Have OutpacedSample Preparation

Healthcare Research and Diagnostic Workflow

Sample PrepDetection and

Analysis

MOVING LIQUIDS with SOUND | Labcyte Overview

3

Positioned to disrupt existing markets / expand current markets

Acoustic Dispensing Addresses ~$3B Market

Robotics

Automated

Liquid

Handling

$640M $140M

Manual

Liquid

Handling

Echo

Benchtop

$600M

High / Mid

Throughput

Readers

Echo-MS

$600M

Genomics

OEM /

New

Configurations

$540M

Biobanking /

Tubes

Acoustic

Tubes

$165M

Disrupting

Access

Workstation

Echo Liquid

Hander

Enabling

$780M ~$2B

4

Precision liquid handling -- for the first time

Labcyte Overview

▸ Established 2000 - Invented touchless liquid handling using focused sound waves.

- Digital acoustic dispensing

- First Echo® Liquid Handler Shipments 2004

- Set up to be a global company to initially support global pharmaceutical firms

▸ Hundreds of Customers- 20 of top 20 pharmaceutical companies

- Large and mid-size pharma, biotech, molecular diagnostics, genome centers,

synthetic biology, precision medicine centers

- Academic & research institutes

- Contract research organizations

▸ Hundreds of Applications- Drug Discovery – Precision Medicine

- Genomics – Molecular Diagnostics

- Proteomics – Mass Spectrometry Interface

▸ Patents- 58 Issued US patents / multiple global patents from in-house inventions

- Additional patent applications filedMOVING LIQUIDS with SOUND | Labcyte Overview

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Hundreds of Customers Worldwide

MOVING LIQUIDS with SOUND | Labcyte Overview

Numerous Prestigious Industry Awards

Labcyte has received a number of awards from organizations like The R&D 100, The World Economic Forum, Ernst & Young, Frost & Sullivan, among others, who are recognizing the Company’s impact

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Top 100 Global Companies (2013)

Select Industry Awards

2007

Top 3 Life Science

Company 2013

World Economic Forum

2015

Echo® Acoustic

LIQUID HANDLING

The Future of Science is Sound

MOVING LIQUIDS with SOUND | Labcyte Overview

Problems with Traditional Systems

8

Traditional Liquid Handling Issues

Human

Errors

55% 50% 44% 36% 28% 19% 8% 6%

Liquids Stick

to Tip

Viscosity

Reduces

Accuracy

Immersed

Tip Carry

Over

Liquid

Surface

Tension

Reduces

Accuracy

Pipettes

Take Up

More

Liquid

Liquids

Evaporate

Liquid

Temperature

Labcyte Acoustic Droplet Ejection

Eliminates the Top 6 Sources of Errors

Top Sources of Pipette Errors

MOVING LIQUIDS with SOUND | Labcyte Overview

Echo® Acoustic

LIQUID HANDLING

The Future of Science is Sound

MOVING LIQUIDS with SOUND | Labcyte Overview

A Sound Solution

Enter Title of Presentation | Enter Date

10

Echo Liquid Handler in Action

Echo® Acoustic

LIQUID HANDLING

The Future of Science is Sound

MOVING LIQUIDS with SOUND | Labcyte Overview

The Labcyte System

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Innovative system centered around the transfer of precise amounts of fluids without contact

Groundbreaking System Solution

Labcyte® Automation

Incorporates Echo Liquid

Handlers for complete

workflow solution

Enables Labcyte to own the

sales process

Labcyte® Consumables

Proprietary, acoustically

qualified source plates

Precise manufacturing and

qualification process

Echo® Software

Applications

Array of applications that

maximize the utility and

flexibility of Echo Liquid

Handlers

Echo® Liquid Handler

Revolutionizes liquid handling

by using acoustic energy to

transfer liquids

MOVING LIQUIDS with SOUND | Labcyte Overview

Direct

Distribution

Both

Global Commercial Organization

Labcyte has been built with the vision to support global pharma from day one

1

3

• 52-person global field team -- sales, field applications, service and support

• Fully integrated field support team with a single CRM for all activities

North America Field Team

Asia / Australia Field Team

Europe Field Team

Source: Company Management.

14

Labcyte has experienced extraordinary momentum from industry-leading science publications. As of 2016,

the Echo acoustic liquid handler has been featured in over 600 cumulative publications.

Extraordinary Momentum Across Applications

4778

106

151

211

281

376

466

635

-

100

200

300

400

500

600

7001 Source: Company Management. Represents

calendar year ending December 31, 2016.

