MOLECULAR ANALYSIS TECHNOLOGY Hyphenating · PDF fileto Liquid and Gas Chromatography. ......

POLYMERS & COPOLYMERS FATTY ACIDS(FAME) FOREN-

SICS PAINT & COATINGS ADDITIVES FLAVORS & FRA-

GRANCES POLYOLEFINS ADHESIVES GENERAL ANALYTI-

CAL PETROLEUM ENVIRONMENTAL FINE CHEMICALS

POLYMERS & COPOLYMERS FATTY ACIDS(FAME) FORENSICS PAINT & COATINGS

ADDITIVES FLAVORS & FRAGRANCES POLYOLEFINS ADHESIVES GENERAL ANA-

LYTICAL PETROLEUM ENVIRONMENTAL FINE CHEMICALS

MOLECULAR ANALYSIS TECHNOLOGY

Spectra Analysis Instruments, Inc.

Hyphenating Infrared Spectroscopyto Liquid and Gas Chromatography

www.spectra-analysis.com

Table of Contents

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Back Page

Value Statement

Technology

DiscovIR-LC® System Features

Applications:

Application Notes

DiscovIR-GC® Technology Adopters

DiscovIR-LC® Technology Adopters

Global Sales Channels

DiscovIR® Product Specifications

Demo and Training Lab

Forensic Drug AnalysisIndustrial Polymer and Copolymer AnalysisPharmaceutical Formulations

Value Statement

Spectra Analysis Instruments, Inc., a leading provider of auto-mated FTIR (Fourier Transform Infrared) detection products, presentsthe DiscovIR-LC®, a ‘breakthrough’ (solvent removing) FTIR detectortechnology, providing solid-phase analysis of HPLC (High PerformanceLiquid Chromatography) and SEC (Size Exclusion Chromatography)separations.

According to Spectra’s Co-Founder and Senior Vice President ofEngineering, William W. Carson, the company recognized the significantlimitations of currently available technology and developed the firstfully-automated high performance HPLC-FTIR detection system ca-pable of achieving the kind of rigorous, repeatable qualitative analysesthat pharmaceutical, polymer chemists and other-industry customersrequire.

By providing an on-line chemistry solution...DiscovIR increases pro-ductivity of a company's most valuable resource - its scientists,chemists and engineers involved in:

• Product development• Process control and troubleshooting• Quality control (incoming and outgoing)• Patent protection and competitive analysis

The company’s DiscovIR products employ FTIR detection, theanalytical method of choice for providing identification and qualitativeinformation of organic compounds in complex chemical mixturesacross multiple market applications.

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Technology

4

The DiscovIR®, is a powerful analytical tool for the identification of compounds in

complex chemical mixtures and materials analysis. When connected to the outlet of aGC, HPLC or GPC (separation systems), the DiscovIR automatically captures and depos-its each compound in the mixture as a continuous track on an infrared transparentsubstrate. The built-in interferometer simultaneously captures a set of time-orientedinfrared spectra from the deposited track. The result is chemical identification andmolecular composition of all compounds.

High MW Low MW GPCElution Time

A/B RatioA

B

Map out Copolymer Compositions (A/B Ratio) across MWD (Sizes)

IR Spectra


A/B RatioA

B


A/B RatioA

B

Map out Copolymer Compositions (A/B Ratio) across MWD (Sizes)

IR Spectra

Controlled Depositionof Each Compound

Elution Time and Intensityof Each Compound

Composition Informationand Advanced Analysis

Unique Spectral Fingerprintfor “Routine” Identification

DiscovIR-LC® System Features

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Solvent RemovalFeatures self-adjusting spray nebulizationand cyclone for centripetal accelerationand film boiling.

LC-FTIR Standard Lab Bench-Top Setup

Right to Left:Liquid Chromatograph (separation), Hyphen (solvent removal), DiscovIR-LC (con-trolled deposition and IR detection), Computer (system controls, data acquisitionand analysis with GramsTM).

Patent Pending:PCT/US2007/025207

FORENSIS ANALYSISDiscovIR how to rapidly and accuratelyidentify unknown substances.


POLYMER CHARACTERIZATIOND isco v IR t h e scien ce o f p o l y m er ch a r act e r i za t i o n .

PHARMACEUTICAL FORMULATIONDiscovIR your excipients again.

