Modularity and three-dimensional isostructurality of...
Transcript of Modularity and three-dimensional isostructurality of...
IUCrJ Volume 2 (2015)
Supporting information for article
Modularity and three-dimensional isostructurality of novel synthons in sulfonamidendashlactam cocrystals
Geetha Bolla Sudhir Mittapalli and Ashwini Nangia
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Table S1 Hydrogen bonding parameters in benzene sulfonamide cocrystals
Compound Interactions HmiddotmiddotmiddotA
Aring
DmiddotmiddotmiddotA Aring DndashHmiddotmiddotmiddotA ordm Symmetry
2ABSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 218(2) 2910(2) 159 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 196(2) 2855(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotO2 228 3108(2) 162 12+x12-y12+z
N2ndashH2BmiddotmiddotmiddotO1 218 2892(2) 140 Intermolecular
N3ndashH3AmiddotmiddotmiddotO3 213 2968(2) 165 1-x-y-z
2ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2829(3) 169 a
N1ndashH1BmiddotmiddotmiddotCl1 281 3295(2) 118 Intermolecular
N1ndashH1BmiddotmiddotmiddotO1 216 2922(2) 151 x12-y-12+z
N2ndashH2AmiddotmiddotmiddotO3 208 2939(3) 177 1-x-y1-z
C5ndashH5middotmiddotmiddotO2 253 3238(3) 133 -x-12+y12-z
2ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 197 2871(1) 176 a
N1ndashH1BmiddotmiddotmiddotO2 235 3088(1) 151 x12-y12+z
N2ndashH2AmiddotmiddotmiddotO3 204 2983(2) 175 1-x-y1-z
4BrBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 206 2866(4) 170 a
N1ndashH1BmiddotmiddotmiddotO3 200 2879(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotN1 250 3172(4) 154 12-x12+y12-z
4BrBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 196 2887(5) 169 -x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 231 2960(5) 159 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 258 3301(6) 144 1-x-12+y12-z
C5ndashH5middotmiddotmiddotO2 240 3151(5) 138 -1+xyz
4ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 208 2881(4) 164 12-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 204 2855(5) 172 a
N2ndashH2AmiddotmiddotmiddotN1 236 3153(5) 153 12-x12+y12-z
4ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 219 2908(1) 147 1-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 189 2850(1) 171 32-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 256 3285(2) 142 -y12+z
C3ndashH3middotmiddotmiddotO1 239 3145(1) 138 1+xyz
BSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 205 2890(1) 164 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 212 2908(2) 161 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 248 3270(1) 152 1+xyz
BSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 204 2871(2) 159 12-x1-y frac12+z
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N1ndashH1BmiddotmiddotmiddotO3 210 2859(1) 170 1-x12+y 32-z
N2ndashH2AmiddotmiddotmiddotN1 249 3252(1) 148 1-x-12+y12-z
C2ndashH2middotmiddotmiddotO3 269 3406(2) 134 -x-12+y12-z
BSAndashAZL N1ndashH1AmiddotmiddotmiddotO3 212 2879(3) 158 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 203 2905(4) 169 12-x-12+y12-z
N2ndashH2AmiddotmiddotmiddotO3 218 2999(3) 168 1-x1-y-z
OTSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2857(2) 161 12-x-12+y12-z
N1ndashH1BmiddotmiddotmiddotO1 210 2988(2) 157 1+xyz
N2ndashH2AmiddotmiddotmiddotO3 209 2948(1) 175 1-x1-y1-z
PTSAndashVLM N1ndashH1AmiddotmiddotmiddotO1 226 3015(3) 163 1+xyz
N1ndashH1BmiddotmiddotmiddotO3 203 2886(3) 179 a
N2ndashH2AmiddotmiddotmiddotO3 215 2904(3) 176 -x1-y-z
SNAndashCPR N1ndashH1AmiddotmiddotmiddotO3 216 2902(5) 150 12-x-y-12+z
N1ndashH1BmiddotmiddotmiddotO3 196 2845(5) 164 -x12+y12-z
N2ndashH2AmiddotmiddotmiddotO1 241 3264(5) 166 1-x-12+y12-z
N2ndashH2BmiddotmiddotmiddotO2 226 2998(5) 142 -x-12+y12-z
N3ndashH3AmiddotmiddotmiddotN1 246 3240(5) 150 1-x-12+y12-z
C3ndashH3middotmiddotmiddotO2 257 3482(5) 168 1-x-12+y12-z
a Molecules in the same asymmetric unit
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Compound Interactions HmiddotmiddotmiddotA
Aring
DmiddotmiddotmiddotA Aring DndashHmiddotmiddotmiddotA ordm Symmetry
2ABSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 218(2) 2910(2) 159 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 196(2) 2855(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotO2 228 3108(2) 162 12+x12-y12+z
N2ndashH2BmiddotmiddotmiddotO1 218 2892(2) 140 Intermolecular
N3ndashH3AmiddotmiddotmiddotO3 213 2968(2) 165 1-x-y-z
2ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2829(3) 169 a
N1ndashH1BmiddotmiddotmiddotCl1 281 3295(2) 118 Intermolecular
N1ndashH1BmiddotmiddotmiddotO1 216 2922(2) 151 x12-y-12+z
N2ndashH2AmiddotmiddotmiddotO3 208 2939(3) 177 1-x-y1-z
C5ndashH5middotmiddotmiddotO2 253 3238(3) 133 -x-12+y12-z
2ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 197 2871(1) 176 a
N1ndashH1BmiddotmiddotmiddotO2 235 3088(1) 151 x12-y12+z
N2ndashH2AmiddotmiddotmiddotO3 204 2983(2) 175 1-x-y1-z
4BrBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 206 2866(4) 170 a
N1ndashH1BmiddotmiddotmiddotO3 200 2879(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotN1 250 3172(4) 154 12-x12+y12-z
4BrBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 196 2887(5) 169 -x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 231 2960(5) 159 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 258 3301(6) 144 1-x-12+y12-z
C5ndashH5middotmiddotmiddotO2 240 3151(5) 138 -1+xyz
4ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 208 2881(4) 164 12-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 204 2855(5) 172 a
N2ndashH2AmiddotmiddotmiddotN1 236 3153(5) 153 12-x12+y12-z
4ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 219 2908(1) 147 1-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 189 2850(1) 171 32-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 256 3285(2) 142 -y12+z
C3ndashH3middotmiddotmiddotO1 239 3145(1) 138 1+xyz
BSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 205 2890(1) 164 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 212 2908(2) 161 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 248 3270(1) 152 1+xyz
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BSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 204 2871(2) 159 12-x1-y frac12+z
N1ndashH1BmiddotmiddotmiddotO3 210 2859(1) 170 1-x12+y 32-z
N2ndashH2AmiddotmiddotmiddotN1 249 3252(1) 148 1-x-12+y12-z
C2ndashH2middotmiddotmiddotO3 269 3406(2) 134 -x-12+y12-z
BSAndashAZL N1ndashH1AmiddotmiddotmiddotO3 212 2879(3) 158 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 203 2905(4) 169 12-x-12+y12-z
N2ndashH2AmiddotmiddotmiddotO3 218 2999(3) 168 1-x1-y-z
OTSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2857(2) 161 12-x-12+y12-z
N1ndashH1BmiddotmiddotmiddotO1 210 2988(2) 157 1+xyz
N2ndashH2AmiddotmiddotmiddotO3 209 2948(1) 175 1-x1-y1-z
PTSAndashVLM N1ndashH1AmiddotmiddotmiddotO1 226 3015(3) 163 1+xyz
N1ndashH1BmiddotmiddotmiddotO3 203 2886(3) 179 a
N2ndashH2AmiddotmiddotmiddotO3 215 2904(3) 176 -x1-y-z
SNAndashCPR N1ndashH1AmiddotmiddotmiddotO3 216 2902(5) 150 12-x-y-12+z
N1ndashH1BmiddotmiddotmiddotO3 196 2845(5) 164 -x12+y12-z
N2ndashH2AmiddotmiddotmiddotO1 241 3264(5) 166 1-x-12+y12-z
N2ndashH2BmiddotmiddotmiddotO2 226 2998(5) 142 -x-12+y12-z
N3ndashH3AmiddotmiddotmiddotN1 246 3240(5) 150 1-x-12+y12-z
C3ndashH3middotmiddotmiddotO2 257 3482(5) 168 1-x-12+y12-z
a Moleculesions in the same asymmetric unit
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Table S2 Classification of primary sulfonamides based on synthons present and their CSD REFCODEs