Cumulative Publications1 Journal of Laboratory Automation Special Issue on ADE

▸ Highlights the impact of acoustic

dispensing throughout research

▸ Key topics include:

• Personalized Medicine

• Synthetic Biology

• Mass Spectrometry Interface

• Combination Screening

• Antibody Screening

• Genotyping

• Impact on High-throughput Screening

▸ 23 papers total

Available at www.labcyte.com/jala

MOVING LIQUIDS with SOUND | Labcyte Overview

Echo® Acoustic

LIQUID HANDLING

The Future of Science is Sound

MOVING LIQUIDS with SOUND | Labcyte Overview

Market / Application Spotlight

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Used in life sciences, research, drug discovery and personalized medicine

Broad Range of Applications

Genomics Drug Discovery

Synthetic

Biology

Increase

efficiency

and speed

while

reducing

costs

Low cost,

highly

efficient

library

preparation

Enabling

high-

throughput

epigenetic

screening

Cost-

effective,

high-

throughput

RT-qPCR

From

personalized

medicine

towards

precision

medicine

Discover the

right drugs

with

improved

transfer

performance

Biologically

relevant

assays with

unmatched

data quality

Simplify

assay

workflows

with precise

reagent

transfers

Enable cost-

effective,

earlier safety

screening

Increase

efficiency

and speed

while

reducing

costs

Sequencing Epigenetics

Gene

Expression

Precision

Medicine

Translational

HTS /

Secondary

Screening

Cell-based

Assays

Biochemical

Assays ADME-Tox

Combination

Screening

▸ Drug Discovery: Enabling miniaturization with unparalleled

throughput and accuracy

- Result: New drugs discovered

▸ Genomic Research: Overcoming traditional barriers by

dramatically reducing sample and reagent volume requirements

- Result: Better experimental data at a fraction of the cost

▸ Cancer Research: Helping research programs drive down assay costs

while enabling new experimental workflows

- Result: Patient sample drives therapy

▸ Molecular Diagnostics: Eliminating cross-contamination and other data

errors while dramatically reducing running costs

- Result: Lower operational costs (critical with reimbursement pressures)

MOVING LIQUIDS with SOUND | Labcyte Overview

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Finds Drugs Missed by Traditional Systems

TABLE A

Compound # Echo IC50 (µM) Tecan Genesis IC50

(µM)

4 0.003 0.146

5 0.002 0.553

6 0.007 0.973

7 0.003 0.778

8 0.004 0.445

9 0.052 0.170

10 0.064 0.817

11 0.486 3.03

▸ Therapeutics would have been missed without the Echo

▸ AstraZeneca patent #7,718,653 presents data showing

compounds ~10x – 300x more potent using acoustics

▸ Pipette tips inhibited accurate drug effectivity analysis

AstraZeneca discovers cancer drugs with the Echo that would

have been missed using traditional technologies

MOVING LIQUIDS with SOUND | Labcyte Overview

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Tips give the wrong answer….

MedImmune study finds touchless acoustic transfer insures quality results for peptides

B

B

AThe EC50

value

changes

when the

diluents are

changed

when using a

pipette

The EC50

value is

constant

when the

Echo

Liquid

Handler is

used

Tip-based System Echo System

A changing

concentratio

n of BSA in

the solution

changes the

apparent

EC50 when

using a

pipette

No such

shift is

seen with

the Echo

system

A BRAVOBSA Curve Shift in rGLP-1R

Echo SystemBSA Curve Shift in rGLP-1R

MOVING LIQUIDS with SOUND | Labcyte Overview

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Comparison of Traditional vs. Echo

Echo® Liquid Handling for Genomics | Labcyte Introduction

▸ Volumes

• Traditional: 20 µL

• Echo: 5 µL

▸ Reaction assembly

• gDNA on Traditional: 8 µM

• gDNA on Echo: 5 µM

• Primers: 625 nM

• Master Mix: 1x Type-It Fast

SNP PCR (Qiagen)

© 2016 LABCYTE INC. All rights reserved. Labcyte®, Echo®, and the Labcyte logo are registered trademarks or trademarks of Labcyte Inc.

Genomics Product PositioningNext-generation Sequencing

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Miniaturization in Genomics

Echo® Liquid Handling for Genomics | Labcyte Introduction

Application Cost per Reaction(at recommended)

Miniaturized

Cost per ReactionVolume Reduction

(up to…)

PCR / qPCR $0.27 $0.05 6X

NGS Library Prep $72.91 $0.73 100X

Sanger Sequencing $0.26 $0.06 5X

MDA Setup $17.64 $4.41 4X

Gibson/Golden Gate DNA Assembly $15.90 $0.16 100X

Use fewer tips

Generate less waste

Reduce cross-contamination

Eliminate carryover errors

Increase throughput

Increase pool density / multiplex

Key Benefits

• Synthetic Biology

• Cancer Research / Personalized Medicine

• Drug Discovery

• Academic Research

• Diagnostics

Areas Impacted

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Enabled Personalized Medicine

• Global leader in personalized medicine

• Real-time patient data decision making for

treatment

• Repurposing cancer drugs with pharma

• Individualized system medicine - seminal

advancement in cancer therapy

• Connecting patient testing at the cell level

with genomic profiling

• Result

• Rescue extremely high risk patients

• Comprehensive data sets driving drug

development and repurposing

• Pfizer renal cancer drug being re-purposed

• Only possible using acoustic liquid

handling

• Initial work in blood cancers now being

expanded into solid tumors

Miniaturization and flexible combinations enable new applications:

Institute of Molecular Medicine Finland (FIMM)

“This research opportunity is changing the way new drugs are introduced for patients: It is truly-game changing. Labcyte technology is a key platform for this next stage.”