Applications

With the DiscovIR-GC® forensic analytical chemists can now perform fast and accu-rate analysis of controlled substances that are routinely secured by law enforcementpersonnel. The DiscovIR utilizes the high specificity of Infrared Spectroscopy (IR) toreduce uncertainty in the identification of isomers. Coupled directly to a gas chro-matograph allows for fast and accurate identification of drugs such as oxycodone,

MDMA, pseudo-ephedrine, cannabinoids, cocaine and methamphetamines.

Polymers are defined by the characteristics of their constituent monomer(s) and theirmicrostructural arrangement. Infrared Spectroscopy coupled with Gel PermeationChromatography (GPC) or Size Exclusion Chromatography (SEC) is well suited todetermine the compositional and structural arrangement of polymers. The DiscovIR isadept at performing a wide range of applications such as formulation, deformulationof polymer blends, compositional drift/variation across the Molecular Weight (MW)distribution and process upsets.

Formulation is a major component in the efficacy, delivery and stability of a drug.Polymeric excipients such as copovidone (PVP/VA64) can serve various functionswhen added to the active pharmaceutical ingredient such as matrix former, bindingagent or sustained release agent. The hyphenated GPC-FTIR provides valuable insightinto the physical properties of polymeric excipients to insure incoming quality of rawmaterial, defining a safe process window and monitoring for shelf life degradation dueto process variations.

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Copolymer Characterization• Full Scan GPC-IR Characterization of Polyolefin Copolymers and Blends• LC-IR Characterization of Polyolefins• Analysis of Polymer Blends by GPC-FTIR• Polymer Additives Analysis• Copolymer Compositional Drift Measurement• Characterization of a Hot-Melt Adhesive by LC-IR• Oxidative Degradation of Polyethyleneglycol (PEG) Studied by LC-IR

Published Articles• Polymer Characterization by Combined Chromatography-Infrared Spectroscopy

Characterizing Pharmaceutical Excipients• Variability of Polymeric Excipients and its Effect on Drug Delivery Performance• Analysis of Polymeric Excipients in Pharmaceutical Formulations

Controlled Substance Analysis• Bath Salts• Forensic Analysis of Drugs• Infrared Spectra of Phenylethylamines Obtained by GC-IR• Amphetamine Analysis

General Analytical• Identification of Explosive Components and Isomers• Lubricants Analysis• GPC Column Calibration using the DiscovIR-LC• Reading Tea Leaves• IR Applied to Isomer Analysis• Determining Benzene Ring Substitution Patterns from IR Spectra• Getting Quality LC-IR Spectra from 1% Mixture Components• Reduction of Spectral Noise through Post-Run Scanning• IR Analysis of Fatty Acid Methyl Esters• Essential Oils Analyzed by GC-IR• Analysis of Commercial Fragrances by GC-IR

The following Application Notes are available on our website:

Application Notes

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DiscovIR-LC® Technology Adopters

DOW CHEMICAL - Midland, Houston ATC, Freeport - polyolefin

DUPONT - fiber analysis, crop protection chemistry

NISSAN ARC - NISSAN MOTOR CO. - automotive lubricants

KIMBERLY CLARK - healthcare products

W.R. GRACE - construction materials

SABIC INNOVATIVE PLASTICS - consumer products

AFTON CHEMICALS - fuel additives

MERCK - API formulations

SHIRE - process contaminants

JOHNSON & JOHNSON, CORDIS - implant coating

CIBA VISION - process contaminants, contact lenses

BASF - API formulations

Website logos are the exclusive trademark and copyright property of the owners. Spectra Analysis Instruments, Inc.

makes no claim of ownership or affiliation with the above organizations beyond the scope set forth above.

PHARMACEUTICAL POLYMERS

INDUSTRIAL POLYMERS

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DiscovIR-GC® Technology Adopters

OAK RIDGE NATIONAL LABORATORY

LAWRENCE LIVERMORE NATIONAL LABORATORY

U.S. NAVAL RESEARCH LABS

U.S. ARMY, ABERDEEN LABS

BUNDESWHER RESEARCH INSTITUTE

TOKYO UNIVERSITY OF AGRICULTURE

CANADIAN BORDER SERVICES

GOVERNMENT OF SOUTH AUSTRALIA

U.S. DRUG ENFORCEMENT ADMINISTRATION (DEA), SOUTHWEST

U.S. ARMY CRIMINAL INVESTIGATION LAB

GENERAL ANALYTICS

FORENSIC DRUG ANALYSIS

Website logos are the exclusive trademark and copyright property of the owners. Spectra Analysis Instruments, Inc.makes no claim of ownership or affiliation with the above organizations beyond the scope set forth above.