Sulfonamides (220)
Alternative dimers (5)
PECTOI RIBQID VUSMEC WOBHUR ZEBYEM
Anti Catemer (50)
ADAGUI AFIMEJ AMEVAP AZADAH AZAGUE BAPYIB BAPYIB BIZPIK
BIZPOQ BSBTHP AZACOU CIVBAK10 DIBBUL DUCVED EWUHAF EXICIX
EXICIX FAVWIJ FAXZIO GEQYIK GODRUM HCSBTZ ICUTOR JEFNOY
JIGCUX KIKCUD KUSVEZ KUZWIM MESXIR PIMZAO POHYER PUFHUU
QUYKOL QUYRIM SODGID SULAMD03 SULTAM SULTAM01 ULIDOJ VUXPUZ
WEPMAH ZEBYOW BATNOB CAFVUA COYVER GOMSAE JEFPAM LAWKUP
NIWPAL OCAMUB
Dimer discrete (9)
AZADEL GUFQED IDIMOY JEFNAK KIXHEF RIHGOF TIGLOL VABFAH
XAVKUB
Continuous dimers (7)
AFONAM GUCMEW JABJAY PERQOT SETHEE USOBAG TIYXII
Finite catemers (7)
IFAXAX JAWHOF SEQJUT VOHZIC ZAPJAD ENIROI GOFYIL
Finite dimers (21)
CIKJAI CSBSMP EFOFAH EVAGUE GODSAT KIXHEF LAPNAT LAPPEZ
LISKUU MEWXAP MUWCUD SEBPAQ SEQKEE WACJIT WAWNAK XETFAF
ZAHBEP ATDZSA CEFMUX PODPUU LISLAB
Rings forms dimers (4)
AMAVIT AZADIP JEFPIU PODQEF
Syn Catemers (16)
CIKSIA CUDDEL ETOMUV GAQBUX HUCSUU JEFMUD JEFNIS LOMWIT
PAVBUL PODQAB PUMPOD PUMPUJ QUYTIO WAWMUD NIGNEY MOKMIJ
Tetramer rings (21)
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BUDYEF JABJEC JEFMAJ JEFNEO JEFNUE JEFPOA KIFZUV KUSVEZ
MESXUD MSULPH01 MUBVOV NIGNEY PERQEJ QISQOZ TIBPAW UJIBAR
WEBWUV ZZZULS01 DOLDIT EXICOD HUFVOU
Three point synthons (4)
ADAGUI FIYYES FOGVIG01 RIFVIM
Miscellaneous (76)
ADILOP AZAMEU BIXMUR BUFMAR CADTEG CANWIX CBSTHP CIKJAI
CIKSIA CIMKOA CSBSMP DOSDOE EFOFAH EVAGUE EVAWAA FUZXUU
GEVBAL GODSAT GOMKUP HABSOS HILRAW HSLSTZ IFAFAX IPSULF
JAWHOF JAZVEL10 JAZVIP10 JAZVOV10 JAZZOZ10 JEFPEQ KEFROC KIXHEF
KIXPIQ KUVFIR LAPNAT LAPPEZ LEFFAF LESZUG LISKUU MUWCUD
PEDBOR PEHWEF PILPIK PODQAB POWBUZ PUMPOD PYMSBZ11 QAKXUX
SEBPAQ SEQJUT SEQKEE SODGID SOJNEK SULPIA10 TELWAI UJIBEV
UJIBIZ UJIBOF VAWMOV VOHZIC VUXPUZ WACJIT WAWNAK WIGXIU
WIXGIV XETFAF YIKZUP ZAHBEP ZAPJAD ZEBYOW XAVKUB01 XAVKUB
DOPVIP GOMRUX MESXOX NARVUZ
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BSAndashVLM
BSAndashCPR
4ClBSAndashCPR
4BrBSAndashCPR
SNAndashCPR
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4ClBSAndashVLM
4BrBSAndashVLM
Figure S1 2D sheet like structure propagation of the catemer chain Synthon 1 in cocrystal structures
(a) 2ABSAndashCPR
(b) BSAndashAZL
Figure S2 Head to face packing thorugh dimer-cyclic ring motif Synthon 2 in cocrystals 2ABSAndashCPR
and BSAndashAZL
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(a) OTSAndashVLM
(b) PTSAndashVLM
Figure S3 2D packing of OTSAndashVLM and PTSAndashVLM cocrystals in the bc-plane
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Figure S4 Powder X-ray diffraction patterns of the 3D isostructural catemer synthon cocrystals pairs The
near identical PXRD lines support isostructurility and isomorphous nature of the structures
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AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
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DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
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NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
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2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
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UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
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XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
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4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
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synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
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BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
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2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
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2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
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Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
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2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
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Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
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Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-1
Table S1 Hydrogen bonding parameters in benzene sulfonamide cocrystals
Compound Interactions HmiddotmiddotmiddotA
Aring
DmiddotmiddotmiddotA Aring DndashHmiddotmiddotmiddotA ordm Symmetry
2ABSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 218(2) 2910(2) 159 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 196(2) 2855(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotO2 228 3108(2) 162 12+x12-y12+z
N2ndashH2BmiddotmiddotmiddotO1 218 2892(2) 140 Intermolecular
N3ndashH3AmiddotmiddotmiddotO3 213 2968(2) 165 1-x-y-z
2ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2829(3) 169 a
N1ndashH1BmiddotmiddotmiddotCl1 281 3295(2) 118 Intermolecular
N1ndashH1BmiddotmiddotmiddotO1 216 2922(2) 151 x12-y-12+z
N2ndashH2AmiddotmiddotmiddotO3 208 2939(3) 177 1-x-y1-z
C5ndashH5middotmiddotmiddotO2 253 3238(3) 133 -x-12+y12-z
2ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 197 2871(1) 176 a
N1ndashH1BmiddotmiddotmiddotO2 235 3088(1) 151 x12-y12+z
N2ndashH2AmiddotmiddotmiddotO3 204 2983(2) 175 1-x-y1-z
4BrBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 206 2866(4) 170 a
N1ndashH1BmiddotmiddotmiddotO3 200 2879(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotN1 250 3172(4) 154 12-x12+y12-z
4BrBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 196 2887(5) 169 -x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 231 2960(5) 159 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 258 3301(6) 144 1-x-12+y12-z
C5ndashH5middotmiddotmiddotO2 240 3151(5) 138 -1+xyz
4ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 208 2881(4) 164 12-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 204 2855(5) 172 a
N2ndashH2AmiddotmiddotmiddotN1 236 3153(5) 153 12-x12+y12-z
4ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 219 2908(1) 147 1-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 189 2850(1) 171 32-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 256 3285(2) 142 -y12+z
C3ndashH3middotmiddotmiddotO1 239 3145(1) 138 1+xyz
BSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 205 2890(1) 164 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 212 2908(2) 161 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 248 3270(1) 152 1+xyz
BSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 204 2871(2) 159 12-x1-y frac12+z
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N1ndashH1BmiddotmiddotmiddotO3 210 2859(1) 170 1-x12+y 32-z
N2ndashH2AmiddotmiddotmiddotN1 249 3252(1) 148 1-x-12+y12-z
C2ndashH2middotmiddotmiddotO3 269 3406(2) 134 -x-12+y12-z
BSAndashAZL N1ndashH1AmiddotmiddotmiddotO3 212 2879(3) 158 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 203 2905(4) 169 12-x-12+y12-z
N2ndashH2AmiddotmiddotmiddotO3 218 2999(3) 168 1-x1-y-z
OTSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2857(2) 161 12-x-12+y12-z
N1ndashH1BmiddotmiddotmiddotO1 210 2988(2) 157 1+xyz
N2ndashH2AmiddotmiddotmiddotO3 209 2948(1) 175 1-x1-y1-z
PTSAndashVLM N1ndashH1AmiddotmiddotmiddotO1 226 3015(3) 163 1+xyz
N1ndashH1BmiddotmiddotmiddotO3 203 2886(3) 179 a
N2ndashH2AmiddotmiddotmiddotO3 215 2904(3) 176 -x1-y-z
