BIOC 311 – METABOLIC BIOCHEMISTRY TIMETABLE - Fall 2020

Location and Time: Lectures: 12:35 PM ‒ 13:25 PM Montreal time / Days: Mondays, Wednesdays & Fridays Review Sessions: 6:00 - 8:30 PM Montreal time Access live sessions via MyCourses/Zoom Instructors: M. Denis (Coordinator), Room 903B, McIntyre Medical Building, Tel: 514-398-1421, maxime.denis@mcgill.ca

L. Kazak, Room 713, McIntyre Building, Tel: 514-398-5605, lawrence.kazak@mcgill.ca K. Gehring, Room 469, Bellini Life Sciences Building, Tel: 514-398-7287, kalle.gehring@mcgill.ca V. Giguère, Room 710A, McIntyre Medical Building, Tel: 514-398-5899, vincent.giguere@mcgill.ca

Teaching Assistants: cynthia.feng@mail.mcgill.ca; gabriella.johnson@mail.mcgill.ca; marina.fukano@mail.mcgill.ca; wided.akik@mail.mcgill.ca

Date Day Lecture Lecture Instructor T.A.

SEPT 2-4 MODULE 1 – Carbohydrates Metabolic Design, Glycolysis, Dietary Carbohydrates,

Pentose pathway, Gluconeogenesis + Problem-based learning

5 h Dr. Max

Denis Wided SEPT 7 No Class Labour Day

SEPT 9, 11, 14

SEPT 15 Review Session Sept 15th, 6:00 – 8:30, Zoom

SEPT 16 - 18 QUIZ #1 (10%); Sept 16, 6 PM - Sept 18, noon

SEPT 16-25 MODULE 2 – Glycogen and TCA cycle

Glycogen, Pyruvate Dehydrogenase, TCA cycle + Problem-based learning

5h Dr.

Lawrence Kazak

Gabriella

SEPT 29 Review Session Sept 29th, 6:00 – 8:30, Zoom

SEPT 30 – OCT 2 QUIZ #2 (10%); Sept 30, 6 PM – Oct 2, noon

SEPT 28 – OCT 9 MODULE 3 – Mitochondria Ana/cataplerotic, Redox reactions, Oxidative Phosphorylation

Problem-based Learning

6h

Dr.

Lawrence Kazak

Cynthia

OCT 12 No Class Thanksgiving

OCT 13 Review Session Oct 13th, 6:00 – 8:30, Zoom

OCT 14 – 16 QUIZ #3 (10 %); Oct 14, 6 PM – Oct 16, noon

OCT 14 – OCT 30

MODULE 4 – Lipids Fatty Acid Synthesis & Degradation, TAG & Phospholipids, Ketogenesis

Lipoproteins, Isoprenoids, Cholesterol + Problem-based Learning

8h Dr. Max

Denis

Gabriella

Wided

NOV 3 Review Session Nov 3rd, 6:00 – 8:30, Zoom

NOV 4 – 6 QUIZ #4 (10%); Nov 4, 6 PM – Nov 6, noon

NOV 2 – 11 MODULE 5 – Amino Acids

Nitrogen Balance, Pyridoxal Phosphate Enzymes, Urea Cycle, Amino Acids as Carbon Sources + Problem-based Learning

5h Dr. Max

Denis

Marina

NOV 17 Review Session Nov 10th, 6:00 – 8:30, Zoom

NOV 18 – 20 QUIZ #5 (10%); Nov 18, 6 PM – Nov 20, noon

NOV 13 – 20 MODULE 6 – Nucleotides Purines, Pyrimidines + Problem-based Learning

4h Dr. Kalle Gehring

Marina

NOV 24 Review Session Nov 24th, 6:00 – 8:30, Zoom

NOV 25 – 27 QUIZ #6 (10%); Nov 25, 6 PM – Nov 27, noon

NOV 23, 25 MODULE 7 – Hormonal Regulation of Metabolism Steroid & thyroid hormones, Gene regulation of Metabolism, Circadian Cycle;

