More than an immune booster

Schedule

• Basics• Avemar and Immunovet• Production• Effects• Results

Introduction

• Albert Szent-Györgyi (Hungarian Nobel laureate)• Biochemical research with fermented wheat germ• Effective molecule complex against cancer cells• Development by Hungarian sciencists, inspired by

His legacy• Avemar available from 1998

• Raw materials• Manufacturing technology

• fermentation• extraction• standardization (2,6 dimethoxy-p-benzoquinone)

• Similarities• same manufacturing line• one fermentative mass

• Differences• different fractions of the fermented mass• different goal

Avemar and Immunovet – FWGE

AU

0,00

0,10

0,20

0,30

0,40

0,50

0,60

0,70

Minutes2,00 4,00 6,00 8,00 10,00 12,00 14,00 16,00 18,00 20,00 22,00 24,00

1,903 2,070

2,224

2,618

2,801

2,991

3,253

3,448

3,692

3,979

4,323

4,860

5,180

5,762

6,262

6,947

7,2407,883

8,901

9,628

10,323

10,615

11,344

12,017

12,443

13,127 14,161

14,799

15,333 15,702 16,260

17,105

17,66418,087

18,854

19,371

20,151

21,092

21,445

22,262

• Raw materials• wheat germ• yeast

• Special fermentation process• Extraction of active compounds• Drying, concentration and

standardization• Tablet pressing and boxing

Immunovet

• Goal is the prevention of healthy status

• Healthy– Not equal to not sick

Fermented Wheat Germ Extract

• Pentose Phosphate Pathway (PPP)– Glucose Ribose5Phosphate mRNA DNA

replication– FWGE blocks Transketolase (Glucose

Ribose5Phosphate)– DNA replication stops, non-oxidative way slows– Selective effect for cancer cells (why?)

FWGE – cell-level effects 1.

• Apoptosis induction– Poly-(ADP-Ribose)-Polimerase (PARP)

important in the repairing of DNA-chains– Extremely high activity in cancer cells– FWGE aktivates the proteolysis of PARP– A DNS-repairing impairs, thus DNA

chains fragment

FWGE – cell-level effects 2.

• FWGE block the synthesis of MHC-I molecules in cancer cells–Major histocompatibility complex (ID

card to present for Leukocytes)– No MHC1 not friendly– NK cells activate

FWGE – cell-level effects 3.

• ICAM-1 (intercellular adhesion molecule)– Stabilizes the cell-cell interaction, facilitates

the leucocyte entdothelial transmigration• Downregulated on surface of tumor vessels – no

help for leucocytic infiltration• FWGE upregulates ICAM-1 expression, making

leucocytic infiltration easier

FWGE – cell-level effects 4.

• COX 1 and 2 non selective inhibitor – immunmodulation, anti-inflammatory effect

FWGE – anti-inflammatory

Reconvalescence timeAfter bone surgeries

78%

19%

3%

ShortenedNot changedNo data

Clinical status in contagious diseases(used PARALLEL the veterinary treatment)

62%17%

18%

3%

ImprovedNot changedWorsenedNo data

Clinical status in oncologic cases(used PARALLEL the veterinary treatment)

90%

4% 4% 2%

ImprovedNot changedWorsenedNo data

• Available since 2002–Millions of animals, so far no adverse

effect• Not toxic („like a slice of bread”)– LD50 > 2500mg/bwkg

Immunovet

Immunovet

• Easy to administer• Good taste, willing to eat

Immunovettablets

• Young animals – quick growth• Hair change• Stress• Chronic diseases• After surgeries• Elder animals – general boost

Immunovet

• With the recommendation of the Hungarian Veterinary Chamber

• With the recommendation of the Hungarian Kennel Club

Immunovet

Thank you for the attention!