SNAndashCPR N1ndashH1AmiddotmiddotmiddotO3 216 2902(5) 150 12-x-y-12+z
N1ndashH1BmiddotmiddotmiddotO3 196 2845(5) 164 -x12+y12-z
N2ndashH2AmiddotmiddotmiddotO1 241 3264(5) 166 1-x-12+y12-z
N2ndashH2BmiddotmiddotmiddotO2 226 2998(5) 142 -x-12+y12-z
N3ndashH3AmiddotmiddotmiddotN1 246 3240(5) 150 1-x-12+y12-z
C3ndashH3middotmiddotmiddotO2 257 3482(5) 168 1-x-12+y12-z
a Molecules in the same asymmetric unit
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Compound Interactions HmiddotmiddotmiddotA
Aring
DmiddotmiddotmiddotA Aring DndashHmiddotmiddotmiddotA ordm Symmetry
2ABSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 218(2) 2910(2) 159 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 196(2) 2855(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotO2 228 3108(2) 162 12+x12-y12+z
N2ndashH2BmiddotmiddotmiddotO1 218 2892(2) 140 Intermolecular
N3ndashH3AmiddotmiddotmiddotO3 213 2968(2) 165 1-x-y-z
2ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2829(3) 169 a
N1ndashH1BmiddotmiddotmiddotCl1 281 3295(2) 118 Intermolecular
N1ndashH1BmiddotmiddotmiddotO1 216 2922(2) 151 x12-y-12+z
N2ndashH2AmiddotmiddotmiddotO3 208 2939(3) 177 1-x-y1-z
C5ndashH5middotmiddotmiddotO2 253 3238(3) 133 -x-12+y12-z
2ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 197 2871(1) 176 a
N1ndashH1BmiddotmiddotmiddotO2 235 3088(1) 151 x12-y12+z
N2ndashH2AmiddotmiddotmiddotO3 204 2983(2) 175 1-x-y1-z
4BrBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 206 2866(4) 170 a
N1ndashH1BmiddotmiddotmiddotO3 200 2879(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotN1 250 3172(4) 154 12-x12+y12-z
4BrBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 196 2887(5) 169 -x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 231 2960(5) 159 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 258 3301(6) 144 1-x-12+y12-z
C5ndashH5middotmiddotmiddotO2 240 3151(5) 138 -1+xyz
4ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 208 2881(4) 164 12-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 204 2855(5) 172 a
N2ndashH2AmiddotmiddotmiddotN1 236 3153(5) 153 12-x12+y12-z
4ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 219 2908(1) 147 1-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 189 2850(1) 171 32-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 256 3285(2) 142 -y12+z
C3ndashH3middotmiddotmiddotO1 239 3145(1) 138 1+xyz
BSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 205 2890(1) 164 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 212 2908(2) 161 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 248 3270(1) 152 1+xyz
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BSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 204 2871(2) 159 12-x1-y frac12+z
N1ndashH1BmiddotmiddotmiddotO3 210 2859(1) 170 1-x12+y 32-z
N2ndashH2AmiddotmiddotmiddotN1 249 3252(1) 148 1-x-12+y12-z
C2ndashH2middotmiddotmiddotO3 269 3406(2) 134 -x-12+y12-z
BSAndashAZL N1ndashH1AmiddotmiddotmiddotO3 212 2879(3) 158 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 203 2905(4) 169 12-x-12+y12-z
N2ndashH2AmiddotmiddotmiddotO3 218 2999(3) 168 1-x1-y-z
OTSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2857(2) 161 12-x-12+y12-z
N1ndashH1BmiddotmiddotmiddotO1 210 2988(2) 157 1+xyz
N2ndashH2AmiddotmiddotmiddotO3 209 2948(1) 175 1-x1-y1-z
PTSAndashVLM N1ndashH1AmiddotmiddotmiddotO1 226 3015(3) 163 1+xyz
N1ndashH1BmiddotmiddotmiddotO3 203 2886(3) 179 a
N2ndashH2AmiddotmiddotmiddotO3 215 2904(3) 176 -x1-y-z
SNAndashCPR N1ndashH1AmiddotmiddotmiddotO3 216 2902(5) 150 12-x-y-12+z
N1ndashH1BmiddotmiddotmiddotO3 196 2845(5) 164 -x12+y12-z
N2ndashH2AmiddotmiddotmiddotO1 241 3264(5) 166 1-x-12+y12-z
N2ndashH2BmiddotmiddotmiddotO2 226 2998(5) 142 -x-12+y12-z
N3ndashH3AmiddotmiddotmiddotN1 246 3240(5) 150 1-x-12+y12-z
C3ndashH3middotmiddotmiddotO2 257 3482(5) 168 1-x-12+y12-z
a Moleculesions in the same asymmetric unit
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-5
Table S2 Classification of primary sulfonamides based on synthons present and their CSD REFCODEs
Sulfonamides (220)
Alternative dimers (5)
PECTOI RIBQID VUSMEC WOBHUR ZEBYEM
Anti Catemer (50)
ADAGUI AFIMEJ AMEVAP AZADAH AZAGUE BAPYIB BAPYIB BIZPIK
BIZPOQ BSBTHP AZACOU CIVBAK10 DIBBUL DUCVED EWUHAF EXICIX
EXICIX FAVWIJ FAXZIO GEQYIK GODRUM HCSBTZ ICUTOR JEFNOY
JIGCUX KIKCUD KUSVEZ KUZWIM MESXIR PIMZAO POHYER PUFHUU
QUYKOL QUYRIM SODGID SULAMD03 SULTAM SULTAM01 ULIDOJ VUXPUZ
WEPMAH ZEBYOW BATNOB CAFVUA COYVER GOMSAE JEFPAM LAWKUP
NIWPAL OCAMUB
Dimer discrete (9)
AZADEL GUFQED IDIMOY JEFNAK KIXHEF RIHGOF TIGLOL VABFAH
XAVKUB
Continuous dimers (7)
AFONAM GUCMEW JABJAY PERQOT SETHEE USOBAG TIYXII
Finite catemers (7)
IFAXAX JAWHOF SEQJUT VOHZIC ZAPJAD ENIROI GOFYIL
Finite dimers (21)
CIKJAI CSBSMP EFOFAH EVAGUE GODSAT KIXHEF LAPNAT LAPPEZ
LISKUU MEWXAP MUWCUD SEBPAQ SEQKEE WACJIT WAWNAK XETFAF
ZAHBEP ATDZSA CEFMUX PODPUU LISLAB
Rings forms dimers (4)
AMAVIT AZADIP JEFPIU PODQEF
Syn Catemers (16)
CIKSIA CUDDEL ETOMUV GAQBUX HUCSUU JEFMUD JEFNIS LOMWIT
PAVBUL PODQAB PUMPOD PUMPUJ QUYTIO WAWMUD NIGNEY MOKMIJ
Tetramer rings (21)
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BUDYEF JABJEC JEFMAJ JEFNEO JEFNUE JEFPOA KIFZUV KUSVEZ
MESXUD MSULPH01 MUBVOV NIGNEY PERQEJ QISQOZ TIBPAW UJIBAR
WEBWUV ZZZULS01 DOLDIT EXICOD HUFVOU
Three point synthons (4)
ADAGUI FIYYES FOGVIG01 RIFVIM
Miscellaneous (76)
ADILOP AZAMEU BIXMUR BUFMAR CADTEG CANWIX CBSTHP CIKJAI
CIKSIA CIMKOA CSBSMP DOSDOE EFOFAH EVAGUE EVAWAA FUZXUU
GEVBAL GODSAT GOMKUP HABSOS HILRAW HSLSTZ IFAFAX IPSULF
JAWHOF JAZVEL10 JAZVIP10 JAZVOV10 JAZZOZ10 JEFPEQ KEFROC KIXHEF
KIXPIQ KUVFIR LAPNAT LAPPEZ LEFFAF LESZUG LISKUU MUWCUD
PEDBOR PEHWEF PILPIK PODQAB POWBUZ PUMPOD PYMSBZ11 QAKXUX
SEBPAQ SEQJUT SEQKEE SODGID SOJNEK SULPIA10 TELWAI UJIBEV
UJIBIZ UJIBOF VAWMOV VOHZIC VUXPUZ WACJIT WAWNAK WIGXIU
WIXGIV XETFAF YIKZUP ZAHBEP ZAPJAD ZEBYOW XAVKUB01 XAVKUB
DOPVIP GOMRUX MESXOX NARVUZ
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-7
BSAndashVLM
BSAndashCPR
4ClBSAndashCPR
4BrBSAndashCPR
SNAndashCPR
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-8
4ClBSAndashVLM
4BrBSAndashVLM
Figure S1 2D sheet like structure propagation of the catemer chain Synthon 1 in cocrystal structures
(a) 2ABSAndashCPR
(b) BSAndashAZL
Figure S2 Head to face packing thorugh dimer-cyclic ring motif Synthon 2 in cocrystals 2ABSAndashCPR
and BSAndashAZL
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-9
(a) OTSAndashVLM
(b) PTSAndashVLM
Figure S3 2D packing of OTSAndashVLM and PTSAndashVLM cocrystals in the bc-plane
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-10
Figure S4 Powder X-ray diffraction patterns of the 3D isostructural catemer synthon cocrystals pairs The
near identical PXRD lines support isostructurility and isomorphous nature of the structures
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-11
AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-12
DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
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NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
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2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
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UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
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XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
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4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