Olli Kallioniemi, FIMM Director

MOVING LIQUIDS with SOUND | Labcyte Overview

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Multiple findings in AML and CML treatment published in leading publications

Enabled Repurposing of Cancer Drugs

May 1, 2015

• Novel drug candidates for advanced phase and blast crisis CML

• Three classes of drugs highly sensitive for most TKI resistant patient samples

February 1, 2015

• Joint development between FIMM and Pfizer

• Axitinib as a potential inhibitor to drug resistance

• Studied cancer cells from patients with CML and AML

• Study relied on FIMM’s Drug Sensitivity and Resistance Testing (DSRT) methods

• Lead the way for proof-of-concept clinical studies

• The market availability of axitinib, (trade name Inlyta) means testing clinical utility for leukemia can be fast-tracked

September 20, 2013

• Identified potential new pathway for targeting AML treatment

• Conducted one or more combination screening of drugs using patient cells

• Had an impact on all patients treated

• Identified 3 drugs that may be considered for re-purposing for AML purposes

MOVING LIQUIDS with SOUND | Labcyte Overview

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Enabled High-throughput Synthetic Biology

• Innovator in microbial engineering and

screening technologies

• Renewable products: fuels, cosmetics,

biopharmaceuticals

• Recent publication demonstrating significant

NGS prep cost savings

• American Chemical Society, April 25, 2015

• Illumina Nextera reagents were reduced 100-fold

($72 to 72 cents)

• Reduced time from 18 hours to 3 hours

Major improvements in cost and processing efficiency for

microbial engineering

"By combining an Illumina MiSeq platform with a Labcyte Echo acoustic liquid dispensing system, we have developed a rigorous, low-cost QC method…”

Elaine Shapland, Scientist

MOVING LIQUIDS with SOUND | Labcyte Overview

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Case Study:

• Progressive adoption of Echo Liquid Handler

and Access workstation

• Compound management

• Protein Crystallography

• Cell based assays (HTRF)

• GMP

• Mouse tail genotyping

Numerous expansion opportunities within

existing customer base will continue to drive

organic growth

“These instruments are phenomenal when comparing them to traditional liquid handling robots - they are much faster, much more accurate and precise, and highly reproducible. The company is a pleasure to interact with and is structured in a collaborative manner that easily facilitates research and partnership projects.”

Colin Cox, Science Manager

8 traditional systems replaced for one application

MOVING LIQUIDS with SOUND | Labcyte Overview

Echo® Acoustic

LIQUID HANDLING

The Future of Science is Sound

MOVING LIQUIDS with SOUND | Labcyte Overview

Research and Development

(announced)

Echo® Acoustic

LIQUID HANDLING

The Future of Science is Sound

MOVING LIQUIDS with SOUND | Labcyte Overview

Echo-MS

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▸ High-throughput, low cost, label-free analysis

Echo-MS: Acoustic Mass Spec Interface

▸ Large pent up demand for improved sample prep and delivery systems for mass

spectrometry

▸ Biopharma, government and academic accounts have limited adoption of MS

based detection for high throughput needs due to performance and cost barriers

▸ Key benefits of MS detection for these customers include:

– Label free detection with multiple end point measurements

– Wide range of end points (Proteins, lipids, sugars, DNA)

– True high content read out enable pathway analysis and metabolomics

MOVING LIQUIDS with SOUND | Labcyte Overview

• Large reagent cost savings on a 1 million compound screen are extremely large.

• Traditional cost: $150,000

• Acoustic MS Cost: $1500

• 10 times faster than fastest options

• Assay developed in 4 days as compared to usual time of 4 months

• Kinetic data acquisition enables assay optimization in 4 days instead of 4 months

• Major game changer in design of experiment

• False positives eliminated

• Z’ values at .70

• All active hits were confirmed with LCMS

Echo-MS SuccessesPresented by AstraZeneca at SLAS and later ASMS

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Echo® Acoustic

LIQUID HANDLING

The Future of Science is Sound

MOVING LIQUIDS with SOUND | Labcyte Overview

Acoustic Tubes and Instrumentation

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Acoustic Tubes: Product Overview

• Funding by AstraZeneca

• Partnership with Brooks

• New, 96 rackable acoustic storage tube as new recurring

revenue source for Labcyte

• Development of updated Echo 555 platform for tube and

plate dispensing

• AstraZeneca is completely revamping their tube storage

system to take advantage of acoustic transfer

Labcyte’s acoustic tube and instruments program delivers a solution to the unmet market need for fully

acoustic workflows for small molecule and biologic storage

Collaboration Overview

MOVING LIQUIDS with SOUND | Labcyte Overview

© 2016 LABCYTE INC. All rights reserved. Labcyte®, Echo, the Labcyte logo are registered trademarks or trademarks of Labcyte Inc., in the U.S. and/or other countries.

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