RTKs, GPCRs, Ghrelin & Leptin + Problem-based Learning

2h Dr. Vincent

Giguere Cynthia

NOV 27, 30 2h Dr. Max Denis

DEC 1 Review Session Dec 1st, 6:00 – 8:30, Zoom

DEC 2 – 4 QUIZ #7 (10%); Dec 2, 6 PM – Dec 4, noon

DEC 2,3,4,7 NO CLASS – PREPARE FOR FINAL

FINAL 30% (40%) Integrative Final: Modules 1 - 7 inclusive (Final exams are held Dec 8 - 22)

7 Quizzes = 70%; Final = 30% The deferred final exams is worth 30% and the supplemental exam is worth 100%. NOTE: Students unable to write the Final must contact the Exam Center (https://www.mcgill.ca/exams/) and register for a deferred Final.

BIOC 311 – METABOLIC BIOCHEMISTRY (3 credits) Workload/week = 3 h lecture + 6 h personal work = 9 h / week

Pre-requisites BIOL 200, BIOC/ANAT 212 or BIOL 201, and CHEM 222 or CHEM 234

Learning Outcomes – Theoretical Content & Higher Skills The aim of this course is to understand the physiological regulation of metabolic reactions.

Theoretical Content - The course material covers the generation of metabolic energy in higher organisms with an emphasis on its regulation at the molecular, cellular and organ level. Chemical concepts and mechanisms of enzymatic catalysis are also emphasized. Included: selected topics in carbohydrate, lipid and nitrogen metabolism; complex lipids and biological membranes; hormonal signal transduction.

Critical Thinking - Solve problems related to biochemical metabolism

Independent Learning - Find reliable sources of information and organize knowledge

Communication - Communicate science to various types of audiences

Team Working - Work in an interdisciplinary environment

Recommended Textbook “Fundamentals of Biochemistry” 2016 (5th Edition) Voet D., Voet J. & Pratt C., Chap. 14 – 23 Wiley Editors ISBN: 978-1-118-91846-3 https://www.wiley.com/en-ca/Fundamentals+of+Biochemistry%3A+Life+at+the+Molecular+Level%2C+5th+Edition-p-9781118918401

Older versions are acceptable surrogates.

The e-textbook is available through McGill's Le James Bookstore https://lejames.ca/wiley-plus-two-semester-fundamentals-of-biochemistry-canadian OR https://learn.wileyplus.com/courses/59030/sections/63237, Course Section ID: A47283

Instructional Methods in this Course Zoom-recorded interactive lectures. Include theoretical content, in-class exercise and problem-based learning.

Seven zoom-recorded review sessions (by Teaching Assistants).

Students access live session through MyCourses/Zoom.

The instructional approach is based on student attendance and active participation to exercices.

Polling: Students are invited to install the Turning Point Cloud polling application (https://www.mcgill.ca/polling/) on their mobile device ahead of classes.

© Instructor generated course materials (e.g., handouts, notes, summaries, exam questions, etc.) are protected by law and may NOT be copied or distributed in any form or in any medium without explicit permission of the instructor . Note that infringements of copyright can be subject to follow up by the University under the Code of Student Conduct and Disciplinary Procedures (Article 18, https://www.mcgill.ca/secretariat/files/secretariat/code_of_student_conduct_and_disciplinary_procedures.pdf )

Online-Learning Etiquette Mute your microphone upon joining sessions. Changing your name is forbidden.

Students' participation makes the course interesting for everyone. Students may use the chat to ask questions or raise their hand while having their camera on during Zoom sessions.

Polite and respectful language must be used at all times. Disrespectful comments and/or disruptive behavior will not be tolerated (Article 5, https://www.mcgill.ca/secretariat/files/secretariat/code_of_student_conduct_and_disciplinary_procedures.pdf ).

Evaluation Method (7 Quizzes + 1 Cumulative Final) 70% (or 60%) Timed quizzes

7 quizzes, one at the end of each module, worth 10% each Quizzes can be answered in about 30 min - or less - and are accessible to students via MyCourses. Once a quiz is started, students have 1:30 h to complete it within a time frame of 42 h.* Quizzes are available Wednesday 6:00 PM - Friday at noon (Montreal time).