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BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
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2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
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2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
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Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-2
N1ndashH1BmiddotmiddotmiddotO3 210 2859(1) 170 1-x12+y 32-z
N2ndashH2AmiddotmiddotmiddotN1 249 3252(1) 148 1-x-12+y12-z
C2ndashH2middotmiddotmiddotO3 269 3406(2) 134 -x-12+y12-z
BSAndashAZL N1ndashH1AmiddotmiddotmiddotO3 212 2879(3) 158 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 203 2905(4) 169 12-x-12+y12-z
N2ndashH2AmiddotmiddotmiddotO3 218 2999(3) 168 1-x1-y-z
OTSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2857(2) 161 12-x-12+y12-z
N1ndashH1BmiddotmiddotmiddotO1 210 2988(2) 157 1+xyz
N2ndashH2AmiddotmiddotmiddotO3 209 2948(1) 175 1-x1-y1-z
PTSAndashVLM N1ndashH1AmiddotmiddotmiddotO1 226 3015(3) 163 1+xyz
N1ndashH1BmiddotmiddotmiddotO3 203 2886(3) 179 a
N2ndashH2AmiddotmiddotmiddotO3 215 2904(3) 176 -x1-y-z
SNAndashCPR N1ndashH1AmiddotmiddotmiddotO3 216 2902(5) 150 12-x-y-12+z
N1ndashH1BmiddotmiddotmiddotO3 196 2845(5) 164 -x12+y12-z
N2ndashH2AmiddotmiddotmiddotO1 241 3264(5) 166 1-x-12+y12-z
N2ndashH2BmiddotmiddotmiddotO2 226 2998(5) 142 -x-12+y12-z
N3ndashH3AmiddotmiddotmiddotN1 246 3240(5) 150 1-x-12+y12-z
C3ndashH3middotmiddotmiddotO2 257 3482(5) 168 1-x-12+y12-z
a Molecules in the same asymmetric unit
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Compound Interactions HmiddotmiddotmiddotA
Aring
DmiddotmiddotmiddotA Aring DndashHmiddotmiddotmiddotA ordm Symmetry
2ABSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 218(2) 2910(2) 159 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 196(2) 2855(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotO2 228 3108(2) 162 12+x12-y12+z
N2ndashH2BmiddotmiddotmiddotO1 218 2892(2) 140 Intermolecular
N3ndashH3AmiddotmiddotmiddotO3 213 2968(2) 165 1-x-y-z
2ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2829(3) 169 a
N1ndashH1BmiddotmiddotmiddotCl1 281 3295(2) 118 Intermolecular
N1ndashH1BmiddotmiddotmiddotO1 216 2922(2) 151 x12-y-12+z
N2ndashH2AmiddotmiddotmiddotO3 208 2939(3) 177 1-x-y1-z
C5ndashH5middotmiddotmiddotO2 253 3238(3) 133 -x-12+y12-z
2ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 197 2871(1) 176 a
N1ndashH1BmiddotmiddotmiddotO2 235 3088(1) 151 x12-y12+z
N2ndashH2AmiddotmiddotmiddotO3 204 2983(2) 175 1-x-y1-z
4BrBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 206 2866(4) 170 a
N1ndashH1BmiddotmiddotmiddotO3 200 2879(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotN1 250 3172(4) 154 12-x12+y12-z
4BrBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 196 2887(5) 169 -x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 231 2960(5) 159 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 258 3301(6) 144 1-x-12+y12-z
C5ndashH5middotmiddotmiddotO2 240 3151(5) 138 -1+xyz
4ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 208 2881(4) 164 12-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 204 2855(5) 172 a
N2ndashH2AmiddotmiddotmiddotN1 236 3153(5) 153 12-x12+y12-z
4ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 219 2908(1) 147 1-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 189 2850(1) 171 32-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 256 3285(2) 142 -y12+z
C3ndashH3middotmiddotmiddotO1 239 3145(1) 138 1+xyz
BSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 205 2890(1) 164 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 212 2908(2) 161 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 248 3270(1) 152 1+xyz
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BSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 204 2871(2) 159 12-x1-y frac12+z
N1ndashH1BmiddotmiddotmiddotO3 210 2859(1) 170 1-x12+y 32-z
N2ndashH2AmiddotmiddotmiddotN1 249 3252(1) 148 1-x-12+y12-z
C2ndashH2middotmiddotmiddotO3 269 3406(2) 134 -x-12+y12-z
BSAndashAZL N1ndashH1AmiddotmiddotmiddotO3 212 2879(3) 158 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 203 2905(4) 169 12-x-12+y12-z
N2ndashH2AmiddotmiddotmiddotO3 218 2999(3) 168 1-x1-y-z
OTSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2857(2) 161 12-x-12+y12-z
N1ndashH1BmiddotmiddotmiddotO1 210 2988(2) 157 1+xyz
N2ndashH2AmiddotmiddotmiddotO3 209 2948(1) 175 1-x1-y1-z
PTSAndashVLM N1ndashH1AmiddotmiddotmiddotO1 226 3015(3) 163 1+xyz
N1ndashH1BmiddotmiddotmiddotO3 203 2886(3) 179 a
N2ndashH2AmiddotmiddotmiddotO3 215 2904(3) 176 -x1-y-z
SNAndashCPR N1ndashH1AmiddotmiddotmiddotO3 216 2902(5) 150 12-x-y-12+z
N1ndashH1BmiddotmiddotmiddotO3 196 2845(5) 164 -x12+y12-z
N2ndashH2AmiddotmiddotmiddotO1 241 3264(5) 166 1-x-12+y12-z
N2ndashH2BmiddotmiddotmiddotO2 226 2998(5) 142 -x-12+y12-z
N3ndashH3AmiddotmiddotmiddotN1 246 3240(5) 150 1-x-12+y12-z
C3ndashH3middotmiddotmiddotO2 257 3482(5) 168 1-x-12+y12-z
a Moleculesions in the same asymmetric unit
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Table S2 Classification of primary sulfonamides based on synthons present and their CSD REFCODEs
Sulfonamides (220)
Alternative dimers (5)
PECTOI RIBQID VUSMEC WOBHUR ZEBYEM
Anti Catemer (50)
ADAGUI AFIMEJ AMEVAP AZADAH AZAGUE BAPYIB BAPYIB BIZPIK
BIZPOQ BSBTHP AZACOU CIVBAK10 DIBBUL DUCVED EWUHAF EXICIX
EXICIX FAVWIJ FAXZIO GEQYIK GODRUM HCSBTZ ICUTOR JEFNOY
JIGCUX KIKCUD KUSVEZ KUZWIM MESXIR PIMZAO POHYER PUFHUU
QUYKOL QUYRIM SODGID SULAMD03 SULTAM SULTAM01 ULIDOJ VUXPUZ
WEPMAH ZEBYOW BATNOB CAFVUA COYVER GOMSAE JEFPAM LAWKUP
NIWPAL OCAMUB
Dimer discrete (9)
AZADEL GUFQED IDIMOY JEFNAK KIXHEF RIHGOF TIGLOL VABFAH
XAVKUB
Continuous dimers (7)
AFONAM GUCMEW JABJAY PERQOT SETHEE USOBAG TIYXII
Finite catemers (7)
IFAXAX JAWHOF SEQJUT VOHZIC ZAPJAD ENIROI GOFYIL
Finite dimers (21)
CIKJAI CSBSMP EFOFAH EVAGUE GODSAT KIXHEF LAPNAT LAPPEZ
LISKUU MEWXAP MUWCUD SEBPAQ SEQKEE WACJIT WAWNAK XETFAF
ZAHBEP ATDZSA CEFMUX PODPUU LISLAB
Rings forms dimers (4)
AMAVIT AZADIP JEFPIU PODQEF
Syn Catemers (16)
CIKSIA CUDDEL ETOMUV GAQBUX HUCSUU JEFMUD JEFNIS LOMWIT
PAVBUL PODQAB PUMPOD PUMPUJ QUYTIO WAWMUD NIGNEY MOKMIJ
Tetramer rings (21)
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BUDYEF JABJEC JEFMAJ JEFNEO JEFNUE JEFPOA KIFZUV KUSVEZ
MESXUD MSULPH01 MUBVOV NIGNEY PERQEJ QISQOZ TIBPAW UJIBAR
WEBWUV ZZZULS01 DOLDIT EXICOD HUFVOU
Three point synthons (4)
ADAGUI FIYYES FOGVIG01 RIFVIM
Miscellaneous (76)
ADILOP AZAMEU BIXMUR BUFMAR CADTEG CANWIX CBSTHP CIKJAI
CIKSIA CIMKOA CSBSMP DOSDOE EFOFAH EVAGUE EVAWAA FUZXUU
GEVBAL GODSAT GOMKUP HABSOS HILRAW HSLSTZ IFAFAX IPSULF
JAWHOF JAZVEL10 JAZVIP10 JAZVOV10 JAZZOZ10 JEFPEQ KEFROC KIXHEF
KIXPIQ KUVFIR LAPNAT LAPPEZ LEFFAF LESZUG LISKUU MUWCUD
PEDBOR PEHWEF PILPIK PODQAB POWBUZ PUMPOD PYMSBZ11 QAKXUX
SEBPAQ SEQJUT SEQKEE SODGID SOJNEK SULPIA10 TELWAI UJIBEV
UJIBIZ UJIBOF VAWMOV VOHZIC VUXPUZ WACJIT WAWNAK WIGXIU
WIXGIV XETFAF YIKZUP ZAHBEP ZAPJAD ZEBYOW XAVKUB01 XAVKUB
DOPVIP GOMRUX MESXOX NARVUZ
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-7
BSAndashVLM
BSAndashCPR
4ClBSAndashCPR
4BrBSAndashCPR
SNAndashCPR
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-8
4ClBSAndashVLM
4BrBSAndashVLM
Figure S1 2D sheet like structure propagation of the catemer chain Synthon 1 in cocrystal structures
(a) 2ABSAndashCPR
(b) BSAndashAZL
Figure S2 Head to face packing thorugh dimer-cyclic ring motif Synthon 2 in cocrystals 2ABSAndashCPR