STATE AND COUNTY POLICE FORENSICS LABS

Alabama; Baltimore County, MD; Georgia; Jefferson Parish, LA; Louisiana; Miami Valley, OH;Virginia - Western and Central; and Vermont

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21380 Sea Ray LaneWilmington, IL 60481

815-926-2166 or [email protected]

Jim Daley1436 Willowdown Road

Oakville, ON L6L1X3 / 905-827-7565info@analyticaldevelopments.comwww.analyticaldevelopments.com

Universal (Hong Kong) Technology Co. LtdRoom 1606-1610, Enterprise Square

No. 228 Meiyuan Road, Shanghai 200070, China(+86-21) 6380-6611 x138

[email protected]

Sachiko Kawata1-7-3 Enokojima, Nishi-ku

Osaka 550-0006, [email protected]

Insung Chroma-TechÂ Co., Ltd.#89-106 Shinjeong2-dong

Yangcheon-guSeoul, Korea 158-849

[email protected] / www.insung.net

www.insungcolumns.com

Beemdstraat 17A5653 MA Eindhoven

Tel: 0031-(0)-40 25 14 753Fax: 0031-(0)-40 25 14 758

[email protected]

C/ Diligencia, 928018 Madrid, Spain

+91 113 08 [email protected]

Wyzynna 8 HKraków

Malopolskie 30-617/12/ 268 01 [email protected]

Global Sales Channels


257 Simarano DriveMarlborough, MA 01752508-281-6274

411 University Ridge, Suite 245Greenville, SC 29601864-751-4833

Please contact us directly or through one of our global partners:

A S I A / P A C I F I C

E U R O P E / M I D D L E E A S T

UNITED STATES(Illinois, Indiana, Iowa, Michigan, Minnesota, Missouri,

Nebraska, North Dakota, South Dakota, Wisconsin)

N O R T H A M E R I C A

CANADA

CHINA JAPAN SOUTH KOREA

BOBKOVA 786198 00 PRAHA 9

CZECH REPUBLIC+420 2 [email protected]

BENELUX AND GERMANYCZECH REPUBLIC AND

SLOVAK REPUBLIC POLAND

Clairet Scientific Ltd.17/18 Scirocco Close

Moulton Park Industrial EstateNorthhampton, UK NN3 6AP

+01604 [email protected]

SPAIN AND PORTUGAL UNITED KINGDOM

MLYNSKÁ 10921 01 PIESTANYSLOVAK REPUBLIC+421 33 [email protected]

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DiscovIR® Specifications

Platform

Detection Method

IR Detection

IR Range

Resolution

Data Collection

Spectrum Type

Disc Capacity

Disc Temperature Control

Unattended Operation

Spectroscopy Package

Standard Features

Flow Rates

Sensitivity

Gradients

Chromatograph

Built-In FTIR

0.1 x 0.1 mm MCT

4000 - 650 Wavenumbers

4 or 8 cm-1

Real Time w/ Post-Run Rescan

Transmittance

8 hours (LN2), Auto-Sampler Compatible

Standard Desktop Computerw/Microsoft Windows

Thermo Galactic GramsTM

Real Time and Post-Run Data CollectChromatographic / Spectral Workup

Band Chromatograms, Chemical ClassRatio Chromatograms, TrendsAlignment and Tuning Tools

Library Search Software Included

Any GC or LC (supplied by user)

DiscovIR-GC® DiscovIR-LC®

40 Hours 12 Hours

-70 to +50°C -30 to +50°C

N/A Yes

0.1 to 5 mL/min 0.25 to 1.5 mL/min

Pico Gram Range 1 µg / Component

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Photo of Lab

SPECTRA ANALYSIS INSTRUMENTS, INC.

NEXT Innovation Center411 University Ridge

Greenville, South Carolina 29601864-751-4833


Demonstration and Customer Training Lab

DiscovIR-GC® DiscovIR-LC®

MOLECULAR ANALYSIS TECHNOLOGY Hyphenating · PDF fileto Liquid and Gas Chromatography. ......

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