30% (or 40%) Final Cumulative final, integrating metabolism and its regulation. Short-answers and problem-solving. The Final exam is designed to be answered in 3h - or less – and is accessible to students via Crowdmark. Students have 72h to complete the exam and upload their answers on Crowdmark.* * Theses settings optimize universal access and were designed to accommodate different time zones, religious observances, technical and/or internet connectivity issues AND barriers to learning. Hence, OSD students are deemed accommodated with these settings, unless otherwise requested by OSD. (Faculty of Science Assessment Policy https://www.mcgill.ca/science/covid-19/undergrads)

Flexible Grading Policy Too busy with writing a lab report in another course? Feeling unprepared or sick? Must attend a funeral service? For any reason, students are allowed to opt out of ONE quiz and automatically have the Final worth 40% instead of 30%. No justification required. Any other skipped quiz gets zero.

Main Scenario Alternative Scenario (opting out 1 quiz)

Answered quizzes 7 / 7 6 / 7

Grading Scheme 70% Quizzes, 30% Final 60% Quizzes, 40% Final

Warning: Once a student has accessed a quiz on MyCourses, he/she cannot change his/her mind. The quiz will be marked based on the submitted answers. An accessed quiz for which no answer is submitted gets zero.

Language Les étudiants peuvent soumettre en anglais ou en français tout travail écrit destiné à l'évaluation. In accord with McGill University’s Charter of Students’ Rights, students have the right to submit in English or in French any written work that is to be graded (except in courses where knowledge of a language is one of the objectives of the course).

In the event of extraordinary circumstances beyond the University’s control, the content and/or evaluation scheme in this course is subject to change. Assessments may be subjected to text-matching in accordance with the Policy on Text-Matching Software.

Deferred Final and Supplemental The Deferred Final (worth like the Final) and Supplemental (worth 100% of the grade) are managed by Exam Center and are usually written during the March break. Students unable to attend the final exam must contact the Exam Center and follow

the procedure stated here https://www.mcgill.ca/exams/. In some cases, a valid medical note may be required.

Grading: The department of Biochemistry will NOT revise/upgrade marks except on sound academic grounds*. Once computed, the marks in this course will NOT be altered/increased. Decimal points will be “rounded of” as follows: if the final aggregate mark is computed to be 79.5%, the mark will be reported as 80% (an A-); a final aggregate mark of 79.4% will be reported as 79% (a B+). These marks are FINAL and NON-NEGOTIABLE.

* Reviewing quiz marking In addition to the abovementioned policy to NOT revise/upgrade marks, the Coordinator may impose a 1% penalty on any marking challenge that is not based on sound academic grounds. Examples: Should the re-read 1) be in favor of the student, the student gets the disputed marks back. 2) NOT be in favor of the student, a 1% penalty is imposed on the final grade.

Useful resources Student Rights and Responsibilities https://www.mcgill.ca/students/srr/academicrights McGill University values academic integrity. Therefore, all students must understand the meaning and consequences of cheating ,

plagiarism and other academic offences under the Code of Student Conduct and Disciplinary Procedures (see http://www.mcgill.ca/students/srr/honest/ for more information).

McGill Academic Calendar (add/drop, withdrawal and other deadlines) https://www.mcgill.ca/study/2020-2021/important-dates

Time management https://www.mcgill.ca/tutoring/channels/event/time-management-your-best-ally-323895 https://www.mcgill.ca/osd/student-resources/learningresources/time-management

Stress management https://www.mcgill.ca/osd/student-resources/learningresources/stress-management

Office for Students with Disabilities (OSD) https://www.mcgill.ca/osd/

Health and Wellness Resources at McGill Student well-being is a priority for the University. All of our health and wellness resources have been integrated into a single Student Wellness Hub, your one-stop shop for everything related to your physical and mental health. If you need to access services or get more information, visit the Virtual Hub at www.mcgill.ca/wellness-hub or drop by the Brown Student Services Building (downtown) or Centennial Centre (Macdonald Campus). Within your faculty, you can also connect with your Local Wellness Advisor (to make an appointment, visit https://mcgill.ca/lwa).

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