and BSAndashAZL
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-9
(a) OTSAndashVLM
(b) PTSAndashVLM
Figure S3 2D packing of OTSAndashVLM and PTSAndashVLM cocrystals in the bc-plane
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-10
Figure S4 Powder X-ray diffraction patterns of the 3D isostructural catemer synthon cocrystals pairs The
near identical PXRD lines support isostructurility and isomorphous nature of the structures
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-11
AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-12
DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-13
NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
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XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
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BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
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2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
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2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
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2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
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Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
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Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-3
Compound Interactions HmiddotmiddotmiddotA
Aring
DmiddotmiddotmiddotA Aring DndashHmiddotmiddotmiddotA ordm Symmetry
2ABSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 218(2) 2910(2) 159 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 196(2) 2855(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotO2 228 3108(2) 162 12+x12-y12+z
N2ndashH2BmiddotmiddotmiddotO1 218 2892(2) 140 Intermolecular
N3ndashH3AmiddotmiddotmiddotO3 213 2968(2) 165 1-x-y-z
2ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2829(3) 169 a
N1ndashH1BmiddotmiddotmiddotCl1 281 3295(2) 118 Intermolecular
N1ndashH1BmiddotmiddotmiddotO1 216 2922(2) 151 x12-y-12+z
N2ndashH2AmiddotmiddotmiddotO3 208 2939(3) 177 1-x-y1-z
C5ndashH5middotmiddotmiddotO2 253 3238(3) 133 -x-12+y12-z
2ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 197 2871(1) 176 a
N1ndashH1BmiddotmiddotmiddotO2 235 3088(1) 151 x12-y12+z
N2ndashH2AmiddotmiddotmiddotO3 204 2983(2) 175 1-x-y1-z
4BrBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 206 2866(4) 170 a
N1ndashH1BmiddotmiddotmiddotO3 200 2879(3) 171 12-x12+y12-z
N2ndashH2AmiddotmiddotmiddotN1 250 3172(4) 154 12-x12+y12-z
4BrBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 196 2887(5) 169 -x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 231 2960(5) 159 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 258 3301(6) 144 1-x-12+y12-z
C5ndashH5middotmiddotmiddotO2 240 3151(5) 138 -1+xyz
4ClBSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 208 2881(4) 164 12-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 204 2855(5) 172 a
N2ndashH2AmiddotmiddotmiddotN1 236 3153(5) 153 12-x12+y12-z
4ClBSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 219 2908(1) 147 1-x12+y12-z
N1ndashH1BmiddotmiddotmiddotO3 189 2850(1) 171 32-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 256 3285(2) 142 -y12+z
C3ndashH3middotmiddotmiddotO1 239 3145(1) 138 1+xyz
BSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 205 2890(1) 164 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 212 2908(2) 161 12-x-y-12+z
N2ndashH2AmiddotmiddotmiddotN1 248 3270(1) 152 1+xyz
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BSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 204 2871(2) 159 12-x1-y frac12+z
N1ndashH1BmiddotmiddotmiddotO3 210 2859(1) 170 1-x12+y 32-z
N2ndashH2AmiddotmiddotmiddotN1 249 3252(1) 148 1-x-12+y12-z
C2ndashH2middotmiddotmiddotO3 269 3406(2) 134 -x-12+y12-z
BSAndashAZL N1ndashH1AmiddotmiddotmiddotO3 212 2879(3) 158 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 203 2905(4) 169 12-x-12+y12-z
N2ndashH2AmiddotmiddotmiddotO3 218 2999(3) 168 1-x1-y-z
OTSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2857(2) 161 12-x-12+y12-z
N1ndashH1BmiddotmiddotmiddotO1 210 2988(2) 157 1+xyz
N2ndashH2AmiddotmiddotmiddotO3 209 2948(1) 175 1-x1-y1-z
PTSAndashVLM N1ndashH1AmiddotmiddotmiddotO1 226 3015(3) 163 1+xyz
N1ndashH1BmiddotmiddotmiddotO3 203 2886(3) 179 a
N2ndashH2AmiddotmiddotmiddotO3 215 2904(3) 176 -x1-y-z
SNAndashCPR N1ndashH1AmiddotmiddotmiddotO3 216 2902(5) 150 12-x-y-12+z
N1ndashH1BmiddotmiddotmiddotO3 196 2845(5) 164 -x12+y12-z
N2ndashH2AmiddotmiddotmiddotO1 241 3264(5) 166 1-x-12+y12-z
N2ndashH2BmiddotmiddotmiddotO2 226 2998(5) 142 -x-12+y12-z
N3ndashH3AmiddotmiddotmiddotN1 246 3240(5) 150 1-x-12+y12-z
C3ndashH3middotmiddotmiddotO2 257 3482(5) 168 1-x-12+y12-z
a Moleculesions in the same asymmetric unit
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Table S2 Classification of primary sulfonamides based on synthons present and their CSD REFCODEs
Sulfonamides (220)
Alternative dimers (5)
PECTOI RIBQID VUSMEC WOBHUR ZEBYEM
Anti Catemer (50)
ADAGUI AFIMEJ AMEVAP AZADAH AZAGUE BAPYIB BAPYIB BIZPIK
BIZPOQ BSBTHP AZACOU CIVBAK10 DIBBUL DUCVED EWUHAF EXICIX
EXICIX FAVWIJ FAXZIO GEQYIK GODRUM HCSBTZ ICUTOR JEFNOY
JIGCUX KIKCUD KUSVEZ KUZWIM MESXIR PIMZAO POHYER PUFHUU
QUYKOL QUYRIM SODGID SULAMD03 SULTAM SULTAM01 ULIDOJ VUXPUZ
WEPMAH ZEBYOW BATNOB CAFVUA COYVER GOMSAE JEFPAM LAWKUP
NIWPAL OCAMUB
Dimer discrete (9)
AZADEL GUFQED IDIMOY JEFNAK KIXHEF RIHGOF TIGLOL VABFAH
XAVKUB
Continuous dimers (7)
AFONAM GUCMEW JABJAY PERQOT SETHEE USOBAG TIYXII
Finite catemers (7)
IFAXAX JAWHOF SEQJUT VOHZIC ZAPJAD ENIROI GOFYIL
Finite dimers (21)
CIKJAI CSBSMP EFOFAH EVAGUE GODSAT KIXHEF LAPNAT LAPPEZ
LISKUU MEWXAP MUWCUD SEBPAQ SEQKEE WACJIT WAWNAK XETFAF
ZAHBEP ATDZSA CEFMUX PODPUU LISLAB
Rings forms dimers (4)
AMAVIT AZADIP JEFPIU PODQEF
Syn Catemers (16)
CIKSIA CUDDEL ETOMUV GAQBUX HUCSUU JEFMUD JEFNIS LOMWIT
PAVBUL PODQAB PUMPOD PUMPUJ QUYTIO WAWMUD NIGNEY MOKMIJ
Tetramer rings (21)
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BUDYEF JABJEC JEFMAJ JEFNEO JEFNUE JEFPOA KIFZUV KUSVEZ
MESXUD MSULPH01 MUBVOV NIGNEY PERQEJ QISQOZ TIBPAW UJIBAR
WEBWUV ZZZULS01 DOLDIT EXICOD HUFVOU
Three point synthons (4)
ADAGUI FIYYES FOGVIG01 RIFVIM
Miscellaneous (76)
ADILOP AZAMEU BIXMUR BUFMAR CADTEG CANWIX CBSTHP CIKJAI
CIKSIA CIMKOA CSBSMP DOSDOE EFOFAH EVAGUE EVAWAA FUZXUU
GEVBAL GODSAT GOMKUP HABSOS HILRAW HSLSTZ IFAFAX IPSULF
JAWHOF JAZVEL10 JAZVIP10 JAZVOV10 JAZZOZ10 JEFPEQ KEFROC KIXHEF
KIXPIQ KUVFIR LAPNAT LAPPEZ LEFFAF LESZUG LISKUU MUWCUD
PEDBOR PEHWEF PILPIK PODQAB POWBUZ PUMPOD PYMSBZ11 QAKXUX
SEBPAQ SEQJUT SEQKEE SODGID SOJNEK SULPIA10 TELWAI UJIBEV
UJIBIZ UJIBOF VAWMOV VOHZIC VUXPUZ WACJIT WAWNAK WIGXIU
WIXGIV XETFAF YIKZUP ZAHBEP ZAPJAD ZEBYOW XAVKUB01 XAVKUB
DOPVIP GOMRUX MESXOX NARVUZ
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BSAndashVLM
BSAndashCPR
4ClBSAndashCPR
4BrBSAndashCPR
SNAndashCPR
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4ClBSAndashVLM
4BrBSAndashVLM
Figure S1 2D sheet like structure propagation of the catemer chain Synthon 1 in cocrystal structures
(a) 2ABSAndashCPR
(b) BSAndashAZL
Figure S2 Head to face packing thorugh dimer-cyclic ring motif Synthon 2 in cocrystals 2ABSAndashCPR
and BSAndashAZL
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(a) OTSAndashVLM
(b) PTSAndashVLM
Figure S3 2D packing of OTSAndashVLM and PTSAndashVLM cocrystals in the bc-plane
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Figure S4 Powder X-ray diffraction patterns of the 3D isostructural catemer synthon cocrystals pairs The
near identical PXRD lines support isostructurility and isomorphous nature of the structures
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-11
AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
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DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
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NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
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2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
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UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
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XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
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4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
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BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-4
BSAndashCPR N1ndashH1AmiddotmiddotmiddotO3 204 2871(2) 159 12-x1-y frac12+z
N1ndashH1BmiddotmiddotmiddotO3 210 2859(1) 170 1-x12+y 32-z
N2ndashH2AmiddotmiddotmiddotN1 249 3252(1) 148 1-x-12+y12-z
C2ndashH2middotmiddotmiddotO3 269 3406(2) 134 -x-12+y12-z
BSAndashAZL N1ndashH1AmiddotmiddotmiddotO3 212 2879(3) 158 12+x12-y12+z
N1ndashH1BmiddotmiddotmiddotO3 203 2905(4) 169 12-x-12+y12-z
N2ndashH2AmiddotmiddotmiddotO3 218 2999(3) 168 1-x1-y-z
OTSAndashVLM N1ndashH1AmiddotmiddotmiddotO3 203 2857(2) 161 12-x-12+y12-z
N1ndashH1BmiddotmiddotmiddotO1 210 2988(2) 157 1+xyz
N2ndashH2AmiddotmiddotmiddotO3 209 2948(1) 175 1-x1-y1-z
PTSAndashVLM N1ndashH1AmiddotmiddotmiddotO1 226 3015(3) 163 1+xyz
N1ndashH1BmiddotmiddotmiddotO3 203 2886(3) 179 a
N2ndashH2AmiddotmiddotmiddotO3 215 2904(3) 176 -x1-y-z
SNAndashCPR N1ndashH1AmiddotmiddotmiddotO3 216 2902(5) 150 12-x-y-12+z
N1ndashH1BmiddotmiddotmiddotO3 196 2845(5) 164 -x12+y12-z
N2ndashH2AmiddotmiddotmiddotO1 241 3264(5) 166 1-x-12+y12-z
N2ndashH2BmiddotmiddotmiddotO2 226 2998(5) 142 -x-12+y12-z
N3ndashH3AmiddotmiddotmiddotN1 246 3240(5) 150 1-x-12+y12-z
C3ndashH3middotmiddotmiddotO2 257 3482(5) 168 1-x-12+y12-z
a Moleculesions in the same asymmetric unit
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-5
Table S2 Classification of primary sulfonamides based on synthons present and their CSD REFCODEs
Sulfonamides (220)
Alternative dimers (5)
PECTOI RIBQID VUSMEC WOBHUR ZEBYEM
Anti Catemer (50)
ADAGUI AFIMEJ AMEVAP AZADAH AZAGUE BAPYIB BAPYIB BIZPIK
BIZPOQ BSBTHP AZACOU CIVBAK10 DIBBUL DUCVED EWUHAF EXICIX
EXICIX FAVWIJ FAXZIO GEQYIK GODRUM HCSBTZ ICUTOR JEFNOY
JIGCUX KIKCUD KUSVEZ KUZWIM MESXIR PIMZAO POHYER PUFHUU
QUYKOL QUYRIM SODGID SULAMD03 SULTAM SULTAM01 ULIDOJ VUXPUZ
WEPMAH ZEBYOW BATNOB CAFVUA COYVER GOMSAE JEFPAM LAWKUP
NIWPAL OCAMUB
Dimer discrete (9)
AZADEL GUFQED IDIMOY JEFNAK KIXHEF RIHGOF TIGLOL VABFAH
XAVKUB
Continuous dimers (7)
AFONAM GUCMEW JABJAY PERQOT SETHEE USOBAG TIYXII
Finite catemers (7)
IFAXAX JAWHOF SEQJUT VOHZIC ZAPJAD ENIROI GOFYIL
Finite dimers (21)
CIKJAI CSBSMP EFOFAH EVAGUE GODSAT KIXHEF LAPNAT LAPPEZ
LISKUU MEWXAP MUWCUD SEBPAQ SEQKEE WACJIT WAWNAK XETFAF
ZAHBEP ATDZSA CEFMUX PODPUU LISLAB
Rings forms dimers (4)
AMAVIT AZADIP JEFPIU PODQEF
Syn Catemers (16)
CIKSIA CUDDEL ETOMUV GAQBUX HUCSUU JEFMUD JEFNIS LOMWIT
PAVBUL PODQAB PUMPOD PUMPUJ QUYTIO WAWMUD NIGNEY MOKMIJ
Tetramer rings (21)
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-6
BUDYEF JABJEC JEFMAJ JEFNEO JEFNUE JEFPOA KIFZUV KUSVEZ
MESXUD MSULPH01 MUBVOV NIGNEY PERQEJ QISQOZ TIBPAW UJIBAR
WEBWUV ZZZULS01 DOLDIT EXICOD HUFVOU
Three point synthons (4)
ADAGUI FIYYES FOGVIG01 RIFVIM
Miscellaneous (76)
ADILOP AZAMEU BIXMUR BUFMAR CADTEG CANWIX CBSTHP CIKJAI
CIKSIA CIMKOA CSBSMP DOSDOE EFOFAH EVAGUE EVAWAA FUZXUU
GEVBAL GODSAT GOMKUP HABSOS HILRAW HSLSTZ IFAFAX IPSULF
JAWHOF JAZVEL10 JAZVIP10 JAZVOV10 JAZZOZ10 JEFPEQ KEFROC KIXHEF
KIXPIQ KUVFIR LAPNAT LAPPEZ LEFFAF LESZUG LISKUU MUWCUD
PEDBOR PEHWEF PILPIK PODQAB POWBUZ PUMPOD PYMSBZ11 QAKXUX
SEBPAQ SEQJUT SEQKEE SODGID SOJNEK SULPIA10 TELWAI UJIBEV
UJIBIZ UJIBOF VAWMOV VOHZIC VUXPUZ WACJIT WAWNAK WIGXIU
WIXGIV XETFAF YIKZUP ZAHBEP ZAPJAD ZEBYOW XAVKUB01 XAVKUB
DOPVIP GOMRUX MESXOX NARVUZ
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-7
BSAndashVLM
BSAndashCPR
4ClBSAndashCPR
4BrBSAndashCPR
SNAndashCPR
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-8
4ClBSAndashVLM
4BrBSAndashVLM
Figure S1 2D sheet like structure propagation of the catemer chain Synthon 1 in cocrystal structures
(a) 2ABSAndashCPR
(b) BSAndashAZL
Figure S2 Head to face packing thorugh dimer-cyclic ring motif Synthon 2 in cocrystals 2ABSAndashCPR
and BSAndashAZL
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-9
(a) OTSAndashVLM
(b) PTSAndashVLM
Figure S3 2D packing of OTSAndashVLM and PTSAndashVLM cocrystals in the bc-plane
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-10
Figure S4 Powder X-ray diffraction patterns of the 3D isostructural catemer synthon cocrystals pairs The
near identical PXRD lines support isostructurility and isomorphous nature of the structures
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-11
AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-12
DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-13
NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-5
Table S2 Classification of primary sulfonamides based on synthons present and their CSD REFCODEs
Sulfonamides (220)
Alternative dimers (5)
PECTOI RIBQID VUSMEC WOBHUR ZEBYEM
Anti Catemer (50)
ADAGUI AFIMEJ AMEVAP AZADAH AZAGUE BAPYIB BAPYIB BIZPIK
BIZPOQ BSBTHP AZACOU CIVBAK10 DIBBUL DUCVED EWUHAF EXICIX
EXICIX FAVWIJ FAXZIO GEQYIK GODRUM HCSBTZ ICUTOR JEFNOY
JIGCUX KIKCUD KUSVEZ KUZWIM MESXIR PIMZAO POHYER PUFHUU
QUYKOL QUYRIM SODGID SULAMD03 SULTAM SULTAM01 ULIDOJ VUXPUZ
WEPMAH ZEBYOW BATNOB CAFVUA COYVER GOMSAE JEFPAM LAWKUP
NIWPAL OCAMUB
Dimer discrete (9)
AZADEL GUFQED IDIMOY JEFNAK KIXHEF RIHGOF TIGLOL VABFAH
XAVKUB
Continuous dimers (7)
AFONAM GUCMEW JABJAY PERQOT SETHEE USOBAG TIYXII
Finite catemers (7)
IFAXAX JAWHOF SEQJUT VOHZIC ZAPJAD ENIROI GOFYIL
Finite dimers (21)
CIKJAI CSBSMP EFOFAH EVAGUE GODSAT KIXHEF LAPNAT LAPPEZ
LISKUU MEWXAP MUWCUD SEBPAQ SEQKEE WACJIT WAWNAK XETFAF
ZAHBEP ATDZSA CEFMUX PODPUU LISLAB
Rings forms dimers (4)
AMAVIT AZADIP JEFPIU PODQEF
Syn Catemers (16)
CIKSIA CUDDEL ETOMUV GAQBUX HUCSUU JEFMUD JEFNIS LOMWIT
PAVBUL PODQAB PUMPOD PUMPUJ QUYTIO WAWMUD NIGNEY MOKMIJ
Tetramer rings (21)
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-6
BUDYEF JABJEC JEFMAJ JEFNEO JEFNUE JEFPOA KIFZUV KUSVEZ
MESXUD MSULPH01 MUBVOV NIGNEY PERQEJ QISQOZ TIBPAW UJIBAR
WEBWUV ZZZULS01 DOLDIT EXICOD HUFVOU
Three point synthons (4)
ADAGUI FIYYES FOGVIG01 RIFVIM
Miscellaneous (76)
ADILOP AZAMEU BIXMUR BUFMAR CADTEG CANWIX CBSTHP CIKJAI
CIKSIA CIMKOA CSBSMP DOSDOE EFOFAH EVAGUE EVAWAA FUZXUU
GEVBAL GODSAT GOMKUP HABSOS HILRAW HSLSTZ IFAFAX IPSULF
JAWHOF JAZVEL10 JAZVIP10 JAZVOV10 JAZZOZ10 JEFPEQ KEFROC KIXHEF
KIXPIQ KUVFIR LAPNAT LAPPEZ LEFFAF LESZUG LISKUU MUWCUD
PEDBOR PEHWEF PILPIK PODQAB POWBUZ PUMPOD PYMSBZ11 QAKXUX
SEBPAQ SEQJUT SEQKEE SODGID SOJNEK SULPIA10 TELWAI UJIBEV
UJIBIZ UJIBOF VAWMOV VOHZIC VUXPUZ WACJIT WAWNAK WIGXIU
WIXGIV XETFAF YIKZUP ZAHBEP ZAPJAD ZEBYOW XAVKUB01 XAVKUB
DOPVIP GOMRUX MESXOX NARVUZ
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-7
BSAndashVLM
BSAndashCPR
4ClBSAndashCPR
4BrBSAndashCPR
SNAndashCPR
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-8
4ClBSAndashVLM
4BrBSAndashVLM
Figure S1 2D sheet like structure propagation of the catemer chain Synthon 1 in cocrystal structures
(a) 2ABSAndashCPR
(b) BSAndashAZL
Figure S2 Head to face packing thorugh dimer-cyclic ring motif Synthon 2 in cocrystals 2ABSAndashCPR
and BSAndashAZL
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-9
(a) OTSAndashVLM
(b) PTSAndashVLM
Figure S3 2D packing of OTSAndashVLM and PTSAndashVLM cocrystals in the bc-plane
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-10
Figure S4 Powder X-ray diffraction patterns of the 3D isostructural catemer synthon cocrystals pairs The
near identical PXRD lines support isostructurility and isomorphous nature of the structures
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-11
AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-12
DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-13
NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-6
BUDYEF JABJEC JEFMAJ JEFNEO JEFNUE JEFPOA KIFZUV KUSVEZ
MESXUD MSULPH01 MUBVOV NIGNEY PERQEJ QISQOZ TIBPAW UJIBAR
WEBWUV ZZZULS01 DOLDIT EXICOD HUFVOU
Three point synthons (4)
ADAGUI FIYYES FOGVIG01 RIFVIM
Miscellaneous (76)
ADILOP AZAMEU BIXMUR BUFMAR CADTEG CANWIX CBSTHP CIKJAI
CIKSIA CIMKOA CSBSMP DOSDOE EFOFAH EVAGUE EVAWAA FUZXUU
GEVBAL GODSAT GOMKUP HABSOS HILRAW HSLSTZ IFAFAX IPSULF
JAWHOF JAZVEL10 JAZVIP10 JAZVOV10 JAZZOZ10 JEFPEQ KEFROC KIXHEF
KIXPIQ KUVFIR LAPNAT LAPPEZ LEFFAF LESZUG LISKUU MUWCUD
PEDBOR PEHWEF PILPIK PODQAB POWBUZ PUMPOD PYMSBZ11 QAKXUX
SEBPAQ SEQJUT SEQKEE SODGID SOJNEK SULPIA10 TELWAI UJIBEV
UJIBIZ UJIBOF VAWMOV VOHZIC VUXPUZ WACJIT WAWNAK WIGXIU
WIXGIV XETFAF YIKZUP ZAHBEP ZAPJAD ZEBYOW XAVKUB01 XAVKUB
DOPVIP GOMRUX MESXOX NARVUZ
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-7
BSAndashVLM
BSAndashCPR
4ClBSAndashCPR
4BrBSAndashCPR
SNAndashCPR
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-8
4ClBSAndashVLM
4BrBSAndashVLM
Figure S1 2D sheet like structure propagation of the catemer chain Synthon 1 in cocrystal structures
(a) 2ABSAndashCPR
(b) BSAndashAZL
Figure S2 Head to face packing thorugh dimer-cyclic ring motif Synthon 2 in cocrystals 2ABSAndashCPR
and BSAndashAZL
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-9
(a) OTSAndashVLM
(b) PTSAndashVLM
Figure S3 2D packing of OTSAndashVLM and PTSAndashVLM cocrystals in the bc-plane
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-10
Figure S4 Powder X-ray diffraction patterns of the 3D isostructural catemer synthon cocrystals pairs The
near identical PXRD lines support isostructurility and isomorphous nature of the structures
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-11
AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-12
DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-13
NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-7
BSAndashVLM
BSAndashCPR
4ClBSAndashCPR
4BrBSAndashCPR
SNAndashCPR
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-8
4ClBSAndashVLM
4BrBSAndashVLM
Figure S1 2D sheet like structure propagation of the catemer chain Synthon 1 in cocrystal structures
(a) 2ABSAndashCPR
(b) BSAndashAZL
Figure S2 Head to face packing thorugh dimer-cyclic ring motif Synthon 2 in cocrystals 2ABSAndashCPR
and BSAndashAZL
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-9
(a) OTSAndashVLM
(b) PTSAndashVLM
Figure S3 2D packing of OTSAndashVLM and PTSAndashVLM cocrystals in the bc-plane
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-10
Figure S4 Powder X-ray diffraction patterns of the 3D isostructural catemer synthon cocrystals pairs The
near identical PXRD lines support isostructurility and isomorphous nature of the structures
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-11
AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-12
DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-13
NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-8
4ClBSAndashVLM
4BrBSAndashVLM
Figure S1 2D sheet like structure propagation of the catemer chain Synthon 1 in cocrystal structures
(a) 2ABSAndashCPR
(b) BSAndashAZL
Figure S2 Head to face packing thorugh dimer-cyclic ring motif Synthon 2 in cocrystals 2ABSAndashCPR
and BSAndashAZL
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-9
(a) OTSAndashVLM
(b) PTSAndashVLM
Figure S3 2D packing of OTSAndashVLM and PTSAndashVLM cocrystals in the bc-plane
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-10
Figure S4 Powder X-ray diffraction patterns of the 3D isostructural catemer synthon cocrystals pairs The
near identical PXRD lines support isostructurility and isomorphous nature of the structures
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-11
AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-12
DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-13
NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-9
(a) OTSAndashVLM
(b) PTSAndashVLM
Figure S3 2D packing of OTSAndashVLM and PTSAndashVLM cocrystals in the bc-plane
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-10
Figure S4 Powder X-ray diffraction patterns of the 3D isostructural catemer synthon cocrystals pairs The
near identical PXRD lines support isostructurility and isomorphous nature of the structures
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-11
AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-12
DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-13
NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-10
Figure S4 Powder X-ray diffraction patterns of the 3D isostructural catemer synthon cocrystals pairs The
near identical PXRD lines support isostructurility and isomorphous nature of the structures
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-11
AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-12
DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-13
NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-11
AQUFEY
NndashHmiddotmiddotmiddotO
BEYZEM
NndashHmiddotmiddotmiddotO
DATFAH
NndashHmiddotmiddotmiddotO
FEFYAS
NndashHmiddotmiddotmiddotO
HSLSTZ
NndashHmiddotmiddotmiddotO
IWERIM
SO2NH2middotmiddotmiddotN-oxide
IWERUY
SO2NH2middotmiddotmiddotN-oxide
IWERAE
SO2NH2middotmiddotmiddotN-oxide
IWEQEX
SO2NH2middotmiddotmiddotN-oxide
IWEREI
SO2NH2middotmiddotmiddotN-oxide
IWEROS
SO2NH2middotmiddotmiddotN-oxide
DATFEL
NndashHmiddotmiddotmiddotO
SANAPY
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-12
DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-13
NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-12
DATFIP
NndashHmiddotmiddotmiddotO
RUYGIC
NndashHmiddotmiddotmiddotO
STHSAM01
NndashHmiddotmiddotmiddotO
NndashHmiddotmiddotmiddotO
JACWEL
SO2NH2middotmiddotmiddotP-oxide
JAYCAN
SO2NH2middotmiddotmiddotAs-oxide
LIQPUY
NndashHmiddotmiddotmiddotO
LIQQIN
NndashHmiddotmiddotmiddotO
LIQQEJ
NndashHmiddotmiddotmiddotO
LIQQAF
NndashHmiddotmiddotmiddotO
LOFLAV
NndashHmiddotmiddotmiddotO
LOFLEZ
NndashHmiddotmiddotmiddotO
LOFLID
NndashHmiddotmiddotmiddotO
MUPPIX
NndashHmiddotmiddotmiddotO
NARWAG
NndashHmiddotmiddotmiddotO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-13
NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-13
NETDIZ
NndashHmiddotmiddotmiddotOndash
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXUL
NndashHmiddotmiddotmiddotO
VIGDAR
NndashHmiddotmiddotmiddotO
VOMMUF
NndashHmiddotmiddotmiddotN
XAVTEV
NndashHmiddotmiddotmiddotO
(a)
ADECIW
SO2NH2middotmiddotmiddotN-oxide
AGOKUC
NndashHmiddotmiddotmiddotO
EXANEX
2-amino-PymiddotmiddotmiddotCOOH
EXANAT
2-amino-PymiddotmiddotmiddotCOOH
EXANIB
EXANOH
EXANUN
FEVKUO
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-14
2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH 2-amino-PymiddotmiddotmiddotCOOH
EXAPAV
2-amino-PymiddotmiddotmiddotCONH
EXAPID
2-amino-PymiddotmiddotmiddotCONH
EXAPUP
2-amino-PymiddotmiddotmiddotCOOH
EXAPUZ
2-amino-PymiddotmiddotmiddotCOOH
HOCCOT
NndashHmiddotmiddotmiddotN
HOCCUZ
NndashHmiddotmiddotmiddotN
HORNEI
NndashHmiddotmiddotmiddotO
OTESAI
NndashHmiddotmiddotmiddotO
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
PIRLUZ
NndashHmiddotmiddotmiddotO
PIRXOF
NndashHmiddotmiddotmiddotO
PIRQUL
2-amino-PymiddotmiddotmiddotCOOH
RILQUA
2-amino-PymiddotmiddotmiddotCOOH
SACCAF
NndashHmiddotmiddotmiddotO
SMZPMP
2-amino-Pymiddotmiddotmiddothetrocylic N
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-15
UFERED
UNEZAO01
Amide dimer type
VIGFOH
SO2NH2middotmiddotmiddotN-oxide
VUGMIT
2-amino-PymiddotmiddotmiddotCOOH
VUGMOJ
2-amino-PymiddotmiddotmiddotCOOH
VUHFIO
NndashHmiddotmiddotmiddotO
YANNEH
NndashHmiddotmiddotmiddotO
YESKIR
NndashHmiddotmiddotmiddotO
SORWEB
2-amino-PymiddotmiddotmiddotCOOH
SORWIF
2-amino-PymiddotmiddotmiddotCOOH
PAVKUU
2-amino-PymiddotmiddotmiddotCOOH
SABDOQ
2-amino-PymiddotmiddotmiddotCOOH
WXAMUM
2-amino-PymiddotmiddotmiddotCOOH
XEXCIE
2-amino-PymiddotmiddotmiddotCOOH
XOBCOH
2-amino-PymiddotmiddotmiddotCOOH
YIZQAA
2-amino-PymiddotmiddotmiddotCONH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-16
XEXCAE
2-amino-PymiddotmiddotmiddotCOOH
HOCCEJ
NndashHmiddotmiddotmiddotN
SACCAF01
NndashHmiddotmiddotmiddotN
ZIMHIO01
NndashHmiddotmiddotmiddotO
(b)
BSA catemer chains forms rings
OTSA results ring motifs
PTSA catemer chains forms rings
2ABSA catemer chains forms rings
2ClBSA catemer chains forms rings
4ClBSA catemer chains forms rings
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-17
4BRBSA catemer chains forms rings
SNA-form I catemer chains forms
rings
SNA form II dimer and
discrete H bond
SNA Form III dimer followed by dimer
VLM lactam hydrate
CPR dimer synthon
AZL shows catemer synthon
(c)
Figure S5 (a) Reported primary sulfonamides cocrystal along with their Refcodes and interactions
presented with coformers (b) Secondary sulfonamides cocrystals along with their Refcodes and interactions
presented with coformers (c) All the sulfonamides as well as coformers crystals structures along with their
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-18
synthons reported in CSD database The trend is that most of the sulfonamide structuress are contains
catemer chains
Table S3 The percentage of intermolecular interactions present in cocrystal structures from Hirshfeld
surface analysis
Cocrystal NhellipH OhellipH XhellipH ChellipH Others
2ABSAndashCPR 43 293 ----- 129 535
2ClBSAndashVLM 28 256 117 57 542
2ClBSAndashCPR 29 318 110 88 455
4BrBSAndashVLM 43 299 135 25 498
4BrBSAndashCPR 26 271 127 124 452
4ClBSAndashVLM 34 294 124 64 484
4ClBSAndashCPR 21 271 123 125 460
BSAndashVLM 35 324 --- 127 514
BSAndashCPR 36 345 ----- 101 518
BSAndashAZL 23 327 ---- 123 527
OTSAndashVLM 42 276 ---- 88 594
PTSAndashVLM 44 310 ---- 76 570
SNAndashCPR 52 299 112 537
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-19
BSAndashVLM All
BSAndashVLM OH
BSAndashVLM CH
BSAndashVLM NH
BSAndashCPR All
BSAndashCPR OH
BSAndashCPR CH
BSAndashCPR NH
4ClBSAndashCPR All
4ClBSAndashCPR OH
4ClBSAndashCPR CH
4ClBSAndashCPR NH
SNAndashCPR All
SNAndashCPR OH
SNAndashCPR CH
SNAndashCPR NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-20
2ClBSAndashVLM All
2ClBSAndash VLM OH
2ClBSAndash VLM CH
2ClBSAndash VLM NH
2BrBSAndashVLM All
2BrBSAndashVLM OH
2BrBSAndashVLM CH
2BrBSAndashVLM NH
2ABSAndashCPR All
2ABSAndashCPR OH
2ABSAndashCPR CH
2ABSAndashCPR NH
BSAndashAZL All
BSAndashAZL OH
BSAndashAZL CH
BSAndashAZL NH
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-21
2ClBSAndashVLM All
2ClBSAndashVLM OH
2ClBSAndashVLM CH
2ClBSAndashVLM NH
2ClBSAndashCPR All
2ClBSAndashCPR OH
2ClBSAndashCPR CH
2ClBSAndashCPR NH
PTSAndashVLM All
PTSAndashVLM OH
PTSAndashVLM CH
PTSAndashVLM NH
OTSAndashVLM All
OTSAndashVLM OH
OTSAndashVLM CH
OTSAndashVLM NH
Figure S6 Hirshfeld 2D finger print plots of the interactions present in sulfonamide-lactam cocrystals
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-22
Figure S7 Percentage intermolecular contacts contributions to the Hirshfeld surface area in sulfonamide-
lactam cocrystals
Analysis of sulfonamide cocrystals by Vibrational Spectroscopy FT-IR spectroscopy is one of the
prominent analytical methods for studying polymorphscocrystals in solid state chemistry Hypsochromic
bathochromic shift of the vibrational frequency values for the ground adducts with starting individuals
confirm new product formation Broad NndashH stretching vibrations for sulfonamides and lactams are observed
in the range 3490ndash3330 cm-1 respectively due to intermolecular hydrogen bonding Asymmetric and
symmetric S=O stretching vibrations appear as strong absorption peaks in the range 1344ndash1305 cm-1 and
1178ndash1144 cm-1 see Table S4 All the spectra comparisons for sulfonamide cocrystals were kept in Figure
S7 SI
Table S4 IR frequency (cmndash1) of sulfonamide-lactam cocrystals
Singlebinary
components
S=O asymsym
stretch (cmndash1)
NndashH stretch
(cmndash1)
NndashH bend
(cmndash1)
C=O stretch
(cmndash1)
BSA 1334111595 33552 14804 -----
BSAndashVLM 1334211559 33525 14990 16347
BSAndashCPR 1332911606 33521 14817 16490
BSAndashAZL 1344111615 32923 14475 16303
2ClBSA 1333211775 33551 14532 -----
2ClBSAndashVLM 1338011597 33572 14532 16514
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-23
2ClBSAndashCPR 1326411575 33483 14875 16447
4BrBSA 1328011482 33311 14699 -----
4BrBSAndashVLM 1349211658 33310 14687 16210
4BrBSAndashCPR 1335511600 33702 14881 16286
4ClBSA 1331711513 33345 14750 -----
4ClBSAndashVLM 1348411627 33288 14685 16228
4ClBSAndashCPR 1341111787 33675 14767 16313
2ABSA 1308311444 34813 14799 -----
2ABSAndashCPR 1312211402 34529 14809 16440
OTSA 1316311487 33905 14723 -----
OTSAndashVLM 1337011610 33802 14761 16639
PTSA 1323911503 ----- 14957 -----
PTSAndashVLM 1340211565 32963 15003 16593
SNA 1313811461 34781 15040 -----
SNAndashCPR 1309511456 34657 ----- 16360
VLM ----- 32732 14975 16324
CPR ----- 34299 14872 16360
AZL ----- ----- 14757 16599
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-24
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-25
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-26
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-27
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-28
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-29
Figure S8 IR spectra of all sulfopnamidendashlactam cocrystals along with starting materials
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-30
Furosemide-Isonicotinamide (11)
Furosemide-Isonicotinamide (21)
Furosemide-Nicotinamide (IV)
Furosemide-Nicotinamide (III)
Hydrochlorothiazide-Isonicotinamide
Hydrochlorothiazide-Nicotinamide
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database
IUCrJ (2015) 2 doi101107S2052252515004960 Supporting information sup-31
Hydrochlorothiazide-succinamide
Acetazolamide-Picolinamide
Celecoxib-Nicotinamide
Sulfonamide-2Pyridone
Figure S9 2D Packing visualization of the primary sulfonamides with amide coformers reported with
sulfonamide-carboxamide heterosynthon in the CSD database